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1.发明申请公开(公告)号：US20120052550A1
公开(公告)日：2012-03-01
申请号：US13062960
申请日：2009-09-22
申请人： Brad William Woonton , Milton Thomas William Hearn , Pankaj Maharjan , Kirthi De Silva , William Roy Jackson
发明人： Brad William Woonton , Milton Thomas William Hearn , Pankaj Maharjan , Kirthi De Silva , William Roy Jackson
CPC分类号： C08L51/02 , B01D15/362 , B01D15/3876 , B01J20/264 , B01J20/267 , B01J20/285 , B01J39/19 , B01J39/26 , C07K1/18 , C08F2/44 , C08F20/56 , C08F26/06 , C08F220/06 , C08F220/56 , C08F222/385 , C08F226/00 , C08H1/00 , C08J3/12 , C08J3/24 , C08J2333/26 , C08L1/08 , C08L5/00 , C08L29/02 , C08L51/003 , C08L2555/80
摘要： The present invention relates to a method for isolating proteins from a solution containing the proteins. The invention also relates to a method for the chromatographic separation of proteins. The present invention also relates to crosslinked hydroxylic polymer particles functionalized with temperature-responsive copolymer, and to methods of preparing such particles.
摘要翻译： 本发明涉及从含有蛋白质的溶液中分离蛋白质的方法。 本发明还涉及一种色谱分离蛋白质的方法。 本发明还涉及用温度响应共聚物官能化的交联羟基聚合物颗粒，以及制备这种颗粒的方法。
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2.发明授权公开(公告)号：US08877477B2
公开(公告)日：2014-11-04
申请号：US13062960
申请日：2009-09-22
申请人： Brad William Woonton , Milton Thomas William Hearn , Pankaj Maharjan , Kirthi De Silva , William Roy Jackson
发明人： Brad William Woonton , Milton Thomas William Hearn , Pankaj Maharjan , Kirthi De Silva , William Roy Jackson
IPC分类号： C09H3/02 , C09H3/00 , C09H1/04 , C08H1/00 , B01J20/26 , C08F2/44 , B01D15/38 , C08F20/56 , C08F226/00 , B01D15/36 , B01J39/26 , C07K1/18 , C08J3/12 , C08J3/24 , C08F26/06 , B01J20/285 , C08F220/56 , C08F222/38 , C08F220/06
CPC分类号： C08L51/02 , B01D15/362 , B01D15/3876 , B01J20/264 , B01J20/267 , B01J20/285 , B01J39/19 , B01J39/26 , C07K1/18 , C08F2/44 , C08F20/56 , C08F26/06 , C08F220/06 , C08F220/56 , C08F222/385 , C08F226/00 , C08H1/00 , C08J3/12 , C08J3/24 , C08J2333/26 , C08L1/08 , C08L5/00 , C08L29/02 , C08L51/003 , C08L2555/80
摘要： The present invention relates to a method for isolating proteins from a solution containing the proteins. The invention also relates to a method for the chromatographic separation of proteins. The present invention also relates to crosslinked hydroxylic polymer particles functionalized with temperature-responsive copolymer, and to methods of preparing such particles.
摘要翻译： 本发明涉及从含有蛋白质的溶液中分离蛋白质的方法。 本发明还涉及一种色谱分离蛋白质的方法。 本发明还涉及用温度响应共聚物官能化的交联羟基聚合物颗粒，以及制备这种颗粒的方法。
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公开(公告)号：US06881740B1
公开(公告)日：2005-04-19
申请号：US09743379
申请日：1999-07-08
申请人： Bevyn Jarrott , Phillip Mark Beart , William Roy Jackson , Alan Duncan Robertson , Maree Patricia Collis , Alexandra Papanikos
发明人： Bevyn Jarrott , Phillip Mark Beart , William Roy Jackson , Alan Duncan Robertson , Maree Patricia Collis , Alexandra Papanikos
IPC分类号： C07D251/48 , A61K31/505 , A61K31/506 , A61K31/53 , A61P1/08 , A61P9/02 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/10 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D239/48 , C07D239/49 , C07D239/50 , C07D251/70 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D417/06 , C07D417/12 , A61P3/10
CPC分类号： C07D239/48 , C07D239/50 , C07D405/12
摘要： This invention relates to compounds to formula (1) wherein B is optionally substituted aryl; R1 and R2 are the same or different and are independently selected from hydrogen or C1-3 alkyl; n is 1 or 2, preferably n is 1; m is 0 or 1; R3 is hydrogen or acyl, R4 and R5 are the same or different and are independently selected from amino, alkylamino, dialkylamino, arylamino and C2-C4 cycloalkylamino; X and Y are independently selected from C, H or N provided at least one of X and Y is N; and salts thereof, solvates thereof, pharmaceutically acceptable derivatives thereof, prodrugs thereof, tautomers thereof and/or isomers thereof, and processes for their reparation and methods of treatment, pharmaceutical formulations and uses involving them.
摘要翻译： 本发明涉及式（1）的化合物，其中B为任选取代的芳基; R 1和R 2相同或不同，并且独立地选自氢或C 1-3烷基; n为1或2，优选n为1; m为0或1; R 3是氢或酰基，R 4和R 5相同或不同，并且独立地选自氨基，烷基氨基，二烷基氨基，芳基氨基 和C 2 -C 4环烷基氨基;和 X和Y独立地选自C，H或N，其中X和Y中的至少一个是N; 其盐，其溶剂合物，其药学上可接受的衍生物，其前药，其互变异构体和/或其异构体，及其修复方法和治疗方法，药物制剂和涉及它们的用途。
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公开(公告)号：US06232314B1
公开(公告)日：2001-05-15
申请号：US09180258
申请日：1999-03-18
申请人： Bevyn Jarrott , Philip Mark Beart , William Roy Jackson , Vijaya Bhaskar Kenche , Alan Duncan Robertson , Maree Patricia Collis
发明人： Bevyn Jarrott , Philip Mark Beart , William Roy Jackson , Vijaya Bhaskar Kenche , Alan Duncan Robertson , Maree Patricia Collis
IPC分类号： C07D295092
CPC分类号： C07D295/185 , C07D213/38 , C07D295/092 , C07D307/81 , C07D311/58 , C07D317/58 , C07D333/28
摘要： Arylalkylpiperazine compounds (1) wherein B is aryl or optionally substituted aryl; R1 is hydroxy; R2 and R3 are the same or different and are independently selected from hydrogen or C1-3 alkyl; m is 0, 1 or 2; D is a linking chain of atoms which may be optionally substituted and which contains from 1 to 8 atoms in the chain; E is a phenolic antioxidant group or a corresponding amino derivative thereof wherein the phenolic hydroxyl is replaced by amino, are disclosed. The compounds have both free radical scavenging activity and block excitatory amino acid activity. Some compounds of the present invention also display an affinity for voltage-sensitive sodium channels.
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公开(公告)号：US08211989B2
公开(公告)日：2012-07-03
申请号：US11988180
申请日：2006-06-30
申请人： Christopher Henry Such , Jim Patel , William Roy Jackson , Andrea Jane Robinson , Algirdas Kazimleras Serelis
发明人： Christopher Henry Such , Jim Patel , William Roy Jackson , Andrea Jane Robinson , Algirdas Kazimleras Serelis
CPC分类号： C09D165/00 , C07C67/333 , C08G61/00 , C11C3/00 , C07C69/533
摘要： The invention provides a method of preparing a crosslinked polymer, which method comprises polymerising branched polyunsaturated monomers by a metathesis polymerisation reaction, wherein the branched polyunsaturated monomers contain acyclic ethylenically unsaturated groups that are capable of undergoing polymerization by a metathesis reaction such that the metathesis polymerisation produces a crosslinked polymer and substantially no non-volatile ethylenically unsaturated by-products.
摘要翻译： 本发明提供了一种制备交联聚合物的方法，该方法包括通过易位聚合反应聚合支链多不饱和单体，其中支化多不饱和单体含有无环烯键式不饱和基团，其能够通过复分解反应进行聚合，使得易位聚合产生 交联聚合物和基本上不含非挥发性烯属不饱和副产物。
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公开(公告)号：US08748582B2
公开(公告)日：2014-06-10
申请号：US13502103
申请日：2010-10-15
IPC分类号： C07K1/22 , C07D213/70 , C07D213/76 , C07D215/36 , C07D217/22 , C07D401/12 , C07D401/14 , C08B37/00
CPC分类号： B01D15/3804 , B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3244 , B01J20/3251 , B01J20/3255 , C07D213/32 , C07D213/70 , C07D215/36 , C07D217/22 , C07K1/22
摘要： The present invention relates generally to affinity ligands and chemical affinity ligand-matrix conjugates for use as chromatographic adsorbents and methods which utilize the adsorbents in the purification of proteins by affinity chromatography. The affinity ligand-matrix conjugates of the present invention comprise ligands of general formula (I): wherein m represents an integer from 0-2, n represents an integer from 0-6, p represents an integer from 0-4, R1 represents H or C1-3 alkyl, R2 is an optional substituent, and X is the position at which the ligand is immobilized, optionally via a linker.
摘要翻译： 本发明一般涉及用作色谱吸附剂的亲和配体和化学亲和配体 - 基质共轭物以及利用吸附剂通过亲和层析纯化蛋白质的方法。 本发明的亲和配体 - 基质缀合物包括通式（I）的配体：其中m表示0-2的整数，n表示0-6的整数，p表示0-4的整数，R1表示H 或C 1-3烷基，R 2是任选的取代基，并且X是任选地通过连接基固定配体的位置。
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公开(公告)号：US20120259094A1
公开(公告)日：2012-10-11
申请号：US13502103
申请日：2010-10-15
IPC分类号： C07K1/22 , C07D213/70 , C08B37/00 , C07D215/36 , C07D217/22 , C07D401/14 , C07D401/12 , C07D213/76
CPC分类号： B01D15/3804 , B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3244 , B01J20/3251 , B01J20/3255 , C07D213/32 , C07D213/70 , C07D215/36 , C07D217/22 , C07K1/22
摘要： The present invention relates generally to affinity ligands and chemical affinity ligand-matrix conjugates for use as chromatographic adsorbents and methods which utilise the adsorbents in the purification of proteins by affinity chromatography. The affinity ligand-matrix conjugates of the present invention comprise ligands of general formula (I): wherein m represents an integer from 0-2, n represents an integer from 0-6, p represents an integer from 0-4, R1 represents H or C1-3 alkyl, R2 is an optional substituent, and X is the position at which the ligand is immobilized, optionally via a linker.
摘要翻译： 本发明一般涉及用作色谱吸附剂的亲和配体和化学亲和配体 - 基质共轭物以及利用吸附剂通过亲和层析纯化蛋白质的方法。 本发明的亲和配体 - 基质缀合物包括通式（I）的配体：其中m表示0-2的整数，n表示0-6的整数，p表示0-4的整数，R1表示H 或C 1-3烷基，R 2是任选的取代基，并且X是任选地通过连接基固定配体的位置。
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公开(公告)号：US09102708B2
公开(公告)日：2015-08-11
申请号：US12279383
申请日：2007-02-16
IPC分类号： C07C2/52 , C07K1/107 , C07K1/06 , C07C2/42 , C07B37/04 , C07C231/12 , C07C271/22 , C07K1/00
CPC分类号： C07K7/54 , C07B37/04 , C07C2/42 , C07C2/52 , C07C231/12 , C07C271/22 , C07C2603/18 , C07K1/006 , C07K1/06 , C07K1/1077 , C07C233/47 , C07C233/83 , C07C233/85 , C07C233/82
摘要： The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis.
摘要翻译： 本发明涉及在有机化合物中形成二桥桥的方法。 这涉及在有机化合物上使用一对互补易位基团，并在微波辐射条件下使化合物进行交叉复分解。 替代方案中，化合物在一对交叉易位组之间含有转向诱导基团，以促进交叉复分解。
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9.发明申请公开(公告)号：US20130023645A1
公开(公告)日：2013-01-24
申请号：US13453766
申请日：2012-04-23
IPC分类号： C07K1/107 , C07C231/12
CPC分类号： C07K7/54 , C07B37/04 , C07C2/42 , C07C2/52 , C07C231/12 , C07C271/22 , C07C2603/18 , C07K1/006 , C07K1/06 , C07K1/1077 , C07C233/47 , C07C233/83 , C07C233/85 , C07C233/82
摘要： The present invention related to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds containing a turn-induced group between the pair of cross metathesisable groups to facilitate the cross-metathesis.
摘要翻译： 本发明涉及在有机化合物中形成二桥桥的方法。 这涉及在有机化合物上使用一对互补易位基团，并在微波辐射条件下使化合物进行交叉复分解。 在另一种方案中，在一对交叉易位组之间含有转向诱导基团的化合物以促进交叉复分解。
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公开(公告)号：US08188217B2
公开(公告)日：2012-05-29
申请号：US12279383
申请日：2007-02-16
IPC分类号： C07K7/54
摘要： The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis.
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