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公开(公告)号：US4746669A
公开(公告)日：1988-05-24
申请号：US30313
申请日：1987-03-26
IPC分类号： C07D277/22 , C07D417/04 , C07D417/14 , A61K31/38 , C07D217/04 , C07D409/04 , C07D409/06
CPC分类号： C07D417/04 , C07D417/14
摘要： Thiazole derivatives have been made, for example, by reacting a 2-aryl-2,2-dialkoxyethylamine with an appropriately substituted aryl acetyl halide followed by treating the resulting amide with diphosphoryl pentasulfide. The thiazole derivatives are found to be effective immunoregulants.
摘要翻译： 噻唑衍生物例如通过使2-芳基-2,2-二烷氧基乙胺与适当取代的芳基乙酰卤反应，然后用二硫代二磷酰基处理得到的酰胺来制备。 发现噻唑衍生物是有效的免疫调节剂。
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2.发明授权6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis 失效6-取代的5-羟基-2,3-二氢苯并呋喃作为白三烯生物合成的抑制剂
公开(公告)号：US4966907A
公开(公告)日：1990-10-30
申请号：US230825
申请日：1988-08-12
申请人： Charles G. Caldwell , Milton L. Hammond , Ihor E. Kopka , Stanley H. B. Wright , Robert A. Zambias
发明人： Charles G. Caldwell , Milton L. Hammond , Ihor E. Kopka , Stanley H. B. Wright , Robert A. Zambias
IPC分类号： C07D307/79
CPC分类号： C07D307/79
摘要： Novel position-4 and/or position-6 substituted 5-hydroxy-2,3-dihydrobenzofuran and analogs of the following general structural formula (I) are disclosed: ##STR1## These compounds are found to be potent inhibitors of leukotriene biosynthesis.
摘要翻译： 公开了新的位置-4和/或位置-6取代的5-羟基-2,3-二氢苯并呋喃以及下列通式（I）的类似物：（I）这些化合物被发现是白细胞三烯的有效抑制剂 生物合成。
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3.发明授权Anti-inflammatory substituted 2-benzyl-mercapto-imidazole and pyrimidine derivatives compositions and method of use therefor 失效抗炎取代的2-苄基 - 巯基 - 咪唑和嘧啶衍生物组合物及其用途的方法
公开(公告)号：US4734421A
公开(公告)日：1988-03-29
申请号：US924391
申请日：1986-10-29
IPC分类号： C07D233/84 , C07D239/38 , C07D277/36 , C07D277/74 , C07D405/12
CPC分类号： C07D405/12 , C07D239/38 , C07D277/36 , C07D277/74
摘要： Substituted 2-benzyl-mercapto-imidazoles and analogs were prepared from the nucleophlic substitution of an appropriately substituted benzoxyacetate with a 2-imidazole mercapto anion or an analog thereof. These compounds were found to be anti-inflammatory agents.
摘要翻译： 由适当取代的苯氧基乙酸酯与2-咪唑巯基阴离子或其类似物的亲核取代制备取代的2-苄基 - 巯基 - 咪唑和类似物。 发现这些化合物是抗炎剂。
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公开(公告)号：US5948753A
公开(公告)日：1999-09-07
申请号：US58657
申请日：1993-05-04
摘要： Certain propanolamine compounds are described which have a cyclohexapeptidyl nucleus and which possess antibiotic activity with physical properties suitable for direct use in therapeutic compositions. A process for their preparation is also described.
摘要翻译： 描述了具有环己基肽基核并且具有适于直接用于治疗组合物的物理性质的抗生素活性的某些丙醇胺化合物。 还描述了其制备方法。
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5.发明授权Substituted 2-(heteroaryl-2-propenyl)phenols useful as anti-inflammatory agents 失效取代的2-（杂芳基-2-丙烯基）酚可用作抗炎剂
公开(公告)号：US4778818A
公开(公告)日：1988-10-18
申请号：US39407
申请日：1987-04-17
申请人： Michael N. Chang , Norman P. Jensen , Milton L. Hammond , Robert A. Zambias , John McDonald , Kathleen M. Rupprecht
发明人： Michael N. Chang , Norman P. Jensen , Milton L. Hammond , Robert A. Zambias , John McDonald , Kathleen M. Rupprecht
IPC分类号： C07C43/225 , C07C43/23 , C07C45/44 , C07C45/68 , C07C47/575 , C07C49/248 , C07C49/835 , C07C49/84 , C07D207/34 , C07D307/79 , C07D311/58 , A61K31/40
CPC分类号： C07D307/79 , C07C255/00 , C07C43/225 , C07C43/23 , C07C45/68 , C07C47/575 , C07C49/248 , C07C49/835 , C07C49/84 , C07D311/58
摘要： Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophlic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.
摘要翻译： 由肉桂酰卤与2,3-二氢苯并呋喃阴离子或其类似物的亲核取代制备取代的肉桂基-2,3-二氢苯并呋喃和类似物。 发现这些化合物是有效的局部抗炎剂。
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公开(公告)号：US5939384A
公开(公告)日：1999-08-17
申请号：US936561
申请日：1992-09-03
摘要： Certain propanolamine compounds which have a cyclohexapeptidyl nucleus and which are found to have extremely active antibiotic activity with physical properties suitable for direct use in therapeutic compositions are described. A novel process for their preparation is also described.
摘要翻译： 描述了具有环己肽基核并且被发现具有非常活跃的抗生素活性的某些丙醇胺化合物，其物理性质适用于直接用于治疗组合物中。 还描述了其制备的新方法。
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7.发明授权Novel 7-aroyl-4-hydroxy-3-methyl-benzofurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase 失效新型7-芳酰基-4-羟基-3-甲基 - 苯并呋喃作为环加氧酶和5-脂氧合酶的双重抑制剂
公开(公告)号：US5006549A
公开(公告)日：1991-04-09
申请号：US356151
申请日：1989-05-24
IPC分类号： C12N9/99 , A61K31/34 , A61K31/343 , A61P29/00 , A61P43/00 , C07D307/79 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06
CPC分类号： C07D307/79 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06
摘要： Novel 7-Aroyl-4-Hydroxy-3-Methyl-Benzofurans of the following general formula (I) are disclosed: ##STR1##The compounds are found to be potent dual inhibitors of cyclooxygenase and 5-lipoxygenase.
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8.发明授权Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents 失效取代的肉桂基-2,3-二氢苯并呋喃和类似物可用作抗炎剂
公开(公告)号：US4537903A
公开(公告)日：1985-08-27
申请号：US541200
申请日：1983-10-12
IPC分类号： C07C69/94 , A61K31/055 , A61K31/215 , A61K31/34 , A61K31/343 , A61K31/35 , A61K31/352 , A61P29/00 , C07C27/00 , C07C39/21 , C07C39/373 , C07C41/00 , C07C43/225 , C07C43/23 , C07C43/295 , C07C45/00 , C07C45/44 , C07C47/575 , C07C49/248 , C07C49/835 , C07C49/84 , C07C51/00 , C07C65/19 , C07C65/40 , C07C67/00 , C07C69/035 , C07C253/00 , C07C255/53 , C07C255/56 , C07C313/00 , C07C315/04 , C07C317/18 , C07C323/20 , C07C323/65 , C07D307/79 , C07D307/83 , C07D311/58
CPC分类号： C07D307/79 , C07C255/00 , C07C43/225 , C07C43/23 , C07C47/575 , C07C49/248 , C07C49/835 , C07C49/84 , C07D311/58
摘要： Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophilic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.
摘要翻译： 由肉桂酰卤与2,3-二氢苯并呋喃阴离子或其类似物的亲核取代制备取代的肉桂基-2,3-二氢苯并呋喃和类似物。 发现这些化合物是有效的局部抗炎剂。
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公开(公告)号：US5229363A
公开(公告)日：1993-07-20
申请号：US658590
申请日：1991-02-19
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or hydroxyl; R.sub.2 is hydrogen; hydroxyl or methyl, R.sub.3 is hydrogen or hydroxyl; R.sub.4 is C.sub.5 -C.sub.23 alkyl, C.sub.5 -C.sub.23 alkenyl, aryl or substituted aryl; R.sub.5 is --CH.sub.2 OH, --CH(CH.sub.3)OH, --CH(CH.sub.2 CONH.sub.2)OH; R.sub.6 is --CH.sub.2 OH or --CH(CH.sub.3)OH; R is --CH.sub.2 OH or --CH(CH.sub.3)OH; provided that when R.sub.4 is --(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2 CH(CH.sub.3)C.sub.2 H.sub.5, R.sub.5 is --CH.sub.2 OH or --CH(CH.sub.3)OH. The compounds are useful as antimicrobial agents, especially as antifungal agents.
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10.发明授权Substituted 5-hydroxy-2,3-dihydrobenzothiophenes as inhibitors of leukotriene biosynthesis 失效取代的5-羟基-2,3-二氢苯并噻吩作为白三烯生物合成的抑制剂
公开(公告)号：US4963580A
公开(公告)日：1990-10-16
申请号：US442497
申请日：1989-11-27
IPC分类号： C07D333/54
CPC分类号： C07D333/54
摘要： Position-4 and/or position-6 substituted 5-hydroxy-2,3-dihydrobenzothiophenes and analogs of the following general structural formula (I) are disclosed: ##STR1## These compounds are found to be potent inhibitors of leukotriene biosynthesis.
摘要翻译： （I）所示的位置-4和/或位置-6取代的5-羟基-2,3-二氢苯并噻吩类似物和其类似物被公开：发现这些化合物是白三烯生物合成的有效抑制剂 。
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