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    Method for Increasing the Dynamic Measuring Range of Test Elements Based on Specific Binding Reactions
    6.
    发明申请
    Method for Increasing the Dynamic Measuring Range of Test Elements Based on Specific Binding Reactions 有权
    基于特定结合反应增加测试元件动态测量范围的方法

    公开(公告)号：US20070259450A1

    公开(公告)日：2007-11-08

    申请号：US11557279

    申请日：2006-11-07

    申请人： Ludger Bodenbach ,  Juergen Schaeffler ,  Juergen Spinke

    发明人： Ludger Bodenbach ,  Juergen Schaeffler ,  Juergen Spinke

    IPC分类号： G01N33/558

    CPC分类号： G01N33/54386 ,  G01N33/538

    摘要： The invention concerns a method for increasing the dynamic measuring range of especially immunological test elements in particular immunological chromatography test strips that can be evaluated optically that are based on specific binding reactions. The invention enables the dynamic measuring range of test elements based on specific binding reagents, especially of immunological test elements to be shifted towards higher analyte concentrations without impairing the lower detection limit. For this purpose it is proposed according to the invention that at least two zones are provided in or on the test element which contain reagents that generate detectable signals of different strengths due to different affinities for the analyte (for example in the case of antibodies that have different affinities for the analyte) or due to different principles of interaction with the analyte or with other reagents involved in the analyte detection (for example antibodies directed against the analyte in one zone and an analyte analogue in another zone). The signals in the at least two zones are used to evaluate the analyte concentration-signal strength relationship and are used to determine the analyte by means of a suitable method (correlation).

    摘要翻译： 本发明涉及用于增加特别是免疫学测试元件的动态测量范围的方法，特别是可以根据特异性结合反应光学评估的免疫色谱测试条。 本发明使得基于特异性结合试剂，特别是免疫测试元件的测试元件的动态测量范围能够转移到更高的分析物浓度而不损害较低的检测限。 为此目的，根据本发明提出，至少两个区域设置在测试元件中或测试元件上，其包含由于分析物的不同亲和力而产生不同强度的可检测信号的试剂（例如在具有 分析物的不同亲和力）或由于与分析物或与分析物检测相关的其它试剂（例如针对一个区域中的分析物和另一区域中的分析物类似物的抗体）的相互作用的不同原理。 至少两个区域中的信号用于评估分析物浓度 - 信号强度关系，并用于通过合适的方法（相关性）确定分析物。

    Method for increasing the dynamic measuring range of test elements based on specific binding reactions
    7.
    发明授权
    Method for increasing the dynamic measuring range of test elements based on specific binding reactions 有权
    基于特异性结合反应增加测试元件的动态测量范围的方法

    公开(公告)号：US08354235B2

    公开(公告)日：2013-01-15

    申请号：US11557279

    申请日：2006-11-07

    申请人： Ludger Bodenbach ,  Juergen Schaeffler ,  Juergen Spinke

    发明人： Ludger Bodenbach ,  Juergen Schaeffler ,  Juergen Spinke

    IPC分类号： G01N33/533

    CPC分类号： G01N33/54386 ,  G01N33/538

    摘要： The invention concerns a method for increasing the dynamic measuring range of especially immunological test elements in particular immunological chromatography test strips that can be evaluated optically that are based on specific binding reactions. The invention enables the dynamic measuring range of test elements based on specific binding reagents, especially of immunological test elements to be shifted towards higher analyte concentrations without impairing the lower detection limit. For this purpose it is proposed according to the invention that at least two zones are provided in or on the test element which contain reagents that generate detectable signals of different strengths due to different affinities for the analyte (for example in the case of antibodies that have different affinities for the analyte) or due to different principles of interaction with the analyte or with other reagents involved in the analyte detection (for example antibodies directed against the analyte in one zone and an analyte analogue in another zone). The signals in the at least two zones are used to evaluate the analyte concentration-signal strength relationship and are used to determine the analyte by means of a suitable method (correlation).

    摘要翻译： 本发明涉及用于增加特别是免疫学测试元件的动态测量范围的方法，特别是可以根据特异性结合反应光学评估的免疫色谱测试条。 本发明使得基于特异性结合试剂，特别是免疫测试元件的测试元件的动态测量范围能够转移到更高的分析物浓度而不损害较低的检测限。 为此目的，根据本发明提出，至少两个区域设置在测试元件中或测试元件上，其包含由于分析物的不同亲和力而产生不同强度的可检测信号的试剂（例如在具有 分析物的不同亲和力）或由于与分析物或与分析物检测相关的其它试剂（例如针对一个区域中的分析物和另一区域中的分析物类似物的抗体）的相互作用的不同原理。 至少两个区域中的信号用于评估分析物浓度 - 信号强度关系，并用于通过合适的方法（相关性）确定分析物。