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    METHOD FOR DETECTION OF SPECIFIC IMMUNOGLOBULIN CLASS G ANTIBODIES
    2.
    发明申请
    METHOD FOR DETECTION OF SPECIFIC IMMUNOGLOBULIN CLASS G ANTIBODIES 有权
    检测特异性免疫球蛋白G类抗体的方法

    公开(公告)号：US20110143454A1

    公开(公告)日：2011-06-16

    申请号：US12817469

    申请日：2010-06-17

    申请人： Barbara Upmeier ,  Ralf Bollhagen ,  Martina Bronold ,  Frederic Donie ,  Christine Markert-Hahn

    发明人： Barbara Upmeier ,  Ralf Bollhagen ,  Martina Bronold ,  Frederic Donie ,  Christine Markert-Hahn

    IPC分类号： G01N33/543 ,  G01N33/566

    CPC分类号： G01N33/6854 ,  G01N33/54313 ,  G01N33/5438

    摘要： The invention relates to a method for determining an analyte in a sample by means of an assay that can be carried out in a one-step format without performing washing steps. The method includes a first analyte-specific receptor that contains at least one bonding point for the analyte, e.g., several antibodies on a particle, as well as a second analyte-specific receptor that can selectively bond to an arrangement comprising at least two analyte molecules which are bound to the first receptor. An antibody sandwich immune assay is described in which the detection is based on electrochemiluminescence.

    摘要翻译： 本发明涉及通过可以以一步格式执行的测定法来测定样品中分析物的方法，而不进行洗涤步骤。 该方法包括第一分析物特异性受体，其包含分析物的至少一个结合点，例如颗粒上的几种抗体，以及可选择性地结合至包含至少两种分析物分子的装置的第二分析物特异性受体 它们与第一受体结合。 描述了抗体夹心免疫测定法，其中检测基于电化学发光。

    Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays
    3.
    发明申请
    Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays 有权
    在免疫测定中使用分子内，共价交联的蛋白质作为结合配偶体

    公开(公告)号：US20070281293A9

    公开(公告)日：2007-12-06

    申请号：US10447129

    申请日：2003-05-28

    申请人： Barbara Upmeier ,  Dittmar Schlieper ,  Frederic Donie

    发明人： Barbara Upmeier ,  Dittmar Schlieper ,  Frederic Donie

    IPC分类号： C12Q1/70 ,  C12N9/22

    CPC分类号： G01N33/531 ,  G01N33/5306 ,  G01N33/54393 ,  G01N33/56988

    摘要： The invention concerns the use of intramolecularly, covalently cross-linked proteins and covalently cross-linked reverse transcriptase from HIV as immunological binding partners in immunoassays. It also concerns immunological test procedures for detecting an analyte in a sample in which intramolecularly, covalently cross-linked proteins are used as binding partners, and it further concerns intramolecularly, covalently cross-linked reverse transcriptase from HIV and a method for producing this reverse transcriptase.

    摘要翻译： 本发明涉及在免疫测定中使用分子内，共价交联的蛋白质和来自HIV的共价交联的逆转录酶作为免疫结合配偶体。 它还涉及用于检测分子内，共价交联的蛋白质用作结合伴侣的样品中的分析物的免疫测试程序，并且还涉及从HIV分子内，共价交联的逆转录酶以及产生该逆转录酶的方法 。

    Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays
    4.
    发明授权
    Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays 有权
    在免疫测定中使用分子内，共价交联的蛋白质作为结合配偶体

    公开(公告)号：US07547533B2

    公开(公告)日：2009-06-16

    申请号：US11968806

    申请日：2008-01-03

    申请人： Barbara Upmeier ,  Dittmar Schlieper ,  Frederic Donie

    发明人： Barbara Upmeier ,  Dittmar Schlieper ,  Frederic Donie

    IPC分类号： C12N9/00

    CPC分类号： G01N33/531 ,  G01N33/5306 ,  G01N33/54393 ,  G01N33/56988

    摘要： The invention concerns the use of intramolecularly, covalently cross-linked proteins and covalently cross-linked reverse transcriptase from HIV as immunological binding partners in immunoassays. It also concerns immunological test procedures for detecting an analyte in a sample in which intramolecularly, covalently cross-linked proteins are used as binding partners, and it further concerns intramolecularly, covalently cross-linked reverse transcriptase from HIV and a method for producing this reverse transcriptase.

    摘要翻译： 本发明涉及在免疫测定中使用分子内，共价交联的蛋白质和来自HIV的共价交联的逆转录酶作为免疫结合配偶体。 它还涉及用于检测分子内，共价交联的蛋白质用作结合伴侣的样品中的分析物的免疫测试程序，并且还涉及从HIV分子内，共价交联的逆转录酶以及产生该逆转录酶的方法 。

    Method for simultaneous detection of HIV antigens and HIV antibodies
    5.
    发明授权
    Method for simultaneous detection of HIV antigens and HIV antibodies 有权
    同时检测HIV抗原和HIV抗体的方法

    公开(公告)号：US06593079B1

    公开(公告)日：2003-07-15

    申请号：US09381009

    申请日：2000-01-12

    申请人： Frederic Donie ,  Elke Faatz ,  Barbara Upmeier ,  Eva Hoess ,  Marie-Ange Buyse ,  Eric Saman

    发明人： Frederic Donie ,  Elke Faatz ,  Barbara Upmeier ,  Eva Hoess ,  Marie-Ange Buyse ,  Eric Saman

    IPC分类号： C12Q106

    CPC分类号： G01N33/56988 ,  C07K16/1054

    摘要： The invention concerns a process for diagnosis of an HIV infection by means of an immunoassay using the specific detection of the p24 antigen of HIV1, HIV1-Sub0 and/or the p26 antigen of HIV2, at least one antibody against the env region of HIV1, HIV1-Sub0 and/or of HIV2 and at least one antibody against the pol and/or gag region of HIV1, HIV1-Sub0 and/or HIV2, reagent kits and test strips suitable for diagnostic procedure as well as monoclonal antibodies against p24 and their use.

    摘要翻译： 本发明涉及通过免疫测定来诊断HIV感染的方法，其使用HIV2的HIV1，HIV1-Sub0和/或p26抗原的p24抗原的特异性检测，至少一种针对HIV1的env区域的抗体， HIV1-Sub0和/或HIV2的抗体和抗HIV1，HIV1-Sub0和/或HIV2的pol和/或gag区域的至少一种抗体，适用于诊断程序的试剂盒和测试条以及针对p24的单克隆抗体及其 使用。

    Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays
    6.
    发明授权
    Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays 有权
    在免疫测定中使用分子内，共价交联的蛋白质作为结合配偶体

    公开(公告)号：US07351799B2

    公开(公告)日：2008-04-01

    申请号：US10447129

    申请日：2003-05-28

    申请人： Barbara Upmeier ,  Dittmar Schlieper ,  Frederic Donie

    发明人： Barbara Upmeier ,  Dittmar Schlieper ,  Frederic Donie

    IPC分类号： C07K14/00

    CPC分类号： G01N33/531 ,  G01N33/5306 ,  G01N33/54393 ,  G01N33/56988

    摘要： The invention concerns the use of intramolecularly, covalently cross-linked proteins and covalently cross-linked reverse transcriptase from HIV as immunological binding partners in immunoassays. It also concerns immunological test procedures for detecting an analyte in a sample in which intramolecularly, covalently cross-linked proteins are used as binding partners, and it further concerns intramolecularly, covalently cross-linked reverse transcriptase from HIV and a method for producing this reverse transcriptase.

    摘要翻译： 本发明涉及在免疫测定中使用分子内，共价交联的蛋白质和来自HIV的共价交联的逆转录酶作为免疫结合配偶体。 它还涉及用于检测分子内，共价交联的蛋白质用作结合伴侣的样品中的分析物的免疫测试程序，并且还涉及从HIV分子内，共价交联的逆转录酶以及产生该逆转录酶的方法 。