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    Methods for reducing contamination in a biological substance
    3.
    发明授权
    Methods for reducing contamination in a biological substance 有权

    公开(公告)号：US11602585B2

    公开(公告)日：2023-03-14

    申请号：US15497640

    申请日：2017-04-26

    Applicant: CytoSorbents Corporation

    Inventor： Phillip P. Chan ,  Vincent J. Capponi ,  Thomas D. Golobish ,  Humayra Begum Ali

    IPC: A61M1/36 ,  A61K9/16 ,  B01J20/28 ,  A61K31/765 ,  B01J20/26 ,  C08F299/00 ,  C08J9/26

    Abstract: Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.

    Hemocompatibility Modifiers for Cross-Linked Polymeric Material
    9.
    发明申请
    Hemocompatibility Modifiers for Cross-Linked Polymeric Material 审中-公开
    交联聚合材料的血液相容性改性剂

    公开(公告)号：US20140294751A1

    公开(公告)日：2014-10-02

    申请号：US14230108

    申请日：2014-03-31

    Applicant: CytoSorbents Corporation

    Inventor： Thomas D. Golobish ,  Vincent J. Capponi ,  David R. Clay

    IPC: A61M1/36 ,  A61K31/785 ,  A61K31/765 ,  A61M1/34

    CPC classification number: A61M1/3679 ,  A01N1/02 ,  A01N1/0215 ,  A61M1/0272 ,  A61M1/34 ,  A61M1/36 ,  B01J20/261 ,  B01J20/267 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28092 ,  B01J20/3208 ,  B01J20/3246 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3272 ,  B01J20/3282 ,  B01J20/3285 ,  B01J2220/62

    Abstract: The invention concerns methods of treating blood, blood product, or physiologic fluid to provide at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; said method comprising contacting said blood, blood product or physiologic fluid with a sorbent, said sorbent being primarily in a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of at least one of (1) zwitterionic moieties and (2) oligo(ethylene glycol) moieties attached to the surface of said cross-linked polymeric material.

    Abstract translation: 本发明涉及治疗血液，血液制品或生理液的方法，以提供以下至少之一：（i）增加血液，血液制品或生理液体的保质期，（ii）保持新鲜血液，血液制品或生理液体的新鲜度 ，和（iii）从血液，血液制品或生理液中除去不需要的分子; 所述方法包括使所述血液，血液制品或生理液体与吸着剂接触，所述吸附剂主要为多种固体形式，并且包含具有多个（1）两性离子部分中的至少一种的交联聚合物材料和（2） ）低聚（乙二醇）部分连接到所述交联聚合物材料的表面。

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