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公开(公告)号：US08323800B2
公开(公告)日：2012-12-04
申请号：US12481291
申请日：2009-06-09
申请人： Daniel Haines , David Yuhas , Eric Urruti
发明人： Daniel Haines , David Yuhas , Eric Urruti
CPC分类号： C03C27/048 , C09J5/06 , C09J2400/123 , C09J2400/143 , C09J2400/163 , Y10T428/31612 , Y10T428/31678
摘要： The present invention relates to a method of bonding a gold surface to a second surface which comprises heating a hybrid organic-inorganic melting gel >50° C., applying the melting gel to either the gold surface or the second surface. The melting gel is heated to above 130° C. until the melting gel has cured sufficiently to bond the surfaces together. The invention also relates to a combination of a gold surface and a second surface that is bonded together with a hybrid organic-inorganic melting gel. In another aspect of the invention the hybrid organic-inorganic melting gel is heated to a workable viscosity and cast into a film, sheet, block or lens. The cast gel is cured or partially cured and then applied between the gold surface and the second surface. Additional uncured melting gel may be applied. The construct is heated to above 130° C. until the melting gel has cured sufficient to bond the surfaces together.
摘要翻译： 本发明涉及一种将金表面粘合到第二表面上的方法，其包括加热> 50℃的杂化有机 - 无机熔融凝胶，将熔融凝胶施加到金表面或第二表面上。 将熔融的凝胶加热至130℃以上，直到熔融的凝胶充分固化以将表面粘合在一起。 本发明还涉及金表面和与混合有机 - 无机熔融凝胶结合在一起的第二表面的组合。 在本发明的另一方面，将混合有机 - 无机熔融凝胶加热至可行的粘度并浇铸成膜，片，块或透镜。 浇铸凝胶固化或部分固化，然后施加在金表面和第二表面之间。 可以应用另外的未固化的熔融凝胶。 将构造体加热至130℃以上，直到熔融凝胶固化足以将表面粘合在一起。
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2.发明申请公开(公告)号：US20100044268A1
公开(公告)日：2010-02-25
申请号：US12160259
申请日：2007-01-09
申请人： Daniel Haines , Luis Burzio , Matthias Bicker , Horst Koller , Jasmina Marjanovic , Robert Hormes
发明人： Daniel Haines , Luis Burzio , Matthias Bicker , Horst Koller , Jasmina Marjanovic , Robert Hormes
CPC分类号： A61L27/34 , A61J1/05 , A61L29/085 , A61L31/10 , A61L2400/10 , B05D1/62 , B05D7/22 , Y10T428/13 , Y10T428/1307
摘要： The present invention relates to a multi-functional pharmaceutical package surface and a method of preparing a multi-functional pharmaceutical package surface. In particular, the present invention relates to a pharmaceutical package having a protein deterrent and lubricious surface and methods of preparing said surface by applying coatings directly to the pharmaceutical package that (a) reduce the adsorption of proteins onto pharmaceutical packaging while not affecting the activity of the protein solution and (b) provide a lubricious surface. The pharmaceutical package surface may also contain a barrier coating. Coatings can be deposited on a variety of pharmaceutical packaging materials and configurations by various methods.
摘要翻译： 本发明涉及一种多功能药物包装表面和一种制备多功能药物包装表面的方法。 特别地，本发明涉及具有蛋白质阻燃和光滑表面的药物包装，以及通过将药物涂层直接施加到药物包装来制备所述表面的方法，（a）减少蛋白质在药物包装上的吸附，同时不影响 蛋白质溶液和（b）提供光滑的表面。 药物包装表面也可以含有阻隔涂层。 涂料可以通过各种方法沉积在各种药物包装材料和配置上。
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3.发明授权Method of preparing a macromolecule deterrent surface on a pharmaceutical package 有权在药物包装上制备大分子威慑表面的方法公开(公告)号：US08025915B2
公开(公告)日：2011-09-27
申请号：US11649361
申请日：2007-01-04
申请人： Daniel Haines , Luis Burzio , Matthias Bicker , Robert Hormes , Horst Koller , Jasmina Buki , Hartmut Bauch , Manfred Lohmeyer
发明人： Daniel Haines , Luis Burzio , Matthias Bicker , Robert Hormes , Horst Koller , Jasmina Buki , Hartmut Bauch , Manfred Lohmeyer
CPC分类号： A61L27/34 , A61J1/05 , A61L29/085 , A61L31/10 , A61L2400/10 , B05D1/62 , B05D7/22 , Y10T428/13 , Y10T428/1307
摘要： A method of preparing a macromolecule deterrent surface on a pharmaceutical package. In particular, the present invention relates to a method of preparing a protein deterrent surface on a pharmaceutical package by applying a coating or coatings directly to the pharmaceutical package that reduces the adsorption of proteins onto pharmaceutical packaging while not affecting the activity of the protein solution contained.
摘要翻译： 一种在药物包装上制备大分子威慑表面的方法。 特别地，本发明涉及通过将涂层或涂层直接施加到药物包装上来制备药物包装上的蛋白质威慑表面的方法，其减少蛋白质在药物包装上的吸附，同时不影响所含蛋白质溶液的活性 。
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4.发明申请Low-fluorescent, chemically durable hydrophobic patterned substrates for the attachment of biomolecules 审中-公开用于附着生物分子的低荧光，化学耐久的疏水图案化基材公开(公告)号：US20050064209A1
公开(公告)日：2005-03-24
申请号：US10778332
申请日：2004-02-17
申请人： Daniel Haines , Christina Knoedler
发明人： Daniel Haines , Christina Knoedler
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00533 , B01J2219/00554 , B01J2219/00576 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01L3/502707 , B01L3/5085 , B01L3/5088 , B01L2200/12 , B01L2300/0816 , B01L2300/0819 , B01L2300/089 , B01L2300/165 , B01L2300/166 , C03C17/30 , C03C17/3405 , C03C2217/445 , C03C2217/478 , C03C2217/75 , C03C2217/76 , C03C2217/77 , Y10T428/25 , Y10T428/259 , Y10T428/31649 , Y10T428/31663
摘要： The invention relates to hydrophobic patterned, low self-fluorescent substrates for attaching biomolecules and a method of making them. The patterned material will not interfere with end use assay analysis because the patterning composition is manufactured so to have very low self-fluorescence in the spectral regions typically used for microarraying applications. Further, the patterning compositions are chemically and physically durable and will not be deleteriously affected by typical chemical or physical processes utilized for cleaning, coating or assaying processes. In a preferred embodiment, the patterned silicone composition is applied to the substrate by screen-printing.
摘要翻译： 本发明涉及用于附着生物分子的疏水图案化的低自发荧光底物及其制备方法。 图案化材料不会干扰最终用途测定分析，因为制造图案化组合物在通常用于微阵列应用的光谱区域中具有非常低的自发荧光。 此外，图案化组合物在化学和物理上是耐久的，并且不会被用于清洁，涂覆或测定过程的典型化学或物理过程的有害影响。 在优选的实施方案中，通过丝网印刷将图案化的有机硅组合物施加到基材上。
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5.发明授权公开(公告)号：US08323166B2
公开(公告)日：2012-12-04
申请号：US12160259
申请日：2007-01-09
申请人： Daniel Haines , Luis Burzio , Matthias Bicker , Horst Koller , Jasmina Marjanovic , Robert Hormes
发明人： Daniel Haines , Luis Burzio , Matthias Bicker , Horst Koller , Jasmina Marjanovic , Robert Hormes
IPC分类号： B65B3/00
CPC分类号： A61L27/34 , A61J1/05 , A61L29/085 , A61L31/10 , A61L2400/10 , B05D1/62 , B05D7/22 , Y10T428/13 , Y10T428/1307
摘要： The present invention relates to a multi-functional pharmaceutical package surface and a method of preparing a multi-functional pharmaceutical package surface. In particular, the present invention relates to a pharmaceutical package having a protein deterrent and lubricious surface and methods of preparing said surface by applying coatings directly to the pharmaceutical package that (a) reduce the adsorption of proteins onto pharmaceutical packaging while not affecting the activity of the protein solution and (b) provide a lubricious surface. The pharmaceutical package surface may also contain a barrier coating. Coatings can be deposited on a variety of pharmaceutical packaging materials and configurations by various methods.
摘要翻译： 本发明涉及一种多功能药物包装表面和一种制备多功能药物包装表面的方法。 特别地，本发明涉及具有蛋白质阻燃和光滑表面的药物包装，以及通过将药物涂层直接施加到药物包装来制备所述表面的方法，（a）减少蛋白质在药物包装上的吸附，同时不影响 蛋白质溶液和（b）提供光滑的表面。 药物包装表面也可以含有阻隔涂层。 涂料可以通过各种方法沉积在各种药物包装材料和配置上。
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6.发明申请Method of preparing a macromolecule deterrent surface on a pharmaceutical package 有权在药物包装上制备大分子威慑表面的方法公开(公告)号：US20070187280A1
公开(公告)日：2007-08-16
申请号：US11649361
申请日：2007-01-04
申请人： Daniel Haines , Luis Burzio , Matthias Bicker , Robert Hormes , Horst Koller , Jasmina Buki
发明人： Daniel Haines , Luis Burzio , Matthias Bicker , Robert Hormes , Horst Koller , Jasmina Buki
CPC分类号： A61L27/34 , A61J1/05 , A61L29/085 , A61L31/10 , A61L2400/10 , B05D1/62 , B05D7/22 , Y10T428/13 , Y10T428/1307
摘要： A method of preparing a macromolecule deterrent surface on a pharmaceutical package. In particular, the present invention relates to a method of preparing a protein deterrent surface on a pharmaceutical package by applying a coating or coatings directly to the pharmaceutical package that reduces the adsorption of proteins onto pharmaceutical packaging while not affecting the activity of the protein solution contained.
摘要翻译： 一种在药物包装上制备大分子威慑表面的方法。 特别地，本发明涉及通过将涂层或涂层直接施加到药物包装上来制备药物包装上的蛋白质威慑表面的方法，其减少蛋白质在药物包装上的吸附，同时不影响所含蛋白质溶液的活性 。
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