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    ELECTROSPUN STRUCTURES AND METHODS FOR FORMING AND USING SAME
    1.
    发明申请
    ELECTROSPUN STRUCTURES AND METHODS FOR FORMING AND USING SAME 有权
    用于形成和使用它们的电极结构和方法

    公开(公告)号：US20100008994A1

    公开(公告)日：2010-01-14

    申请号：US12299830

    申请日：2007-05-09

    申请人： Darrell Reneker ,  Tao Han ,  Daniel Smith ,  Camden Ertley ,  Joseph W. Reneker

    发明人： Darrell Reneker ,  Tao Han ,  Daniel Smith ,  Camden Ertley ,  Joseph W. Reneker

    IPC分类号： B32B5/02 ,  D02J3/00 ,  B32B9/00 ,  B29C70/00 ,  B29C47/00 ,  B01J31/06 ,  H01B1/12 ,  H01B1/24 ,  A61K9/14 ,  A61K38/16 ,  A61K39/395 ,  A61K39/00 ,  A61K38/43 ,  A61P25/22 ,  A61P25/26

    CPC分类号： D01D5/0092 ,  Y10T428/2918 ,  Y10T428/292 ,  Y10T428/2927

    摘要： The present invention relates to structures that contain one or more fiber and/or nanofiber structures where such structures can be formed on a wide variety of structures or surfaces (e.g., asperities, flat surfaces, angled surface, hierarchical structures, etc.). In one embodiment, the present invention relates to a process for forming one or more fibers, nanofibers or structures made therefrom on a wide variety of structures or surfaces (e.g., asperities, flat surfaces, angled surface, hierarchical structures, etc.). In another embodiment, the present invention relates to a process for forming one or more fibers, nanofibers or structures made therefrom on a wide variety of structures or surfaces (e.g., asperities, flat surfaces, angled surface, hierarchical structures, etc.) where such fibers and/or structures are designed to sequester, carry and/or encapsulate one or more substances. In still another embodiment, the present invention relates to structures that contain one or more fiber and/or nanofiber structures on asperities where the nanofiber and/or fiber structures are designed to sequester, carry and/or encapsulate one or more substances.

    摘要翻译： 本发明涉及包含一种或多种纤维和/或纳米纤维结构的结构，其中这种结构可以形成在各种各样的结构或表面（例如，凹凸，平坦表面，成角度的表面，分级结构等）上。 在一个实施方案中，本发明涉及在各种结构或表面（例如，凹凸，平坦表面，倾斜表面，分层结构等）上形成一种或多种纤维，纳米纤维或由其制成的结构的方法。 在另一个实施方案中，本发明涉及一种在多种结构或表面（例如，凹凸，平坦表面，成角度表面，分级结构等）上形成一种或多种纤维，纳米纤维或由其制成的结构的方法， 纤维和/或结构被设计成隔离，携带和/或封装一种或多种物质。 在另一个实施方案中，本发明涉及在凹凸上含有一种或多种纤维和/或纳米纤维结构的结构，其中纳米纤维和/或纤维结构被设计为螯合，携带和/或封装一种或多种物质。

    Electrospun structures and methods for forming and using same
    2.
    发明授权
    Electrospun structures and methods for forming and using same 有权
    电纺结构及其形成和使用方法

    公开(公告)号：US08574315B2

    公开(公告)日：2013-11-05

    申请号：US12299830

    申请日：2007-05-09

    申请人： Darrell Reneker ,  Tao Han ,  Daniel Smith ,  Camden Ertley ,  Joseph W. Reneker

    发明人： Darrell Reneker ,  Tao Han ,  Daniel Smith ,  Camden Ertley ,  Joseph W. Reneker

    IPC分类号： A61K9/14 ,  A61K38/16 ,  A61K39/395 ,  A61K39/00 ,  A61K38/43 ,  A61P25/22 ,  A61P25/26 ,  B32B5/02

    CPC分类号： D01D5/0092 ,  Y10T428/2918 ,  Y10T428/292 ,  Y10T428/2927

    摘要： The present invention relates to structures that contain one or more fiber and/or nanofiber structures where such structures can be formed on a wide variety of structures or surfaces (e.g., asperities, flat surfaces, angled surface, hierarchical structures, etc.). In one embodiment, the present invention relates to a process for forming one or more fibers, nanofibers or structures made therefrom on a wide variety of structures or surfaces (e.g., asperities, flat surfaces, angled surface, hierarchical structures, etc.). In another embodiment, the present invention relates to a process for forming one or more fibers, nanofibers or structures made therefrom on a wide variety of structures or surfaces (e.g., asperities, flat surfaces, angled surface, hierarchical structures, etc.) where such fibers and/or structures are designed to sequester, carry and/or encapsulate one or more substances. In still another embodiment, the present invention relates to structures that contain one or more fiber and/or nanofiber structures on asperities where the nanofiber and/or fiber structures are designed to sequester, carry and/or encapsulate one or more substances.

    摘要翻译： 本发明涉及包含一种或多种纤维和/或纳米纤维结构的结构，其中这种结构可以形成在各种各样的结构或表面（例如，凹凸，平坦表面，成角度的表面，分级结构等）上。 在一个实施方案中，本发明涉及在各种结构或表面（例如，凹凸，平坦表面，倾斜表面，分层结构等）上形成一种或多种纤维，纳米纤维或由其制成的结构的方法。 在另一个实施方案中，本发明涉及一种在多种结构或表面（例如，凹凸，平坦表面，成角度表面，分级结构等）上形成一种或多种纤维，纳米纤维或由其制成的结构的方法， 纤维和/或结构被设计成隔离，携带和/或封装一种或多种物质。 在另一个实施方案中，本发明涉及在凹凸上含有一种或多种纤维和/或纳米纤维结构的结构，其中纳米纤维和/或纤维结构被设计为螯合，携带和/或封装一种或多种物质。

    METHOD OF CHARACTERIZATION OF VISCOELASTIC STRESS IN ELONGATED FLOW MATERIALS
    3.
    发明申请
    METHOD OF CHARACTERIZATION OF VISCOELASTIC STRESS IN ELONGATED FLOW MATERIALS 有权
    长期流动材料中粘弹性应力的表征方法

    公开(公告)号：US20110274825A1

    公开(公告)日：2011-11-10

    申请号：US12741836

    申请日：2008-11-10

    申请人： Darrell Reneker ,  Tao Han ,  Alexander L. Yarin

    发明人： Darrell Reneker ,  Tao Han ,  Alexander L. Yarin

    IPC分类号： B05C13/02

    CPC分类号： D01D5/0069 ,  D01D5/0023 ,  D01D5/003 ,  D01D5/0076 ,  D01D5/0092 ,  G01N11/02 ,  G01N2011/0026 ,  G01N2011/0073

    摘要： The present invention generally relates to a device for measuring characteristics of polymeric fluids (semi-dilute and concentrated polymer solutions and melts) in extremely strong elongational flows. In one embodiment, the present invention relates to a device for measuring characteristics of polymeric fluids (semi-dilute and concentrated polymer solutions and melts) in extremely strong elongational flows in spinning jets and/or electrified jets. In another embodiment, the present invention relates to a method for determining the elastic modulus and the relaxation time of a polymeric fluid. Also, the present invention enables one to determine and/or measure the primary parameters needed to describe a viscoelastic material.

    摘要翻译： 本发明一般涉及用于测量极强伸长流中的聚合流体（半稀释和浓缩的聚合物溶液和熔体）特性的装置。 在一个实施方案中，本发明涉及用于测量纺丝射流和/或带电喷射中极强伸长流中聚合流体（半稀释和浓缩聚合物溶液和熔体）特性的装置。 在另一个实施方案中，本发明涉及确定聚合物流体的弹性模量和松弛时间的方法。 此外，本发明使得能够确定和/或测量描述粘弹性材料所需的主要参数。

    Method of characterization of viscoelastic stress in elongated flow materials
    4.
    发明授权
    Method of characterization of viscoelastic stress in elongated flow materials 有权
    拉伸流动材料粘弹性应力表征方法

    公开(公告)号：US08636493B2

    公开(公告)日：2014-01-28

    申请号：US12741836

    申请日：2008-11-10

    申请人： Darrell Reneker ,  Tao Han ,  Alexander L. Yarin

    发明人： Darrell Reneker ,  Tao Han ,  Alexander L. Yarin

    IPC分类号： D01D13/00 ,  D06M10/00 ,  D06M10/02 ,  H05B6/00

    CPC分类号： D01D5/0069 ,  D01D5/0023 ,  D01D5/003 ,  D01D5/0076 ,  D01D5/0092 ,  G01N11/02 ,  G01N2011/0026 ,  G01N2011/0073

    摘要： The present invention generally relates to a device for measuring characteristics of polymeric fluids (semi-dilute and concentrated polymer solutions and melts) in extremely strong elongational flows. In one embodiment, the present invention relates to a device for measuring characteristics of polymeric fluids (semi-dilute and concentrated polymer solutions and melts) in extremely strong elongational flows in spinning jets and/or electrified jets. In another embodiment, the present invention relates to a method for determining the elastic modulus and the relaxation time of a polymeric fluid. Also, the present invention enables one to determine and/or measure the primary parameters needed to describe a viscoelastic material.

    摘要翻译： 本发明一般涉及用于测量极强伸长流中的聚合流体（半稀释和浓缩的聚合物溶液和熔体）特性的装置。 在一个实施方案中，本发明涉及用于测量纺丝射流和/或带电喷射中极强伸长流中聚合流体（半稀释和浓缩聚合物溶液和熔体）特性的装置。 在另一个实施方案中，本发明涉及确定聚合物流体的弹性模量和松弛时间的方法。 此外，本发明使得能够确定和/或测量描述粘弹性材料所需的主要参数。

    Sequestered reactive materials
    5.
    发明申请
    Sequestered reactive materials 有权
    隔离反应材料

    公开(公告)号：US20060280781A1

    公开(公告)日：2006-12-14

    申请号：US10554191

    申请日：2004-04-23

    申请人： Darrell Reneker ,  Daniel Smith

    发明人： Darrell Reneker ,  Daniel Smith

    IPC分类号： A61K9/70

    CPC分类号： A61K9/70 ,  Y10T442/2525

    摘要： A fibrous assembly is provided for performing site-specific chemistry. In general the present invention provides a fibrous assembly comprising a first fiber that sequesters a first reactive component; and a second fiber that sequesters a second reactive component, wherein at least the first or second fiber releases its reactive component when the fiber is in the presence of a releasing agent, and wherein when the at least first or second fiber releases its reactive component, the first and second reactive components react with each other to form a reaction product Related methods of manufacture and use are also provided.

    摘要翻译： 提供纤维组件用于进行特定场地的化学。 通常，本发明提供了一种纤维组合件，其包括隔离第一反应组分的第一纤维; 以及隔离第二反应性组分的第二纤维，其中当纤维存在脱模剂时，至少第一或第二纤维释放其反应性组分，并且其中当所述至少第一或第二纤维释放其反应性组分时， 第一和第二反应性组分彼此反应以形成反应产物。还提供了相关的制造和使用方法。

    Balloon for Use in Angioplasty
    7.
    发明申请
    Balloon for Use in Angioplasty 审中-公开
    气球用于血管成形术

    公开(公告)号：US20070255206A1

    公开(公告)日：2007-11-01

    申请号：US10595329

    申请日：2004-10-14

    申请人： Darrell Reneker ,  Daniel Smith ,  Erik Andersen

    发明人： Darrell Reneker ,  Daniel Smith ,  Erik Andersen

    IPC分类号： A61L29/14

    CPC分类号： A61L31/10 ,  A61B17/12022 ,  A61B17/1215 ,  A61B17/12172 ,  A61B17/12177 ,  A61B17/12186 ,  A61B2017/00004 ,  A61B2017/00893 ,  A61F2/82 ,  A61F2250/0067 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/00 ,  A61L2400/12 ,  A61M25/0043 ,  A61M25/09 ,  C08L79/02

    摘要： An expandable balloon for use in angioplasty procedures comprises a balloon having an outer surface layer, the outer surface layer being made from electrospun nanofibers and incorporating at least one pharmaceutically active substance, such as nitric oxide (NO). The outer surface layer may be formed on a separate flexible tubular member or sock, which is slipped over the balloon. An acidic agent, such as ascorbic acid, may be included in the balloon for enhancing NO release. A method of treating cell disorders in tubular structures of a living being comprises the steps of placing a coated balloon at a treatment site within the tubular structures, expanding the balloon at the treatment site, and releasing the pharmaceutically active substance at the treatment site. Optionally, a stent may be crimped onto the balloon prior to insertion of the balloon and stent into the tubular structures of the living being.

    摘要翻译： 用于血管成形术程序的可膨胀气囊包括具有外表面层的球囊，外表面层由静电纺丝纳米纤维制成并且并入至少一种药物活性物质，例如一氧化氮（NO）。 外表面层可以形成在单独的柔性管状构件或袜子上，该弹性管状构件或袜子滑过气球。 气球中可以含有抗坏血酸等酸性剂，以增强NO释放。 一种治疗生物体管状结构中的细胞病症的方法包括以下步骤：将涂覆的球囊放置在管状结构内的治疗部位，使治疗部位膨胀，并在治疗部位释放药物活性物质。 任选地，在将球囊和支架插入生命体的管状结构之前，可以将支架卷曲到球囊上。

    Non-woven fiber assemblies
    9.
    发明申请
    Non-woven fiber assemblies 有权
    无纺布纤维集合体

    公开(公告)号：US20060153904A1

    公开(公告)日：2006-07-13

    申请号：US10510457

    申请日：2003-04-04

    申请人： Daniel Smith ,  Darrell Reneker

    发明人： Daniel Smith ,  Darrell Reneker

    IPC分类号： A61F13/02

    CPC分类号： D04H3/16 ,  A61F13/0206 ,  A61F13/0209 ,  A61F13/0223 ,  A61F13/0226 ,  A61F13/0253 ,  A61L15/225 ,  A61L15/58 ,  A61L26/0052 ,  D04H1/728 ,  Y10T442/608 ,  Y10T442/642

    摘要： A non-woven fiber assembly comprises one or more fibers containing an adhesive component, an elastomeric component, and a hydrophilic component. A method of making a non-woven fiber assembly comprises the steps of providing one or more fiber-forming materials comprising an adhesive component, an elastomeric component, and a hydrophilic component, and forming said one or more fiber-forming materials into at least one fiber. A method of treating a patient comprises applying a medical dressing comprising the fiber assembly of the present invention to a patient. An apparatus (10) for forming a non-woven fiber assembly comprises a plurality of reservoirs (12, 16, 20) for containing more than one type of fiber-forming material, a plurality of valves (14, 18, 22), each independently in communication with a reservoir, and a fiber-forming device (28) selected from the group consisting of a spinnerette, a NGJ nozzle, and an electrospinning device, in communication with the valves.

    摘要翻译： 无纺纤维组合件包括一种或多种含有粘合剂组分，弹性体组分和亲水组分的纤维。 制造无纺纤维组件的方法包括以下步骤：提供一种或多种纤维形成材料，其包括粘合剂组分，弹性体组分和亲水组分，并将所述一种或多种纤维形成材料形成至少一种 纤维。 治疗患者的方法包括将包含本发明的纤维集合体的医用敷料施用于患者。 一种用于形成无纺纤维组件的装置（10）包括多个储存器（12,16,20），用于容纳多于一种类型的纤维形成材料，多个阀（14,18,22），每个 独立地与储存器连通，以及选自由与喷射阀连通的喷丝板，NGJ喷嘴和静电纺丝装置组成的组的纤维形成装置（28）。

    Polymer structures formed on fibers and/or nanofiber
    10.
    发明申请
    Polymer structures formed on fibers and/or nanofiber 审中-公开
    在纤维和/或纳米纤维上形成的聚合物结构

    公开(公告)号：US20060148978A1

    公开(公告)日：2006-07-06

    申请号：US11237154

    申请日：2005-09-28

    申请人： Darrell Reneker ,  George Chase ,  Daniel Smith ,  Sphurti Doiphode

    发明人： Darrell Reneker ,  George Chase ,  Daniel Smith ,  Sphurti Doiphode

    IPC分类号： C08L31/00

    CPC分类号： C08F2/00 ,  C08F222/32 ,  D01D5/0007 ,  D06M14/16 ,  D06M15/31

    摘要： In one embodiment, the present invention relates to a method for producing polymer nanostructures, the method comprising the steps of: forming at least one nanostructure substrate, web, membrane or mat; exposing the at least one nanostructure substrate, web, membrane or mat to at least one monomer composition, where the at least one monomer composition is in a vapor phase and the at least one monomer composition is deposited on the surface of and/or within the at least one nanostructure substrate, web, membrane or mat; and subjecting the at least one exposed nanostructure substrate, web, membrane or mat to conditions suitable to polymerize the at least one monomer composition, thereby yielding polymer nanostructures where the polymer nanostructures are formed on and/or in the nanostructure substrate, web, membrane or mat.

    摘要翻译： 在一个实施方案中，本发明涉及一种生产聚合物纳米结构的方法，所述方法包括以下步骤：形成至少一个纳米结构基材，网，膜或垫; 将至少一种纳米结构基材，纤维网，膜或垫暴露于至少一种单体组合物，其中所述至少一种单体组合物为气相，并且所述至少一种单体组合物沉积在所述单体组合物的表面上和/ 至少一个纳米结构基材，网，膜或垫; 以及对所述至少一个暴露的纳米结构基材，纤维网，膜或垫进行适合聚合所述至少一种单体组合物的条件，由此产生聚合物纳米结构，其中所述聚合物纳米结构在纳米结构基材，网，膜或/ 垫。