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公开(公告)号：US20060276444A1
公开(公告)日：2006-12-07
申请号：US11350308
申请日：2006-02-07
申请人： Benjamin Frydman , Linda Clifford , Aldonia Valasinas , Venodhar Reddy , Hirak Basu , Aparajita Sarkar , Subhra Bhattacharya , Yu Wang , Laurence Marton , Andrei Blokhin
发明人： Benjamin Frydman , Linda Clifford , Aldonia Valasinas , Venodhar Reddy , Hirak Basu , Aparajita Sarkar , Subhra Bhattacharya , Yu Wang , Laurence Marton , Andrei Blokhin
IPC分类号： A61K31/409 , A61K31/555
CPC分类号： C07D487/22
摘要： Porphyrin-polyamine conjugate compounds are disclosed which have anticancer and antitumor effects. The porphyrin moiety selectively localizes in tumors, while the polyamine moiety serves as a cytotoxic agent. Methods of making and using the porphyrin-polyamine conjugate compounds are also disclosed.
摘要翻译： 公开了具有抗癌和抗肿瘤作用的卟啉 - 多胺缀合物。 卟啉部分选择性定位在肿瘤中，而多胺部分用作细胞毒性剂。 还公开了制备和使用卟啉 - 多胺缀合物的方法。
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公开(公告)号：US20060030735A1
公开(公告)日：2006-02-09
申请号：US11205341
申请日：2005-08-16
申请人： Benjamin Frydman , Linda Clifford , Aldonia Valasinas , Andrei Blokhin , Aparajita Sarkar , Hirak Basu , Venodhar Reddy , Laurence Marton , Yu Wang
发明人： Benjamin Frydman , Linda Clifford , Aldonia Valasinas , Andrei Blokhin , Aparajita Sarkar , Hirak Basu , Venodhar Reddy , Laurence Marton , Yu Wang
IPC分类号： C07C211/34
CPC分类号： A61K31/132 , C07C211/18 , C07C2601/02
摘要： Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
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3.发明申请Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor 失效用于癌症治疗的环烷基取代多胺及其合成方法公开(公告)号：US20070287754A1
公开(公告)日：2007-12-13
申请号：US11810409
申请日：2007-06-04
申请人： Benjamin Frydman , Linda Clifford , Aldonia Valasinas , Andrei Blokhin , Aparajita Sarkar , Hirak Basu , Venodhar Reddy , Laurence Marton , Yu Wang
发明人： Benjamin Frydman , Linda Clifford , Aldonia Valasinas , Andrei Blokhin , Aparajita Sarkar , Hirak Basu , Venodhar Reddy , Laurence Marton , Yu Wang
IPC分类号： A61K31/13 , A61P35/00 , C07C211/13
CPC分类号： A61K31/132 , C07C211/18 , C07C2601/02
摘要： Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.
摘要翻译： 公开了可用于治疗由异常细胞增殖表现的癌症和其它疾病的构象限制性多胺化合物。 还公开了合成这些化合物的改进方法。 在本发明的一种方法中，含有含碳或含碳原子的化合物与烯烃化合物的双键反应形成环丙基环作为合成中的第一步。
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公开(公告)号：US20070161692A1
公开(公告)日：2007-07-12
申请号：US11643592
申请日：2006-12-20
申请人： Benjamin Frydman , Linda Clifford , Laurence Marton , Venodhar Reddy , Aldonia Valasinas , Andrei Blokhin , Hirak Basu
发明人： Benjamin Frydman , Linda Clifford , Laurence Marton , Venodhar Reddy , Aldonia Valasinas , Andrei Blokhin , Hirak Basu
IPC分类号： A61K31/409 , A61K31/13 , C07D487/22 , C07C211/13 , C07C211/17
CPC分类号： C07C211/09 , A61K38/00 , A61K47/65 , C07C45/46 , C07C67/343 , C07C211/18 , C07C211/22 , C07C211/23 , C07C211/36 , C07C215/14 , C07C257/18 , C07C2601/04 , C07C2601/08 , C07D207/34 , C07D219/10 , C07D235/18 , C07D295/185 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D487/22 , C07D493/04 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of delivering these analogs specifically to tumor cells by covalently attaching polyamine analogs to porphyrin compounds, along with novel polyamine-porphyrin covalent conjugates.
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公开(公告)号：US20090124832A1
公开(公告)日：2009-05-14
申请号：US12357323
申请日：2009-01-21
申请人： Benjamin Frydman , Linda Clifford , Aldonia L. Valasinas , Andrei V. Blokhin , Hirak S. Basu , Laurence J. Marton , Venodhar K. Reddy
发明人： Benjamin Frydman , Linda Clifford , Aldonia L. Valasinas , Andrei V. Blokhin , Hirak S. Basu , Laurence J. Marton , Venodhar K. Reddy
IPC分类号： C07C237/06
CPC分类号： C07C215/18 , C07C211/14
摘要： Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.
摘要翻译： 提供具有抗癌和抗增殖活性的寡胺化合物，以及制备和使用该化合物的方法。 该化合物显示出对前列腺癌细胞系和抗小鼠前列腺癌肿瘤的活性。 该化合物也可用于治疗乳腺癌和其它癌症。
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6.发明申请NOVEL POLYAMINE ANALOG CONJUGATES AND QUINONE CONJUGATES AS THERAPIES FOR CANCERS AND PROSTATE DISEASES 审中-公开新型聚氨酯类似物和喹诺酮类似物作为癌症和前列腺疾病的治疗方案公开(公告)号：US20090275664A1
公开(公告)日：2009-11-05
申请号：US12503801
申请日：2009-07-15
IPC分类号： A61K31/132 , C07C211/27 , C07C211/18 , C07C211/22 , C07C211/13 , A61P35/00 , A61K31/137
CPC分类号： C07D295/185 , A61K38/00 , A61K47/65 , C07C45/46 , C07C67/343 , C07C211/13 , C07C211/18 , C07C2601/02 , C07D207/34 , C07D219/10 , C07D235/18 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D493/04 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.
摘要翻译： 提供了其中细胞死亡和细胞生长抑制剂（例如多胺类似物或萘醌）与由诸如前列腺特异性抗原（PSA）和组织蛋白酶B之类的酶识别和切割的多肽缀合的肽缀合物，以及包含这些缀合物的组合物。 还提供了使用这些缀合物治疗前列腺疾病的方法。
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7.发明申请NOVEL POLYAMINE ANALOG CONJUGATES AND QUINONE CONJUGATES AS THERAPIES FOR CANCERS AND PROSTATE DISEASES 审中-公开新型聚氨酯类似物和喹诺酮类似物作为癌症和前列腺疾病的治疗方案公开(公告)号：US20080194697A1
公开(公告)日：2008-08-14
申请号：US11868910
申请日：2007-10-08
IPC分类号： A61K31/132 , A61P35/00
CPC分类号： C07D295/185 , A61K38/00 , A61K47/65 , C07C45/46 , C07C67/343 , C07C211/13 , C07C211/18 , C07C2601/02 , C07D207/34 , C07D219/10 , C07D235/18 , C07D307/79 , C07D307/92 , C07D311/92 , C07D317/70 , C07D493/04 , C07K5/1013 , C07K7/06 , C07C47/575 , C07C69/734
摘要： Peptide conjugates in which cytostatic and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.
摘要翻译： 提供了其中细胞抑制剂和细胞抑制剂如多胺类似物或萘醌与与诸如前列腺特异性抗原（PSA）和组织蛋白酶B之类的酶识别和切割的多肽缀合的肽缀合物，以及包含这些缀合物的组合物。 还提供了使用这些缀合物治疗前列腺疾病的方法。
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