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    Microfluidic system with fluid pickups
    2.
    发明授权
    Microfluidic system with fluid pickups 有权

    公开(公告)号：US10682647B2

    公开(公告)日：2020-06-16

    申请号：US15633413

    申请日：2017-06-26

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Anthony J. Makarewicz, Jr. ,  Luc Bousse ,  Stefano Schiaffino

    IPC: G01N1/00 ,  B01L3/00 ,  B01L7/00 ,  C12N15/10 ,  C12Q1/6806

    Abstract: Microfluidic system, including methods and apparatus, for processing fluid, such as by droplet generation. In an exemplary method, a sample-containing fluid may be dispensed into a well through a sample port of a channel component. The channel component may include (a) a body having a bottom surface attached to the well, and a top surface with a microchannel formed therein, and (b) an input tube projecting into the well from the bottom surface of the body. The sample-containing fluid when dispensed may contact a bottom end of the input tube and may be retained, with assistance from gravity, out of contact with the microchannel. A pressure differential may be created that drives at least a portion of the sample-containing fluid from the well via the input tube and through the microchannel.

    DROPLET ASSAY SYSTEM WITH AUTOMATIC CALIBRATION
    3.
    发明申请
    DROPLET ASSAY SYSTEM WITH AUTOMATIC CALIBRATION 审中-公开

    公开(公告)号：US20170189908A1

    公开(公告)日：2017-07-06

    申请号：US15395199

    申请日：2016-12-30

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： John Dzenitis ,  Stefano Schiaffino

    IPC: B01L3/00

    CPC classification number: B01L3/502784 ,  B01L3/0241 ,  B01L3/545 ,  B01L2200/12 ,  B01L2200/147 ,  B01L2200/148 ,  B01L2300/021 ,  B01L2300/0663 ,  B01L2300/0864 ,  B01L2400/049

    Abstract: The present disclosure provides systems and methods for performing droplet assays with automatic calibration. An exemplary assay system may comprise a cartridge including a plurality of droplet generators to form emulsions of droplets having a same nominal volume. A tag may be associated with the cartridge and may encode calibration data or an identifier thereof. The calibration data may include a respective value specific to each droplet generator. The system further may include a detection system to detect a signal representing an analyte from droplets of each emulsion, and a reader to read the calibration data or the identifier from the tag. The system still further may include a processor configured to receive the signal and the calibration data and to calculate, for each emulsion, a concentration of an analyte using at least the signal and the respective value specific to the droplet generator that formed the emulsion.

    MICROFLUIDIC SYSTEM WITH FLUID PICKUPS
    7.
    发明申请
    MICROFLUIDIC SYSTEM WITH FLUID PICKUPS 审中-公开

    公开(公告)号：US20170291174A1

    公开(公告)日：2017-10-12

    申请号：US15633413

    申请日：2017-06-26

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Anthony J. Makarewicz, JR. ,  Luc Bousse ,  Stefano Schiaffino

    IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/68

    Abstract: Microfluidic system, including methods and apparatus, for processing fluid, such as by droplet generation. In an exemplary method, a sample-containing fluid may be dispensed into a well through a sample port of a channel component. The channel component may include (a) a body having a bottom surface attached to the well, and a top surface with a microchannel formed therein, and (b) an input tube projecting into the well from the bottom surface of the body. The sample-containing fluid when dispensed may contact a bottom end of the input tube and may be retained, with assistance from gravity, out of contact with the microchannel. A pressure differential may be created that drives at least a portion of the sample-containing fluid from the well via the input tube and through the microchannel.

    System, method, and device for forming an array of emulsions
    9.
    发明授权
    System, method, and device for forming an array of emulsions 有权

    公开(公告)号：US11207685B2

    公开(公告)日：2021-12-28

    申请号：US15894836

    申请日：2018-02-12

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Thomas Henry Cauley, III ,  John Dzenitis ,  Steve Hobbs ,  Stefano Schiaffino

    IPC: B01L3/00 ,  G01N1/38 ,  B01F3/08 ,  B01F13/10 ,  B01L9/00

    Abstract: Systems, methods, and devices for forming an array of emulsions. An exemplary device comprises a frame and at least one or a plurality of separate microfluidic modules mounted to the frame and each configured to form an array of emulsions. In some embodiments, each module may be mounted by snap-fit attachment. The device also may include the same sealing member bonded to a top side of each module and hermetically sealing each of the modules. Another exemplary microfluidic device for forming an array of emulsions comprises a stack of layers bonded together. The stack may comprise a port layer forming a plurality of ports. Each port may have a top rim formed by a protrusion that encircles the central axis of the port. The rims may be coplanar with one another to facilitate bonding of a sealing member to each rim.

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