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公开(公告)号：US20080161376A1
公开(公告)日：2008-07-03
申请号：US11954731
申请日：2007-12-12
IPC分类号： A61K31/4164 , A61P31/10
CPC分类号： A61K31/01 , A61K9/0014 , A61K31/22 , A61K31/4178 , A61K45/06 , A61K47/44
摘要： The present invention relates to methods of treatment of vulvovaginitis caused by nonspecified Candida isolates using controlled release antimycotic delivery systems. The invention utilizes a minimal number of administrations to obtain cessation of the condition. The methods and systems are especially effective against any Candida species causing vaginal irritation, and thus reduce the need for identification of the isolate prior to treatment.
摘要翻译： 本发明涉及使用控制释放的抗真菌递送系统治疗由非特异性假丝酵母属分离物引起的外阴阴道炎的方法。 本发明利用最少数量的施用来获得条件的停止。 所述方法和系统对于引起阴道刺激的任何念珠菌属物种特别有效，因此减少了在治疗前鉴定分离物的需要。
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公开(公告)号：US08859011B2
公开(公告)日：2014-10-14
申请号：US11746832
申请日：2007-05-10
CPC分类号： A61K9/2059 , A23L29/015 , A23L33/16 , A23P10/25 , A23V2002/00 , A61K9/16 , A61K9/2027 , A61K33/10 , Y10S514/96 , A23V2250/1578 , A23V2250/7106
摘要： Compositions comprising calcium carbonate and processes for making such compositions are provided. The invention provides a granulation comprising about 95% to about 99% by weight calcium carbonate, about 0.5% to about 5% by weight of a binder and about 0.03% to about 3% by weight of a porosity increasing agent. A pharmaceutical or nutritional composition prepared from such a granulation comprises about 90% to about 99% by weight calcium carbonate, about 0.03% to about 3% by weight of a porosity increasing agent, and about 1% to about 10% by weight of other excipients. The composition provides a smaller tablet than conventional calcium carbonate compositions, for improved ease of swallowing.
摘要翻译： 提供了包含碳酸钙的组合物及其制备方法。 本发明提供了一种颗粒，其包含约95重量％至约99重量％的碳酸钙，约0.5重量％至约5重量％的粘合剂和约0.03重量％至约3重量％的孔隙率增加剂。 由这种造粒剂制备的药物或营养组合物包含约90％至约99％重量的碳酸钙，约0.03％至约3％重量的孔隙率增加剂和约1％至约10％重量的其它 赋形剂。 组合物提供比常规碳酸钙组合物更小的片剂，以改善容易吞咽。
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公开(公告)号：US20130172279A1
公开(公告)日：2013-07-04
申请号：US13557527
申请日：2012-07-25
IPC分类号： A61K31/7056 , A61K9/00 , A61K31/4174
CPC分类号： A61K31/7056 , A61K9/0034 , A61K31/00 , A61K31/4174 , A61K31/56 , A61K31/7034 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition comprises (a) an antibacterial agent in an antibacterially effective amount, illustratively comprising clindamycin or a pharmaceutically acceptable salt or ester thereof; and (b) an antifungal agent in an antifungally effective amount, illustratively comprising butoconazole or a pharmaceutically acceptable salt or ester thereof. The composition is adapted for application in a unit dose amount to a vulvovaginal surface and has at least one nonlipoidal internal phase and at least one lipoidal external phase that is bioadhesive to the vulvovaginal surface. The composition is useful for administration to a vulvovaginal surface to treat a mixed bacterial vaginosis and vulvovaginal candidiasis infection.
摘要翻译： 药物组合物包含（a）抗菌有效量的抗菌剂，例如包括克林霉素或其药学上可接受的盐或酯; 和（b）抗真菌有效量的抗真菌剂，例如包括布康唑或其药学上可接受的盐或酯。 该组合物适用于以外阴阴道表面的单位剂量施用，并且具有至少一个非脂性内相和至少一个与外阴阴道表面生物粘附的脂质外相。 该组合物可用于给予外阴阴道表面以治疗混合的细菌性阴道炎和外阴阴道念珠菌病感染。
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公开(公告)号：US07687485B2
公开(公告)日：2010-03-30
申请号：US10106381
申请日：2002-03-27
IPC分类号： A61K31/56 , A61K31/44 , A61K31/335 , A61K31/34
CPC分类号： A61K45/06 , A23L33/12 , A23L33/15 , A23L33/16 , A23V2002/00 , Y10S514/899 , A23V2250/211 , A23V2250/70 , A23V2250/156 , A23V2250/1868 , A23V2250/1874 , A23V2250/1872 , A23V2250/71 , A23V2250/712 , A23V2250/708 , A23V2250/704 , A23V2250/1578 , A23V2250/1588 , A23V2250/1642 , A23V2250/1626 , A23V2250/18 , A23V2250/30 , A23V2250/1592 , A23V2250/161 , A23V2200/224 , A23V2250/5432
摘要： The present disclosure relates to novel compositions which provide improved nutritional support for premenopausal and menopausal women and/or relief from symptoms associated with menopause, as well as prophylactic effects, and methods for using same.
摘要翻译： 本公开涉及提供改善的对绝经前和绝经期妇女的营养支持和/或缓解与绝经相关的症状以及预防效果的新型组合物及其使用方法。
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公开(公告)号：US06258846B1
公开(公告)日：2001-07-10
申请号：US09323159
申请日：1999-06-01
IPC分类号： A61K3120
CPC分类号： A23L33/12 , A23L33/10 , A23V2002/00 , Y10S514/87 , A23V2250/1872 , A23V2250/1874 , A23V2250/1882 , A23V2250/70 , A23V2250/156 , A23V2250/51084 , A23V2250/5118 , A23V2250/51088 , A23V2250/612 , A23V2250/1592
摘要： The present disclosure relates to novel nutritional compositions containing linoleic acid and/or linolenic acid which optimize child neurological development and provide improved nutritional support for women prior to and during lactation. The nutritional compositions are intended for use by women to optimize infant neurological development and provide improved nutritional support for women prior to, during and after lactation.
摘要翻译： 本公开涉及包含亚油酸和/或亚麻酸的新型营养组合物，其优化儿童神经发育并且在哺乳期间和哺乳期间为女性提供改善的营养支持。 营养组合物旨在供妇女使用以优化婴儿神经发育，并在哺乳期间，期间和之后为女性提供改善的营养支持。
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公开(公告)号：US5648093A
公开(公告)日：1997-07-15
申请号：US447253
申请日：1995-05-22
IPC分类号： A23L27/00 , A61K8/02 , A61K8/04 , A61K8/34 , A61K8/44 , A61K8/60 , A61K8/65 , A61K8/81 , A61K8/92 , A61K9/10 , A61K9/20 , A61K47/16 , A61K47/42 , A61Q19/00 , F26B5/00 , A61K9/14
CPC分类号： A61K8/0241 , A23L27/70 , A61K8/0208 , A61K8/34 , A61K8/44 , A61K8/60 , A61K8/65 , A61K8/8176 , A61K8/922 , A61K9/2095 , A61Q19/00 , F26B5/00 , A61K2800/56
摘要： A fast dissolving, solid dosage form defined by a matrix containing gelatin, pectin and/or soy fiber protein and one or more amino acids having from about 2 to 12 carbon atoms is disclosed.
摘要翻译： 公开了由含有明胶，果胶和/或大豆纤维蛋白质的基质和一个或多个具有约2至12个碳原子的氨基酸定义的快速溶解固体剂型。
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公开(公告)号：US5558880A
公开(公告)日：1996-09-24
申请号：US234295
申请日：1994-04-28
IPC分类号： A23L27/00 , A61K8/02 , A61K8/04 , A61K8/34 , A61K8/44 , A61K8/60 , A61K8/65 , A61K8/81 , A61K8/92 , A61K9/10 , A61K9/20 , A61K47/16 , A61K47/42 , A61Q19/00 , F26B5/00 , A61K9/14
CPC分类号： A61K8/0241 , A23L27/70 , A61K8/0208 , A61K8/34 , A61K8/44 , A61K8/60 , A61K8/65 , A61K8/8176 , A61K8/922 , A61K9/2095 , A61Q19/00 , F26B5/00 , A61K2800/56
摘要： A fast dissolving, solid dosage form defined by a matrix containing gelatin, pectin and/or soy fiber protein and one or more amino acids having from about 2 to 12 carbon atoms is disclosed.
摘要翻译： 公开了由含有明胶，果胶和/或大豆纤维蛋白质的基质和一个或多个具有约2至12个碳原子的氨基酸定义的快速溶解固体剂型。
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公开(公告)号：US5494681A
公开(公告)日：1996-02-27
申请号：US288849
申请日：1994-08-11
CPC分类号： A61K9/1617 , A61K9/1652
摘要： A substantially tasteless pharmaceutical delivery system, which comprises a) an active material; and b) a spatially oriented matrix comprising (i) a wax core material having a melting point within the range of about 50.degree. C. and about 200.degree. C.; and (ii) a regional hydrophobic polymer material and method for making the same.
摘要翻译： 一种基本无味的药物递送系统，其包括a）活性物质; 和b）空间取向的基质，其包含（i）熔点在约50℃和约200℃范围内的蜡芯材料; 和（ii）区域疏水性聚合物材料及其制造方法。
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公开(公告)号：US5330763A
公开(公告)日：1994-07-19
申请号：US734505
申请日：1991-07-23
IPC分类号： A23G3/00 , A01N25/10 , A23G3/34 , A23L3/44 , A23L27/00 , A61K8/00 , A61K8/02 , A61K8/04 , A61K8/34 , A61K8/44 , A61K8/64 , A61K8/65 , A61K8/66 , A61K8/73 , A61K8/81 , A61K8/92 , A61K9/14 , A61K9/20 , A61Q11/00 , A61Q19/00 , B32B29/06 , B65D81/38 , C05G5/00 , F26B5/00
CPC分类号： F26B5/00 , A23L27/70 , A61K8/0208 , A61K8/34 , A61K8/44 , A61K8/65 , A61K8/8176 , A61K8/922 , A61K9/2095 , A61Q19/00 , B32B29/06 , B65D81/3823 , A61K2800/56 , Y10S514/948
摘要： A method is disclosed for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composition dissolved or dispersed in a first solvent and subsequently contacting the solidified matrix with a second solvent that is substantially miscible with the first solvent at a temperature lower than the solidification point of the first solvent, the matrix components being substantially insoluble in the second solvent, whereby the first solvent is substantially removed resulting in a usable matrix.
摘要翻译： 公开了一种用于制备药物和其它基质体系的方法，其包括将溶解或分散在第一溶剂中的基质组合物固化，随后使固化的基质与低于凝固点的温度与第一溶剂基本上可混溶的第二溶剂接触 的第一溶剂，基质组分基本上不溶于第二溶剂，由此基本除去第一溶剂，得到可用的基质。
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公开(公告)号：US08057433B2
公开(公告)日：2011-11-15
申请号：US11571863
申请日：2005-07-08
IPC分类号： A61M1/00
CPC分类号： A61M31/00
摘要： A pharmaceutical delivery system that releases an active agent in a controlled manner for an extended period in the vaginal cavity to treat or cure ailments associated with the vaginal cavity or proximal areas. The delivery system includes an applicator which is composed of a high internal phase emulsion, allowing the delivery system to adhere to the mueosal surfaces of the body, primarily the lining of vaginal cavity. The delivery system can maintain the high internal phase emulsion at a temperature of 86° F. for at least one month, without decomposition or instability of the emulsion.
摘要翻译： 药物递送系统，其以阴道腔中的受控方式长时间释放活性剂以治疗或治愈与阴道腔或近端区域相关的疾病。 递送系统包括由高内相乳液组成的施用器，允许递送系统粘附到身体的月球表面，主要是阴道腔的衬里。 输送系统可以将高内相乳液保持在86°F的温度下至少一个月，而不会使乳液分解或不稳定。
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