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公开(公告)号：US08318508B2
公开(公告)日：2012-11-27
申请号：US12213301
申请日：2008-06-17
申请人： Chad A. Mirkin , Ling Huang , Rafael Vega , Steven Lenhert
发明人： Chad A. Mirkin , Ling Huang , Rafael Vega , Steven Lenhert
IPC分类号： G01N1/00
CPC分类号： C09D11/03 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B82Y30/00 , C09D11/30 , C40B50/14 , Y10T428/24802 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： Better patterning methods, including for better methods for forming biomolecular arrays, including a method comprising: providing a tip and a substrate surface, disposing a patterning composition at the end of the tip, depositing at least some of the patterning composition from the tip to the substrate surface to form a deposit disposed on the substrate surface, wherein the patterning composition comprises at least one lipid, optionally at least one solvent, and at least one patterning species different from the lipid and the optional solvent. The lipid can be a phospholipid such as DOPC. The patterning species can be an oligonucleotide or a protein. Microarrays and nanoarrays can be prepared including nanoscale resolution of deposits. The lipid can activate patterning or increase the rate of patterning. Simplified tip preparation can be achieved. Nanoscopic, SPM, and AFM tips can be used.
摘要翻译： 更好的图案化方法，包括用于形成生物分子阵列的更好的方法，包括一种方法，包括：提供尖端和基底表面，在尖端的末端设置图案化组合物，将至少一些图案化组合物从尖端沉积到 衬底表面以形成设置在衬底表面上的沉积物，其中所述图案化组合物包含至少一种脂质，任选的至少一种溶剂和至少一种不同于脂质和任选溶剂的图案化物种。 脂质可以是磷脂如DOPC。 图案化物质可以是寡核苷酸或蛋白质。 可以制备微阵列和纳米阵列，包括沉积物的纳米级分辨率。 脂质可以激活图案化或增加图案化速率。 可以实现简化的尖端准备。 可以使用纳米镜，SPM和AFM提示。
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公开(公告)号：US20090143246A1
公开(公告)日：2009-06-04
申请号：US12213301
申请日：2008-06-17
申请人： Chad A. Mirkin , Ling Huang , Rafael A. Vega , Steven Lenhert
发明人： Chad A. Mirkin , Ling Huang , Rafael A. Vega , Steven Lenhert
CPC分类号： C09D11/03 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B82Y30/00 , C09D11/30 , C40B50/14 , Y10T428/24802 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： Better patterning methods, including for better methods for forming biomolecular arrays, including a method comprising: providing a tip and a substrate surface, disposing a patterning composition at the end of the tip, depositing at least some of the patterning composition from the tip to the substrate surface to form a deposit disposed on the substrate surface, wherein the patterning composition comprises at least one lipid, optionally at least one solvent, and at least one patterning species different from the lipid and the optional solvent. The lipid can be a phospholipid such as DOPC. The patterning species can be an oligonucleotide or a protein. Microarrays and nanoarrays can be prepared including nanoscale resolution of deposits. The lipid can activate patterning or increase the rate of patterning. Simplified tip preparation can be achieved. Nanoscopic, SPM, and AFM tips can be used.
摘要翻译： 更好的图案化方法，包括用于形成生物分子阵列的更好的方法，包括一种方法，包括：提供尖端和基底表面，在尖端的末端设置图案化组合物，将至少一些图案化组合物从尖端沉积到 衬底表面以形成设置在衬底表面上的沉积物，其中所述图案化组合物包含至少一种脂质，任选的至少一种溶剂和至少一种不同于脂质和任选溶剂的图案化物种。 脂质可以是磷脂如DOPC。 图案化物质可以是寡核苷酸或蛋白质。 可以制备微阵列和纳米阵列，包括沉积物的纳米级分辨率。 脂质可以激活图案化或增加图案化速率。 可以实现简化的尖端准备。 可以使用纳米镜，SPM和AFM提示。
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公开(公告)号：US20090155587A1
公开(公告)日：2009-06-18
申请号：US12196960
申请日：2008-08-22
申请人： Chad A. Mirkin , Lidong Qin , Sungho Park , Ling Huang , Sung-Wook Chung
发明人： Chad A. Mirkin , Lidong Qin , Sungho Park , Ling Huang , Sung-Wook Chung
CPC分类号： H01C17/06513 , B82Y5/00 , B82Y10/00 , B82Y20/00 , G01N33/531 , H01L29/0665 , H01L29/0673 , H01L29/068 , H01L29/861 , Y10S977/762 , Y10S977/81 , Y10S977/849 , Y10S977/856 , Y10S977/857 , Y10T428/2938 , Y10T428/2982
摘要： Multicomponent nanorods having segments with differing electronic and/or chemical properties are disclosed. The nanorods can be tailored with high precision to create controlled gaps within the nanorods or to produce diodes or resistors, based upon the identities of the components making up the segments of the nanorods. Macrostructural composites of these nanorods also are disclosed.
摘要翻译： 公开了具有不同电子和/或化学性质的多组分纳米棒。 纳米棒可以以高精度进行定制，以在纳米棒内产生可控制的间隙，或者基于组成纳米棒段的部件的特性来产生二极管或电阻器。 还公开了这些纳米棒的宏观结构复合材料。
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公开(公告)号：US20080225287A1
公开(公告)日：2008-09-18
申请号：US11372583
申请日：2006-03-10
申请人： Chad A. Mirkin , Lidong Qin , Can Xue , Sungho Park , Ling Huang
发明人： Chad A. Mirkin , Lidong Qin , Can Xue , Sungho Park , Ling Huang
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , B82Y15/00 , G01N21/658 , Y10S977/762
摘要： The present invention relates to methods of detecting analytes using nanowires having nanodisk arrays. In particular, the present invention discloses methods of detecting analytes via surface enhanced Raman scattering (SERS) and employing nanowires prepared using on-wire lithography (OWL).
摘要翻译： 本发明涉及使用具有纳米盘阵列的纳米线检测分析物的方法。 特别地，本发明公开了通过表面增强拉曼散射（SERS）检测分析物并使用在线光刻（OWL）制备的纳米线的方法。
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5.发明申请公开(公告)号：US20120141731A1
公开(公告)日：2012-06-07
申请号：US11958350
申请日：2007-12-17
申请人： Chad A. Mirkin , Ling Huang , Raymond Sanedrin
发明人： Chad A. Mirkin , Ling Huang , Raymond Sanedrin
IPC分类号： B32B3/00 , H01L21/306 , B44C1/22 , C23F1/00 , B82Y40/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C23F1/02 , C23F1/14 , Y10T428/24355
摘要： Nanostructures and microstructures are formed by patterning methods such as Dip Pen Nanolithography (DPN) or microcontact printing of organic molecules functioning as a resist on a substrate followed by an etching step. The etch resist is a patterning composition and can contain on a substrate including polyethylene glycol (PEG). Positive and negative etch methods can be used.
摘要翻译： 纳米结构和微结构通过诸如Dip Pen Nanoithography（DPN）的图案化方法或用作基底上的抗蚀剂的有机分子的微接触印刷形成，然后进行蚀刻步骤。 抗蚀剂是图案化组合物，并且可以包含在包含聚乙二醇（PEG）的基材上。 可以使用正和负蚀刻方法。
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公开(公告)号：US07466406B2
公开(公告)日：2008-12-16
申请号：US11372583
申请日：2006-03-10
申请人： Chad A. Mirkin , Lidong Qin , Can Xue , Sungho Park , Ling Huang
发明人： Chad A. Mirkin , Lidong Qin , Can Xue , Sungho Park , Ling Huang
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , B82Y15/00 , G01N21/658 , Y10S977/762
摘要： The present invention relates to methods of detecting analytes using nanowires having nanodisk arrays. In particular, the present invention discloses methods of detecting analytes via surface enhanced Raman scattering (SERS) and employing nanowires prepared using on-wire lithography (OWL).
摘要翻译： 本发明涉及使用具有纳米盘阵列的纳米线检测分析物的方法。 特别地，本发明公开了通过表面增强拉曼散射（SERS）检测分析物并使用在线光刻（OWL）制备的纳米线的方法。
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公开(公告)号：US20120164396A1
公开(公告)日：2012-06-28
申请号：US12140780
申请日：2008-06-17
申请人： Chad A. Mirkin , Ling Huang , Fengwei Huo , Sarah J. Hurst , Lidong Qin , Jae-Won Jang , Joseph J. Kakkassery
发明人： Chad A. Mirkin , Ling Huang , Fengwei Huo , Sarah J. Hurst , Lidong Qin , Jae-Won Jang , Joseph J. Kakkassery
CPC分类号： C09D11/03 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B82Y30/00 , C09D11/30 , C40B50/14 , Y10T428/24802 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： Provided is a direct write patterning method utilizing a mixture comprising an ink of choice and an ink carrier matrix. The method involves disposing the mixture on a tip or stamp and transporting the mixture from the tip or stamp on a surface to form a pattern that contains the ink. The method does not require chemical or physical modification of either the tip or stamp or the surface prior to transporting the mixture to the surface. The method can be applied for patterning hard inks such as nanomaterials and crystallized polymers and soft inks such as biomaterials including peptides and proteins. Also provided are related biomaterial and hard ink arrays.
摘要翻译： 提供了一种使用包括选择的墨水和墨水载体基质的混合物的直接写入图案化方法。 该方法包括将混合物设置在尖端或印模上，并将混合物从尖端或印模输送到表面上以形成包含油墨的图案。 在将混合物输送到表面之前，该方法不需要对尖端或印模或表面进行化学或物理改性。 该方法可以应用于诸如纳米材料和结晶聚合物的硬油墨和软油墨如包括肽和蛋白质的生物材料的图形化。 还提供了相关的生物材料和硬油墨阵列。
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公开(公告)号：US07422696B2
公开(公告)日：2008-09-09
申请号：US11171894
申请日：2005-06-30
申请人： Chad A. Mirkin , Lidong Qin , Sungho Park , Ling Huang , Sung-Wook Chung
发明人： Chad A. Mirkin , Lidong Qin , Sungho Park , Ling Huang , Sung-Wook Chung
IPC分类号： C23F1/00 , H01L21/302 , B82B3/00
CPC分类号： H01C17/06513 , B82Y5/00 , B82Y10/00 , B82Y20/00 , G01N33/531 , H01L29/0665 , H01L29/0673 , H01L29/068 , H01L29/861 , Y10S977/762 , Y10S977/81 , Y10S977/849 , Y10S977/856 , Y10S977/857 , Y10T428/2938 , Y10T428/2982
摘要： Multicomponent nanorods having segments with differing electronic and/or chemical properties are disclosed. The nanorods can be tailored with high precision to create controlled gaps within the nanorods or to produce diodes or resistors, based upon the identities of the components-making up the segments of the nanorods. Macrostructural composites of these nanorods also are disclosed.
摘要翻译： 公开了具有不同电子和/或化学性质的多组分纳米棒。 纳米棒可以以高精度进行定制，以在纳米棒内产生受控间隙，或者基于构成纳米棒段的部件的身份产生二极管或电阻器。 还公开了这些纳米棒的宏观结构复合材料。
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9.发明授权Deimmunized serum-binding domains and their use in extending serum half-life 有权去免疫的血清结合结构域及其在延长血清半衰期中的应用公开(公告)号：US09376495B2
公开(公告)日：2016-06-28
申请号：US14118516
申请日：2012-05-16
申请人： Ezio Bonvini , Bhaswati Barat , Ling Huang , Leslie S. Johnson
发明人： Ezio Bonvini , Bhaswati Barat , Ling Huang , Leslie S. Johnson
CPC分类号： C07K16/32 , C07K14/315 , C07K16/2803 , C07K16/2809 , C07K16/283 , C07K16/2851 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/567 , C07K2317/62 , C07K2317/624 , C07K2317/626 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2319/31 , C07K2319/32 , C07K2319/73
摘要： The present invention is directed to a polypeptide (for example, an antigen-binding molecule) that comprises a polypeptide portion of a deimmunized serum-binding protein capable of binding to said serum protein. The presence of the serum-binding protein extends the serum half-life of the polypeptide, relative to the serum half-life of the polypeptide if lacking the polypeptide portion of the deimmunized serum-binding protein. The invention also pertains to methods and uses that employ such molecules.
摘要翻译： 本发明涉及包含能够结合所述血清蛋白的解除免疫的血清结合蛋白的多肽部分的多肽（例如，抗原结合分子）。 如果缺乏去免疫的血清结合蛋白的多肽部分，则血清结合蛋白的存在相对于多肽的血清半衰期延长了多肽的血清半衰期。 本发明还涉及使用这种分子的方法和用途。
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10.发明授权Turing test based user authentication and user presence verification system, device, and method 有权基于图灵测试的用户认证和用户存在验证系统，设备和方法公开(公告)号：US09081947B2
公开(公告)日：2015-07-14
申请号：US13976918
申请日：2011-12-27
CPC分类号： G06F21/32 , G06K9/00288 , G06K9/00899
摘要： A password-less method for authenticating a user includes capturing one or more images of a face of the user and comparing the one or more images with a previously collected face template. Randomly selected colored light and randomized blinking patterns are used to capture the images of the user. Such captured images are compared to previously collected face templates, thereby thwarting spoof attacks. A secret image, known only to the user and the device, is moved from one area of the display to another randomly selected area, using the movements of the user's head or face, thereby providing a Turing based challenge. Protected audio video path (PAVP) enabled devices and components are used to protect the challenge from malware attacks.
摘要翻译： 用于认证用户的无密码方法包括捕获用户的脸部的一个或多个图像并将一个或多个图像与先前收集的面部模板进行比较。 随机选择的彩色光和随机闪烁图案用于捕获用户的图像。 将这样的拍摄图像与先前收集的面部模板进行比较，从而阻止欺骗攻击。 使用用户和设备已知的秘密图像使用用户头部或脸部的移动从显示器的一个区域移动到另一个随机选择的区域，从而提供基于图灵的挑战。 受保护的音频视频路径（PAVP）启用的设备和组件用于保护挑战免受恶意软件攻击。
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