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公开(公告)号：US20240358892A1
公开(公告)日：2024-10-31
申请号：US18647746
申请日：2024-04-26
Applicant: Boston Scientific Scimed, Inc.
Inventor： Nicolas Ball-Jones , Samuel Michael Hanson , Gary Thomas Ohrt , Sasha Viola Rios , Paul Vincent Grosso
CPC classification number: A61L27/26 , A61L27/52 , A61L2400/06
Abstract: In some embodiments, the present disclosure pertains to an injectable shear-thinning composition that comprises (a) one or more types of polymers, (b) one or more types of microparticles and (c) water. In some embodiments, the present disclosure pertains to a kit that comprises (a) one or more containers that contain an injectable shear-thinning composition that comprises one or more types of polymers, one or more types of microparticles and water and (b) a delivery device. In some embodiments, the present disclosure pertains to a medical procedure comprising administering to a subject an injectable shear-thinning composition that comprises one or more types of polymers, one or more types of microparticles and water.
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公开(公告)号：US20240043643A1
公开(公告)日：2024-02-08
申请号：US18221595
申请日：2023-07-13
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Joseph Thomas Delaney , Paul Vincent Grosso , Patrick Willoughby
CPC classification number: C08J7/12 , A61L31/10 , C08J2375/14
Abstract: A medical device include a polyurethane layer and a hydro-specific layer that is covalently bonded to the polyurethane layer. The polyurethane layer may include a plurality of monomer residues, at least some of which include pendent alkene groups. The hydro-specific layer may be a hydrophilic layer or a hydrophobic layer depending on the specific molecules used to form the hydro-specific layer. As an example, the hydro-specific layer may be covalently bonded to the polyurethane layer via a thiol-ene or alkene hydrothiolation reaction between the plurality of pendent alkene groups and a plurality of thiol-terminated hydro-specific molecules forming the hydro-specific layer.
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公开(公告)号：US20130190525A1
公开(公告)日：2013-07-25
申请号：US13748046
申请日：2013-01-23
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph Thomas Delaney, JR. , Kasyap Seethamraju , Paul Vincent Grosso
CPC classification number: C07C41/01 , C07C41/16 , C07C67/08 , C07C43/164 , C07C69/76
Abstract: According to some aspects, the present disclosure pertains to methods of forming dimethyl 5-tert-butylisophthalate which comprise comprising converting 5-tert-butylisophthalic acid into dimethyl 5-tert-butylisophthalate in synthesis procedures that comprises methanol and a dehydrating agent as chemical reagents. In other aspects, the present disclosure pertains to methods of forming 5-tert-butyl-1,3-bis(1-methoxy-1-methylethyl)benzene that comprise deprotonating 5-tert-butyl-1,3-bis(1-hydroxy-1-methylethyl)benzene with a Brønsted-Lowry superbase and methylating the deprotonated 5-tert-butyl-1,3-bis(1-hydroxy-1-methylethyl)benzene to form the 5-tert-butyl-1,3-bis(1-methoxy-1-methylethyl)benzene.
Abstract translation: 根据一些方面，本公开涉及形成5-叔丁基间苯二甲酸二甲酯的方法，其包括在包含甲醇和脱水剂作为化学试剂的合成方法中将5-叔丁基间苯二甲酸转化为5-叔丁基间苯二甲酸二甲酯。 在其它方面，本公开涉及形成5-叔丁基-1,3-双（1-甲氧基-1-甲基乙基）苯的方法，其包括将5-叔丁基-1,3-双（1- 羟基-1-甲基乙基）苯与Brnnsted-Lowry超级碱基进行甲基化，将去质子化的5-叔丁基-1,3-双（1-羟基-1-甲基乙基）苯甲基化，形成5-叔丁基-1,3 - 双（1-甲氧基-1-甲基乙基）苯。
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公开(公告)号：US20240325594A1
公开(公告)日：2024-10-03
申请号：US18618262
申请日：2024-03-27
Applicant: Boston Scientific Scimed, Inc.
Inventor： Nicolas Ball-Jones , Victoria Szlag , Paul Vincent Grosso , Samuel Michael Hanson , Sasha Viola Rios , Steven L. Kangas , Boxin Tang
CPC classification number: A61L24/06 , A61L24/0015 , A61L2400/04 , A61L2400/06
Abstract: Aqueous liquid embolic compositions as well as method for making and using aqueous liquid embolic compositions are disclosed. An example aqueous liquid embolic composition may include a di-block or tri-block copolymer including a hydrophobic monomer block and a charged (polycationic or polyanionic) block. The charged (polycationic or polyanionic) block may include one or more anions. The aqueous liquid embolic composition may also include templating agent.
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Patent Agency Ranking
公开(公告)号：US20220249676A1
公开(公告)日：2022-08-11
申请号：US17616576
申请日：2020-05-11
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph Thomas Delaney, JR. , Sarah Melissa Gruba , Tatyana Dyndikova , Paul Vincent Grosso , Amanda Maxwell , Ajay Gupta , Andrew J. Ro , Douglas Pennington
Abstract: A chemotherapy agent comprising a chemotherapy group and a ligand secured to the chemotherapy group is disclosed, the ligand comprising a reactive group capable of bonding to a capture substrate. A method of removing chemotherapy agents from a patient is disclosed, the method comprising providing a chemotherapy agent containing a reactive group; providing a capture substrate in contact with a patient's bloodstream; administering the chemotherapy agent to the patient; and sequestering the chemotherapy agent on the capture substrate. A system for removing chemotherapy agents is also disclosed.
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公开(公告)号：US09839725B2
公开(公告)日：2017-12-12
申请号：US14820342
申请日：2015-08-06
Applicant: BOSTON SCIENTIFIC SCIMED, INC.
Inventor： Joseph Thomas Delaney, Jr. , Kasyap Seethamraju , Paul Vincent Grosso
IPC: A61F2/00 , C08L75/00 , B05D3/00 , C08F2/50 , A61L31/10 , A61L29/08 , A61L31/08 , A61L31/14 , C09D175/04
CPC classification number: A61L31/10 , A61L29/085 , A61L31/082 , A61L31/14 , A61L2400/10 , A61L2420/02 , A61L2420/06 , C09D175/04
Abstract: A lubricious coating for use on an implantable medical device includes a heterochelic component, a homotelechelic polymer and biocompatible initiator. Methods of forming such lubricious coatings are also provided.
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公开(公告)号：US20250073373A1
公开(公告)日：2025-03-06
申请号：US18817662
申请日：2024-08-28
Applicant: Boston Scientific Scimed, Inc.
Inventor： Nicolas Ball-Jones , Samuel Michael Hanson , Paul Vincent Grosso , Karen Dubbin , Gary Thomas Ohrt
Abstract: The present disclosure pertains to injectable shear-thinning compositions that comprise (a) one or more types of fibrous proteins, (b) one or more types of silicate microparticles, (c) one or more types of radiopaque additives, (d) one or more types of cryoprotectants, and (e) water. Other aspects of the present disclosure pertain to kits that contains such compositions and medical procedures that comprise administering such compositions to a patient.
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公开(公告)号：US20220125381A1
公开(公告)日：2022-04-28
申请号：US17507982
申请日：2021-10-22
Applicant: Boston Scientific Scimed, Inc.
Inventor： Paul Vincent Grosso
Abstract: Embodiments herein relate to medical devices and methods for monitoring and/or treatment including the use of synthetic polymers exhibiting specific binding for compounds such as disease state markers or toxic substances. In an embodiment, a method of testing a patient for a disease state is included, the method can include withdrawing a fluid sample from the patient and contacting the fluid sample with an extracorporeal monitoring device. The extracorporeal monitoring device can include a microporous membrane. The microporous membrane can include a synthetic polymer, wherein the synthetic polymer exhibits binding specificity with a disease state marker. The method can further include evaluating the extracorporeal monitoring device for the presence of the disease state marker. Other embodiments are included herein.
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公开(公告)号：US20150182673A1
公开(公告)日：2015-07-02
申请号：US14581404
申请日：2014-12-23
Applicant: Boston Scientific Scimed, Inc.
CPC classification number: A61L31/14 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/085 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2400/10
Abstract: In some aspects of the present invention, coatings are provided which provide lubricity as well as additional functionality. Further aspects of the invention pertain to medical devices having such coatings and methods of forming such coatings.
Abstract translation: 在本发明的一些方面，提供了提供润滑性以及附加功能的涂层。 本发明的其它方面涉及具有这种涂层的医疗装置和形成这种涂层的方法。
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