摘要:
The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of the Formula (I) and a method of imaging amyloid deposits, as well as new compounds of Formula (I).
摘要:
Anytime obtained is uniform crystal of N-(4-fluorophenyl)-N′-phenyl-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound A) and/or N,N′-bis (4-fluorophenyl)-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound B) as a medicament or a starting material for the preparation of the medicament, and provided are a fumarate of the compound A and/or the compound B having excellent stability and a novel crystal thereof. A salt of the compound A and/or the compound B with fumaric acid enables uniform crystal to be anytime obtained, and thus, it is a compound that is very useful as a medicament or a starting material for the preparation of the medicament having excellent stability.
摘要:
The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.
摘要:
Thiophene derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof. Said compounds act as an anti-PCP agonist and therefore are useful as psychotropic or antischizophrenic agents and so on. ##STR1## (In the above formula, R.sub.1 is a formula --A.sub.1 --X.sub.1 --R.sub.3 ; R.sub.2 is a formula --A.sub.2 --X.sub.2 --R.sub.4 or does not exist; B ring is a 7- to 10-membered nitrogen-containing cycloalkyl ring; Ar ring is an aryl or heteroaryl ring; A.sub.1, A.sub.2 and A.sub.3 may be the same or different from one another and each represents a bond or a lower alkylene group; X.sub.1 and X.sub.2 may be the same or different from each other and each represents a bond or a formula --O--, --S--or the like; R.sub.3 and R.sub.4 may be the same or different from each other and each represents a hydrogen atom, a cyclic imido group or a lower alkyl group, a cycloalkyl group, an aryl group or an aralkyl group; with the proviso that, when Ar ring is thiazole ring, either one of A.sub.1 and A.sub.2 is a lower alkylene group. Also, when Ar ring is a benzene ring, a case in which one of R.sub.1 and R.sub.2 is methyl group or a halogen group and the other is a hydrogen atom is excluded.)
摘要:
A prismatic secondary battery is provided with a negative/positive electrode collector (18), which are disposed on either one of a wound negative/positive electrode substrate exposed portion (15), and a negative/positive electrode collector receiving member (19) which is disposed on another surface. At least one of the negative/positive electrode collector has a recess portion (30) formed in part on a surface on the side not facing the negative/positive electrode substrate exposed portions so as to be thinner than the thickness of the other portion. Resistance welding is carried out in this recessed part, thereby a large welding nugget is formed between the negative/positive electrode exposed portion and the negative/positive electrode collector.
摘要:
In a prismatic sealed secondary battery according to an embodiment of the present invention, at least one of positive electrode substrate exposed portions and negative electrode substrate exposed portions of an electrode assembly is split into two groups, and therebetween are disposed intermediate members that are made of a resin material and hold one or more connecting conductive members. The two split substrate exposed portions are electrically connected to collector members and to at least one of the connecting conductive members by resistance-welding. Voids are formed in resin material portions of the intermediate members that are located around the resistance-welded portions of the connecting conductive members. Therefore, lowered resistance between the substrate exposed portions and the collector members and stabilized quality of the welds are realized and the manufacturing yield of the prismatic sealed secondary battery is improved.
摘要:
The positive electrode substrate exposed portions or the negative electrode substrate exposed portions, or both, of an electrode assembly is split into two groups, and therebetween is disposed an intermediate member made of a resin material and holding one or more connecting conductive members. Collector members for the substrate exposed portions split into two groups is electrically joined by a resistance welding method to the substrate exposed portions split into two groups, together with the connecting conductive member(s) of the intermediate member. The resin material portion of the intermediate member protrudes, in the extension direction of the substrate exposed portions split into two groups, beyond the ends of the substrate exposed portions split into two groups and the ends of the collector member to a prismatic outer can. This structure enables enhanced resistance between the substrate exposed portions and the collector member and curbs variation in the welding strength.
摘要:
A Maillard reaction inhibitor containing, as an active ingredient, an amidinoheterocyclic derivative or its pharmaceutically acceptable salt, which is useful for the prevention and/or cure of various complications of diabetes and maturity-onset disorders. The amidinoheterocyclic derivatives are also useful as Maillard reaction inhibitors for cosmetics, external endermic medicines, foods, drinks, luxury grocery items and functional foods.
摘要:
In a sealed battery, a metal current carrying block 24A having a protrusion 24b on each of the two opposing faces is placed between positive or negative electrode substrate exposed portions that are divided into two so as to bring the protrusion 24b on each of the two opposing faces into contact with the positive or negative electrode substrate exposed portions that are stacked, a pair of electrodes 31 and 32 for resistance welding are brought into contact with positive electrode collector members 16 or negative electrode collector members that are each placed on the outermost surfaces of the positive electrode substrate exposed portions 14 or negative electrode substrate exposed portions, and resistance welding is performed with pressure applied between the pair of electrodes 31 and 32 for resistance welding.
摘要:
A prismatic sealed secondary battery according to an embodiment of the present invention includes an electrode assembly having stacked or wound positive and negative electrode substrate exposed portions and a pair of collector members electrically joined to the respective electrode substrate exposed portions. At least one of the electrode substrate exposed portions is split into two groups, and therebetween is disposed an intermediate member made of resin material and holding a plurality of connective conducting members. The collector member for the substrate exposed portions split into two groups is disposed on at least one of the outermost faces of the substrate exposed portions, and is electrically joined by a resistance welding method to the substrate exposed portions, together with the connecting conductive members of the intermediate member. This configuration lowers resistance of the electrode substrate exposed portions and the collector members and curbs variation in the welding strength.