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1.发明申请Wound Healing Compositions Comprising Biocompatible Cellulose Hydrogel Membranes and Methods of Use Thereof 有权包含生物相容性纤维素水凝胶膜的伤口愈合组合物及其使用方法公开(公告)号：US20120231038A1
公开(公告)日：2012-09-13
申请号：US13295515
申请日：2011-11-14
申请人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon
发明人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon
IPC分类号： A61K9/70 , A61K38/02 , A61K31/70 , A61K31/20 , A61K48/00 , A61K49/00 , A61K38/43 , A61K38/22 , A61K35/76 , A61K38/18 , A61K38/14 , A61K39/395 , A61K39/00 , A61K47/30 , A61K35/12 , A61P17/02 , A61P27/02 , A61K47/38
CPC分类号： A61K47/38 , A61K9/0051 , A61K31/00 , A61K35/12 , A61K35/76 , A61K38/18 , A61K38/22 , A61K38/39 , A61K38/43 , A61K39/00 , A61K49/00 , A61L15/42 , A61L15/44 , A61L15/60 , A61L2300/62 , A61L2300/64 , A61L2430/16 , C07K16/00 , C12N7/00 , C08L1/00
摘要： The present invention provides a wound healing composition comprising a biocompatible hydrogel membrane wherein the hydrogel membrane has one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The invention further provides methods of treating a wound in a subject in need thereof, comprising contacting the wound with a biocompatible cellulose hydrogel membrane of the invention.
摘要翻译： 本发明提供了包含生物相容性水凝胶膜的伤口愈合组合物，其中所述水凝胶膜具有以下性质中的一种或多种：高水含量，高透明度，高渗透性，高生物相容性，高拉伸强度和最佳厚度。 本发明还提供了治疗有需要的受试者的伤口的方法，包括使伤口与本发明的生物相容性纤维素水凝胶膜接触。
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公开(公告)号：US20130032059A1
公开(公告)日：2013-02-07
申请号：US13197116
申请日：2011-08-03
申请人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon
发明人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon
IPC分类号： G02C7/04 , C08L33/14 , C08L33/20 , C08L39/06 , B29B15/00 , C08L83/04 , C08L97/02 , B29C35/16 , B29D11/00 , C08L33/26 , C08L29/04
CPC分类号： B29D11/00038 , C08B1/003 , C08J3/075 , C08J2301/02 , C08L1/02 , C08L33/066 , C08L33/20 , C08L33/26 , C08L2205/02 , C08L2205/16 , G02B1/04 , G02B1/043 , G02C7/049 , C08L101/14 , C08L33/10 , C08L71/02 , C08L29/04 , C08L39/06 , C08L83/04
摘要： The present invention provides cellulose hydrogels having one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The present invention further provides a process for preparing a cellulose hydrogel comprising: (i) contacting cellulose with a solvent to activate the cellulose; (ii) optionally removing the solvent from the activated cellulose; (iii) substantially dissolving the activated cellulose to form a solution; (iv) allowing the solution to gel; and optionally (v) drying the gel and rehydrating the gel. The cellulose hydrogel can have many uses, including uses as contact lenses.
摘要翻译： 本发明提供具有以下性质的一种或多种纤维素水凝胶：高含水量，高透明度，高渗透性，高生物相容性，高拉伸强度和最佳厚度。 本发明还提供一种制备纤维素水凝胶的方法，包括：（i）使纤维素与溶剂接触以活化纤维素; （ii）任选地从活化的纤维素中除去溶剂; （iii）基本上溶解活化的纤维素以形成溶液; （iv）使溶液凝胶化; 并且任选地（v）干燥凝胶并使凝胶再水合。 纤维素水凝胶可以具有许多用途，包括用作隐形眼镜。
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3.发明授权Wound healing compositions comprising biocompatible cellulose hydrogel membranes and methods of use thereof 有权包含生物相容性纤维素水凝胶膜的伤口愈合组合物及其使用方法公开(公告)号：US09211256B2
公开(公告)日：2015-12-15
申请号：US13295515
申请日：2011-11-14
申请人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon , Daniel Mulreany , Qiongyu Guo
发明人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon , Daniel Mulreany , Qiongyu Guo
IPC分类号： A61K31/74 , A61K9/00 , A61L15/42 , A61L15/44 , A61L15/60 , A61K31/00 , A61K38/39 , A61K35/12
CPC分类号： A61K47/38 , A61K9/0051 , A61K31/00 , A61K35/12 , A61K35/76 , A61K38/18 , A61K38/22 , A61K38/39 , A61K38/43 , A61K39/00 , A61K49/00 , A61L15/42 , A61L15/44 , A61L15/60 , A61L2300/62 , A61L2300/64 , A61L2430/16 , C07K16/00 , C12N7/00 , C08L1/00
摘要： The present invention provides a wound healing composition comprising a biocompatible hydrogel membrane wherein the hydrogel membrane has one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The invention further provides methods of treating a wound in a subject in need thereof, comprising contacting the wound with a biocompatible cellulose hydrogel membrane of the invention.
摘要翻译： 本发明提供了包含生物相容性水凝胶膜的伤口愈合组合物，其中所述水凝胶膜具有以下性质中的一种或多种：高水含量，高透明度，高渗透性，高生物相容性，高拉伸强度和最佳厚度。 本发明还提供了治疗有需要的受试者的伤口的方法，包括使伤口与本发明的生物相容性纤维素水凝胶膜接触。
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公开(公告)号：US08871016B2
公开(公告)日：2014-10-28
申请号：US13197116
申请日：2011-08-03
申请人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon
发明人： Morgana M. Trexler , Jenna L. Graham , Jennifer L. Breidenich , Jeffrey P. Maranchi , Julia B. Patrone , Marcia W. Patchan , Jennifer H. Elisseeff , Xiomara Calderon-Colon
IPC分类号： G02C7/04 , C08L33/14 , C08L33/20 , G02B1/04 , B29D11/00 , C08J3/075 , C08B1/00 , C08L1/02 , C08L33/26 , C08L33/06
CPC分类号： B29D11/00038 , C08B1/003 , C08J3/075 , C08J2301/02 , C08L1/02 , C08L33/066 , C08L33/20 , C08L33/26 , C08L2205/02 , C08L2205/16 , G02B1/04 , G02B1/043 , G02C7/049 , C08L101/14 , C08L33/10 , C08L71/02 , C08L29/04 , C08L39/06 , C08L83/04
摘要： The present invention provides cellulose hydrogels having one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The present invention further provides a process for preparing a cellulose hydrogel comprising: (i) contacting cellulose with a solvent to activate the cellulose; (ii) optionally removing the solvent from the activated cellulose; (iii) substantially dissolving the activated cellulose to form a solution; (iv) allowing the solution to gel; and optionally (v) drying the gel and rehydrating the gel. The cellulose hydrogel can have many uses, including uses as contact lenses.
摘要翻译： 本发明提供具有以下性质的一种或多种纤维素水凝胶：高含水量，高透明度，高渗透性，高生物相容性，高拉伸强度和最佳厚度。 本发明还提供一种制备纤维素水凝胶的方法，包括：（i）使纤维素与溶剂接触以活化纤维素; （ii）任选地从活化的纤维素中除去溶剂; （iii）基本上溶解活化的纤维素以形成溶液; （iv）使溶液凝胶化; 并且任选地（v）干燥凝胶并使凝胶再水合。 纤维素水凝胶可以具有许多用途，包括用作隐形眼镜。
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5.发明授权公开(公告)号：US08785167B2
公开(公告)日：2014-07-22
申请号：US13116617
申请日：2011-05-26
摘要： A biocompatible article including (a) a biocompatible hydrogel; (b) an adhesive coating on at least a portion of the hydrogel; and (c) one or more organisms adhered to at least a portion of the adhesive coating is disclosed.
摘要翻译： 生物相容性制品，包括（a）生物相容性水凝胶; （b）在所述水凝胶的至少一部分上的粘合剂涂层; 并且（c）公开了粘附到粘合剂涂层的至少一部分的一种或多种生物体。
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6.发明申请公开(公告)号：US20110294159A1
公开(公告)日：2011-12-01
申请号：US13116617
申请日：2011-05-26
摘要： A biocompatible article including (a) a biocompatible hydrogel; (b) an adhesive coating on at least a portion of the hydrogel; and (c) one or more organisms adhered to at least a portion of the adhesive coating is disclosed.
摘要翻译： 生物相容性制品，包括（a）生物相容性水凝胶; （b）在所述水凝胶的至少一部分上的粘合剂涂层; 并且（c）公开了粘附到粘合剂涂层的至少一部分的一种或多种生物体。
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公开(公告)号：US20120039814A1
公开(公告)日：2012-02-16
申请号：US13208874
申请日：2011-08-12
申请人： Jennifer L. Sample , Julia B. Patrone , Jason J. Benkoski , James C. Crookston , Huong Le , Jennifer L. Breidenich , Lisa A. Kelly
发明人： Jennifer L. Sample , Julia B. Patrone , Jason J. Benkoski , James C. Crookston , Huong Le , Jennifer L. Breidenich , Lisa A. Kelly
CPC分类号： A61K49/0021 , A61K9/0014 , A61K9/1075 , A61K49/0078
摘要： A topical composition includes a nanoemulsion of a plurality of hydrophobic particles having a hydrophilic coating therein. The hydrophobic particles are derived from the same or different hydrophobic material and each hydrophobic particle has a melting point below the melting point of the respective hydrophobic material. The nanoemulsion further includes one or more pharmaceutically active agents and/or one or more chemiluminescent disease-detecting systems.
摘要翻译： 局部组合物包括其中具有亲水性涂层的多个疏水性颗粒的纳米乳剂。 疏水性颗粒来自相同或不同的疏水性材料，每个疏水性颗粒的熔点低于相应疏水性材料的熔点。 纳米乳液还包括一种或多种药学活性剂和/或一种或多种化学发光疾病检测系统。
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