公开(公告)号：US5883310A

公开(公告)日：1999-03-16

申请号：US428334

申请日：1995-04-25

申请人： Chih-Ming Ho ,  Yu-Chong Tai ,  Fukang Jiang ,  Chang Liu ,  Jin-Biao Huang

发明人： Chih-Ming Ho ,  Yu-Chong Tai ,  Fukang Jiang ,  Chang Liu ,  Jin-Biao Huang

IPC分类号： G01F1/684 ,  G01P5/12 ,  G01B7/16

CPC分类号： G01P5/12 ,  G01F1/6845

摘要： A micromachined hot-wire anemometer having fast response times and higher sensitivities than conventional hot-wire anemometers is provided by micromachining doped polysilicon wires carried on silicon supports cantilevered from a substrate including one or more insulating layers disposed between said substrate and supports. The micromachined polysilicon hot-wire anemometer is fabricated using surface micromachining techniques.A shear stress sensor is micromachined to define a thin diaphragm over a cavity defined in a substrate underlying the diaphragm. The cavity is evacuated, sealed, and a thermistor disposed over the diaphragm. The thermistor is thus thermally insulated from the substrate and provides a low profile shear stress sensor for measuring flow rates in boundary layers above a flow surface.

摘要翻译： 具有比常规热线风速计更快的响应时间和更高灵敏度的微加工热线风速计通过微机械加工在从包括设置在所述衬底和支撑件之间的一个或多个绝缘层悬垂的硅衬底上的掺杂多晶硅线提供。 使用表面微加工技术制造微加工多晶硅热丝风速计。 剪切应力传感器被微加工以在限定在隔膜下方的基板中的空腔上限定薄膜。 空腔被抽真空，密封，并且设置在隔膜上方的热敏电阻。 因此，热敏电阻与基板热绝缘，并提供用于测量流动表面上方边界层中的流速的低剖面剪切应力传感器。

公开(公告)号：US5629918A

公开(公告)日：1997-05-13

申请号：US377018

申请日：1995-01-20

申请人： Chih-Ming Ho ,  Denny K. Miu ,  Jeremy Tzong-Shyng Leu ,  Raanan Miller ,  Amish Desai ,  Chang Liu ,  Tom Tsao ,  Yu-Chong Tai

发明人： Chih-Ming Ho ,  Denny K. Miu ,  Jeremy Tzong-Shyng Leu ,  Raanan Miller ,  Amish Desai ,  Chang Liu ,  Tom Tsao ,  Yu-Chong Tai

IPC分类号： B44C1/22

CPC分类号： H02K99/00

摘要： A surface micromachined micromagnetic actuator is provided with a flap capable of achieving large deflections above 100 microns using magnetic force as the actuating force. The flap is coupled by one or more beams to a substrate and is cantilevered over the substrate. A Permalloy layer or a magnetic coil is disposed on the flap such that when the flap is placed in a magnetic field, it can be caused to selectively interact and rotate out of the plane of the magnetic actuator. The cantilevered flap is released from the underlying substrate by etching out an underlying sacrificial layer disposed between the flap and the substrate. The etched out and now cantilevered flap is magnetically actuated to maintain it out of contact with the substrate while the just etched device is dried in order to obtain high release yields.

摘要翻译： 表面微加工微磁致动器设置有能够使用磁力作为致动力来实现高于100微米的大偏转的挡板。 翼片通过一个或多个梁耦合到基底并且在基底上悬臂。 坡度合金层或磁性线圈设置在翼片上，使得当翼片被放置在磁场中时，可以使其选择性地相互作用并旋转出磁致动器的平面。 通过蚀刻设置在翼片和基底之间的下面的牺牲层，将悬臂翼片从下面的基底释放。 蚀刻出来的和现在的悬臂翼片被磁力驱动，以保持其与基底不接触，同时刚刚蚀刻的装置被干燥以获得高的释放产率。

公开(公告)号：US07101514B2

公开(公告)日：2006-09-05

申请号：US10060737

申请日：2002-01-30

申请人： Po-Hao Adam Huang ,  Chih-Ming Ho

发明人： Po-Hao Adam Huang ,  Chih-Ming Ho

IPC分类号： B01J19/00 ,  B01J19/24 ,  B81B7/00 ,  F02K7/00

CPC分类号： B01F3/022 ,  B01B1/005 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00907

摘要： An improved chemical mixing micro-device with features on the micro- and nano-scale. The micro-device is comprised of at least one chemical inlet port and one chemical outlet port, a micro-evaporator, a micro-chamber and a micro-initiator. Also, a method of mixing at least one chemical in an evaporative mixing and/or reacting chamber is disclosed.

公开(公告)号：US5905007A

公开(公告)日：1999-05-18

申请号：US904729

申请日：1997-08-01

申请人： Chih-Ming Ho ,  Wen J. Li

发明人： Chih-Ming Ho ,  Wen J. Li

IPC分类号： B81C99/00 ,  G03F7/24 ,  G03F9/00

CPC分类号： B81C1/00214 ,  G03F7/24

摘要： An integrated circuit, or microelectromechanical structure is defined onto a contour surface by utilizing a flexible mask upon which photolithographic patterns are first defined using conventional planar photolithographic techniques. The contour surface is provided with a thin film uniformly distributed on the surface and then the flexible mask is aligned with the contour substrate. Alignments are made through multiple stages of yaw alignment, translation alignment and rotational alignment. Once the mask is aligned with contour substrate it is then subjected while rotating to developing field, such as uniform illumination of ultraviolet light shining on the side of the contour substrate as it is rotated in the illumination field. The developed photoresist layer disposed on the surface of the contour substrate is thus developed and the underlying film etched according to the patterned mask in a manner similar to a conventional planar photolithography. Multiple layers are thus disposed masked and etched to result in complex multilayered integrated circuit and/or microelectromechanical devices disposed on the contour surface of a macromechanical component or structure.

摘要翻译： 通过使用柔性掩模将集成电路或微机电结构限定在轮廓表面上，柔性掩模首先使用柔性掩模使用常规平面光刻技术来定义光刻图案。 轮廓表面设置有均匀分布在表面上的薄膜，然后柔性掩模与轮廓基底对准。 对齐是通过偏转对准，平移对准和旋转对准的多个阶段进行的。 一旦掩模与轮廓基底对准，然后在旋转到显影场的同时受到影响，例如当在照明场中旋转时在轮廓基底的侧面上照射紫外光的均匀照明。 因此，设置在轮廓基底的表面上的显影的光致抗蚀剂层被显影，并且以与常规平面光刻相似的方式根据图案化掩模蚀刻下面的膜。 因此，将多层掩模和蚀刻以形成设置在大型机械部件或结构的轮廓表面上的复合多层集成电路和/或微机电装置。

公开(公告)号：US07291457B2

公开(公告)日：2007-11-06

申请号：US10177537

申请日：2002-06-21

申请人： Jeffrey F. Miller ,  Jun Huang ,  Tza-Huei Wang ,  Chih-Ming Ho ,  Minghsun Liu

发明人： Jeffrey F. Miller ,  Jun Huang ,  Tza-Huei Wang ,  Chih-Ming Ho ,  Minghsun Liu

IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12Q1/6816 ,  C12Q1/6827 ,  C12Q2565/607 ,  C12Q2537/125 ,  C12Q2525/301 ,  C12Q2563/113

摘要： A method and system for specifically detecting perfectly matched probe-target hybrids by annealing a hairpin-based probe to a nucleic acid target under conditions favoring the formation of perfectly matched targets over mismatched targets, and electrochemically detecting the annealed probe. Sensitivity of detection can be enhanced by catalyzed reporter deposition of probe signal prior to electrochemical detection. Specificity can be enhanced by including hairpin-based competitor probes in the annealing step. The detection assay is particularly applicable to typing single nucleotide polymorphisms by DNA sandwich hybridization.

摘要翻译： 一种用于特异性检测完全匹配的探针 - 靶杂交体的方法和系统，所述方法和系统通过在有助于在失配靶上形成完全匹配的靶的条件下将发夹基探针退火至核酸靶，以及电化学检测退火的探针。 在电化学检测之前，探测信号的催化报道沉积可以提高检测灵敏度。 通过在退火步骤中包含基于发夹的竞争者探针可以提高特异性。 检测方法特别适用于通过DNA夹心杂交分型单核苷酸多态性。

公开(公告)号：US20090075360A1

公开(公告)日：2009-03-19

申请号：US11719749

申请日：2005-11-18

申请人： Chih-Ming Ho ,  Pak Kin Wong ,  Ren Sun ,  Fuqu Yu

发明人： Chih-Ming Ho ,  Pak Kin Wong ,  Ren Sun ,  Fuqu Yu

IPC分类号： C12M3/00 ,  C12M1/36 ,  G05B13/02

CPC分类号： C12Q1/02 ,  C12M41/48 ,  C12Q3/00 ,  G01N35/0092 ,  G01N2035/0094 ,  Y02A90/26

摘要： The invention provides systems and methods for manipulating, e.g., optimizing and controlling, biological systems, e.g., for eliciting a more desired biological response of biological sample, such as a tissue, organ, and/or a cell. In one aspect, systems and methods of the invention operate by efficiently searching through a large parametric space of stimuli and system parameters to manipulate, control, and optimize the response of biological samples sustained in the system, e.g., a bioreactor. In alternative aspects, systems include a device for sustaining cells or tissue samples, one or more actuators for stimulating the samples via biochemical, electromagnetic, thermal, mechanical, and/or optical stimulation, one or more sensors for measuring a biological response signal of the samples resulting from the stimulation of the sample. In one aspect, the systems and methods of the invention use at least one optimization algorithm to modify the actuator's control inputs for stimulation, responsive to the sensor's output of response signals. The compositions and methods of the invention can be used, e.g., to for systems optimization of any biological manufacturing or experimental system, e.g., bioreactors for proteins, e.g., therapeutic proteins, polypeptides or peptides for vaccines, and the like, small molecules (e.g., antibiotics), polysaccharides, lipids, and the like. Another use of the apparatus and methods includes combination drug therapy, e.g. optimal drug cocktail, directed cell proliferations and differentiations, e.g. in tissue engineering, e.g. neural progenitor cells differentiation, and discovery of key parameters in complex biological systems.

摘要翻译： 本发明提供了用于操纵，例如优化和控制生物系统的系统和方法，例如用于引发生物样品例如组织，器官和/或细胞的更期望的生物反应。 在一个方面，本发明的系统和方法通过有效地搜索刺激和系统参数的大参数空间来操作，控制和优化在系统例如生物反应器中维持的生物样品的响应。 在替代方面，系统包括用于维持细胞或组织样本的装置，用于通过生物化学，电磁，热，机械和/或光刺激刺激样品的一个或多个致动器，用于测量生物反应信号的一个或多个传感器 样品刺激产生的样品。 在一个方面，本发明的系统和方法使用至少一种优化算法，以响应于传感器的响应信号的输出来修改致动器的用于刺激的控制输入。 本发明的组合物和方法可用于例如任何生物制备或实验系统的系统优化，例如用于蛋白质的生物反应器，例如用于疫苗的治疗性蛋白质，多肽或肽等，小分子（例如， ，抗生素），多糖，脂质等。 该装置和方法的另一用途包括组合药物治疗，例如， 最佳药物混合物，定向细胞增殖和分化，例如。 在组织工程中。 神经祖细胞分化，以及复杂生物系统中关键参数的发现。

公开(公告)号：US4158310A

公开(公告)日：1979-06-19

申请号：US873757

申请日：1978-01-30

申请人： Chih-Ming Ho

发明人： Chih-Ming Ho

IPC分类号： G01L9/00

CPC分类号： G01L9/0077

摘要： An optical pressure transducer utilizing a deformable diaphragm having a reflective surface in which a fiber optic bundle having at least 100 optical fibers is randomly divided at one end into two bundles consisting of a light source bundle, the end of which is irradiated by a light source, and a reflected light bundle, the end of which conveys light reflected from a pressure-sensitive diaphragm to a light detection means.

摘要翻译： 一种使用具有反射表面的可变形隔膜的光学压力传感器，其中具有至少100根光纤的光纤束在一端被随机分成由光源束组成的两束，其中光源束被光源照射 以及反射光束，其端部将从压敏膜反射的光传送到光检测装置。

公开(公告)号：US08765459B2

公开(公告)日：2014-07-01

申请号：US13562216

申请日：2012-07-30

申请人： Chih-Ming Ho ,  Pak Kin Wong ,  Ren Sun ,  Fuqu Yu

发明人： Chih-Ming Ho ,  Pak Kin Wong ,  Ren Sun ,  Fuqu Yu

IPC分类号： C12M1/00 ,  G05B19/42

CPC分类号： C12Q1/02 ,  C12M41/48 ,  C12Q3/00 ,  G01N35/0092 ,  G01N2035/0094 ,  Y02A90/26

摘要： The invention provides systems and methods for manipulating biological systems, for example to elicit a more desired biological response from a biological sample, such as a tissue, organ, and/or a cell. In one aspect, the invention operates by efficiently searching through a large parametric space of stimuli and system parameters to manipulate, control, and optimize the response of biological samples sustained in the system. In one aspect, the systems and methods of the invention use at least one optimization algorithm to modify the actuator's control inputs for stimulation, responsive to the sensor's output of response signals. The invention can be used, e.g., to optimize any biological system, e.g., bioreactors for proteins, and the like, small molecules, polysaccharides, lipids, and the like. Another use of the apparatus and methods includes is for the discovery of key parameters in complex biological systems.

摘要翻译： 本发明提供了用于操纵生物系统的系统和方法，例如从生物样品（例如组织，器官和/或细胞）引出更希望的生物反应。 在一个方面，本发明通过有效搜索刺激的大参数空间和系统参数来操作，控制和优化系统中持续的生物样品的响应。 在一个方面，本发明的系统和方法使用至少一种优化算法，以响应于传感器的响应信号的输出来修改致动器的用于刺激的控制输入。 本发明可用于例如优化任何生物系统，例如用于蛋白质的生物反应器等，小分子，多糖，脂质等。 该装置和方法的另一用途包括在复杂生物系统中发现关键参数。

公开(公告)号：US08411344B2

公开(公告)日：2013-04-02

申请号：US12805545

申请日：2010-08-05

申请人： Tsung-Hui Tsai ,  Fu-cheng Wang ,  Chih-Ming Ho ,  Chi-Te Liang

发明人： Tsung-Hui Tsai ,  Fu-cheng Wang ,  Chih-Ming Ho ,  Chi-Te Liang

IPC分类号： G02B26/02

CPC分类号： G02B26/004

摘要： The present invention discloses an electrical control light valve apparatus having liquid gallium. The invention comprises the transparent glass as a substrate, ITO transparent conductive film as the electrodes, the liquid gallium as the valve located on the ITO transparent conductive film, and the partial-transparent glass is located on the top of the electrical control light valve apparatus.

摘要翻译： 本发明公开了一种具有液态镓的电控光阀装置。 本发明包括作为基板的透明玻璃，作为电极的ITO透明导电膜，作为阀的液态镓位于ITO透明导电膜上，部分透明玻璃位于电动控制光阀装置的顶部 。

公开(公告)号：US06273553B1

公开(公告)日：2001-08-14

申请号：US09535903

申请日：2000-03-24

申请人： Chang-Jin Kim ,  Fan-Gang Tseng ,  Chih-Ming Ho

发明人： Chang-Jin Kim ,  Fan-Gang Tseng ,  Chih-Ming Ho

IPC分类号： B41J214

CPC分类号： B41J2/1404 ,  B05B1/14 ,  B05B17/04 ,  B41J2/14056 ,  B41J2/14072 ,  B41J2/14137 ,  B41J2002/1437 ,  B41J2002/14387 ,  B41J2202/05

摘要： An apparatus and method for forming a bubble within a microchannel of a microinjector to function as a valve mechanism between the chamber and manifold, that provides for a high resistance to liquid exiting the chamber through the manifold during fluid ejection through an orifice and that also provides a low resistance to refilling of liquid into the chamber after ejection of fluid and collapse of the bubble. This effectively minimizes cross talk between adjacent chambers and increases injection frequency of the microinjector. The formation of a second bubble within the chamber coalesces with a first formed bubble between the chamber and manifold to abruptly terminate the ejection of fluid, thereby eliminating satellite droplets.

摘要翻译： 一种用于在微型注射器的微通道内形成气泡的装置和方法，用作腔室和歧管之间的阀机构，其在通过孔口的流体喷射期间提供通过歧管离开腔室的液体的高抵抗力，并且还提供 弹出液体后液体进入室内的低阻力和气泡崩溃。 这有效地最小化相邻室之间的串扰，并增加微型注射器的注射频率。 室内的第二个气泡的形成与腔室和歧管之间的第一个形成的气泡结合在一起，从而突然终止流体的喷射，从而消除卫星液滴。