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公开(公告)号：US20250099752A1
公开(公告)日：2025-03-27
申请号：US18904484
申请日：2024-10-02
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Benjamin Keith Stein , Keith R. Maile , Ron A. Balczewski , Aleksandra Kharam
Abstract: Embodiments herein relate to a method for treating a cancerous tumor located within a subject. The method can include applying one or more electric fields at or near a site of the cancerous tumor, where the cancerous tumor can include a cancerous cell population. The one or more applied electric fields are effective to delay mitosis and cause mitotic synchronization within a proportion of the cancerous cell population. The method can include removing the one or more electric fields to allow mitosis to proceed within the cancerous cell population. The method can include administering a chemotherapeutic agent to the subject after the one or more electric fields have been removed. Other embodiments are also included herein.
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公开(公告)号：US20240115856A1
公开(公告)日：2024-04-11
申请号：US18215603
申请日：2023-06-28
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Devon N. Arnholt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Ron A. Balczewski , Aleksandra Kharam
IPC: A61N1/36 , A61B5/0538 , A61N1/05
CPC classification number: A61N1/36002 , A61B5/0538 , A61N1/05
Abstract: Embodiments herein relate to a medical device for treating a cancerous tumor, the medical device having a first lead including a first wire and second wire; a second lead can include a third wire and fourth wire; and a first electrode in electrical communication with the first wire, a second electrode in electrical communication with the second wire, a third electrode in electrical communication with the third wire, and a fourth electrode in electrical communication with the fourth wire. The first and third electrodes form a supply electrode pair configured to deliver one or more electric fields to the cancerous tumor. The second and fourth electrodes form a sensing electrode pair configured to measure an impedance of the cancerous tumor independent of an impedance of the first electrode, the first wire, the third electrode, the third wire, and components in electrical communication therewith. Other embodiments are also included herein.
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公开(公告)号：US11596353B2
公开(公告)日：2023-03-07
申请号：US16655537
申请日：2019-10-17
Applicant: Boston Scientific Scimed Inc.
Inventor： Jan Weber , Jeffrey E. Stahmann , James M. Peck , Keith R. Maile
Abstract: Embodiments of the present disclosure relate to monitoring one or more physiological parameters of a subject using a multilayer wearable device. In an embodiment, a multilayer wearable device is configured to be attached to a subject. The multilayer wearable device comprises a substrate having multiple layers including a first portion connected to a second portion. The first portion has a first side and a second, opposite side. And the second portion has a first side and a second, opposite side. The first side of the first portion is configured to be attached to the subject and the second portion is arranged on top of the first portion such that the first side of the second portion is disposed adjacent the second side of the first portion. And, the wearable device includes one or more electrical components configured to sense a physiological parameter of the subject.
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公开(公告)号：US11576614B2
公开(公告)日：2023-02-14
申请号：US16656349
申请日：2019-10-17
Applicant: Boston Scientific Scimed Inc.
Inventor： Jan Weber , Jeffrey E. Stahmann , Keith R. Maile , James M. Peck
IPC: A61B5/00 , A61B5/1455
Abstract: Embodiments disclosed herein relate to devices and methods for monitoring one or more physiological parameters of a subject. In an embodiment, a wearable device comprises a substrate configured to attached to a subject's skin. The substrate comprises a middle portion arranged between two end portions, wherein the middle portion is more flexible than at least one of the end portions. The wearable device also comprises a physiological sensor arranged on the middle portion. The physiological sensor is configured to sense a physiological signal of the subject when the wearable device is attached to the subject's skin. And, the wearable device comprises one or more electrical components arranged on at least one of the end portions, wherein at least one of the one or more electrical components is coupled to the physiological sensor.
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公开(公告)号：US20200330757A1
公开(公告)日：2020-10-22
申请号：US16850720
申请日：2020-04-16
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Ron A. Balczewski , Sarah Melissa Gruba , Tucker James Nelson , Aleksandra Kharam
Abstract: Embodiments herein relate to a medical device for treating a cancerous tumor, including an electric field generating circuit configured to generate one or more electric fields at or near a site of the cancerous tumor and control circuitry in communication with the electric field generating circuit. The medical device includes one or more supply wires in electrical communication with the electric field generating circuit and one or more supply electrodes. The supply electrodes are configured to deliver an electric field at or near the site of the cancerous tumor. The medical device can include one or more sensing wires in electrical communication with the control circuitry and one or more sensing electrodes. The sensing electrodes can be configured to measure an impedance of the cancerous tumor at at least two different electric field strengths. Other embodiments are also included herein.
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Patent Agency Ranking
公开(公告)号：US20240226547A1
公开(公告)日：2024-07-11
申请号：US18543879
申请日：2023-12-18
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Devon N. Arnholt , Keith R. Maile , Sarah Melissa Gruba , William J. Linder
CPC classification number: A61N1/36002 , A61L31/16 , A61N1/05 , A61N1/08
Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having an electric field generating circuit and control circuitry configured to control delivery of the one or more electric fields from the electric field generating circuit to the site of the cancerous tissue. An implantable lead is included having a lead body including a first electrical conductor disposed within the lead body, and a first electrode coupled to the lead body, the first electrode in electrical communication with the first electrical conductor, wherein the first electrical conductor forms part of an electrical circuit by which the electric fields from the electric field generating circuit are delivered to the site of the cancerous tissue, and the first electrode can include a conductive coil filar disposed around the lead body. Other embodiments are also included herein.
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公开(公告)号：US11903589B2
公开(公告)日：2024-02-20
申请号：US17209938
申请日：2021-03-23
Applicant: BOSTON SCIENTIFIC SCIMED, INC.
Inventor： Jeffrey E. Stahmann , Bin Mi , Eric Wedul , Keith R. Maile
CPC classification number: A61B17/12122 , A61B17/12031 , A61B17/12131 , A61B2017/00221 , A61B2017/12095 , A61B2562/0214 , A61B2562/0247
Abstract: A medical system may include a left atrial appendage closure device including an expandable framework and a proximal hub centered on a central longitudinal axis of the framework. An insert may be disposed within the proximal hub and include a collar configured to engage the proximal hub, a recess extending into the insert from a proximal end, and a post member disposed within the recess. The post member may be radially spaced apart from the collar and may extend proximally from a distal end of the recess to a proximal surface. The insert may include a first connection structure disposed distal of the proximal surface. The medical system may include a delivery catheter having a second connection structure configured to engage the first connection structure in a delivery configuration. The distal end of the delivery catheter includes a hollow portion configured to receive the post member in the delivery configuration.
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公开(公告)号：US20230330416A1
公开(公告)日：2023-10-19
申请号：US18123776
申请日：2023-03-20
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Devon N. Arnholt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Ron A. Balczewski , Jacob M. Ludwig , Aleksandra Kharam
CPC classification number: A61N1/36002 , A61N1/36034 , A61N1/0408 , A61N1/05 , A61N1/36017 , A61N1/3787
Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having at least one electric field generating circuit configured to generate one or more electric fields; control circuitry in communication with the electric field generating circuit, the control circuitry configured to control delivery of the one or more electric fields from the at least one electric field generating circuit; and two or more electrodes to deliver the electric fields to the site of a cancerous tumor within a patient. At least one electrode can be configured to be implanted. At least one electrode can be configured to be external. The control circuitry can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz.
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公开(公告)号：US11712561B2
公开(公告)日：2023-08-01
申请号：US16855448
申请日：2020-04-22
Applicant: Boston Scientific Scimed, Inc.
Inventor： Brian L. Schmidt , Benjamin Keith Stein , Keith R. Maile , William J. Linder , Aleksandra Kharam
CPC classification number: A61N1/36002 , A61F7/007 , A61F2007/0073 , A61F2007/0096
Abstract: Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having an electric field generating circuit configured to generate one or more electric fields and a control circuit in communication with the electric field generating circuit. The control circuit configured to control delivery of the one or more electric fields from the electric field generating circuit. The system can include two or more electrodes to deliver the electric fields to a site of a cancerous tumor within a patient and a temperature sensor to measure the temperature of tissue at the site of the cancerous tumor. The control circuit can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz. Other embodiments are also included herein.
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公开(公告)号：US20230157640A1
公开(公告)日：2023-05-25
申请号：US18094893
申请日：2023-01-09
Applicant: Boston Scientific Scimed Inc.
Inventor： Jan Weber , Jeffrey E. Stahmann , Keith R. Maile , James M. Peck
IPC: A61B5/00 , A61B5/1455
CPC classification number: A61B5/6843 , A61B5/1455 , A61B5/6833 , A61B2562/12 , A61B2562/164
Abstract: Embodiments disclosed herein relate to devices and methods for monitoring one or more physiological parameters of a subject. In an embodiment, a wearable device comprises a substrate configured to be attached to a subject's skin. The substrate comprises a middle portion arranged between two end portions. The wearable device also comprises a physiological sensor. The physiological sensor is configured to sense a physiological signal of the subject when the wearable device is attached to the subject's skin. And, the wearable device comprises one or more electrical components arranged on at least one of the end portions, wherein at least one of the one or more electrical components is coupled to the physiological sensor.
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