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公开(公告)号:US20120177724A1
公开(公告)日:2012-07-12
申请号:US13400076
申请日:2012-02-19
申请人: Darrell J. Irvine , Anjali Yadava , Jaehyun Moon
发明人: Darrell J. Irvine , Anjali Yadava , Jaehyun Moon
IPC分类号: A61K9/127 , A61K47/44 , A61P33/06 , C12N5/071 , C07C51/347 , A61K39/015
CPC分类号: A61K39/385 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2046 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/217 , A61K38/45 , A61K39/00 , A61K39/015 , A61K39/12 , A61K39/21 , A61K39/39 , A61K39/39533 , A61K47/6811 , A61K47/6911 , A61K2039/55511 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/6018 , C07K14/005 , C12N15/88 , C12N2740/15034 , C12N2740/16234 , C12Y207/10001 , Y02A50/412
摘要: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
摘要翻译: 本发明提供由稳定的多层囊泡构成的递送系统,以及组合物,合成方法及其使用方法。 稳定的多层囊泡在其表面和/或内部包含带有末端半胱氨酸的抗原或半胱氨酸修饰的抗原。
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公开(公告)号:US20110229529A1
公开(公告)日:2011-09-22
申请号:US13052067
申请日:2011-03-19
申请人: DARRELL J. IRVINE , Jaehyun Moon
发明人: DARRELL J. IRVINE , Jaehyun Moon
IPC分类号: A61K9/00 , C12N5/071 , C07C51/347 , A61K47/00
CPC分类号: A61K9/1271 , A61K9/127 , A61K9/1273 , A61K31/437 , A61K31/713 , A61K38/19 , A61K38/20 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/35 , A61K39/39 , A61K39/39558 , A61K45/06 , A61K47/48815 , A61K47/6911 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/575 , C07K14/005 , C07K16/28 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , Y10T428/2984
摘要: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
摘要翻译: 本发明提供由稳定的多层泡囊组成的递送系统,以及组合物,合成方法及其使用方法。 稳定的多层囊泡可以包含预防性,治疗和/或诊断剂。
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公开(公告)号:US20110229556A1
公开(公告)日:2011-09-22
申请号:US13053101
申请日:2011-03-21
申请人: Darrell J. Irvine , Anna Bershteyn , Jaehyun Moon
发明人: Darrell J. Irvine , Anna Bershteyn , Jaehyun Moon
IPC分类号: A61K9/127 , A61K39/385 , A61P37/04 , B82Y5/00
CPC分类号: A61K39/39 , A61K9/127 , A61K39/385 , A61K47/6921 , A61K47/6935 , A61K2039/55555 , A61K2039/55572 , A61K2039/6093
摘要: The invention provides delivery systems comprised of lipid coated polymer core particles, as well as compositions, methods of synthesis, and methods of use thereof. The particles can be used to carry antigen and adjuvant, resulting in enhanced immune responses.
摘要翻译: 本发明提供由脂质包被的聚合物核心颗粒组成的递送系统,以及组合物,合成方法及其使用方法。 该颗粒可用于携带抗原和佐剂,导致增强的免疫应答。
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公开(公告)号:US09149432B2
公开(公告)日:2015-10-06
申请号:US13400076
申请日:2012-02-19
申请人: Darrell J. Irvine , Jaehyun Moon
发明人: Darrell J. Irvine , Jaehyun Moon
IPC分类号: A61K9/127 , A61K47/44 , A61P33/06 , C12N5/071 , A61K39/015 , A61K39/21 , A61K39/39 , A61K47/48 , C07K14/005 , C12N15/88 , A61K39/00
CPC分类号: A61K39/385 , A61K9/127 , A61K9/1271 , A61K9/1273 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2046 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/217 , A61K38/45 , A61K39/00 , A61K39/015 , A61K39/12 , A61K39/21 , A61K39/39 , A61K39/39533 , A61K47/6811 , A61K47/6911 , A61K2039/55511 , A61K2039/55555 , A61K2039/55572 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/6018 , C07K14/005 , C12N15/88 , C12N2740/15034 , C12N2740/16234 , C12Y207/10001 , Y02A50/412
摘要: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.
摘要翻译: 本发明提供由稳定的多层泡囊组成的递送系统,以及组合物,合成方法及其使用方法。 稳定的多层囊泡在其表面和/或内部包含带有末端半胱氨酸的抗原或半胱氨酸修饰的抗原。
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公开(公告)号:US20110293705A1
公开(公告)日:2011-12-01
申请号:US13130845
申请日:2009-11-24
IPC分类号: A61K9/127 , A61K9/14 , A61P35/00 , A61P37/06 , A61P31/00 , A61K35/12 , C12N5/0783 , B82Y5/00
CPC分类号: A61K9/127 , A61K9/146 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/7105 , A61K31/711 , A61K35/28 , A61K38/19 , A61K38/20 , A61K38/2086 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61K47/46 , A61K47/6901 , A61K47/6911 , A61K47/6937 , A61K2035/124 , B82Y5/00 , C07K16/00 , C12N5/0006 , C12N5/0636 , C12N5/0647 , C12N15/113 , C12N15/87 , C12N2310/14 , A61K2300/00
摘要: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
摘要翻译: 本发明提供了通过将负载载体的纳米颗粒与具有归巢能力的细胞结合来将药剂递送到体内的局部区域,组织或器官的组合物和方法。 这些试剂可以分别是治疗剂或诊断剂,例如癌症化学治疗剂和成像剂。
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公开(公告)号:US09283184B2
公开(公告)日:2016-03-15
申请号:US13130845
申请日:2009-11-24
IPC分类号: A61K35/17 , A61K38/19 , A61K9/127 , A61K9/51 , A61K31/7105 , A61K31/711 , A61K38/20 , A61K45/06 , A61K47/48 , B82Y5/00 , C12N5/00 , C12N5/0783 , C12N5/0789 , C12N15/87 , A61K39/00 , A61K39/395 , A61K47/46 , A61K35/12
CPC分类号: A61K9/127 , A61K9/146 , A61K9/19 , A61K9/5146 , A61K9/5153 , A61K31/7105 , A61K31/711 , A61K35/28 , A61K38/19 , A61K38/20 , A61K38/2086 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61K47/46 , A61K47/6901 , A61K47/6911 , A61K47/6937 , A61K2035/124 , B82Y5/00 , C07K16/00 , C12N5/0006 , C12N5/0636 , C12N5/0647 , C12N15/113 , C12N15/87 , C12N2310/14 , A61K2300/00
摘要: The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
摘要翻译: 本发明提供了通过将负载载体的纳米颗粒与具有归巢能力的细胞结合来将药剂递送到体内的局部区域,组织或器官的组合物和方法。 这些试剂可以分别是治疗剂或诊断剂,例如癌症化学治疗剂和成像剂。
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公开(公告)号:US08747869B2
公开(公告)日:2014-06-10
申请号:US13052067
申请日:2011-03-19
申请人: Darrell J. Irvine , Jaehyun Moon
发明人: Darrell J. Irvine , Jaehyun Moon
CPC分类号: A61K9/1271 , A61K9/127 , A61K9/1273 , A61K31/437 , A61K31/713 , A61K38/19 , A61K38/20 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/35 , A61K39/39 , A61K39/39558 , A61K45/06 , A61K47/48815 , A61K47/6911 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , A61K2039/572 , A61K2039/575 , C07K14/005 , C07K16/28 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , Y10T428/2984
摘要: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.
摘要翻译: 本发明提供由稳定的多层泡囊组成的递送系统,以及组合物,合成方法及其使用方法。 稳定的多层囊泡可以包含预防性,治疗和/或诊断剂。
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公开(公告)号:US20130032840A1
公开(公告)日:2013-02-07
申请号:US13483500
申请日:2012-05-30
申请人: Doo-Hee CHO , Hey Yong Chu , Jeong Ik Lee , Jaehyun Moon , Jin Wook Shin , Jun-Han Han , Jin Woo Huh , Joo Hyun Hwang , Chul Woong Joo
发明人: Doo-Hee CHO , Hey Yong Chu , Jeong Ik Lee , Jaehyun Moon , Jin Wook Shin , Jun-Han Han , Jin Woo Huh , Joo Hyun Hwang , Chul Woong Joo
IPC分类号: H01L51/52
CPC分类号: H01L51/5212 , H01L51/5268 , H01L51/5275 , H01L2251/558
摘要: Organic light emitting devices are provided. The organic light emitting device may include a substrate having a first refractive index, a first electrode on the substrate, a second electrode disposed between the substrate and the first electrode and having a thickness equal to or greater than one-hundredth of a minimum wavelength of visible light and equal to or smaller than five-hundredths of a maximum wavelength of the visible light, and an organic light emitting layer disposed between the first and second electrodes and having a second refractive index.
摘要翻译: 提供有机发光装置。 有机发光器件可以包括具有第一折射率的衬底,衬底上的第一电极,设置在衬底和第一电极之间并具有等于或大于最小波长的百分之一的厚度的第二电极 可见光和等于或小于可见光的最大波长的五分之一的有机发光层,以及设置在第一和第二电极之间并具有第二折射率的有机发光层。
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公开(公告)号:US08975649B2
公开(公告)日:2015-03-10
申请号:US13478919
申请日:2012-05-23
申请人: Jeong Ik Lee , Jin Woo Huh , Hye Yong Chu , Doo-Hee Cho , Jun-Han Han , Jin Wook Shin , Jaehyun Moon , Joo Hyun Hwang , Chul Woong Joo
发明人: Jeong Ik Lee , Jin Woo Huh , Hye Yong Chu , Doo-Hee Cho , Jun-Han Han , Jin Wook Shin , Jaehyun Moon , Joo Hyun Hwang , Chul Woong Joo
CPC分类号: H01L51/56 , H01L51/0096 , H01L51/5212 , H01L51/5234 , H01L51/5268 , H01L51/5275
摘要: The inventive concept provides light emitting devices and methods of manufacturing a light emitting device. The light emitting device may include a transparent substrate including a first region and a second region, a first transparent electrode disposed on a first surface of the transparent substrate, a second transparent electrode facing and spaced apart from the first transparent electrode, an organic light emitting layer disposed between the first and second transparent electrodes, an assistant electrode disposed between the first and second transparent electrodes and selectively masking the second region, and a light path changing structure disposed on a second surface of the transparent substrate and selectively masking the second region.
摘要翻译: 本发明的概念提供了发光器件和制造发光器件的方法。 发光装置可以包括包括第一区域和第二区域的透明基板,设置在透明基板的第一表面上的第一透明电极,面对并与第一透明电极间隔开的第二透明电极,有机发光 设置在第一和第二透明电极之间的辅助电极,设置在第一和第二透明电极之间并选择性地掩蔽第二区域的辅助电极以及设置在透明基板的第二表面上并选择性地掩蔽第二区域的光路改变结构。
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公开(公告)号:US20130056711A1
公开(公告)日:2013-03-07
申请号:US13494532
申请日:2012-06-12
申请人: Jin Woo Huh , Jeong Ik Lee , Chul Woong Joo , Doo-Hee Cho , Jin Wook Shin , Jaehyun Moon , Jun-Han Han , Joo Hyun Hwang , Hye Yong Chu , Byoung Gon Yu
发明人: Jin Woo Huh , Jeong Ik Lee , Chul Woong Joo , Doo-Hee Cho , Jin Wook Shin , Jaehyun Moon , Jun-Han Han , Joo Hyun Hwang , Hye Yong Chu , Byoung Gon Yu
CPC分类号: H01L51/5268 , H01L51/5275
摘要: The inventive concept provides organic light emitting diodes and methods of manufacturing an organic light emitting diode. The organic light emitting diode includes a substrate, a first electrode layer and a second electrode layer formed on the substrate, an organic light emitting layer disposed between the first electrode layer and the second electrode layer and generating light, and a scattering layer between the first electrode layer and the substrate or between the first electrode layer and the organic light emitting layer. The scattering layer scatters the light.
摘要翻译: 本发明构思提供有机发光二极管和制造有机发光二极管的方法。 有机发光二极管包括基板,第一电极层和形成在基板上的第二电极层,设置在第一电极层和第二电极层之间并产生光的有机发光层和在第一电极层之间的散射层 电极层和基板之间或第一电极层和有机发光层之间。 散射层散射光。
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