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    Functional optical coherent imaging
    5.
    发明授权
    Functional optical coherent imaging 有权
    功能光学相干成像

    公开(公告)号：US09066686B2

    公开(公告)日：2015-06-30

    申请号：US13057593

    申请日：2008-07-10

    申请人： Theo Lasser ,  Dimitri Van De Ville ,  Erica Martin-Williams ,  Marcel Leutenegger ,  Iwan Maerki ,  Michael Friedrich ,  Martin Villiger

    发明人： Theo Lasser ,  Dimitri Van De Ville ,  Erica Martin-Williams ,  Marcel Leutenegger ,  Iwan Maerki ,  Michael Friedrich ,  Martin Villiger

    IPC分类号： H04N5/228 ,  A61B3/12 ,  A61B5/00 ,  H04N9/47 ,  H04N7/18 ,  H04N5/253 ,  A61B3/10

    CPC分类号： A61B5/0066 ,  A61B3/102 ,  A61B3/1233 ,  A61B5/0048 ,  A61B5/0059 ,  A61B5/02028 ,  A61B5/413 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742

    摘要： The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD. Further the invention relates to a process for acquiring stimuli activated subject data comprising the steps of aligning a body function unit at a subject and monitoring pre-selected body function; selecting a stimulus or stimuli; imaging a body area of interest; exerting one or a series of stimuli on the subject; imaging the body area of interest synchronous with said stimuli and the preselected body functions; and transferring said synchronized image, stimuli and body function data to a statistical analysis unit (SAU) and performing calculations to generate results pertaining to body functions.

    摘要翻译： 功能性光学相干成像（fOCI）平台本发明涉及包括至少一个包括相干和/或部分相干光源的有源相机单元（ACU）的功能性光学相干成像（fOCI）平台，以及用于对感兴趣的所选择的身体区域进行频谱滤波和成像的装置; 用于预处理从ACU接收的数据的图像处理单元（IPU）; 向受试者传送刺激的至少一个刺激单元（STU）; 至少一个身体功能参考测量单元（BFMU）; 中央时钟和处理单元（CCU），与ACU，IPU，STU的互连，用于从IPU收集预处理的数据，以同步方式从BFMU的STU主体功能参考数据的刺激; 后处理单位（统计分析单位，SAU）; 另外本发明涉及一种用于获取刺激激活的被摄体数据的处理，包括以下步骤：对准对象的身体功能单元并监视预先选择的身体功能;选择刺激或刺激;对身体区域进行成像 对所述受试者施加一个或一系列刺激;对与所述刺激和预选身体功能同步的感兴趣体部成像;将所述同步图像，刺激和身体功能数据传送到统计分析单元（SAU）和 执行计算以生成与身体功能相关的结果。

    FUNCTIONAL OPTICAL COHERENT IMAGING
    6.
    发明申请
    FUNCTIONAL OPTICAL COHERENT IMAGING 有权
    功能光学相干成像

    公开(公告)号：US20110169978A1

    公开(公告)日：2011-07-14

    申请号：US13057593

    申请日：2008-07-10

    申请人： Theo Lasser ,  Dimitri Van De Ville ,  Erica Martin-Williams ,  Marcel Leutenegger ,  Iwan Maerki ,  Michael Friedrich ,  Martin Villiger

    发明人： Theo Lasser ,  Dimitri Van De Ville ,  Erica Martin-Williams ,  Marcel Leutenegger ,  Iwan Maerki ,  Michael Friedrich ,  Martin Villiger

    IPC分类号： H04N5/228

    CPC分类号： A61B5/0066 ,  A61B3/102 ,  A61B3/1233 ,  A61B5/0048 ,  A61B5/0059 ,  A61B5/02028 ,  A61B5/413 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7278 ,  A61B5/742

    摘要： The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD. Further the invention relates to a process for acquiring stimuli activated subject data comprising the steps of aligning a body function unit at a subject and monitoring pre-selected body function; selecting a stimulus or stimuli; imaging a body area of interest; exerting one or a series of stimuli on the subject; imaging the body area of interest synchronous with said stimuli and the preselected body functions; and transferring said synchronized image, stimuli and body function data to a statistical analysis unit (SAU) and performing calculations to generate results pertaining to body functions.

    摘要翻译： 功能性光学相干成像（fOCI）平台本发明涉及包括至少一个包括相干和/或部分相干光源的有源相机单元（ACU）的功能性光学相干成像（fOCI）平台，以及用于对感兴趣的所选择的身体区域进行频谱滤波和成像的装置; 用于预处理从ACU接收的数据的图像处理单元（IPU）; 向受试者传送刺激的至少一个刺激单元（STU）; 至少一个身体功能参考测量单元（BFMU）; 中央时钟和处理单元（CCU），与ACU，IPU，STU的互连，用于从IPU收集预处理的数据，以同步方式从BFMU的STU主体功能参考数据的刺激; 后处理单位（统计分析单位，SAU）; 另外本发明涉及一种用于获取刺激激活的被摄体数据的处理，包括以下步骤：对准对象的身体功能单元并监视预先选择的身体功能;选择刺激或刺激;对身体区域进行成像 对所述受试者施加一个或一系列刺激;对与所述刺激和预选身体功能同步的感兴趣体部成像;将所述同步图像，刺激和身体功能数据传送到统计分析单元（SAU）和 执行计算以生成与身体功能相关的结果。

    Method and apparatus for fixing a location
    7.
    发明授权
    Method and apparatus for fixing a location 有权
    固定位置的方法和装置

    公开(公告)号：US06741948B2

    公开(公告)日：2004-05-25

    申请号：US10034845

    申请日：2001-12-28

    申请人： Christoph Hauger ,  Werner Pöltinger ,  Peter Reimer ,  Margit Krause-Bonte ,  Theo Lasser

    发明人： Christoph Hauger ,  Werner Pöltinger ,  Peter Reimer ,  Margit Krause-Bonte ,  Theo Lasser

    IPC分类号： G01C1700

    CPC分类号： G02B21/0012 ,  A61B34/20 ,  A61B90/20 ,  A61B90/25 ,  A61B90/36 ,  A61B2017/00699 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2090/364 ,  A61B2090/371 ,  G01S5/16

    摘要： A method is disclosed for fixing at least one location in an examination field (9) with respect to a coordinate system (13). The method includes determining, in response to a request (65), coordinates of a first location (59) as a first coordinate set (x, y, z) allocated to the first location (59). A first recording and a second recording of topological data (69) in a spatially extended area around the first location (59) in the examination field (9) are obtained. The first and second recordings are compared to determine a displacement (&Dgr;x, &Dgr;y, &Dgr;z) of the first location (59) of the examination field (9) with respect to the coordinate system (13), the coordinates of the first coordinate set (x, y, z) allocated to the first location (59) are changed dependent upon the determined displacement (&Dgr;x, &Dgr;y, &Dgr;z) such that the changed coordinates substantially correspond to the coordinates of the first location (59) in the examination field (9) after the displacement thereof.

    摘要翻译： 公开了一种用于相对于坐标系（13）固定检查区（9）中的至少一个位置的方法。 该方法包括响应于请求（65）确定作为分配给第一位置（59）的第一坐标集（x，y，z）的第一位置（59）的坐标。 获得在检查区域（9）中围绕第一位置（59）的空间延伸区域中的拓扑数据（69）的第一记录和第二记录。 将第一和第二记录进行比较以确定检查区域（9）相对于坐标系（13）的第一位置（59）的位移（Deltax，Deltay，Deltaz），第一坐标集（ 分配给第一位置（59）的x，y，z）根据所确定的位移（Deltax，Deltay，Deltaz）而改变，使得改变的坐标基本上对应于检查场中的第一位置（59）的坐标 9）。

    Adjustable Pinhole
    8.
    发明申请
    Adjustable Pinhole 失效
    可调针孔

    公开(公告)号：US20070285813A1

    公开(公告)日：2007-12-13

    申请号：US10557903

    申请日：2004-04-28

    申请人： Theo Lasser ,  Antonio Lopez ,  Thomas Sidler ,  Sebastian Favre ,  Ronald Gianotti

    发明人： Theo Lasser ,  Antonio Lopez ,  Thomas Sidler ,  Sebastian Favre ,  Ronald Gianotti

    IPC分类号： G02B26/00

    CPC分类号： G01J3/04 ,  G02B5/005 ,  G02B21/0032 ,  G03B9/06

    摘要： An adjustable pinhole, in particular for a beam path for illumination and/or detection in a laser-scanning microscope. The pinhole consists of at least two planar basic modules, which have frame-like joints, on which at least one sharp edge is arranged in a displaceable manner in one direction, whereby the basic component advantageously contains at least one integrated, preferably optical or electromagnetic positioning element. A device is provided at the sharp edge, or connected with it, for preferably optical or electromagnetic detection of the position, and is provided, advantageously, with two asymmetric apertures, with mutually opposite orientation, for optical detection of the position, whereby in front of or behind the apertures, a slit is provided, oriented preferably at a right angle to the direction of displacement, and the quantity of light passing through the slit is detected separately for each aperture.

    摘要翻译： 特别是用于在激光扫描显微镜中用于照明和/或检测的光束路径的可调针孔。 针孔由至少两个具有框架状接头的平面基本模块组成，其上至少一个锋利边缘以一个可移动的方式在一个方向上布置，其中该基本部件有利地包含至少一个集成的，优选的光学或电磁 定位元件 一个装置设置在锋利的边缘处或者与之相连接，以优选地对该位置进行光学或电磁检测，并且有利地具有两个具有相互取向的不对称孔，用于位置的光学检测，由此在前面 设置有狭缝，其优选地以相对于位移方向成直角定向，并且对于每个孔单独地检测通过狭缝的光量。

    Adjustable pinhole for a laser scanning microscope
    9.
    发明授权
    Adjustable pinhole for a laser scanning microscope 失效
    激光扫描显微镜可调针孔

    公开(公告)号：US08077413B2

    公开(公告)日：2011-12-13

    申请号：US10557903

    申请日：2004-04-28

    申请人： Theo Lasser ,  Antonio Lopez ,  Thomas Sidler ,  Sebastian Favre ,  Ronald Gianotti

    发明人： Theo Lasser ,  Antonio Lopez ,  Thomas Sidler ,  Sebastian Favre ,  Ronald Gianotti

    IPC分类号： G02B27/00 ,  G02B5/00

    CPC分类号： G01J3/04 ,  G02B5/005 ,  G02B21/0032 ,  G03B9/06

    摘要： An adjustable pinhole, in particular for a beam path for illumination and/or detection in a laser-scanning microscope. The pinhole consists of at least two planar basic modules, which have frame-like joints, on which at least one blade is arranged in a displaceable manner in one direction, whereby the basic component advantageously contains at least one integrated, preferably optical or electromagnetic actuator. A device is provided at the blade, or connected with it, for preferably optical or electromagnetic detection of the position, and is provided, advantageously, with two asymmetric apertures, with mutually opposite orientation, for optical detection of the position, whereby in front of or behind the apertures, a slit is provided, oriented preferably at a right angle to the direction of displacement, and the quantity of light passing through the slit is detected separately for each aperture.

    摘要翻译： 特别是用于在激光扫描显微镜中用于照明和/或检测的光束路径的可调针孔。 针孔由具有框架状接头的至少两个平面基本模块组成，在该至少两个平面基本模块上，至少一个叶片在一个方向上以可置换的方式布置在其上，由此基本部件有利地包含至少一个集成的，优选的光学或电磁致动器 。 设备设置在叶片处或与之相连，以优选地对该位置进行光学或电磁检测，并且有利地具有两个具有相互取向的不对称孔，用于位置的光学检测，由此在 或者在孔的后面，提供狭缝，其优选地与位移方向成直角定向，并且针对每个孔单独检测通过狭缝的光量。