公开(公告)号：US20050133482A1

公开(公告)日：2005-06-23

申请号：US11010479

申请日：2004-12-14

申请人： Daniel Clark ,  Barry Smith

发明人： Daniel Clark ,  Barry Smith

IPC分类号： B23K9/04 ,  B23K10/02 ,  B23K15/00 ,  B23K26/34 ,  B23K35/32 ,  B23K37/04 ,  B23Q1/03 ,  B23Q3/10 ,  C21D1/30 ,  C21D1/44 ,  C21D1/70 ,  C21D9/00 ,  C21D9/50

CPC分类号： B23K9/044 ,  B23K10/027 ,  B23K15/0086 ,  B23K26/32 ,  B23K26/342 ,  B23K35/0261 ,  B23K35/325 ,  B23K35/383 ,  B23K37/04 ,  B23K37/0461 ,  B23K2103/08 ,  B23K2103/14 ,  B23K2103/50 ,  C21D1/30 ,  C21D1/70 ,  C21D9/0025 ,  C21D9/50

摘要： A substrate (33) is clamped into a fixture (32) and material is deposited thereon to form a complex article (40). The article (40) produced is packed, using ceramic inserts (42) and a coating (41). The packing (42) ensures that the article (40) maintains its true shape and allows for expansion during the subsequent heat treatment process. The packed article (40), mounted on the fixture (32), is then placed in a box (44), encased in a granular material (43) and heated. It is heated to a temperature sufficient to relieve stresses and is maintained at this temperature for a time period such that the stresses in the article (40) are relieved.

摘要翻译： 将基材（33）夹紧到固定装置（32）中，并将材料沉积在其上以形成复杂制品（40）。 所制造的制品（40）使用陶瓷插入件（42）和涂层（41）进行包装。 包装（42）确保制品（40）保持其真实形状并且允许在随后的热处理过程中的膨胀。 然后将安装在固定装置（32）上的包装物品（40）放置在箱体（44）中，装在颗粒状材料（43）中并加热。 将其加热到足以缓解应力的温度并在该温度下保持一段时间，使得制品（40）中的应力得以缓解。

公开(公告)号：US20080029927A1

公开(公告)日：2008-02-07

申请号：US11905695

申请日：2007-10-03

申请人： Daniel Clark ,  Barry Smith

发明人： Daniel Clark ,  Barry Smith

IPC分类号： B29C33/40

CPC分类号： B23K9/044 ,  B23K10/027 ,  B23K15/0086 ,  B23K26/32 ,  B23K26/342 ,  B23K35/0261 ,  B23K35/325 ,  B23K35/383 ,  B23K37/04 ,  B23K37/0461 ,  B23K2103/08 ,  B23K2103/14 ,  B23K2103/50 ,  C21D1/30 ,  C21D1/70 ,  C21D9/0025 ,  C21D9/50

摘要： A substrate (33) is clamped into a fixture (32) and material is deposited thereon to form a complex article (40). The article (40) produced is packed, using ceramic inserts (42) and a coating (41). The packing (42) ensures that the article (40) maintains its true shape and allows for expansion during the subsequent heat treatment process. The packed article (40), mounted on the fixture (32), is then placed in a box (44), encased in a granular material (43) and heated. It is heated to a temperature sufficient to relieve stresses and is maintained at this temperature for a time period such that the stresses in the article (40) are relieved.

摘要翻译： 将基材（33）夹紧到固定装置（32）中，并将材料沉积在其上以形成复杂制品（40）。 所制造的制品（40）使用陶瓷插入件（42）和涂层（41）进行包装。 包装（42）确保制品（40）保持其真实形状并且允许在随后的热处理过程中的膨胀。 然后将安装在固定装置（32）上的包装物品（40）放置在箱体（44）中，装在颗粒状材料（43）中并加热。 将其加热到足以缓解应力的温度并在该温度下保持一段时间，使得制品（40）中的应力得以缓解。

公开(公告)号：US20050173379A1

公开(公告)日：2005-08-11

申请号：US11036363

申请日：2005-01-18

申请人： Mark Ireland ,  Daniel Clark ,  Jeffrey Allen ,  Barry Smith ,  Alexander Kutscherawy

发明人： Mark Ireland ,  Daniel Clark ,  Jeffrey Allen ,  Barry Smith ,  Alexander Kutscherawy

IPC分类号： B23K9/29 ,  B23K9/32 ,  B23K26/14 ,  B23K9/167

CPC分类号： B23K26/037 ,  B23K9/293 ,  B23K9/295 ,  B23K9/325 ,  B23K26/123 ,  B23K26/147 ,  B23K26/1476 ,  B23K26/706 ,  B23K2103/14

摘要： A welding torch (10) for welding on a component has an electrode (12) within a nozzle (14) through which a flow of gas passes. A shield (20) defines an enclosure (22) around the nozzle (14). Means are provided for supplying weld filler material (18) into the vicinity of the electrode (12) through the shield (20). One end of the shield (20) is attached to the welding torch (10). The other end of the shield (20) is open and extends towards the component (16). An inflatable seal (28) is mounted on the end of the shield (20) to seal between the shield (20) and the component (16).

摘要翻译： 用于在部件上焊接的焊枪（10）具有在喷嘴（14）内的气体通过的电极（12）。 护罩（20）限定围绕喷嘴（14）的外壳（22）。 提供了用于通过屏蔽件（20）将焊接填充材料（18）提供到电极（12）附近的装置。 护罩（20）的一端安装在焊炬（10）上。 屏蔽件（20）的另一端是开口的并且朝向部件（16）延伸。 一个可充气的密封件（28）安装在屏蔽（20）的端部上，以密封屏蔽（20）和组件（16）之间。

公开(公告)号：USRE39542E1

公开(公告)日：2007-04-03

申请号：US10336442

申请日：2003-01-02

申请人： Kanti Jain ,  Albert L. Rubin ,  Barry Smith

发明人： Kanti Jain ,  Albert L. Rubin ,  Barry Smith

IPC分类号： A61K35/12 ,  C12N11/02 ,  C12N11/10 ,  C12N5/00 ,  C12N5/08

CPC分类号： C12N11/04 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/5036 ,  A61K35/39 ,  A61K38/00 ,  A61K2035/126 ,  C12N5/0012 ,  C12N5/0677 ,  C12N2533/54 ,  C12N2533/76

摘要： Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and secretory cells such as pancreatic islets, the collagen is polymerized to form solid, agarose-collagen beads and the solid beads are coated with agarose. Coating is preferably by rolling the solid beads in about 5-10% agarose, contacting the rolled beads with mineral oil and washing oil from the beads. Beads containing secretory cells can be transplanted into a mammal to treat a condition caused by impaired secretory cell function.

摘要翻译： 生物制剂如分泌细胞被包封在由琼脂糖或胶原 - 琼脂糖和明胶海绵 - 琼脂糖组合制成的亲水凝胶中。 在优选的实施方案中，半固体珠粒由含有胶原蛋白，琼脂糖和分泌细胞例如胰岛的悬浮液形成，胶原聚合形成固体，琼脂糖胶原珠粒，固体珠粒用琼脂糖涂覆。 涂覆优选通过在约5-10％的琼脂糖中滚动固体珠粒，使滚珠与矿物油接触并从珠粒洗涤油。 含有分泌细胞的珠可以移植到哺乳动物中以治疗由分泌细胞功能受损引起的病症。

公开(公告)号：US20060216278A1

公开(公告)日：2006-09-28

申请号：US11447405

申请日：2006-06-05

申请人： Bryan Conn ,  Barry Smith ,  Albert Rubin ,  Kurt Stenzel

发明人： Bryan Conn ,  Barry Smith ,  Albert Rubin ,  Kurt Stenzel

IPC分类号： A61K48/00 ,  C12N5/08

CPC分类号： C12N5/0693 ,  A01N1/0205 ,  A01N1/0231 ,  A61K35/13 ,  A61K35/545 ,  C12N5/0012 ,  C12N5/0606 ,  C12N2502/02 ,  C12N2533/76

摘要： The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.

摘要翻译： 本发明特别涉及干细胞，特别是胚胎干细胞。 已经发现，当这些干细胞被捕获使得其增殖被抑制时，它们产生抑制其它非包埋细胞（包括干细胞，肿瘤和/或过度增殖，但是其他正常细胞）增殖的材料。 也已经发现，截留的癌细胞将产生抑制干细胞增殖的物质。 此外，已经发现，干细胞的捕获抑制其分化，因此捕获过程可以用作长期存储装置，用于保持至少一部分包埋细胞的未分化状态。

公开(公告)号：US07041504B2

公开(公告)日：2006-05-09

申请号：US09735073

申请日：2000-12-12

申请人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

发明人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

IPC分类号： C12N5/06 ,  C12N5/08 ,  C12N11/10 ,  C12N11/04 ,  A61K35/12

CPC分类号： A61K35/13 ,  A61K35/36 ,  C12N5/0693 ,  C12N11/04

摘要： Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

摘要翻译： 描述了含有限制性癌细胞的物质组成。 当受限制时，细胞产生意想不到的高量的抑制癌细胞增殖的材料。 这种现象跨越癌症类型和种类。 还描述了制备这些组合物的方法及其用途。

公开(公告)号：US20050229698A1

公开(公告)日：2005-10-20

申请号：US11103699

申请日：2005-04-11

申请人： Michael Beecroft ,  Marian Szczesniak ,  Barry Smith ,  John Matsumoto ,  James Ferguson

发明人： Michael Beecroft ,  Marian Szczesniak ,  Barry Smith ,  John Matsumoto ,  James Ferguson

IPC分类号： G01F23/00 ,  G01J3/02 ,  G01J3/42 ,  G01N21/31 ,  G01N21/33 ,  G01N21/35 ,  G01N21/55

CPC分类号： G01J3/02 ,  G01J3/0208 ,  G01J3/0235 ,  G01J3/0254 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0291 ,  G01J3/42 ,  G01N21/31 ,  G01N21/33 ,  G01N21/3504 ,  G01N21/552 ,  G01N21/645 ,  G01N2021/3595 ,  G01N2201/0221 ,  G01N2201/065

摘要： A hand-held portable modular spectrometer unit. The unit includes a detachable head containing a light source and optical components for detecting spectral information from light reflected from or transmitted through a target and a processor for converting the detected spectral information into digital information. The unit also includes a plug-in rechargeable power supply and a control module for controlling the components in the measurement head. The controller includes a computer processor for analyzing the digital information produced by the measurement head and a display monitor for displaying spectral information produced by the control unit. In preferred embodiments the plug-in rechargeable power supply is a 12-volt off-the-shelf power-tool rechargeable battery unit. In preferred embodiments several measuring heads are available. These include a gas cell measuring head, a surface reflectance measuring head that includes and integrating sphere, a specular reflectance measuring head, a grazing angle measuring head, an attenuated total reflectance measuring head, a diffuse reflection measuring head, a non-volatile residues measuring head, a liquid transmission cell measuring head and a fluorescence measuring head. Each of these measurement heads includes a spectrometer. Several types of spectrometers are available including those based on filters, prisms, gratings and interferometers. The unit can operate in a wide range of wavelengths including the infrared, visible and ultraviolet spectral ranges.

摘要翻译： 手持便携式模块化光谱仪单元。 该单元包括一个包含光源的可拆卸头和用于从由目标反射或透过目标的光检测光谱信息的光学部件和用于将检测到的光谱信息转换为数字信息的处理器。 该装置还包括插入式可充电电源和用于控制测量头部件的控制模块。 控制器包括用于分析测量头产生的数字信息的计算机处理器和用于显示控制单元产生的频谱信息的显示监视器。 在优选实施例中，插入式可再充电电源是12伏现货电动工具可再充电电池单元。 在优选实施例中，可以使用多个测量头。 这些包括气体电池测量头，包括和积分球的表面反射测量头，镜面反射测量头，掠角测量头，衰减全反射测量头，漫反射测量头，非挥发性残留测量 头，液体传播细胞测量头和荧光测量头。 这些测量头中的每一个包括光谱仪。 可以使用几种类型的光谱仪，包括基于滤光片，棱镜，光栅和干涉仪的光谱仪。 该单元可以在宽范围的波长范围内工作，包括红外线，可见光谱和紫外光谱范围。

公开(公告)号：US20050053586A1

公开(公告)日：2005-03-10

申请号：US10655275

申请日：2003-09-04

申请人： Bryan Conn ,  Barry Smith ,  Albert Rubin ,  Kurt Stenzel

发明人： Bryan Conn ,  Barry Smith ,  Albert Rubin ,  Kurt Stenzel

IPC分类号： C12N5/074 ,  A01N1/02 ,  A61K35/13 ,  A61K35/14 ,  A61K35/48 ,  A61K35/545 ,  A61K48/00 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0789 ,  C12N5/08

CPC分类号： C12N5/0693 ,  A01N1/0205 ,  A01N1/0231 ,  A61K35/13 ,  A61K35/545 ,  C12N5/0012 ,  C12N5/0606 ,  C12N2502/02 ,  C12N2533/76

摘要： The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.

摘要翻译： 本发明特别涉及干细胞，胚胎干细胞。 已经发现，当这些干细胞被捕获使得其增殖被抑制时，它们产生抑制其它非包埋细胞（包括干细胞，肿瘤和/或过度增殖，但是其他正常细胞）增殖的材料。 也已经发现，截留的癌细胞将产生抑制干细胞增殖的物质。 此外，已经发现，干细胞的捕获抑制其分化，因此捕获过程可以用作长期存储装置，用于保持至少一部分包埋细胞的未分化状态。

公开(公告)号：US20050028453A1

公开(公告)日：2005-02-10

申请号：US10636942

申请日：2003-08-06

申请人： Barry Smith

发明人： Barry Smith

IPC分类号： A47K3/00 ,  B32B21/04 ,  E04F13/08 ,  E04F13/14 ,  A47K3/16 ,  E04B5/00

CPC分类号： B32B7/12 ,  A47K3/008 ,  B32B9/002 ,  B32B9/005 ,  B32B9/042 ,  B32B21/04 ,  B32B37/10 ,  B32B37/12 ,  E04F13/0885 ,  E04F13/144

摘要： The present invention relates to a laminated vertical structure. One embodiment includes a structure having a substantially vertical wall surface. A solid surface material sheet is provided that has a stone content of at least 90%, an area of at least four square feet, and an approximate thickness of between ¼ inch and ⅗ inch. In one embodiment, the thickness is approximately ⅜ inch. An adhesive material contacts the sheet and the wall surface to fix them together. In another embodiment, a method of constructing a laminated vertical structure includes providing a structure with a substantially vertical wall surface and a solid surface material sheet with a stone content of at least 90%, an area of at least four square feet, and an approximate thickness of between ¼ inch and ⅗ inch. An adhesive material is then applied onto the wall surface in a substantially uniform distribution. The sheet is then pressed onto the applied adhesive material for an amount of time sufficient to fix the sheet to the wall surface.

摘要翻译： 本发明涉及层叠垂直结构。 一个实施例包括具有基本上垂直的壁表面的结构。 提供了一种固体表面材料片，其具有至少90％的石材含量，至少4平方英尺的面积，以及约1/4英寸和3/5英寸之间的大致厚度。 在一个实施例中，厚度约为3/8英寸。 粘合剂材料接触片材和壁表面以将它们固定在一起。 在另一个实施例中，构造层压垂直结构的方法包括提供具有基本上垂直的壁表面的结构和具有至少90％，至少四平方英尺的面积的石头含量的固体表面材料片和近似 ¼英寸和3/5英寸之间的厚度。 然后将粘合剂材料以基本均匀的分布施加到壁表面上。 然后将片材压到施加的粘合剂材料上一段足以将片材固定到壁表面的时间。

公开(公告)号：US06303151B1

公开(公告)日：2001-10-16

申请号：US09437193

申请日：1999-11-09

申请人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

发明人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

IPC分类号： A61K3512

CPC分类号： C12N5/0693 ,  A61K35/13 ,  C12N11/04

摘要： A material for suppressing proliferation of cancer cells is produced by entrapping cancer cells in a selectively-permeable structure such as a bead, and culturing the entrapped cells in a culture medium. Entrapment restricts growth of the cancel cells during culturing and causes the cells to produce in the culture medium a material having a molecular weight of at least about 30 kd as measured by filtration that suppresses proliferation of cancer cells. The material is separated from the culture medium by filtering the medium through a filter that separates material having a molecular weight of at least about 30 kd from material having a molecular weight of less than 30 kd. The structure that entraps the cells may contain 10,000 to 500,000 cells. The material or the structure containing the entrapped cells that produce the material can be administered to a subject to suppress cancer cell proliferation.

摘要翻译： 用于抑制癌细胞增殖的材料是通过将癌细胞包埋在选择性可渗透的结构如珠中产生的，并在培养基中培养包埋的细胞。 包埋限制了培养过程中消除细胞的生长，并导致细胞在培养基中产生通过过滤测量的分子量至少为约30kd的材料，其抑制癌细胞的增殖。 通过过滤器将培养基与培养基分离，该过滤器将具有至少约30kd分子量的材料与分子量小于30kd的材料分离。 截留细胞的结构可能含有10,000至500,000个细胞。 可以向受试者施用含有产生该物质的包埋细胞的材料或结构，以抑制癌细胞增殖。