公开(公告)号：US20090098175A1

公开(公告)日：2009-04-16

申请号：US12204731

申请日：2008-09-04

申请人： Benjamin Marcus Buehrer ,  Paul Theodore Hamilton ,  Dalia Izolda Juzumiene ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen

发明人： Benjamin Marcus Buehrer ,  Paul Theodore Hamilton ,  Dalia Izolda Juzumiene ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen

IPC分类号： A61K9/00 ,  C07K7/08 ,  C07K14/00 ,  A61P19/04 ,  A61K38/10 ,  A61K38/16

CPC分类号： C07K14/71 ,  A61K9/0024 ,  A61K38/00 ,  A61L27/227 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/414 ,  A61L2300/606 ,  C07K2319/20

摘要： The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.

摘要翻译： 目前公开的主题涉及用于非共价定位的纤维结缔组织诱导生长因子到植入物表面的肽组合物，该组合物包含与对具有结合的肽偶联的植入物的表面材料具有结合亲和力的肽 对纤维结缔组织诱导生长因子的亲和力。 提供用于递送纤维结缔组织诱导生长因子GDF-7的方法，其量有效促进纤维结缔组织修复和纤维结缔组织形成。 还提供了通过使组合物与植入物的表面接触来将肽组合物施用于植入物的方法; 和包含该组合物的试剂盒。

公开(公告)号：US08691946B2

公开(公告)日：2014-04-08

申请号：US13109802

申请日：2011-05-17

申请人： Isaac Gilliam Sanford ,  Martyn Kerry Darby ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen ,  Paul Theodore Hamilton ,  Ganesan Sathya ,  Hanne Gron ,  Michelle Steffen Jansen

发明人： Isaac Gilliam Sanford ,  Martyn Kerry Darby ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen ,  Paul Theodore Hamilton ,  Ganesan Sathya ,  Hanne Gron ,  Michelle Steffen Jansen

IPC分类号： A61K38/04 ,  A61K38/00 ,  A61K38/03 ,  C07K17/12 ,  C07K17/04 ,  C07K17/08 ,  C07K17/10 ,  C07K7/08

CPC分类号： A61K47/48992 ,  A61K9/0024 ,  A61K38/10 ,  A61K47/02 ,  A61K47/42 ,  A61K47/64 ,  A61K47/6957 ,  A61L27/425 ,  A61L27/427 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/02

摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

摘要翻译： 提供组织修复的组合物和方法，包括细胞结合肽和生长因子结合肽。 细胞结合肽与干细胞，成纤维细胞或内皮细胞中的一种或多种结合。 生长因子结合肽包括血小板衍生生长因子（PDGF）结合肽和生长分化因子（GDF）结合肽。 用于修复的组织包括肌腱，肌肉，结缔组织，韧带，心脏组织，血管组织或真皮。 提供用于组织修复的可植入装置，细胞和生长因子结合肽所连接的装置，例如具有连接结合肽的细胞外细胞基质。

公开(公告)号：US20110223142A1

公开(公告)日：2011-09-15

申请号：US13109802

申请日：2011-05-17

申请人： Isaac Gilliam Sanford ,  Martyn Kerry Darby ,  Shrikumar Ambujakshan Nair ,  Jonathan Allen Hodges ,  Yuchen Chen ,  Ganesan Sathya ,  Hanne Gron ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton

发明人： Isaac Gilliam Sanford ,  Martyn Kerry Darby ,  Shrikumar Ambujakshan Nair ,  Jonathan Allen Hodges ,  Yuchen Chen ,  Ganesan Sathya ,  Hanne Gron ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton

IPC分类号： A61K35/12 ,  C07K7/08 ,  C07K14/00 ,  A61K38/10 ,  A61K38/16 ,  A61K38/39 ,  C12N5/071 ,  A61P43/00

CPC分类号： A61K47/48992 ,  A61K9/0024 ,  A61K38/10 ,  A61K47/02 ,  A61K47/42 ,  A61K47/64 ,  A61K47/6957 ,  A61L27/425 ,  A61L27/427 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/02

摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

摘要翻译： 提供组织修复的组合物和方法，包括细胞结合肽和生长因子结合肽。 细胞结合肽与干细胞，成纤维细胞或内皮细胞中的一种或多种结合。 生长因子结合肽包括血小板衍生生长因子（PDGF）结合肽和生长分化因子（GDF）结合肽。 用于修复的组织包括肌腱，肌肉，结缔组织，韧带，心脏组织，血管组织或真皮。 提供用于组织修复的可植入装置，细胞和生长因子结合肽所连接的装置，例如具有连接结合肽的细胞外细胞基质。

公开(公告)号：US20110117167A1

公开(公告)日：2011-05-19

申请号：US12949104

申请日：2010-11-18

申请人： Isaac Gilliam Sanford ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen ,  Martyn Kerry Darby ,  Hanne Gron ,  Ganesan Sathya

发明人： Isaac Gilliam Sanford ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen ,  Martyn Kerry Darby ,  Hanne Gron ,  Ganesan Sathya

IPC分类号： A61K9/00 ,  C07K14/00 ,  C07K7/08 ,  C07K14/78 ,  C12N5/071 ,  C12N5/078 ,  A61K35/12 ,  A61K35/32 ,  A61K35/28 ,  A61K35/14 ,  A61K35/16 ,  A61K35/48 ,  A61K35/50 ,  C07K19/00 ,  A61K38/16 ,  A61K38/10 ,  A61K38/39 ,  A61P17/02 ,  A61P19/04 ,  A61P21/00 ,  A61P19/00 ,  A61P9/00 ,  C07K9/00 ,  C08G63/91 ,  A61K38/14 ,  A61K31/765 ,  C12N5/077

CPC分类号： A61K47/48992 ,  A61K9/0024 ,  A61K38/10 ,  A61K47/02 ,  A61K47/42 ,  A61K47/64 ,  A61K47/6957 ,  A61L27/425 ,  A61L27/427 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/02

摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

公开(公告)号：US08779089B2

公开(公告)日：2014-07-15

申请号：US12949104

申请日：2010-11-18

申请人： Isaac Gilliam Sanford ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen ,  Martyn Kerry Darby ,  Hanne Gron ,  Ganesan Sathya

发明人： Isaac Gilliam Sanford ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen ,  Martyn Kerry Darby ,  Hanne Gron ,  Ganesan Sathya

IPC分类号： A61K38/10 ,  C07K17/00 ,  C07K17/12 ,  C07K7/08 ,  C07K17/08 ,  C07K17/10 ,  A61K47/48 ,  A61K47/02 ,  A61K9/00 ,  A61L27/54 ,  A61L27/58 ,  A61K47/42 ,  A61L27/42

CPC分类号： A61K47/48992 ,  A61K9/0024 ,  A61K38/10 ,  A61K47/02 ,  A61K47/42 ,  A61K47/64 ,  A61K47/6957 ,  A61L27/425 ,  A61L27/427 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/02

摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

公开(公告)号：US20110117165A1

公开(公告)日：2011-05-19

申请号：US12948978

申请日：2010-11-18

申请人： Mora Carolynne Melican ,  Paul Theodore Hamilton ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen

发明人： Mora Carolynne Melican ,  Paul Theodore Hamilton ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Yuchen Chen

IPC分类号： A61F2/00 ,  A61K33/06 ,  A61K33/42 ,  A61K33/10 ,  A61K31/74

CPC分类号： A61K47/64 ,  A61K9/0024 ,  A61K38/10 ,  A61K47/02 ,  A61K47/42 ,  A61K47/6957 ,  A61L27/425 ,  A61L27/427 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/02

摘要： Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached BMP binding peptide. In addition, an implantable bone graft material is provided consisting essentially of a resorbable β-TCP and a resorbable polymer, wherein the β-TCP has a total porosity of about 50% or greater and wherein the β-TCP has a particle size ranging from about 100 micron to about 300 micron. The implantable bone graft materials are useful for promoting bone growth in a subject.

公开(公告)号：US20100098737A1

公开(公告)日：2010-04-22

申请号：US12253750

申请日：2008-10-17

申请人： Martyn Kerry Darby ,  Isaac Gilliam Sanford ,  Ray Edward Benson, III ,  Hanne Gron ,  Paul Theodore Hamilton ,  Shrikumar Ambujakshan Nair

发明人： Martyn Kerry Darby ,  Isaac Gilliam Sanford ,  Ray Edward Benson, III ,  Hanne Gron ,  Paul Theodore Hamilton ,  Shrikumar Ambujakshan Nair

IPC分类号： A61F2/00 ,  A61K38/16 ,  A61L33/12 ,  C07H21/04 ,  C12N15/64 ,  A61P31/04

CPC分类号： A61L27/34 ,  A61K38/16 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/406 ,  C07K2319/20

摘要： The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.

摘要翻译： 目前公开的主题涉及对糖肽抗生素具有结合亲和力的肽以及将糖肽抗生素递送到医疗器械表面的方法和组合物。 肽组合物可以包含对与对糖肽抗生素具有结合亲和力的肽偶联的医疗器械的表面材料具有结合亲和力的肽。 还提供了通过使肽组合物与医疗装置的表面接触来将肽组合物应用于医疗装置的方法。 此外，提供了包含肽组合物的试剂盒。

公开(公告)号：US20110117168A1

公开(公告)日：2011-05-19

申请号：US12949149

申请日：2010-11-18

申请人： Ganesan Sathya ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Hanne Gron

发明人： Ganesan Sathya ,  Michelle Steffen Jansen ,  Paul Theodore Hamilton ,  Jonathan Allen Hodges ,  Shrikumar Ambujakshan Nair ,  Hanne Gron

IPC分类号： A61K9/00 ,  C07K7/08 ,  C07K7/06 ,  C07K19/00 ,  C07K9/00 ,  C08G63/91 ,  A61K38/39 ,  A61K38/17 ,  A61K38/02 ,  A61K31/785 ,  A61F2/10 ,  A61F2/08 ,  A61F2/12 ,  A61P43/00 ,  A61P9/00 ,  A61P17/00 ,  A61P19/04

CPC分类号： A61K47/64 ,  A61K9/0024 ,  A61K38/10 ,  A61K47/02 ,  A61K47/42 ,  A61K47/6957 ,  A61L27/425 ,  A61L27/427 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/02

摘要： Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

公开(公告)号：US07807624B2

公开(公告)日：2010-10-05

申请号：US11649950

申请日：2007-01-05

申请人： Daniel James Kenan ,  Paul Theodore Hamilton

发明人： Daniel James Kenan ,  Paul Theodore Hamilton

IPC分类号： C07K14/00

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61L27/34 ,  A61L31/10 ,  C07K7/06 ,  C07K7/08

摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.

摘要翻译： 本发明提供用于医疗装置的改进涂层的组合物和方法。 本发明提供一种生物功能性涂料组合物，其包含至少一个对医疗装置的表面材料具有结合特异性的结合结构域和至少一个对内皮细胞谱系细胞具有结合特异性的结合结构域。 用于涂覆医疗装置的表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的表面与生物功能性涂层材料接触，并且还可以包括使涂覆的表面与 内皮细胞谱系将内皮细胞谱系的细胞与涂层表面结合。

公开(公告)号：US07531505B2

公开(公告)日：2009-05-12

申请号：US11649935

申请日：2007-01-05

申请人： Paul Theodore Hamilton ,  Daniel James Kenan ,  Amy Katherine Solan

发明人： Paul Theodore Hamilton ,  Daniel James Kenan ,  Amy Katherine Solan

IPC分类号： A61K38/00 ,  A61F2/04

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61L27/34 ,  A61L31/10 ,  C07K7/06 ,  C07K7/08 ,  C07K2319/00

摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a metallic surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a metallic surface of a medical device, and for manufacturing of a medical device, comprise contacting the metallic surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.

摘要翻译： 本发明提供用于医疗装置的改进涂层的组合物和方法。 本发明提供一种生物功能性涂料组合物，其包含至少一个对医疗器械的金属表面材料具有结合特异性的结合结构域和至少一个对内皮细胞谱系细胞具有结合特异性的结合结构域。 用于涂覆医疗装置的金属表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的金属表面与生物功能性涂层接触，并且还可以包括使涂覆的表面与 内皮细胞谱系的细胞将内皮细胞谱系的细胞结合到包被的表面。