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公开(公告)号：US08404445B2
公开(公告)日：2013-03-26
申请号：US12570897
申请日：2009-09-30
CPC分类号： C40B50/06 , C07K16/00 , C07K16/1018 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/622 , C12Q2563/185 , C40B40/08
摘要： The present invention features improved in vitro RNA display libraries to allow reliable expression and selection of scFv antibody molecules from expression libraries. The scFv antibody libraries of the invention contain an optimized, shortened inter-domain linker that improves expression scFv antibody expression. The scFv antibody libraries also include short nucleic acid barcodes that allow for identification of individual library clones, libraries or subsets thereof. Primers for generating, amplifying and spectratyping the scFv antibody libraries of the invention are also provided.
摘要翻译： 本发明的特征在于改进的体外RNA显示文库以允许来自表达文库的scFv抗体分子的可靠表达和选择。 本发明的scFv抗体文库含有改善表达scFv抗体表达的优化的，缩短的域间连接体。 scFv抗体文库还包括允许识别单个文库克隆，文库或其子集的短核酸条形码。 还提供了用于产生，扩增和分光本发明的scFv抗体文库的引物。
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公开(公告)号：US20100105569A1
公开(公告)日：2010-04-29
申请号：US12570931
申请日：2009-09-30
IPC分类号： C40B30/04
CPC分类号： G01N33/54326 , C12N15/1041
摘要： The present invention features improved methods of in vitro RNA display to allow reliable expression and selection of scFv antibody molecules from expression libraries. The improved methods, in part, involve the use of mildly reducing conditions, which favor of scFv intra-chain disulphide bond and thus correct folding of the scFv antibody molecules. Although particularly suited to expression and selection of scFv antibody molecules, the methods of the invention are also expedient for in vitro RNA display of all classes of protein.
摘要翻译： 本发明的特征在于体外RNA显示的改进方法，以允许来自表达文库的scFv抗体分子的可靠表达和选择。 改进的方法部分地涉及使用轻度还原条件，其有利于scFv链内二硫键，从而正确折叠scFv抗体分子。 尽管特别适合于scFv抗体分子的表达和选择，本发明的方法也适用于所有类别的蛋白质的体外RNA显示。
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公开(公告)号：US08916504B2
公开(公告)日：2014-12-23
申请号：US12570931
申请日：2009-09-30
CPC分类号： G01N33/54326 , C12N15/1041
摘要： The present invention features improved methods of in vitro RNA display to allow reliable expression and selection of scFv antibody molecules from expression libraries. The improved methods, in part, involve the use of mildly reducing conditions, which favor of scFv intra-chain disulphide bond and thus correct folding of the scFv antibody molecules. Although particularly suited to expression and selection of scFv antibody molecules, the methods of the invention are also expedient for in vitro RNA display of all classes of protein.
摘要翻译： 本发明的特征在于体外RNA显示的改进方法，以允许来自表达文库的scFv抗体分子的可靠表达和选择。 改进的方法部分地涉及使用轻度还原条件，其有利于scFv链内二硫键，从而正确折叠scFv抗体分子。 尽管特别适合于scFv抗体分子的表达和选择，本发明的方法也适用于所有类别的蛋白质的体外RNA显示。
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公开(公告)号：US20100099103A1
公开(公告)日：2010-04-22
申请号：US12570897
申请日：2009-09-30
CPC分类号： C40B50/06 , C07K16/00 , C07K16/1018 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/622 , C12Q2563/185 , C40B40/08
摘要： The present invention features improved in vitro RNA display libraries to allow reliable expression and selection of scFv antibody molecules from expression libraries. The scFv antibody libraries of the invention contain an optimized, shortened inter-domain linker that improves expression scFv antibody expression. The scFv antibody libraries also include short nucleic acid barcodes that allow for identification of individual library clones, libraries or subsets thereof. Primers for generating, amplifying and spectratyping the scFv antibody libraries of the invention are also provided.
摘要翻译： 本发明的特征在于改进的体外RNA显示文库以允许来自表达文库的scFv抗体分子的可靠表达和选择。 本发明的scFv抗体文库含有改善表达scFv抗体表达的优化的缩短的域间连接体。 scFv抗体文库还包括允许识别单个文库克隆，文库或其子集的短核酸条形码。 还提供了用于产生，扩增和分光本发明的scFv抗体文库的引物。
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公开(公告)号：US20140335564A1
公开(公告)日：2014-11-13
申请号：US14258994
申请日：2014-04-22
申请人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
IPC分类号： C07K16/24
CPC分类号： C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
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公开(公告)号：US20140356909A1
公开(公告)日：2014-12-04
申请号：US14263724
申请日：2014-04-28
申请人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
CPC分类号： C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
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公开(公告)号：US08779101B2
公开(公告)日：2014-07-15
申请号：US13959648
申请日：2013-08-05
申请人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
IPC分类号： A61K39/00
CPC分类号： C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
摘要翻译： 与用于治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法一起描述了结合IL-17和/或IL-17F的蛋白质。
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公开(公告)号：US08324350B2
公开(公告)日：2012-12-04
申请号：US12006068
申请日：2007-12-28
申请人： Chung-ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
发明人： Chung-ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
IPC分类号： C07K16/00
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , C07K16/245 , C07K2317/569 , C07K2317/92
摘要： The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1α and human IL-1β. The dual specific antibodies of the invention also neutralize both human IL-1α and human IL-1β. The invention also provides domain antibodies (dAbs) specific for human IL-1α and human IL-1β.
摘要翻译： 本发明提供了对人IL-1α和人IL-1和bgr特异的分离的双重特异性抗体或其抗原结合部分。 本发明的双重特异性抗体也中和人IL-1α和人IL-1和bgr两者。 本发明还提供对人IL-1α和人IL-1和bgr特异性的结构域抗体（dAb）。
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公开(公告)号：US20140343267A1
公开(公告)日：2014-11-20
申请号：US14261257
申请日：2014-04-24
申请人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
发明人： Chung-Ming Hsieh , Margaret Hugunin , Anwar Murtaza , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Jennifer M. Perez , Suju Zhong , Edit Tarcsa , Anca Clabbers , Craig Wallace , Shaughn H. Bryant , Mary R. Leddy
CPC分类号： C07K16/468 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/241 , C07K16/244 , C07K2317/21 , C07K2317/31 , C07K2317/50 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.
摘要翻译： 与用于治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法一起描述了结合IL-17和/或IL-17F的蛋白质。
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公开(公告)号：US20090291081A1
公开(公告)日：2009-11-26
申请号：US12006068
申请日：2007-12-28
申请人： Chung-Ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
发明人： Chung-Ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , C07K16/245 , C07K2317/569 , C07K2317/92
摘要： The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1α and human IL-1β. The dual specific antibodies of the invention also neutralize both human IL-1α and human IL-1β. The invention also provides domain antibodies (dAbs) specific for human IL-1α and human IL-1β.
摘要翻译： 本发明提供了对人IL-1α和人IL-1β特异的分离的双重特异性抗体或其抗原结合部分。 本发明的双重特异性抗体也中和人IL-1α和人IL-1beta。 本发明还提供了对人IL-1α和人IL-1β特异性的结构域抗体（dAb）。
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