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1.发明申请公开(公告)号：US20090169597A1
公开(公告)日：2009-07-02
申请号：US12337439
申请日：2008-12-17
CPC分类号： A61K35/50 , A61K35/12 , C12N5/0605
摘要： Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
摘要翻译： 提供了治疗患有与IVD变性相关的疾病或病症的患者的方法。 所述方法包括施用从人脐带组织获得的细胞，或施用包含此类细胞的药物组合物或由此类细胞制备。 在一些实施方案中，施用细胞促进患者中退化的IVD组织的修复和再生。 还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。
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2.发明申请TREATMENT OF STROKE AND OTHER ACUTE NEURAL DEGENERATIVE DISORDERS VIA INTRANASAL ADMINISTRATION OF UMBILICAL CORD-DERIVED CELLS 有权通过脐带导管细胞的内窥镜治疗来治疗其他急性神经衰弱性疾病公开(公告)号：US20120014921A1
公开(公告)日：2012-01-19
申请号：US13184378
申请日：2011-07-15
申请人： Brian C. Kramer , Anthony J. Kihm
发明人： Brian C. Kramer , Anthony J. Kihm
CPC分类号： A61K35/30 , A61K35/48 , A61K35/51 , A61K38/13 , A61K38/47 , C12N5/0605 , C12N5/0668 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2533/50 , A61K2300/00
摘要： This invention relates to methods of treating stroke by intranasal administration of umbilical cord tissue-derived cells, which are isolated from mammalian umbilical cord tissue substantially free of blood or expanded in culture from a cell isolated from mammalian umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion in culture, and do not produce CD117 and/or telomerase. The methods of the invention regenerate, repair and improve neural tissue and improve behavior and neurological function in stroke patients.
摘要翻译： 本发明涉及通过鼻内施用脐带组织来源的细胞来治疗中风的方法，所述细胞从基本上不含血液的哺乳动物脐带组织分离，或从基本上不含血液的哺乳动物脐带组织分离的细胞中扩增培养物 能够自我更新和扩大文化，不生产CD117和/或端粒酶。 本发明的方法再生，修复和改善神经组织，改善中风患者的行为和神经功能。
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3.发明授权公开(公告)号：US08518390B2
公开(公告)日：2013-08-27
申请号：US13184378
申请日：2011-07-15
申请人： Brian C. Kramer , Anthony J. Kihm
发明人： Brian C. Kramer , Anthony J. Kihm
CPC分类号： A61K35/30 , A61K35/48 , A61K35/51 , A61K38/13 , A61K38/47 , C12N5/0605 , C12N5/0668 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2533/50 , A61K2300/00
摘要： This invention relates to methods of treating stroke by intranasal administration of umbilical cord tissue-derived cells, which are isolated from mammalian umbilical cord tissue substantially free of blood or expanded in culture from a cell isolated from mammalian umbilical cord tissue substantially free of blood, are capable of self-renewal and expansion in culture, and do not produce CD117 and/or telomerase. The methods of the invention regenerate, repair and improve neural tissue and improve behavior and neurological function in stroke patients.
摘要翻译： 本发明涉及通过鼻内施用脐带组织来源的细胞来治疗中风的方法，所述细胞从基本上不含血液的哺乳动物脐带组织分离，或从基本上不含血液的哺乳动物脐带组织分离的细胞中扩增培养物 能够自我更新和扩大文化，不生产CD117和/或端粒酶。 本发明的方法再生，修复和改善神经组织，改善中风患者的行为和神经功能。
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4.发明申请公开(公告)号：US20110280838A1
公开(公告)日：2011-11-17
申请号：US13111933
申请日：2011-05-19
申请人： Brian C. Kramer , Laura J. Brown , Anthony J. Kihm
发明人： Brian C. Kramer , Laura J. Brown , Anthony J. Kihm
CPC分类号： A61L27/3878 , A61K35/12 , A61K35/50 , A61K35/51 , A61K38/1774 , A61K38/1841 , A61K38/1858 , A61L27/225 , A61L27/227 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2400/06 , A61L2430/38 , C12N5/0605
摘要： Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells and optionally a hydrogel. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
摘要翻译： 提供了治疗患有与IVD变性相关的疾病或病症的患者的方法。 所述方法包括施用从人脐带组织获得的细胞，或施用包含此类细胞的药物组合物或由此类细胞制备，以及任选的水凝胶。 在一些实施方案中，施用细胞促进患者中退化的IVD组织的修复和再生。 还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。
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5.发明授权Treatment of Parkinson's disease and related disorders using postpartum derived cells 有权使用产后衍生细胞治疗帕金森病和相关疾病公开(公告)号：US07875273B2
公开(公告)日：2011-01-25
申请号：US11315943
申请日：2005-12-22
CPC分类号： C12N5/0619 , A61K35/30 , A61K35/44 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2506/03 , A61K2300/00
摘要： Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to treat patients having a neurodegenerative condition of the substantia nigra or striatum, such as Parkinson's disease, are provided.
摘要翻译： 提供衍生自产后组织如脐带和胎盘的细胞，包含这种细胞的药物组合物，以及使用这些细胞和药物组合物治疗患有黑质或纹状体如神经退行性疾病如帕金森病的患者的方法。
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公开(公告)号：US20100159025A1
公开(公告)日：2010-06-24
申请号：US12642775
申请日：2009-12-19
申请人： Brian C. Kramer , Uri Herzberg
发明人： Brian C. Kramer , Uri Herzberg
CPC分类号： A61K35/44 , C12N5/0634
摘要： Methods for treating chronic pain, neuropathic pain or spasticity are provided. Some embodiments are to methods for treatment comprising administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of nerves in the patient to decrease chronic pain, neuropathic pain or spasticity. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
摘要翻译： 提供了治疗慢性疼痛，神经性疼痛或痉挛症的方法。 一些实施方案涉及治疗方法，包括施用从人脐带组织获得的细胞，或施用包含这种细胞的药物组合物或由这样的细胞制备。 在一些实施方案中，施用细胞促进患者神经的修复和再生以减少慢性疼痛，神经性疼痛或痉挛状态。 还提供了用于本发明方法的药物组合物，以及用于实施该方法的试剂盒。
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7.发明授权Treatment of stroke and other acute neural degenerative disorders using postpartum-derived cells 有权使用产后来源的细胞治疗中风和其他急性神经退行性疾病公开(公告)号：US08361459B2
公开(公告)日：2013-01-29
申请号：US12697081
申请日：2010-01-29
申请人： Darin J. Messina , Sanjay K. Mistry , L. S. Klaudyne Hong , Brian C. Kramer , Michael J. Romanko , Anna Gosiewska
发明人： Darin J. Messina , Sanjay K. Mistry , L. S. Klaudyne Hong , Brian C. Kramer , Michael J. Romanko , Anna Gosiewska
CPC分类号： A61K35/30 , A61K35/12 , A61K35/48 , C12N5/0605 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2533/50 , A61K2300/00
摘要： Cells derived from postpartum tissue such as the umbilical cord and placenta, and methods for their use to regenerate, repair, and improve neural tissue, and to improve behavior and neurological function in stroke patients are disclosed.
摘要翻译： 公开了衍生自产后组织如脐带和胎盘的细胞，以及用于再生，修复和改善神经组织以及改善中风患者的行为和神经功能的方法。
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公开(公告)号：US20190105351A9
公开(公告)日：2019-04-11
申请号：US12642775
申请日：2009-12-19
申请人： Brian C. Kramer , Uri Herzberg
发明人： Brian C. Kramer , Uri Herzberg
摘要： Methods for treating chronic pain, neuropathic pain or spasticity are provided. Some embodiments are to methods for treatment comprising administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of nerves in the patient to decrease chronic pain, neuropathic pain or spasticity. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.
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公开(公告)号：US20100151575A1
公开(公告)日：2010-06-17
申请号：US12335186
申请日：2008-12-15
IPC分类号： C12N5/02
CPC分类号： C12N5/0686 , C12N2533/40
摘要： Methods of making conditioned media by culturing cells on nonwoven substrates are disclosed. More specifically, methods of making conditioned media by culturing mammalian kidney-derived cells on nonwoven substrates are disclosed.
摘要翻译： 公开了通过在非织造基底上培养细胞来制备条件培养基的方法。 更具体地，公开了通过在非织造基底上培养哺乳动物肾源细胞来制备条件培养基的方法。
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10.发明授权Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells 有权使用产后衍生细胞治疗中风和其他急性神经变性疾病公开(公告)号：US07875272B2
公开(公告)日：2011-01-25
申请号：US11315898
申请日：2005-12-22
申请人： Darin J. Messina , Sanjay Mistry , L. S. Klaudyne Hong , Brian C. Kramer , Michael J. Romanko , Anna Gosiewska
发明人： Darin J. Messina , Sanjay Mistry , L. S. Klaudyne Hong , Brian C. Kramer , Michael J. Romanko , Anna Gosiewska
CPC分类号： A61K35/30 , A61K35/12 , A61K35/48 , C12N5/0605 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2533/50 , A61K2300/00
摘要： Cells derived from postpartum tissue such as the umbilical cord and placenta, and methods for their use to regenerate, repair, and improve neural tissue, and to improve behavior and neurological function in stroke patients are disclosed.
摘要翻译： 公开了衍生自产后组织如脐带和胎盘的细胞，以及用于再生，修复和改善神经组织以及改善中风患者的行为和神经功能的方法。
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