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公开(公告)号：US20050233328A1
公开(公告)日：2005-10-20
申请号：US10635407
申请日：2003-08-06
申请人： Constance Berghs , Karen Ellerman , Xiaojia Guo , Li Li , Tatiana Ort , Daniel Rieger , Corine Vernet , Mei Zhong
发明人： Constance Berghs , Karen Ellerman , Xiaojia Guo , Li Li , Tatiana Ort , Daniel Rieger , Corine Vernet , Mei Zhong
IPC分类号： A61K38/00 , A61K48/00 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P17/06 , A61P21/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07K14/47 , C12N1/21 , C12N5/02 , C12N5/08 , C12N9/00 , C12N15/12 , C12N15/16 , C12N15/18 , C12N15/19 , C12N15/53 , C12N15/54 , C12N15/57 , C12Q1/68 , C07H21/04 , C12N9/64 , C12N15/09 , C12P21/06 , G01N33/53
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N9/00
摘要： Methods of identifying compounds that modulate target polypeptide activity, where a test compound is combined with a target polypeptide and a substrate of the target polypeptide and where a determination is made as to whether the test compound modulates activity of the target polypeptide. The test compounds could be small molecule drugs used for treatment of obesity, diabetes, insulin resistance, and for enhancement of insulin secretion. Target polypeptides and their corresponding nucleic acids as well as their variants are also disclosed.
摘要翻译： 鉴定调节靶多肽活性的化合物的方法，其中测试化合物与靶多肽和靶多肽的底物组合，并且确定测试化合物是否调节靶多肽的活性。 测试化合物可以是用于治疗肥胖症，糖尿病，胰岛素抵抗和增强胰岛素分泌的小分子药物。 还公开了靶多肽及其相应的核酸及其变体。
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公开(公告)号：US20060084054A1
公开(公告)日：2006-04-20
申请号：US10455772
申请日：2003-06-04
申请人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
发明人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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3.发明申请公开(公告)号：US20050053930A1
公开(公告)日：2005-03-10
申请号：US10454246
申请日：2003-06-03
申请人： David Anderson , Ferenc Boldog , Catherine Burgess , Stacie Casman , Shlomit Edinger , Andrew Eisen , Karen Ellerman , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Vladimir Gusev , Weizhen Ji , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Tatiana Ort , Muralidhara Padigaru , Sudhirdas Prayaga , Meera Patturajan , Carol Pena , John Peyman , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Glennda Smithson , Kimberly Spytek , David Stone , Raymond Taupier , Velizar Tchernev , Corine Vernet , Edward Voss , Bryan Zerhusen , Mei Zhong
发明人： David Anderson , Ferenc Boldog , Catherine Burgess , Stacie Casman , Shlomit Edinger , Andrew Eisen , Karen Ellerman , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Vladimir Gusev , Weizhen Ji , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Tatiana Ort , Muralidhara Padigaru , Sudhirdas Prayaga , Meera Patturajan , Carol Pena , John Peyman , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Glennda Smithson , Kimberly Spytek , David Stone , Raymond Taupier , Velizar Tchernev , Corine Vernet , Edward Voss , Bryan Zerhusen , Mei Zhong
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：US20060003323A1
公开(公告)日：2006-01-05
申请号：US10453372
申请日：2003-06-03
申请人： John Alsobrook , Enrique Alvarez , David Anderson , Ferenc Boldog , Stacie Casman , Elina Catterton , Andrei Chapoval , Julie Crabtree-Bokor , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , Erik Gunther , Xiaojia (Sasha) Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Li Li , Xiaohong Liu , John MacDougall , Timothy Machlachlan , Uriel Malyankar , Amanda Mezick , Isabelle Millet , Vishnu Mishra , Muralidhara Padigaru , Meera Patturajan , Carol Pena , John Peyman , Debasish Raha , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Corine Vernet , Edward Voss , Mei Zhong , Hiahong Zhong
发明人： John Alsobrook , Enrique Alvarez , David Anderson , Ferenc Boldog , Stacie Casman , Elina Catterton , Andrei Chapoval , Julie Crabtree-Bokor , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , Erik Gunther , Xiaojia (Sasha) Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Li Li , Xiaohong Liu , John MacDougall , Timothy Machlachlan , Uriel Malyankar , Amanda Mezick , Isabelle Millet , Vishnu Mishra , Muralidhara Padigaru , Meera Patturajan , Carol Pena , John Peyman , Debasish Raha , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Paul Sciore , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Corine Vernet , Edward Voss , Mei Zhong , Hiahong Zhong
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20050037957A1
公开(公告)日：2005-02-17
申请号：US10635398
申请日：2003-08-06
申请人： David Anderson , Constance Berghs , Elina Catterton , Shlomit Edinger , Linda Gorman , Xiaojia Guo , John Herrmann , Ramesh Kekuda , Li Li , Daniel Rieger , Mei Zhong
发明人： David Anderson , Constance Berghs , Elina Catterton , Shlomit Edinger , Linda Gorman , Xiaojia Guo , John Herrmann , Ramesh Kekuda , Li Li , Daniel Rieger , Mei Zhong
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：US20060009634A1
公开(公告)日：2006-01-12
申请号：US11019711
申请日：2004-12-21
申请人： Ramesh Kekuda , John Alsobrook , Velizar Tchernev , Xiaohong Liu , Kimberly Spytek , Meera Patturajan , William Grosse , Denise Lepley , Catherine Burgess , Corine Vernet , Li Li , Linda Gorman , Shlomit Edinger , Paul Sciore , Karen Ellerman , Uriel Malyankar , Mark Rothenberg , David Stone , Ferenc Boldog , Xiaojia Guo , Suresh Shenoy , David Anderson , Muralidhara Padigaru , Raymond Taupier , Charles Miller , Andrew Eisen
发明人： Ramesh Kekuda , John Alsobrook , Velizar Tchernev , Xiaohong Liu , Kimberly Spytek , Meera Patturajan , William Grosse , Denise Lepley , Catherine Burgess , Corine Vernet , Li Li , Linda Gorman , Shlomit Edinger , Paul Sciore , Karen Ellerman , Uriel Malyankar , Mark Rothenberg , David Stone , Ferenc Boldog , Xiaojia Guo , Suresh Shenoy , David Anderson , Muralidhara Padigaru , Raymond Taupier , Charles Miller , Andrew Eisen
IPC分类号： C07H21/04
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20060063200A1
公开(公告)日：2006-03-23
申请号：US11051724
申请日：2005-02-02
申请人： David Anderson , Jason Baumgartner , Ferenc Boldog , Stacie Casman , Shlomit Edinger , Esha Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol Pena , Luca Rastelli , Richard Shimkets , David Stone , Kimberly Spytek , Corine Vernet , Edward Voss , Bryan Zerhusen
发明人： David Anderson , Jason Baumgartner , Ferenc Boldog , Stacie Casman , Shlomit Edinger , Esha Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John MacDougall , Uriel Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol Pena , Luca Rastelli , Richard Shimkets , David Stone , Kimberly Spytek , Corine Vernet , Edward Voss , Bryan Zerhusen
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/18
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US07109000B2
公开(公告)日：2006-09-19
申请号：US10087684
申请日：2002-03-01
申请人： Shlomit R. Edinger , John R. MacDougall , Isabelle Millet , Karen Ellerman , David J. Stone , Valerie Gerlach , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , Catherine E. Burgess , Stacie J. Casman , Kimberly A. Spytek , Ferenc L. Boldog , Li Li , Muralidhara Padigaru , Vishnu Mishra , Meera Patturajan , Suresh G. Shenoy , Luca Rastelli , Velizar T. Tchernev , Corine A. M. Vernet , Bryan D. Zerhusen , Uriel M. Malyankar , Xiaojia Guo , Charles E. Miller , Esha A. Gangolli
发明人： Shlomit R. Edinger , John R. MacDougall , Isabelle Millet , Karen Ellerman , David J. Stone , Valerie Gerlach , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , Catherine E. Burgess , Stacie J. Casman , Kimberly A. Spytek , Ferenc L. Boldog , Li Li , Muralidhara Padigaru , Vishnu Mishra , Meera Patturajan , Suresh G. Shenoy , Luca Rastelli , Velizar T. Tchernev , Corine A. M. Vernet , Bryan D. Zerhusen , Uriel M. Malyankar , Xiaojia Guo , Charles E. Miller , Esha A. Gangolli
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/705
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20050170380A1
公开(公告)日：2005-08-04
申请号：US10971479
申请日：2004-10-21
申请人： Elma Fernandes , Corine Vernet , Richard Shimkets , David Anderson , Muralidhara Padigaru , Ferenc Boldog , Li Li , Suresh Shenoy , Stacie Casman , Luca Rastelli
发明人： Elma Fernandes , Corine Vernet , Richard Shimkets , David Anderson , Muralidhara Padigaru , Ferenc Boldog , Li Li , Suresh Shenoy , Stacie Casman , Luca Rastelli
CPC分类号： C07K14/47 , A61K38/00 , C07K14/54 , C07K14/705 , C07K14/70571
摘要： The present invention provides novel isolated SECX polynucleotides and the membrane-associated or secreted polypeptides encoded by the SECX polynucleotides. Also provided are the antibodies that immunospecifically bind to a SECX polypeptide or any derivative, variant, mutant or fragment of the SECX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the SECX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.
摘要翻译： 本发明提供新的分离的SECX多核苷酸和由SECX多核苷酸编码的膜相关或分泌的多肽。 还提供免疫特异性结合SECX多肽或SECX多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。 本发明还提供了其中SECX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。
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公开(公告)号：US20050260713A1
公开(公告)日：2005-11-24
申请号：US11113424
申请日：2005-04-21
申请人： Esha Gangolli , Meera Patturajan , Corine Vernet , Uriel Malyankar , Ramesh Kekuda , David Stone , David Anderson , Richard Shimkets , Catherine Burgess , Bryan Zerhusen , Xiaohong Liu , Kimberly Spytek , Stacie Casman , Ference Boldog , Glennda Smithson , Li Li , Weizhen Ji , John MacDougall
发明人： Esha Gangolli , Meera Patturajan , Corine Vernet , Uriel Malyankar , Ramesh Kekuda , David Stone , David Anderson , Richard Shimkets , Catherine Burgess , Bryan Zerhusen , Xiaohong Liu , Kimberly Spytek , Stacie Casman , Ference Boldog , Glennda Smithson , Li Li , Weizhen Ji , John MacDougall
CPC分类号： C07K14/47 , A61K38/00 , G01N2500/04
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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