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22 条记录 (耗时 0.038 秒)

    Cyclic polyamine compounds for cancer therapy
    8.
    发明申请
    Cyclic polyamine compounds for cancer therapy 审中-公开
    循环多胺化合物用于癌症治疗

    公开(公告)号：US20050130949A1

    公开(公告)日：2005-06-16

    申请号：US11046344

    申请日：2005-01-27

    申请人： Benjamin Frydman ,  Manfred Hesse ,  Armin Guggisberg ,  Kasim Popaj ,  Konstantin Drandarov ,  Hirak Basu ,  Subhra Bhattacharya ,  Yu Wang

    发明人： Benjamin Frydman ,  Manfred Hesse ,  Armin Guggisberg ,  Kasim Popaj ,  Konstantin Drandarov ,  Hirak Basu ,  Subhra Bhattacharya ,  Yu Wang

    IPC分类号： C07D255/02 ,  C07D257/02 ,  C07D245/02 ,  A61K31/506

    CPC分类号： C07D255/02 ,  C07D257/02

    摘要： Novel cyclic polyamine compounds of the form where A1, each A2 (if present), and A3 are independently selected from C1-C8 alkyl, where each Y is independently selected from H or C1-C4 alkyl, where M is selected from C1-C4 alkyl, where k is 0, 2, or 3, and where R is selected from C1-C32 alkyl, as well as all stereoisomers and salts thereof, are disclosed. Additional compounds where k is 1 and A2 is independently selected from C1-C3 alkyl or C5-C8 alkyl are also disclosed. Cyclic polyamines, where the amide group is reduced to a secondary amino group, and various derivatives of these compounds, are also described. Synthetic methods for the compounds are described. The compounds are useful for treating diseases caused by uncontrolled proliferation of cells, such as cancer, especially prostate cancer, and for inducing intracellular ATP hydrolysis for treatment of other disorders.

    摘要翻译： 其中A 1 A 1，每个A 2（如果存在）和A 3 N 3的形式的新型环状多胺化合物独立地选自C SUB 其中每个Y独立地选自H或C 1 -C 4烷基，其中M（C 1 -C 4）烷基，其中每个Y独立地选自H或C 1 -C 4烷基，其中M 选自C 1 -C 4烷基，其中k是0,1,2或3，并且其中R选自C 1 -C 4 - C 32烷基，以及其全部立体异构体和盐。 其中k为1且A 2 H 2的其它化合物独立地选自C 1 -C 3烷基或C 5 - -C 8烷基也被公开。 还描述了其中酰胺基还原为仲氨基的环状多胺，以及这些化合物的各种衍生物。 描述了化合物的合成方法。 该化合物可用于治疗由不受控制的细胞增殖（例如癌症，特别是前列腺癌）引起的疾病，并用于诱导细胞内ATP水解以治疗其他疾病。

    Polyamine Analogs as Modulators of Cell Migration and Cell Motility
    10.
    发明申请
    Polyamine Analogs as Modulators of Cell Migration and Cell Motility 审中-公开
    多胺类似物作为细胞迁移和细胞运动的调节剂

    公开(公告)号：US20090143456A1

    公开(公告)日：2009-06-04

    申请号：US11884165

    申请日：2006-02-13

    申请人： Laurence J. Marton ,  Michael E. Berens ,  Benjamin Frydman ,  Linda CLifford

    发明人： Laurence J. Marton ,  Michael E. Berens ,  Benjamin Frydman ,  Linda CLifford

    IPC分类号： A61K31/409 ,  A61K31/132 ,  A61P43/00

    CPC分类号： A61K31/137 ,  Y02A50/401

    摘要： This disclosure relates to methods of inhibiting cell motility or cell migration, and of treating diseases involving cell migration or cell motility, using polyamine analogs, such as conformationally restricted polyamine analogs. The diseases to be treated include immune disorders, inflammatory conditions, infection, abnormal immune responses, undesired angiogenesis, tumor cell metastasis or invasion, atherosclerosis, vascular graft occlusion, transplant rejection, other complications of transplants, glomerulonephritis, arthritis, inflammatory responses subsequent to stroke or ischemia, and asthma.

    摘要翻译： 本公开涉及使用多胺类似物如构象限制性多胺类似物来抑制细胞运动或细胞迁移以及涉及细胞迁移或细胞运动的疾病的方法。 待治疗的疾病包括免疫疾病，炎症状况，感染，免疫反应异常，不希望的血管生成，肿瘤细胞转移或侵袭，动脉粥样硬化，血管移植物阻塞，移植排斥反应，其他移植并发症，肾小球肾炎，关节炎，中风后炎症反应 或缺血和哮喘。