公开(公告)号：US08686749B2

公开(公告)日：2014-04-01

申请号：US12770948

申请日：2010-04-30

申请人： Brian M. Erwin ,  David L. Gardell ,  James N. Humenik ,  Rajneesh Kumar ,  John Lawson

发明人： Brian M. Erwin ,  David L. Gardell ,  James N. Humenik ,  Rajneesh Kumar ,  John Lawson

IPC分类号： G01R31/02

CPC分类号： G01R31/2884 ,  G01R31/2874

摘要： Non-corrosive thermal interface materials for use in a test structure and method of use. The test structure includes a heat sink for dissipating heat away from a device under test. The test structure further includes a non-corrosive thermal interface material disposed between the heat sink and the device under test. The non-corrosive thermal interface material is capable of withstanding test conditions for at least 60 minutes for at least 115° C. without staining or leaving residue on the device under test after baking.

摘要翻译： 用于测试结构和使用方法的非腐蚀性热界面材料。 测试结构包括散热器，用于从被测设备中散热。 测试结构还包括设置在散热器和被测器件之间的非腐蚀性热界面材料。 非腐蚀性热界面材料能够耐受至少60分钟的测试条件至少115℃，而不会在烘烤后在被测设备上污染或留下残留物。

公开(公告)号：US20050052755A1

公开(公告)日：2005-03-10

申请号：US10658212

申请日：2003-09-09

申请人： John Lawson ,  Jan Ter Louw

发明人： John Lawson ,  Jan Ter Louw

IPC分类号： G02B13/14 ,  G02B15/00 ,  G02B3/00 ,  G02B13/00

CPC分类号： G02B3/10 ,  G02B13/146 ,  G02B15/00

摘要： A single lens or optical system is used to image two different optical bands, for example visible and infrared, with the same possible adjustments in zoom and/or focus. A dual band singlet is formed of a first, larger, optical element, suitable for operating on light of a first optical band, with an aperture cut out of it. A smaller element, suitable for operating on light of a second optical band, is secured in, or on either side of, the aperture cut through the larger optical element, thus forming a dual band singlet that can operate on two different wavelength bands. Combinations of dual band lenses, lens elements, and lenses with cut-out apertures are used to form dual-band optical systems, including systems with dual-band focus and zoom.

摘要翻译： 单个透镜或光学系统用于对两个不同的光学带，例如可见光和红外线进行成像，并且在缩放和/或对焦中具有相同的可能调整。 双频单声道由第一，较大的光学元件形成，适合于在第一光学带的光上进行操作，并从其中切出孔。 适合于在第二光学带的光线上操作的较小的元件被固定在通过较大的光学元件切割的孔的两侧或其两侧，从而形成可在两个不同波长带上操作的双频带单线态。 双波段透镜，透镜元件和带切口的透镜的组合被用于形成双波段光学系统，包括具有双波段聚焦和变焦的系统。

公开(公告)号：US06837974B2

公开(公告)日：2005-01-04

申请号：US10349661

申请日：2003-01-23

申请人： John Lawson ,  Dale Irwin ,  Steve Chervenak

发明人： John Lawson ,  Dale Irwin ,  Steve Chervenak

IPC分类号： C23C14/34 ,  C23C14/56 ,  H01J37/34

CPC分类号： H01J37/3441 ,  C23C14/34 ,  C23C14/564 ,  H01J37/34

摘要： A replacement chamber shield is provided for a wafer processing machine that replaces many prior art shield components with a single piece shield. The shield is particularly suitable for use in a processing chamber of a vacuum processing machine of a type for processing a wafer in a vertically-oriented split-plenum, such as machines of the type described in U.S. Pat. Nos. 4,909,695 and 4,915,564 and the machine marketed under the trademark ECLIPSE MARK II by Tokyo Electron Limited. The shield is formed of sheet material formed into an axially-extending cylindrical sidewall that turns radially inwardly into an annular shoulder that oppositely turns into an at least partially axially-extending section that further turns oppositely back radially inwardly into an annular disc having a central circular opening that is larger in diameter than the given wafer diameter. Advantageous dimensions and geometric relationships to components of the machine are described and claimed.

摘要翻译： 为晶片处理机器提供替换室屏蔽，其用单件屏蔽替代许多现有技术的屏蔽部件。 该屏蔽特别适用于在垂直取向的分流式充气室中处理晶片的类型的真空处理机的处理室，例如美国专利No. 第4,909,695和4,915,564号，以及东京电子有限公司以商标ECLIPSE MARK II出售的机器。 屏蔽由形成为轴向延伸的圆柱形侧壁的片状材料形成，该圆形侧壁径向向内变成环形肩部，该环形肩部相对地变成至少部分轴向延伸的部分，该部分进一步相对地径向向内旋转成具有中心圆形的环形盘 直径大于给定晶圆直径的开口。 描述和要求保护与机器部件有关的尺寸和几何关系。

公开(公告)号：US6014201A

公开(公告)日：2000-01-11

申请号：US306577

申请日：1999-05-06

申请人： E. John Adolphi ,  Gerald A. Jensen ,  Michael Breckenridge ,  Todd Kuester ,  John Lawson ,  Patrick J. Galloway

发明人： E. John Adolphi ,  Gerald A. Jensen ,  Michael Breckenridge ,  Todd Kuester ,  John Lawson ,  Patrick J. Galloway

IPC分类号： G03B27/40 ,  G03B27/44 ,  G03B27/46 ,  G03B27/48 ,  G03B27/58 ,  G03D15/00 ,  G03B27/52

CPC分类号： G03B27/48 ,  G03B27/40 ,  G03B27/44 ,  G03B27/462 ,  G03B27/587 ,  G03D15/00 ,  G03B2227/005

摘要： An improved high speed package printer for producing a plurality of high quality photographs of varying size, shape, and style based on one or a plurality of different film negatives. The improved package printer of the present invention accomplishes the goal of increased throughput and speed through the use of an automatic paper-loading feature, ultrasonic proximity sensors for dynamically measuring paper-slack loops, off-center printing for eliminating the need to advance the paper for punching after each exposure, a rotational prism for creating 10".times.13" photographs without physically rotating the film, a 13-UP lens deck including 12 wallet lenses and a single 5".times.7" retro-focus lens for creating 12 wallet-sized photographs and one 5".times.7" photograph from a single exposure, an automatic diffusion plate cleaner for eliminating the system down time associated with manual diffusion plate cleaning, an improved filtering arrangement for equalizing the amount of energy emitted from each lamp within a photographic lamphouse, and bi-directional film movement for producing a single composite containing a plurality of different images or poses. The high speed package printer of the present invention also boasts an improved film cleaning arrangement for increasing the quality of the prints, as well as penumbra masking for producing photographs having sharply delineated borders.

摘要翻译： 一种改进的高速包装印刷机，用于根据一种或多种不同的胶片底片生产不同尺寸，形状和风格的多种高质量照片。 本发明的改进的包装打印机通过使用自动纸张加载功能实现增加的吞吐量和速度的目标，用于动态测量纸张松弛循环的超声波接近传感器，用于消除纸张推进的需要的偏心打印 在每次曝光后进行冲压，用于在不物理旋转胶片的情况下创建10''13“照片的旋转棱镜，包括12个钱包镜头的13-UP透镜板和一个单独的5''x7”复焦透镜，用于创建12 钱包尺寸的照片和单次曝光的一张5''x7“照片，自动扩散板清洁器，用于消除与手动扩散板清洁相关的系统停机时间，改进的滤光装置，用于均衡每个灯发射的能量的数量 在摄影灯塔内，以及用于产生包含多个不同图像或姿势的单一复合体的双向膜运动。 本发明的高速包装印刷机还具有改进的胶片清洁装置，用于提高印刷品的质量，以及用于产生具有清楚界定的边框的照片的半影掩模。

公开(公告)号：US4982055A

公开(公告)日：1991-01-01

申请号：US442892

申请日：1989-11-29

申请人： Michael J. Pollack ,  John Lawson

发明人： Michael J. Pollack ,  John Lawson

IPC分类号： G01K7/02 ,  H01R13/523

CPC分类号： H01R13/523 ,  G01K7/023

摘要： The feedthrough device includes first and second half housing members, each of which has an internal chamber. The feedthrough device further includes a removable header member that fits within the chambers of the first and second half housing members when they are threaded together. The first half housing member has a threaded protrusion which fits into a threaded aperture located in the wall of a sealed structure, such as the wall of a vacuum furnace. The threaded protrusion arrangement includes a first "O" ring which seals the periphery of the aperture in the wall of the sealed structure. The header has first connectable terminals on one end and second connectable terminals on the other end. In between the first and second connectable terminals of the header there is located a plate member which fits along the edge of the first half housing member chamber; and located between that edge and the plate is a second "O" ring. Wires connecting the first and second terminals pass through the plate member in a sealed arrangement. The second half housing member has an abutting structure located at the end of its chamber so that when the second half housing member threads with the first housing member, the plate is pushed by the abutting structure to squeeze the second "O" ring to complete a seal of the first half housing member chamber. Accordingly, the first connectors are sealed against the outside world, but are connected to the circuitry within and outside of the sealed structure.

摘要翻译： 馈通装置包括第一和第二半壳体构件，每个壳体具有内部腔室。 馈通装置还包括可拆卸的头部构件，当它们被拧在一起时，其可装配在第一和第二半壳体构件的腔室内。 第一半壳体构件具有螺纹突起，其配合到位于诸如真空炉的壁的密封结构的壁中的螺纹孔中。 螺纹突出装置包括密封密封结构的壁中的孔的周边的第一“O”环。 集管在一端具有第一可连接端子，在另一端具有第二可连接端子。 在集管的第一和第二可连接端子之间位于沿着第一半壳体构件室的边缘配合的板构件; 并且位于该边缘和板之间是第二“O”形环。 连接第一和第二端子的电线以密封的方式穿过板构件。 第二半壳体构件具有位于其室的端部处的抵接结构，使得当第二半壳体构件与第一壳体构件螺纹连接时，板被抵靠结构推动以挤压第二“O”形环以完成 第一半壳体构件腔的密封。 因此，第一连接器被密封抵靠外界，但是连接到密封结构内部和外部的电路。

公开(公告)号：US08987293B2

公开(公告)日：2015-03-24

申请号：US13981160

申请日：2011-12-23

申请人： John Lawson

发明人： John Lawson

IPC分类号： C07D221/28 ,  C07D221/22

CPC分类号： C07D221/28 ,  C07D221/22

摘要： Compounds of Formula (I) are disclosed. The variables R1-R11 are described herein. Certain compounds of Formula (I) are partial agonists of the mu, delta, and kappa opioid receptors, and are useful for treating pain and opioid addiction, with fewer side effects than conventional opioids. Methods for preparing the disclosed compounds, pharmaceutical compositions containing compounds of Formula (I), and methods of treating pain and opioid addiction in patients are also disclosed.

摘要翻译： 公开了式（I）的化合物。 这里描述了变量R1-R11。 某些式（I）化合物是mu，δ和κ阿片样物质受体的部分激动剂，可用于治疗疼痛和阿片样物质成瘾，副作用少于常规阿片样物质。 还公开了制备所公开的化合物的方法，含有式（I）的化合物的药物组合物，以及治疗患者的疼痛和阿片样物质成瘾的方法。

公开(公告)号：US20130338182A1

公开(公告)日：2013-12-19

申请号：US13981160

申请日：2011-12-23

申请人： John Lawson

发明人： John Lawson

IPC分类号： C07D221/28

CPC分类号： C07D221/28 ,  C07D221/22

摘要： Compounds of Formula (I) are disclosed. The variables R1-R11 are described herein. Certain compounds of Formula (I) are partial agonists of the mu, delta, and kappa opioid receptors, and are useful for treating pain and opioid addiction, with fewer side effects than conventional opioids. Methods for preparing the disclosed compounds, pharmaceutical compositions containing compounds of Formula (I), and methods of treating pain and opioid addiction in patients are also disclosed.

摘要翻译： 公开了式（I）化合物。 这里描述了变量R1-R11。 某些式（I）化合物是mu，δ和κ阿片样物质受体的部分激动剂，可用于治疗疼痛和阿片样物质成瘾，副作用少于常规阿片样物质。 还公开了制备所公开的化合物的方法，含有式（I）的化合物的药物组合物，以及治疗患者的疼痛和阿片样物质成瘾的方法。

公开(公告)号：US20090129980A1

公开(公告)日：2009-05-21

申请号：US11997382

申请日：2006-08-04

申请人： John Lawson ,  Parris Wellsman ,  Sepehr Kiani

发明人： John Lawson ,  Parris Wellsman ,  Sepehr Kiani

IPC分类号： B01J19/00

CPC分类号： B01L3/502715 ,  B01J2219/00522 ,  B01J2219/00605 ,  B01J2219/00621 ,  B01L3/5025 ,  B01L3/502761 ,  B01L2200/027 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/16 ,  B01L2300/163 ,  B01L2400/0406 ,  B01L2400/049 ,  G01N21/05 ,  G01N35/1095 ,  G01N2021/0346

摘要： A multi-channel flow cell can allow for reduced cross-contamination in sample loading and the ability to observe activity within the flow cell once the channels are loaded. A multi-channel flow cell includes a plurality of independently-addressable channels sandwiched between a two substrates. Each of the channels can be coated with a layer that facilitates support-binding of an analyte. Each of the channels terminates on one end in an inlet and on the other end in an outlet. A loading block having inlet ports that match the inlets of the channels can be mated to the inlets of the channels, and an outlet block can be mated to the outlets of the channels. Analytes can be introduced into the channels via the inlet ports of the loading block and are pulled through the channels by capillary action or by vacuum. Once analyte has been introduced into each of the channels, the loading and outlet blocks can be removed and the device turned over Such a flow cell can be used for streamlining the process of reaction and interrogation of biochemical assays at the microfluidic level. Reagents can be introduced into each of the channels of the flow cell for chemical reactions therein, excess reagent being washed out through the channel outlets. Observation of optically-detectable moieties is then conducted. With such a flow cell optical labels associated with incorporation in a sequencing-by-synthesis reaction can be observed.

摘要翻译： 多通道流通池可以允许在样品加载中减少交叉污染，并且一旦加载通道，就能够观察流动池内的活性。 多通道流动池包括夹在两个基板之间的多个可独立寻址的通道。 每个通道可以涂覆有促进分析物的支持结合的层。 每个通道的一端在入口处终止，另一端在出口处终止。 具有与通道的入口匹配的入口端口的装载块可以配合到通道的入口，并且出口块可以配合到通道的出口。 分析物可以通过装载块的入口引入通道，并通过毛细作用或真空被吸引通过通道。 一旦分析物被引入到每个通道中，就可以去除负载和出口嵌段并将器件翻转。这样的流动池可以用于在微流体水平上简化生物化学测定的反应和询问过程。 可以将试剂引入流动池的每个通道中用于其中的化学反应，多余的试剂通过通道出口被洗出。 然后进行光学可检测部分的观察。 通过这样的流动池，可以观察到与逐步合成反应相结合的光学标记。

公开(公告)号：US20080219890A1

公开(公告)日：2008-09-11

申请号：US12043116

申请日：2008-03-05

申请人： John Lawson ,  Parris Wellman ,  Sepehr Kiani

发明人： John Lawson ,  Parris Wellman ,  Sepehr Kiani

IPC分类号： B01L3/00 ,  G01N1/10 ,  C12M1/00

CPC分类号： B01L3/502715 ,  B01L3/50273 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0861 ,  B01L2300/0877 ,  B01L2400/049 ,  G01N15/1484

摘要： A apparatus and method for loading a sample into a microfluidic flow cell allows for more precise loading, reduced cross-contamination, and more efficient use of samples to be analyzed. The system for loading a sample into a flow cell includes a flow cell defining a plurality of individually isolated channels through which fluid can flow. The flow cell also defines an inlet port and an outlet port for each of the channels. The system also includes a base that defines a chamber for receiving the flow cell, a cover pivotally attached to the base, and a passive vacuum source for pulling a volume through the flow cell. The method of loading a sample includes inserting the flow cell into the sample loading apparatus, placing a sample in at least one of the wells of the loading block, activating a vacuum source fluidly coupled to the outlet ports to pull the sample into the channel, and optionally aspirating the unused sample from the well.

摘要翻译： 用于将样品装载到微流体流动池中的装置和方法允许更精确的加载，减少的交叉污染和更有效地使用要分析的样品。 用于将样品装载到流动池中的系统包括限定多个单独隔离的通道的流动池，流体可以通过该通道流动。 流动池还限定了每个通道的入口和出口。 该系统还包括限定用于接收流动池的室的基座，可枢转地附接到基座的盖以及用于将体积拉动通过流动池的被动真空源。 装载样品的方法包括将流动池插入到样品加载装置中，将样品放置在装载块的至少一个孔中，启动流体连接到出口端口的真空源以将样品拉入通道， 并且可选地从井中吸出未使用的样品。

公开(公告)号：US20080219888A1

公开(公告)日：2008-09-11

申请号：US11928799

申请日：2007-10-30

申请人： John Lawson ,  Parris Wellsman ,  Sepehr Kiani

发明人： John Lawson ,  Parris Wellsman ,  Sepehr Kiani

IPC分类号： B01J19/00

CPC分类号： B01L3/502715 ,  B01J2219/00522 ,  B01J2219/00605 ,  B01J2219/00621 ,  B01L3/5025 ,  B01L3/502761 ,  B01L2200/027 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/16 ,  B01L2300/163 ,  B01L2400/0406 ,  B01L2400/049 ,  G01N21/05 ,  G01N35/1095 ,  G01N2021/0346

摘要： A multi-channel flow cell can allow for reduced cross-contamination in sample loading and the ability to observe activity within the flow cell once the channels are loaded. A multi-channel flow cell includes a plurality of independently-addressable channels sandwiched between a two substrates. Each of the channels can be coated with a layer that facilitates support-binding of an analyte. Each of the channels terminates on one end in an inlet and on the other end in an outlet. A loading block having inlet ports that match the inlets of the channels can be mated to the inlets of the channels, and an outlet block can be mated to the outlets of the channels. Analytes can be introduced into the channels via the inlet ports of the loading block and are pulled through the channels by capillary action or by vacuum. Once analyte has been introduced into each of the channels, the loading and outlet blocks can be removed and the device turned over. Such a flow cell can be used for streamlining the process of reaction and interrogation of biochemical assays at the microfluidic level. Reagents can be introduced into each of the channels of the flow cell for chemical reactions therein, excess reagent being washed out through the channel outlets. Observation of optically-detectable moieties is then conducted. With such a flow cell optical labels associated with incorporation in a sequencing-by-synthesis reaction can be observed.

摘要翻译： 多通道流通池可以允许在样品加载中减少交叉污染，并且一旦加载通道，就能够观察流动池内的活性。 多通道流动池包括夹在两个基板之间的多个可独立寻址的通道。 每个通道可以涂覆有促进分析物的支持结合的层。 每个通道的一端在入口处终止，另一端在出口处终止。 具有与通道的入口匹配的入口端口的装载块可以配合到通道的入口，并且出口块可以配合到通道的出口。 分析物可以通过装载块的入口引入通道，并通过毛细作用或真空被吸引通过通道。 一旦分析物被引入到每个通道中，则可以去除装载和出口块并且将装置翻转。 这样的流动池可以用于在微流控水平下精简生物化学测定的反应和询问过程。 可以将试剂引入流动池的每个通道中用于其中的化学反应，多余的试剂通过通道出口被洗出。 然后进行光学可检测部分的观察。 通过这样的流动池，可以观察到与逐步合成反应相结合的光学标记。