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    Cell motility and chemotaxis test device and methods of using same
    1.
    发明授权
    Cell motility and chemotaxis test device and methods of using same 失效
    细胞运动性和趋化性试验装置及其使用方法

    公开(公告)号：US06921660B2

    公开(公告)日：2005-07-26

    申请号：US10097351

    申请日：2002-03-15

    Applicant: Gregory L. Kirk ,  Matthew Brown ,  Emanuele Ostuni ,  Enoch Kim ,  Bernardo D. Aumond ,  Olivier Schueller ,  Paul Sweetnam ,  Brian Benoit

    Inventor： Gregory L. Kirk ,  Matthew Brown ,  Emanuele Ostuni ,  Enoch Kim ,  Bernardo D. Aumond ,  Olivier Schueller ,  Paul Sweetnam ,  Brian Benoit

    IPC: B01L3/00 ,  C12M1/34

    CPC classification number: B82Y30/00 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502746 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2400/0406 ,  Y10S435/809

    Abstract: The present invention discloses a device for monitoring chemotaxis or chemoinvasion including a housing comprising: a support member and a top member, the top member mounted to the support member by being placed in substantially fluid-tight conformal contact with the support member. The support member and the top member are configured such that they together define a discrete chamber adapted to allow a monitoring of chemotaxis or chemoinvasion therein. The discrete chamber includes a first well region including at least one first well, the at least one first well configured to received a test agent therein; a second well region including at least one second well, the at least one second well configured to receive a sample comprising cells therein; and a channel region including at least one channel connecting the first well region and the second well region with one another. The second well region is preferably horizontally offset with respect to the first well region in a test orientation of the device.

    Abstract translation: 本发明公开了一种用于监测趋化性或化学侵蚀的装置，包括：壳体，包括：支撑构件和顶部构件，顶部构件通过与支撑构件基本上不流体密封地共形接触而安装到支撑构件。 支撑构件和顶部构件被构造成使得它们一起限定适于允许监测其中的趋化性或化学侵蚀的离散室。 离散室包括包括至少一个第一井的第一井区，所述至少一个第一井构造成在其中接收测试剂; 包括至少一个第二阱的第二阱区，所述至少一个第二阱被配置为在其中接收包含电池的样品; 以及沟道区域，其包括将第一阱区域和第二阱区域彼此连接的至少一个沟道。 在设备的测试方向上，第二阱区域优选地相对于第一阱区域水平偏移。

    Method of monitoring haptotaxis
    3.
    发明授权
    Method of monitoring haptotaxis 失效
    监测触觉的方法

    公开(公告)号：US06818403B2

    公开(公告)日：2004-11-16

    申请号：US10097304

    申请日：2002-03-15

    Applicant: Gregory L. Kirk ,  Matthew Brown ,  Emanuele Ostuni ,  Enoch Kim ,  Bernardo D. Aumond ,  Olivier Schueller ,  Paul Sweetnam ,  Brian Benoit

    Inventor： Gregory L. Kirk ,  Matthew Brown ,  Emanuele Ostuni ,  Enoch Kim ,  Bernardo D. Aumond ,  Olivier Schueller ,  Paul Sweetnam ,  Brian Benoit

    IPC: C12Q168

    CPC classification number: B82Y30/00 ,  B01J2219/00317 ,  B01J2219/00662 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0829 ,  B01L2300/0887 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/54366 ,  G06T7/0012 ,  G06T7/70 ,  G06T2207/30072

    Abstract: The present invention discloses a method of monitoring haptotaxis comprising: providing a device for monitoring haptotaxis having a housing defining a chamber. The chamber includes: a first well region including at least one first well, the first well region configured to receive a test agent therein and further including biomolecules immobilized therein; a second well region including at least one second well, the second well region configured to receive a sample comprising cells therein and further being horizontally offset with respect to the first well region in a test orientation of the device; and a channel region with biomolecules immobilized therein and including at least one channel connecting the first well region and the second well region with one another. The method also includes forming a surface concentration gradient along a longitudinal axis of the chamber by decreasing the concentration of biomolecules from the at least one first well to the at least one second well; placing a first sample comprising cells in the at least one second well; and monitoring haptotaxis of the cells.

    Abstract translation: 本发明公开了一种监测触觉性的方法，包括：提供一种用于监测触觉性的装置，其具有限定腔室的外壳。 所述腔室包括：第一井区域，其包括至少一个第一井，所述第一井区域构造成在其中接收测试剂并且还包括固定在其中的生物分子; 包括至少一个第二阱的第二阱区域，所述第二阱区域被配置为接收包含单元的样品，并且在所述器件的测试取向中进一步相对于所述第一阱区域水平偏移; 以及具有固定在其中的生物分子的通道区域，并且包括将第一阱区域和第二阱区域彼此连接的至少一个通道。 该方法还包括通过降低生物分子从至少一个第一孔到至少一个第二孔的浓度来形成沿腔室的纵向轴线的表面浓度梯度; 将包含细胞的第一样品置于所述至少一个第二孔中; 并监测细胞的触发性。

    Method of monitoring cell motility and chemotaxis
    6.
    发明授权
    Method of monitoring cell motility and chemotaxis 失效
    监测细胞运动性和趋化性的方法

    公开(公告)号：US06811968B2

    公开(公告)日：2004-11-02

    申请号：US10097322

    申请日：2002-03-15

    Applicant: Gregory L. Kirk ,  Matthew Brown ,  Emanuele Ostuni ,  Enoch Kim ,  Bernardo D. Aumond ,  Olivier Schueller ,  Paul Sweetnam ,  Brian Benoit

    Inventor： Gregory L. Kirk ,  Matthew Brown ,  Emanuele Ostuni ,  Enoch Kim ,  Bernardo D. Aumond ,  Olivier Schueller ,  Paul Sweetnam ,  Brian Benoit

    IPC: C12Q100

    CPC classification number: B01L3/5085 ,  B01D2325/08 ,  B01J2219/00317 ,  B01J2219/00662 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01L3/5025 ,  B01L3/5027 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0829 ,  B01L2300/0887 ,  B82Y30/00 ,  C12Q1/025 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N15/1468 ,  G01N33/54366 ,  G01N2015/1497 ,  G06T7/0012 ,  G06T7/70 ,  G06T2207/30072 ,  Y10S435/81

    Abstract: The present invention discloses a method of monitoring chemotaxis or chemoinvasion comprising: providing a device for monitoring chemotaxis. The device includes a support member; a top member mounted to the support member by being placed in substantially fluid-tight, conformal contact with the support member. The support member and the top member are configured such that they together define a discrete assay chamber. The discrete assay chamber includes a first well region including at least one first well, the at least one first well being configured to receive a soluble test substance therein; a second well region including at least one second well, the at least one second well being configured to receive a sample comprising cells therein; and a channel region including at least one channel connecting the first well region and the second well region. Preferably, at least one second well is horizontally offset with respect to the first well region in a test orientation of the device. The method further comprises placing the soluble test substance in the at least one first well; forming a solution concentration gradient along a longitudinal axis of the chamber; placing a first sample comprising cells in the at least one second well; and monitoring chemotaxis of the cells.

    Abstract translation: 本发明公开了一种监测趋化性或化学侵蚀的方法，包括：提供用于监测趋化性的装置。 该装置包括支撑构件; 顶部构件通过与支撑构件基本上流体密封地共形接触而安装到支撑构件。 支撑构件和顶部构件被构造成使得它们在一起限定离散的测定室。 离散测定室包括包括至少一个第一阱的第一阱区，所述至少一个第一阱被配置为在其中接收可溶性测试物质; 包括至少一个第二阱的第二阱区，所述至少一个第二阱被配置为在其中接收包含电池的样品; 以及包括连接第一阱区域和第二阱区域的至少一个沟道的沟道区域。 优选地，至少一个第二井在装置的测试方向上相对于第一井区水平偏移。 该方法还包括将可溶性测试物质置于至少一个第一井中; 沿着所述室的纵向轴线形成溶液浓度梯度; 将包含细胞的第一样品置于所述至少一个第二孔中; 并监测细胞的趋化性。

    Network security system appliance and systems based thereon
    8.
    发明申请
    Network security system appliance and systems based thereon 审中-公开
    网络安全系统设备及其系统

    公开(公告)号：US20060161960A1

    公开(公告)日：2006-07-20

    申请号：US11039560

    申请日：2005-01-20

    Applicant: Brian Benoit

    Inventor： Brian Benoit

    IPC: H04N7/173 ,  H04N7/18

    CPC classification number: H04L61/2015 ,  G08B13/19656 ,  G08B13/19667 ,  G08B13/19669 ,  G08B13/1968 ,  G08B13/19682 ,  H04L12/2803 ,  H04L12/2807 ,  H04L41/0843 ,  H04L41/0869 ,  H04L41/0886 ,  H04L2012/2841 ,  H04L2012/2849 ,  H04L2012/285 ,  H04N7/181 ,  H04W28/18 ,  H04W48/08 ,  H04W48/16

    Abstract: A network apparatus for use with a plurality of network cameras includes a system housing with a network interface (wireless access point and/or network switch), a router, and processing means that are operably coupled to one another and integrally housed within the system housing. The network interface provides communication links between the apparatus and the network cameras. The processing means preferaby performs automatic connection and configuration operations that upload default configuration settings to the network cameras through said communication links. Such automatic configuration operations are preferably carried out as part of DHCP address assignment. The processing means also preferably performs video proxy operations that buffer a plurality of video signals and that read out and multiplex together portions of the buffered video signals to form a composite signal for subsequent communication over the Internet. The apparatus may also include one or more of the following components integrally housed within the system housing: a hard disk for dvr recording, a battery backup power source, non-volatile storage (e.g., compact flash memory or hard disk) for storing digital video signals during a battery backup power mode, a plulality of ports that interface to alarm sensors and other alarm devices for alarm monitoring and automatic notification, and VPN processing. The processing means preferably includes an embedded web server for the configuration of the apparatus and possibly the network cameras. Kits and systems utilizing the network apparatus is also described and claimed.

    Abstract translation: 一种用于多个网络摄像机的网络设备包括具有网络接口（无线接入点和/或网络交换机）的系统外壳，路由器和可操作地彼此耦合并且整体地容纳在系统外壳内的处理装置 。 网络接口提供设备和网络摄像机之间的通信链路。 处理装置优先执行通过所述通信链路将默认配置设置上传到网络摄像机的自动连接和配置操作。 这样的自动配置操作优选地作为DHCP地址分配的一部分来执行。 处理装置还优选地执行缓冲多个视频信号的视频代理操作，并且将缓冲的视频信号的一部分读出和多路复用在一起以形成用于通过因特网进行后续通信的复合信号。 该装置还可以包括整体容纳在系统外壳内的一个或多个以下组件：用于记录的硬盘，电池备用电源，用于存储数字视频的非易失性存储（例如，紧凑型闪存或硬盘） 电池备用电源模式下的信号，与报警传感器和其他报警设备接口的报警监控和自动通知以及VPN处理的端口的通用性。 处理装置优选地包括用于配置装置和可能的网络摄像机的嵌入式web服务器。 还描述和要求保护使用网络设备的套件和系统。

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