公开(公告)号：US20200078518A1

公开(公告)日：2020-03-12

申请号：US16687034

申请日：2019-11-18

Applicant: BAYER HEALTHCARE LLC

Inventor： ARTHUR UBER, III ,  MICHAEL YANNIELLO ,  BARRY TUCKER ,  DAVID MISHLER ,  EDWARD RHINEHART ,  MARK TROCKI ,  MARTIN URAM ,  KEVIN COWAN ,  JOHN BROSOVICH

IPC: A61M5/172 ,  A61M5/145 ,  A61M5/168

Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue are described. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity

公开(公告)号：US20180008780A1

公开(公告)日：2018-01-11

申请号：US15687641

申请日：2017-08-28

Applicant: BAYER HEALTHCARE LLC

Inventor： KEVIN P. COWAN ,  EDWARD J. RHINEHART ,  MARK TROCKI ,  BARRY L. TUCKER

IPC: A61M5/315 ,  A61M5/50

CPC classification number: A61M5/31513 ,  A61M5/315 ,  A61M5/31511 ,  A61M5/31515 ,  A61M5/5066 ,  A61M2005/31521

Abstract: A syringe system and components thereof are disclosed. The system may include a syringe body having a hollow lumen, a proximal open end, and a distal end. The syringe body may be configured to house a fluid therein. The syringe system may further include a plunger positioned in the hollow lumen of the syringe body, forming a seal with an inner wall of the syringe body. The plunger may include a removable piston having a shaft extending from the distal end towards the proximal open end, a stopper removably connected to a distal portion of the shaft, and at least one coupler attached to the distal portion of the shaft. The stopper may be configured to slidably move within the hollow lumen to facilitate movement of the fluid within the syringe body. The coupler may be configured to facilitate removal and attachment of the stopper from the piston.

公开(公告)号：US20170224913A1

公开(公告)日：2017-08-10

申请号：US15497756

申请日：2017-04-26

Applicant: BAYER HEALTHCARE LLC

Inventor： MARK TROCKI ,  MARK W. HITCHINS ,  KEVIN P. COWAN ,  EDWARD J. RHINEHART

IPC: A61M5/145 ,  A61M5/315 ,  A61M5/28 ,  A61M39/10

CPC classification number: A61M5/14546 ,  A61M5/14566 ,  A61M5/28 ,  A61M5/31515 ,  A61M5/31576 ,  A61M39/10 ,  A61M2039/1077 ,  A61M2205/60 ,  A61M2205/6063 ,  A61M2205/6072

Abstract: A syringe for use with an injector includes a body having a rear end and a front end, a plunger movably disposed within the body, an attachment member associated with the body and adapted to releasably engage a syringe retaining mechanism of the injector regardless of the orientation of the syringe with respect to the injector, and an encoding device operable to provide syringe information to the injector.

公开(公告)号：US20180256882A1

公开(公告)日：2018-09-13

申请号：US15974764

申请日：2018-05-09

Applicant: BAYER HEALTHCARE LLC

Inventor： ARTHUR E. UBER, III ,  KEVIN COWAN ,  JAMES A. DEDIG ,  DAVID M. GRIFFITHS ,  EDWARD J. RHINEHART ,  BENJAMIN TAGGART ,  MARK TROCKI

IPC: A61M39/16 ,  F16L25/00 ,  A61M39/20 ,  A61M39/10 ,  A61M39/18 ,  A61M39/26

CPC classification number: A61M39/165 ,  A61M39/10 ,  A61M39/1011 ,  A61M39/18 ,  A61M39/20 ,  A61M2039/1044 ,  A61M2039/1061 ,  A61M2039/267 ,  F16L25/00 ,  Y10T137/8811

Abstract: A medical connector assembly for establishing a fluid connection between a first medical device and a second medical device includes a multi-use connector and a plurality of single-use connectors connected in series. The multi-use connector has a proximal end opposite a distal end along a longitudinal length thereof. The plurality of single-use connectors each have a proximal end opposite a distal end along a longitudinal length thereof. The distal end of the multi-use connector is releasably connected to the proximal end of a first of the serially-connected single-use connectors. When a second of the serially-connected single-use connectors is disconnected from the first single-use connector, the first single-use connector remains connected to the multi-use medical connector as a sterility retaining cover.

公开(公告)号：US20160303397A1

公开(公告)日：2016-10-20

申请号：US15142000

申请日：2016-04-29

Applicant: BAYER HEALTHCARE LLC

Inventor： ALAN D. HIRSCHMAN ,  ARTHUR E. UBER, III ,  DAVID M. REILLY ,  JOHN F. KALAFUT ,  FREDERICK W. TROMBLEY, III ,  STEVEN J. REMIS ,  SCOTT GRIFFITH ,  DOUGLAS DESCALZI ,  RICHARD DEWIT ,  DAVID M. GRIFFITHS ,  MARC A. MABIE ,  MARK TROCKI

IPC: A61N5/10 ,  A61M5/168 ,  G21G4/08 ,  A61B6/03 ,  G06F19/00 ,  A61M5/172 ,  A61B5/055

CPC classification number: A61N5/1001 ,  A61B5/0205 ,  A61B5/055 ,  A61B5/7289 ,  A61B6/032 ,  A61B6/037 ,  A61B6/0478 ,  A61B6/107 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4423 ,  A61B6/507 ,  A61B6/508 ,  A61B6/5288 ,  A61B6/548 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1456 ,  A61M5/16827 ,  A61M5/16881 ,  A61M5/1723 ,  A61M5/1785 ,  A61M2205/3576 ,  A61N5/1071 ,  A61N2005/1021 ,  A61N2005/1094 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G21F5/015 ,  G21G4/08

Abstract: An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.

Abstract translation: 公开了一种集成的放射性药物患者治疗系统，其包括具有相关联的患者刺激装置的患者支撑平台，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统，与 患者以及与患者刺激装置，成像器，放射性药物流体输送系统和患者监护器可操作地相关联以控制和协调其操作的集成系统控制器。 在患者治疗系统内，可以包括放射性药物流体递送系统，包括放射性核素供应模块，放射性药物处理模块，质量控制模块，患者注射模块和控制器。 进一步公开了一种危险的流体处理系统，其包括对接站和适于与对接站可拆卸地对接的危险流体输送装置。

公开(公告)号：US20210338922A1

公开(公告)日：2021-11-04

申请号：US17372673

申请日：2021-07-12

Applicant: BAYER HEALTHCARE LLC

Inventor： ARTHUR UBER, III ,  MARK TROCKI

IPC: A61M5/00 ,  A61M5/172 ,  A61N5/10 ,  A61M39/24 ,  A61M5/168 ,  A61M5/145 ,  A61M5/142 ,  A61M5/14

Abstract: A high crack pressure valve is described. The high crack pressure valve includes an inlet adapted to receive a medical fluid pressurized by a pump; an outlet in fluid communication with a fluid path element, wherein the fluid path element is in fluid communication with downstream system components of a fluid delivery system; and a moveable element having a crack pressure threshold. The moveable element has a first closed position and a second open position and is configured to move from the first closed position to the second open position when a fluid pressure at the inlet is greater than or equal to the crack pressure threshold. The pressure of fluid at the outlet of the high crack pressure valve has little or no effect on movement of the moveable element from the first closed position to the second open position. Fluid injector systems and fluid path elements which include the high crack pressure valve are also described.

公开(公告)号：US20170087303A1

公开(公告)日：2017-03-30

申请号：US15375481

申请日：2016-12-12

Applicant: BAYER HEALTHCARE LLC

Inventor： MARTIN J. URAM ,  MICHAEL J. YANNIELLO ,  BARRY L. TUCKER ,  DAVID A. MISHLER ,  EDWARD J. RHINEHART ,  MARK TROCKI ,  ARTHUR E. UBER, III ,  KEVIN P. COWAN ,  JOHN A. BROSOVICH

IPC: A61M5/172 ,  A61M5/168 ,  A61M5/145

Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue are described. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity

公开(公告)号：US20170035974A1

公开(公告)日：2017-02-09

申请号：US15305285

申请日：2015-04-24

Applicant: BAYER HEALTHCARE LLC

Inventor： DAVE BERRY ,  BARRY L. TUCKER ,  EDWARD J. RHINEHART ,  MARK TROCKI ,  GERALD W. CALLAN ,  ARTHUR E. UBER, III ,  MARTIN J. URAM ,  DAVE CALLEN ,  KEVIN P. COWAN ,  RAYMOND C. HOFFMAN ,  BENJAMIN T. KRUPP ,  MARTIN J. GIBLER ,  MATTHEW MCGEE ,  MICHAEL A. SPOHN

IPC: A61M5/315 ,  A61M5/24

Abstract: A syringe for a fluid delivery system includes a pressure jacket having a distal end, a proximal end, and a throughbore therebetween. The syringe further includes a rolling diaphragm having a proximal end with an end wall for engaging a plunger, a distal end received within the throughbore of the pressure jacket. A sidewall extends between the proximal end and the distal end of the rolling diaphragm along a longitudinal axis. At least a portion of one of the sidewall and the end wall has non-uniform thickness. At least a portion of the sidewall is flexible and rolls upon itself when acted upon by the plunger such that an outer surface of the sidewall at a folding region is folded in a radially inward direction as the plunger is advanced from the proximal end to the distal end of the rolling diaphragm.

Abstract translation: 用于流体输送系统的注射器包括具有远端，近端和其间的通孔的压力套。 注射器还包括一个滚动隔膜，其具有近端，该近端具有用于接合柱塞的端壁，远端接纳在压力套的通孔内。 侧壁沿着纵向轴线延伸在滚动膜片的近端和远端之间。 侧壁和端壁中的一个的至少一部分具有不均匀的厚度。 侧壁的至少一部分是柔性的并且在被柱塞作用时自身滚动，使得当折叠区域的侧壁从近端向远侧方向前进时，在折叠区域处的侧壁的外表面沿径向向内的方向折叠 滚动隔膜的端部。

公开(公告)号：US20160271330A1

公开(公告)日：2016-09-22

申请号：US15032425

申请日：2014-10-31

Applicant: BAYER HEALTHCARE LLC

Inventor： EDWARD J. RHINEHART ,  KEVIN P. COWAN ,  MARK TROCKI ,  BARRY L. TUCKER

IPC: A61M5/315 ,  B29C49/18 ,  B29B11/14

CPC classification number: A61M5/31513 ,  A61M5/178 ,  A61M2207/00 ,  A61M2207/10 ,  B29B11/14 ,  B29B2911/1402 ,  B29B2911/14026 ,  B29B2911/14033 ,  B29B2911/1404 ,  B29B2911/14328 ,  B29B2911/14332 ,  B29B2911/14335 ,  B29B2911/1442 ,  B29B2911/14486 ,  B29B2911/14533 ,  B29B2911/14573 ,  B29C49/12 ,  B29C49/18 ,  B29C2049/1228 ,  B29C2049/1238 ,  B29C2791/006 ,  B29C2791/007 ,  B29L2031/753 ,  B29L2031/7544

Abstract: A syringe for use in pressurized injection of a fluid is provided herein. The syringe includes a syringe barrel comprising a polymeric material having undergone expansion by stretch blow molding and by compression molding of an inner diameter of the barrel with a core member. In certain configurations of the syringe barrel, the stretch blow molding is provided through a nozzle of the syringe. Similarly, according to a further embodiment, a syringe for use in pressurized injection of a fluid is provided. The syringe includes a syringe barrel comprising a polymeric material having undergone expansion by stretch blow molding and by shrinking an inner diameter of the syringe barrel about a core member.

Abstract translation: 本文提供了用于加压注射流体的注射器。 注射器包括注射器筒，该注射器筒包括通过拉伸吹塑成型而经历膨胀的聚合物材料，并且通过用芯部件压缩成型筒的内径。 在注射器筒的某些构造中，通过注射器的喷嘴提供拉伸吹塑成型。 类似地，根据另一实施例，提供了用于加压注射流体的注射器。 注射器包括注射器筒，其包括通过拉伸吹塑成型而经历膨胀的聚合物材料，并且通过使注射器筒的内径围绕芯部件收缩。

公开(公告)号：US20160151570A1

公开(公告)日：2016-06-02

申请号：US14903890

申请日：2014-07-09

Applicant: BAYER HEALTHCARE LLC

Inventor： EDWARD J. RHINEHART ,  KEVIN P. COWAN ,  BARRY L. TUCKER ,  MARK TROCKI

IPC: A61M5/178 ,  A61M5/315 ,  A61M5/31

CPC classification number: A61M5/1782 ,  A61M5/3148 ,  A61M5/31511 ,  A61M2005/3123 ,  A61M2209/045

Abstract: A syringe interface between a piston and plunger is provided. The syringe interface includes a piston configured to be driven by an injector and a syringe. The syringe includes: a syringe barrel having a proximal end and a distal end; and a plunger having a proximal end, a distal end, and a sidewall extending therebetween. The plunger is slidably inserted in the syringe barrel such that the sidewall of the plunger forms a moveable seal against an inner surface of the syringe barrel. The piston is configured to form a removable suction engagement with the plunger for advancing or retracting the plunger through the syringe barrel as the piston is driven by the injector. A method for filling a syringe including a suction interface between a piston and plunger, as well as a filling station including a vacuum source, such as a vacuum pump, are also provided.

Abstract translation: 提供活塞和柱塞之间的注射器接口。 注射器接口包括被注射器和注射器驱动的活塞。 注射器包括：具有近端和远端的注射器筒; 以及具有近端，远端和在其间延伸的侧壁的柱塞。 柱塞可滑动地插入注射器筒中，使得柱塞的侧壁形成抵靠注射器筒的内表面的可移动密封。 活塞构造成与柱塞形成可移除的吸入接合，用于当活塞由喷射器驱动时，通过注射器筒推动或缩回柱塞。 还提供了一种用于填充包括活塞和柱塞之间的吸入界面的注射器的方法以及包括诸如真空泵的真空源的填充站。