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公开(公告)号：US10941445B2
公开(公告)日：2021-03-09
申请号：US15926341
申请日：2018-03-20
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Tal Raz , Pascaline Mary
IPC: C12Q1/6876 , C12Q1/6869 , C12Q1/6848 , C12Q1/6806 , C12Q1/682
Abstract: The present invention relates to methods of target nucleic acid amplification and uses thereof in methods of sequencing, or other down-stream applications such a genotyping or cloning. More specifically, the methods relate to methods of target nucleic acid amplification through the use of a universal hairpin primer.
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公开(公告)号：US10343167B2
公开(公告)日：2019-07-09
申请号：US15691196
申请日：2017-08-30
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Adnan Esmail , Tal Raz , John Healy , Tony Hung , Sepehr Kiani , Pascaline Mary
IPC: B01L3/00 , B01L7/00 , G01N35/08 , C12Q1/6869
Abstract: The present invention provides a microfluidic system, method and kit for performing assays. The system may comprise a microfluidic device and a detector, wherein the assay yields results that may be read by a detector and analyzed by the system. The assay may comprise one or more chemical or biological reaction against, or performed on, a sample or multiple samples. The sample(s) may become larger and/or smaller during the performance of the assay. The sample(s) may be present within a vehicle, or on a carrier within a vehicle, in the microfluidic device, and wherein the vehicle may become larger and/or smaller during the performance of the assay. The assay may be a cascading assay comprising a series of multiple assays, wherein each assay may be the same or different, and wherein each assay in the series of multiple assays may further comprise one or more process or step.
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公开(公告)号：US10533212B2
公开(公告)日：2020-01-14
申请号：US15408191
申请日：2017-01-17
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Tal Raz , Pascaline Mary
IPC: C12Q1/68 , C07H21/00 , C12Q1/6818 , C12Q1/6858 , G01N21/64 , C12Q1/6804
Abstract: The present invention generally pertains to methods for detecting the presence or absence of a particular nucleic acid sequence. The present invention generally relates to incorporating a detector into a target nucleic acid, adding an oligonucleotide probe, polymerase enzyme and an inhibitor to the reaction, and detecting interference of the oligonucleotide probe with the inhibitor as an indication of the presence of a particular target nucleic acid sequence as well as kits encompassing the same.
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公开(公告)号：US10022721B2
公开(公告)日：2018-07-17
申请号：US14470860
申请日：2014-08-27
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Sepehr Kiani , Joshua Blouwolff , Adnan Esmail , Jason Hung , Tony Hung , Adam R. Abate , Scott Powers , Pascaline Mary
Abstract: Methods and systems for manipulating drops in microfluidic channels are provided.
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Patent Agency Ranking
5.发明授权公开(公告)号：US10012592B2
公开(公告)日：2018-07-03
申请号：US15722486
申请日：2017-10-02
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Adam Abate , John Lawrence Emhoff , Tony Hung , Adnan Moez Esmail , Sepehr Kiani , Pascaline Mary
CPC classification number: G01N21/6486 , C12Q1/6806 , G01N21/255 , G01N21/76 , G01N2201/06113 , G01N2201/062 , C12Q2545/101 , C12Q2563/107 , C12Q2563/159 , C12Q2563/161 , C12Q2565/629
Abstract: The present invention generally pertains to methods and kits for managing the variation in spectroscopic intensity measurements through the use of a reference component. The reference component may comprise a reference spectroscopic substance and may be contained together with a sample of interest in a sample to be tested, wherein the sample of interest may comprise a sample spectroscopic substance. Each sample to be tested may be uniquely identified and, hence, “barcoded” by combinations of different colors and concentrations of spectroscopic substances, contained therein.
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公开(公告)号：US10589274B2
公开(公告)日：2020-03-17
申请号：US15986718
申请日：2018-05-22
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Sepehr Kiani , Joshua Blouwolff , Adnan Esmail , Jason Hung , Tony Hung , Adam R. Abate , Scott Powers , Pascaline Mary
Abstract: Methods and systems for manipulating drops in microfluidic channels are provided.
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公开(公告)号：US10569268B2
公开(公告)日：2020-02-25
申请号：US15822742
申请日：2017-11-27
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Adam Abate , Sepehr Kiani , Tony Hung , Pascaline Mary , Adnan Moez Esmail
Abstract: The present invention generally pertains to a system for performing injection of multiple substantially controlled volumes into or out of a droplet, and methods and kits comprising the same. The system of the present invention comprises at least one microfluidic channel, one or more injection channels, an injection inlet associated with each of the one or more injection channels, and a mechanism for disrupting an interface between a droplet and a fluid and/or emulsion, wherein the at least one microfluidic channel comprises one or more droplets are flowing therein, and wherein each of the one or more injection channels comprises at least one fluid and/or emulsion therein.
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公开(公告)号：US09821312B2
公开(公告)日：2017-11-21
申请号：US14427404
申请日：2013-09-12
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Adnan Esmail , John Healy , Tony Hung , Sepehr Kiani , Pascaline Mary , Tal Raz
CPC classification number: B01L3/502784 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/14 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0883 , B01L2300/18 , B01L2300/1861 , B01L2400/0415 , B01L2400/0433 , B01L2400/0448 , B01L2400/088 , G01N35/08 , Y10T436/143333 , Y10T436/2575
Abstract: The present invention provides a microfluidic system, method and kit for performing assays. The system may comprise a microfluidic device and a detector, wherein the assay yields results that may be read by a detector and analyzed by the system. The assay may comprise one or more chemical or biological reaction against, or performed on, a sample or multiple samples. The sample(s) may become larger and/or smaller during the performance of the assay. The sample(s) may be present within a vehicle, or on a carrier within a vehicle, in the microfluidic device, and wherein the vehicle may become larger and/or smaller during the performance of the assay. The assay may be a cascading assay comprising a series of multiple assays, wherein each assay may be the same or different, and wherein each assay in the series of multiple assays may further comprise one or more process or step.
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公开(公告)号：US20170226568A1
公开(公告)日：2017-08-10
申请号：US15408191
申请日：2017-01-17
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Tal Raz , Pascaline Mary
CPC classification number: C12Q1/6818 , C12Q1/6804 , C12Q1/6858 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , C12Q2535/125 , C12Q2565/101 , C12Q2563/159 , C12Q2565/629
Abstract: The present invention generally pertains to methods for detecting the presence or absence of a particular nucleic acid sequence. The present invention generally relates to incorporating a detector into a target nucleic acid, adding an oligonucleotide probe, polymerase enzyme and an inhibitor to the reaction, and detecting interference of the oligonucleotide probe with the inhibitor as an indication of the presence of a particular target nucleic acid sequence as well as kits encompassing the same.
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