公开(公告)号：US06445075B1

公开(公告)日：2002-09-03

申请号：US09770859

申请日：2001-01-26

Applicant: Christopher Scanlan ,  Jon G. Aday

Inventor： Christopher Scanlan ,  Jon G. Aday

IPC: H01L2348

CPC classification number: H01L24/81 ,  H01L2224/81801 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/0105 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/01322 ,  H01L2924/01327 ,  H01L2924/014 ,  H01L2924/14 ,  H01L2924/15311 ,  H05K3/282

Abstract: A substrate includes a flip chip bond pad and a first bond pad on a dielectric substrate layer. First and second organic solderability protectant (OSP) layers are on the flip chip bond and first bond pad, respectively. A solder paste is on the first OSP layer. The solder paste is reflowed in an inert atmosphere to form a solder-on-pad (SOP) directly on and in contact with the flip chip bond pad. A sufficient thickness of the second OSP layer remains after reflow to inhibit oxidation of the first bond pad.

Abstract translation: 衬底包括倒装芯片接合焊盘和电介质基底层上的第一接合焊盘。 第一和第二有机可焊性保护剂（OSP）层分别在倒装芯片接合和第一接合焊盘上。 焊膏位于第一个OSP层上。 焊膏在惰性气氛中回流，直接在倒装芯片接合焊盘上并与其接触形成焊锡焊盘（SOP）。 第二OSP层的足够的厚度在回流之后保留以抑制第一接合焊盘的氧化。

公开(公告)号：US06494361B1

公开(公告)日：2002-12-17

申请号：US09770861

申请日：2001-01-26

Applicant: Christopher Scanlan ,  Jon G. Aday

Inventor： Christopher Scanlan ,  Jon G. Aday

IPC: B23K3102

CPC classification number: H01L24/81 ,  B23K2101/40 ,  H01L21/4853 ,  H01L2224/81801 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/0105 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/01322 ,  H01L2924/01327 ,  H01L2924/014 ,  H01L2924/14 ,  H01L2924/15311 ,  H05K3/282 ,  H05K3/3484

Abstract: Organic solderability protectant (OSP) is applied to copper bond pads. The copper bond pads include flip chip bond pads and SMD bond pads on a dielectric upper surface and BGA bond pads on a dielectric lower surface. Solder paste is applied to the flip chip bond pads. This solder paste is reflowed in an inert atmosphere to form solder-on-pads (SOPs) on the flip chip bond pads. Flux residue from the solder paste is then removed with water. By reflowing the solder paste in an inert atmosphere and removing the flux residue with water, degradation of the OSP and oxidation of the SMD and BGA bond pads is inhibited.

Abstract translation: 有机可焊性保护剂（OSP）应用于铜焊盘。 铜接合焊盘包括在电介质上表面上的倒装芯片接合焊盘和SMD接合焊盘，以及介电下表面上的BGA接合焊盘。 将焊膏施加到倒装芯片接合焊盘。 该焊膏在惰性气氛中回流以在倒装芯片接合焊盘上形成焊接焊盘（SOP）。 然后用水去除焊膏中的焊剂残留物。 通过在惰性气氛中回流焊膏并用水除去助焊剂残留物，抑制OSP的降解和SMD和BGA接合焊盘的氧化。

公开(公告)号：US08093691B1

公开(公告)日：2012-01-10

申请号：US12502409

申请日：2009-07-14

Applicant: Ruben Fuentes ,  Christopher Scanlan ,  Jong Chun

Inventor： Ruben Fuentes ,  Christopher Scanlan ,  Jong Chun

IPC: H01L23/552 ,  H01L23/52 ,  H01L293/40 ,  H01L23/48 ,  H01L23/28

CPC classification number: H01L23/552 ,  H01L23/3128 ,  H01L23/49805 ,  H01L24/16 ,  H01L24/29 ,  H01L24/32 ,  H01L24/48 ,  H01L24/73 ,  H01L24/97 ,  H01L25/0655 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/73265 ,  H01L2224/97 ,  H01L2924/00014 ,  H01L2924/01033 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/014 ,  H01L2924/078 ,  H01L2924/15311 ,  H01L2924/1617 ,  H01L2924/181 ,  H01L2924/1815 ,  H01L2924/19107 ,  H01L2924/3025 ,  H01L2224/85 ,  H01L2224/83 ,  H01L2924/00012 ,  H01L2924/00 ,  H01L2224/45099 ,  H01L2224/45015 ,  H01L2924/207

Abstract: A semiconductor device has a substrate having a plurality of metal traces. At least one electronic component is electrically coupled to a first surface of the substrate. A mold compound is used for encapsulating portions of the electronic component and the first surface of the substrate, wherein a portion of the mold compound is removed around at least one side of the electronic component. A conductive coating is applied to the mold compound and an area where the portion of the mold compound is removed.

Abstract translation: 半导体器件具有具有多个金属迹线的衬底。 至少一个电子部件电连接到基板的第一表面。 模具化合物用于封装电子部件和基板的第一表面的部分，其中模制化合物的一部分在电子部件的至少一侧被移除。 将导电涂层施加到模制化合物和去除模具化合物的部分的区域。

公开(公告)号：US20080181913A1

公开(公告)日：2008-07-31

申请号：US12010654

申请日：2008-01-28

Applicant: Raymond Allen Dwek ,  Christopher Scanlan ,  David Cameron Dunlop ,  Fatma MH Mansab ,  Sarah Erin Tully ,  Paul Wentworth ,  Nicole Zitzmann

Inventor： Raymond Allen Dwek ,  Christopher Scanlan ,  David Cameron Dunlop ,  Fatma MH Mansab ,  Sarah Erin Tully ,  Paul Wentworth ,  Nicole Zitzmann

IPC: A61K39/21 ,  A61P31/12

CPC classification number: A61K39/21 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/6087 ,  A61K2039/645 ,  C07K14/005 ,  C12N2740/16122 ,  C12N2740/16134

Abstract: Disclosed are compositions and methods useful for inducing an immunogenic response in a subject or host. In particular, the compositions and methods may be directed to carbohydrate HIV vaccines and to methods of producing a carbohydrate HIV vaccine by introducing antigenic sugars into mimics of the glycans of the HIV envelope glycoproteins gp120 and gp41.

Abstract translation: 公开了用于在受试者或宿主中诱导免疫原性应答的组合物和方法。 特别地，组合物和方法可以针对碳水化合物HIV疫苗以及通过将抗原性糖引入HIV包膜糖蛋白gp120和gp41的聚糖的模拟物来生产碳水化合物HIV疫苗的方法。

公开(公告)号：US20110182982A1

公开(公告)日：2011-07-28

申请号：US13069603

申请日：2011-03-23

Applicant: Raymond A. Dwek ,  Norica Nichita-Branza ,  Stefana Petrescu ,  Stephanie Pollock ,  Pauline Rudd ,  Christopher Scanlan ,  Nicole Zitzmann

Inventor： Raymond A. Dwek ,  Norica Nichita-Branza ,  Stefana Petrescu ,  Stephanie Pollock ,  Pauline Rudd ,  Christopher Scanlan ,  Nicole Zitzmann

IPC: A61K9/127 ,  A61K31/445 ,  A61K31/7056 ,  A61K38/21 ,  A61P31/12

CPC classification number: A61K31/70 ,  A61K9/1271 ,  A61K9/1272 ,  A61K38/212 ,  A61K47/6425 ,  A61K47/6911 ,  A61K2300/00

Abstract: One can treat a viral infection such as hepatitis B (HBV), hepatitis C(HCV), and bovine viral diarrhea virus (BVDV) infections via the delivery of pH sensitive liposomes directly into the endoplasmic reticulum (ER) membrane. Two exemplary liposome formulations are DOPE/CHEMS (DC liposomes) and DOPE/CHEMS/PEG-PE (DCPP liposomes). DC and DCPP liposomes can optimize the intracellular delivery of N-butyl deoxynojirimycin (NB-DNJ), and consequently increase the in vivo activity of this iminosugar several orders of magnitude, and could be used in combination with other therapeutic agents such as interferon and/or ribavirin. The optimized release of NB-DNJ directly into the ER can be also applied for the treatment of other viruses, for which NB-DNJ is known to be an effective antiviral, such as human immunodeficiency virus (HIV).

Abstract translation: 通过将pH敏感的脂质体直接递送到内质网（ER）膜中，可以治疗乙型肝炎（HBV），丙型肝炎（HCV）和牛病毒性腹泻病毒（BVDV）感染的病毒感染。 两种示例性的脂质体制剂是DOPE / CHEMS（DC脂质体）和DOPE / CHEMS / PEG-PE（DCPP脂质体）。 DC和DCPP脂质体可以优化N-丁基脱氧野尻霉素（NB-DNJ）的细胞内递送，从而增加这种亚氨基二糖的体内活性几个数量级，并且可以与其它治疗剂如干扰素和/ 或利巴韦林。 NB-DNJ直接进入ER的优化释放也可以用于其他病毒的治疗，已知NB-DNJ是有效的抗病毒药物，如人类免疫缺陷病毒（HIV）。

公开(公告)号：US20100022620A1

公开(公告)日：2010-01-28

申请号：US12375068

申请日：2007-07-27

Applicant: Matthew David Max Crispin ,  Christopher Scanlan ,  Frances Mary Platt ,  Hugh John Willison

Inventor： Matthew David Max Crispin ,  Christopher Scanlan ,  Frances Mary Platt ,  Hugh John Willison

IPC: A61K31/7088 ,  A61K31/70 ,  A61P25/28 ,  A61P3/10

CPC classification number: A61K31/195 ,  A61K31/197 ,  A61K31/40 ,  A61K31/42 ,  A61K31/431 ,  A61K31/445 ,  A61K31/513 ,  A61K31/52 ,  A61K31/5375 ,  A61K31/58 ,  A61K31/6615 ,  A61K31/675 ,  A61K31/685 ,  A61K31/7008 ,  A61K31/7012 ,  A61K31/7034 ,  A61K31/704 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/708

Abstract: The present invention provides the use of an inhibitor of glycolipid biosynthesis in the manufacture of a medicament for the treatment of a glycolipid-mediated autoimmune disease.

Abstract translation: 本发明提供糖脂生物合成抑制剂在制备用于治疗糖脂介导的自身免疫疾病的药物中的用途。

公开(公告)号：US20080138351A1

公开(公告)日：2008-06-12

申请号：US11832891

申请日：2007-08-02

Applicant: Raymond A. Dwek ,  Norica Nichita-Branza ,  Stefana Petrescu ,  Stephanie Pollock ,  Pauline Rudd ,  Christopher Scanlan ,  Nicole Zitzmann

Inventor： Raymond A. Dwek ,  Norica Nichita-Branza ,  Stefana Petrescu ,  Stephanie Pollock ,  Pauline Rudd ,  Christopher Scanlan ,  Nicole Zitzmann

IPC: A61K39/395 ,  A61K9/127 ,  A61K31/70 ,  A61K38/02 ,  A61K38/08

CPC classification number: A61K31/70 ,  A61K9/1271 ,  A61K9/1272 ,  A61K38/212 ,  A61K47/6425 ,  A61K47/6911 ,  A61K2300/00

Abstract: One can treat a viral infection such as hepatitis B (HBV), hepatitis C (HCV), and bovine viral diarrhea virus (BVDV) infections via the delivery of pH sensitive liposomes directly into the endoplasmic reticulum (ER) membrane. Two exemplary liposome formulations are DOPE/CHEMS (DC liposomes) and DOPE/CHEMS/PEG-PE (DCPP liposomes). DC and DCPP liposomes can optimize the intracellular delivery of N-butyl deoxynojirimycin (NB-DNJ), and consequently increase the in vivo activity of this iminosugar several orders of magnitude, and could be used in combination with other therapeutic agents such as interferon and/or ribavirin. The optimized release of NB-DNJ directly into the ER can be also applied for the treatment of other viruses, for which NB-DNJ is known to be an effective antiviral, such as human immunodeficiency virus (HIV).

Abstract translation: 通过将pH敏感的脂质体直接递送到内质网（ER）膜中，可以治疗乙型肝炎（HBV），丙型肝炎（HCV）和牛病毒性腹泻病毒（BVDV）感染的病毒感染。 两种示例性的脂质体制剂是DOPE / CHEMS（DC脂质体）和DOPE / CHEMS / PEG-PE（DCPP脂质体）。 DC和DCPP脂质体可以优化N-丁基脱氧野尻霉素（NB-DNJ）的细胞内递送，从而增加这种亚氨基二糖的体内活性几个数量级，并且可以与其它治疗剂如干扰素和/ 或利巴韦林。 NB-DNJ直接进入ER的优化释放也可以用于其他病毒的治疗，已知NB-DNJ是有效的抗病毒药物，如人类免疫缺陷病毒（HIV）。

公开(公告)号：US20060251680A1

公开(公告)日：2006-11-09

申请号：US11376549

申请日：2006-03-16

Applicant: Raymond Dwek ,  Pauline Rudd ,  Gayle Ritchie ,  Christopher Scanlan ,  M. Crispin

Inventor： Raymond Dwek ,  Pauline Rudd ,  Gayle Ritchie ,  Christopher Scanlan ,  M. Crispin

IPC: A61K39/395 ,  A61K39/12

CPC classification number: C12P21/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  C07K14/005 ,  C07K14/70596 ,  C07K16/1063 ,  C07K16/2803 ,  C12N9/16 ,  C12N9/48 ,  C12N2740/16122 ,  C12N2740/16134

Abstract: Methods of producing a carbohydrate HIV vaccine or immunogenic composition are provided. One method comprises expressing a glycoprotein with a modified glycosylation, which facilitates binding of the glycoprotein to the 2G12 antibody. Another method comprises iteratively selecting cells with a high affinity for the 2G12 antibody.

Abstract translation: 提供了生产碳水化合物HIV疫苗或免疫原性组合物的方法。 一种方法包括表达具有修饰的糖基化的糖蛋白，其有助于糖蛋白与2G12抗体的结合。 另一种方法包括迭代地选择对2G12抗体具有高亲和力的细胞。

公开(公告)号：US08656333B1

公开(公告)日：2014-02-18

申请号：US13466049

申请日：2012-05-07

Applicant: Craig Bishop ,  Christopher Scanlan ,  Tim Olson

Inventor： Craig Bishop ,  Christopher Scanlan ,  Tim Olson

IPC: G06F17/50 ,  H01L23/48 ,  H01L23/52 ,  H01L29/40

CPC classification number: H01L23/49838 ,  G06F17/5068 ,  G06F2217/40 ,  H01L24/05 ,  H01L24/06 ,  H01L24/19 ,  H01L24/20 ,  H01L2223/6677 ,  H01L2224/02375 ,  H01L2224/02377 ,  H01L2224/02379 ,  H01L2224/0401 ,  H01L2224/04105 ,  H01L2224/06154 ,  H01L2224/12105 ,  H01L2224/131 ,  H01L2224/96 ,  H01L2924/181 ,  H01L2224/03 ,  H01L2224/11 ,  H01L2924/014 ,  H01L2924/00

Abstract: A plurality of approaches for forming a semiconductor device using an adaptive patterning method is disclosed. Some approaches include placing a semiconductor die unit on a carrier element, calculating trace geometry for a second set of traces, constructing a prestratum comprising a first set of traces, and constructing the second set of traces according to the calculated trace geometry. Forming the semiconductor device may further include electrically connecting at least one of the first set of traces to at least one of the second set of traces, and electrically connecting at least one bond pad of the semiconductor die unit to a destination pad through the at least one of the first set of traces and the at least one of the second set of traces.

Abstract translation: 公开了使用自适应图案化方法形成半导体器件的多种方法。 一些方法包括将半导体管芯单元放置在载体元件上，计算第二组迹线的迹线几何形状，构造包含第一组迹线的前置纹理，以及根据所计算的轨迹几何构造第二组轨迹。 形成半导体器件还可以包括将第一组迹线中的至少一个电连接到第二组迹线中的至少一个，并且将至少一个半导体管芯单元的接合焊盘至少通过至少一个电连接到目的地焊盘 第一组轨迹之一和第二组轨迹中的至少一个。

公开(公告)号：US20110045021A1

公开(公告)日：2011-02-24

申请号：US12903671

申请日：2010-10-13

Applicant: Ramond Allen Dwek ,  Christopher Scanlan ,  David Cameron Dunlop ,  Fatma MH Mansab ,  Sarah Erin Tully ,  Paul Wentworth ,  Nicole Zitmann

Inventor： Ramond Allen Dwek ,  Christopher Scanlan ,  David Cameron Dunlop ,  Fatma MH Mansab ,  Sarah Erin Tully ,  Paul Wentworth ,  Nicole Zitmann

IPC: A61K39/21 ,  C07H3/02 ,  A61P31/18

CPC classification number: A61K39/21 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/6087 ,  A61K2039/645 ,  C07K14/005 ,  C12N2740/16122 ,  C12N2740/16134

Abstract: Disclosed are compositions and methods useful for inducing an immunogenic response in a subject or host. In particular, the compositions and methods may be directed to carbohydrate HIV vaccines and to methods of producing a carbohydrate HIV vaccine by introducing antigenic sugars into mimics of the glycans of the HIV envelope glycoproteins gp120 and gp41.

Abstract translation: 公开了用于在受试者或宿主中诱导免疫原性应答的组合物和方法。 特别地，组合物和方法可以针对碳水化合物HIV疫苗以及通过将抗原性糖引入HIV包膜糖蛋白gp120和gp41的聚糖的模拟物来生产碳水化合物HIV疫苗的方法。