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公开(公告)号：US06599699B1
公开(公告)日：2003-07-29
申请号：US09312464
申请日：1999-05-17
IPC分类号： C12Q168
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , C07K14/4748
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Uses of these materials in therapeutic and diagnostic contexts are also a part of the invention.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体MAGE-3的核酸分子。 还公开了利用核酸分子和任选的编码人白细胞抗原HLA-A1的分子的载体，细胞系等。 这些材料在治疗和诊断环境中的使用也是本发明的一部分。
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2.发明授权Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-2 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-2的分离的核酸分子及其用途公开(公告)号：US06552180B1
公开(公告)日：2003-04-22
申请号：US09579197
申请日：2000-05-26
IPC分类号： C07H2104
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , C07K14/4748
摘要： Isolated nucleic acid molecules are described, which have complements that hybridize to a nucleic acid molecule referred to as MAGE-2. The isolated nucleic acid molecules are expressed in some melanoma cells, as well as other types of cancer cells. The invention also relates to nucleic acid molecules which encode fragments of the proteins encoded by these nucleic acid molecules, and nucleic acid molecules which encode the ultimate product, the so-called tumor rejection antigens.
摘要翻译： 描述了分离的核酸分子，其具有与被称为MAGE-2的核酸分子杂交的互补序列。 分离的核酸分子在一些黑素瘤细胞以及其它类型的癌细胞中表达。 本发明还涉及编码由这些核酸分子编码的蛋白质的片段的核酸分子和编码最终产物的核酸分子，所谓的肿瘤排斥抗原。
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公开(公告)号：US07495074B2
公开(公告)日：2009-02-24
申请号：US11253240
申请日：2005-10-17
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Uses of these materials in therapeutic and diagnostic contexts are also a part of the invention.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体MAGE-3的核酸分子。 还公开了利用核酸分子和任选的编码人白细胞抗原HLA-A1的分子的载体，细胞系等。 这些材料在治疗和诊断环境中的使用也是本发明的一部分。
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4.发明授权Methods for treating a disorder by using Mage-3 or Mage-3 related materials 失效使用Mage-3或Mage-3相关材料治疗病症的方法公开(公告)号：US06565857B1
公开(公告)日：2003-05-20
申请号：US09404026
申请日：1999-09-23
IPC分类号： A61K3900
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , C07K14/4748
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Uses of these materials in therapeutic and diagnostic contexts are also a part of the invention.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体MAGE-3的核酸分子。 还公开了利用核酸分子和任选的编码人白细胞抗原HLA-A1的分子的载体，细胞系等。 这些材料在治疗和诊断环境中的使用也是本发明的一部分。
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5.发明授权Isolated nucleic acid molecules coding for tumor rejection antigen precursor mage-3 and uses thereof 失效编码肿瘤排斥抗原前体法师-3的分离的核酸分子及其用途
公开(公告)号：US6025474A
公开(公告)日：2000-02-15
申请号：US967727
申请日：1997-11-12
IPC分类号： A61K31/70 , A61K9/127 , A61K35/12 , A61K35/14 , A61K35/18 , A61K38/00 , A61K39/00 , A61K39/39 , A61K39/395 , A61K48/00 , A61P35/00 , C07K7/06 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/525 , C07K14/54 , C07K14/55 , C07K14/705 , C07K16/00 , C07K16/30 , C07K16/42 , C07K17/00 , C12N1/00 , C12N1/20 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/68 , C12R1/19 , C12R1/91 , G01N33/50 , G01N33/53 , G01N33/574 , G01N33/577 , G01N33/68 , C07K1/00
CPC分类号： C07K16/30 , C07K14/4748 , A61K38/00 , A61K39/00
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Uses of these materials in therapeutic and diagnostic contexts are also a part of the invention.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体MAGE-3的核酸分子。 还公开了利用核酸分子和任选的编码人白细胞抗原HLA-A1的分子的载体，细胞系等。 这些材料在治疗和诊断环境中的使用也是本发明的一部分。
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6.发明授权Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-6 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-6的分离的核酸分子及其用途公开(公告)号：US06946289B1
公开(公告)日：2005-09-20
申请号：US09583848
申请日：2000-05-31
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-6. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Use of these materials in therapeutic and diagnostic contexts are also a part of the invention.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体MAGE-6的核酸分子。 还公开了利用核酸分子和任选的编码人白细胞抗原HLA-A1的分子的载体，细胞系等。 在治疗和诊断环境中使用这些材料也是本发明的一部分。
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7.发明授权Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-4 and 41 and uses thereof 失效编码肿瘤排斥抗原前体MAGE-4和41的分离的核酸分子及其用途公开(公告)号：US07199231B1
公开(公告)日：2007-04-03
申请号：US09579543
申请日：2000-05-26
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
摘要： The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-4 and 41. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Use of these materials in therapeutic and diagnostic contexts are also a part of the invention.
摘要翻译： 本发明涉及编码肿瘤排斥抗原前体MAGE-4和41的核酸分子。还公开了利用核酸分子和任选地编码人白细胞抗原HLA的分子的载体，细胞系等 -A1 在治疗和诊断环境中使用这些材料也是本发明的一部分。
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公开(公告)号：US07998483B2
公开(公告)日：2011-08-16
申请号：US12502274
申请日：2009-07-14
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/154
摘要： The invention describes the LAGE-1 tumor associated gene, including fragments, allelic variants and splice variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LAGE-1 gene product.
摘要翻译： 本发明描述了LAGE-1肿瘤相关基因，包括片段，等位变体和剪接变体。 还包括由这些基因编码的多肽及其片段，以及与之相关的抗体。 还提供了用于诊断和治疗以LAGE-1基因产物表达为特征的病症的方法和产品。
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9.发明授权公开(公告)号：US07851212B2
公开(公告)日：2010-12-14
申请号：US10275993
申请日：2001-05-07
申请人： Neil Berinstein , James Tartaglia , John A. Tine , Philippe Moingeon , Thierry Boon-Falleur , Pierre Vander Bruggen
发明人： Neil Berinstein , James Tartaglia , John A. Tine , Philippe Moingeon , Thierry Boon-Falleur , Pierre Vander Bruggen
IPC分类号： C12N15/63
CPC分类号： C07K14/47 , A61K39/00 , A61K48/00 , A61K2039/53 , C07K14/4748 , C12N15/62 , C12N2799/021 , C12N2799/023
摘要： The invention discloses immunogenic polypeptides comprising several MAGE-specific antigen epitopes selected from different (i.e. discrete) members of the MAGE protein family, nucleic acids coding therefor, recombinant viruses and/or cells comprising said nucleic acids, and compositions thereof. Methods for eliciting or inducing MAGE-specific immune responses utilizing the aforementioned immunogenic agents are also disclosed.
摘要翻译： 本发明公开了包含选自MAGE蛋白家族的不同（即不连续的）成员的几种MAGE特异性抗原表位的免疫原性多肽，其编码的核酸，包含所述核酸的重组病毒和/或细胞及其组合物。 还公开了使用上述免疫原性诱导或诱导MAGE特异性免疫应答的方法。
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公开(公告)号：US20060211091A1
公开(公告)日：2006-09-21
申请号：US11439334
申请日：2006-05-23
申请人： Yi Zhang , Pascal Chaux , Thierry Boon-Falleur , Pierre Bruggen
发明人： Yi Zhang , Pascal Chaux , Thierry Boon-Falleur , Pierre Bruggen
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE-A3 gene.
摘要翻译： 本发明描述了由MAGE-A3肿瘤相关基因编码的HLA II类结合肽，以及编码这样的肽和与之有关的抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE-A3基因表达为特征的病症的方法和产品。
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