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公开(公告)号：US08546405B2
公开(公告)日：2013-10-01
申请号：US12644432
申请日：2009-12-22
申请人： David A. DeGoey , Pamela L. Donner , Warren M. Kati , Charles W. Hutchins , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Preethi Krishnan , Neeta C. Mistry , Tami J. Pilot-Matias , Sachin V. Patel , Xiaoyan Li , Todd N. Soltwedel , Lissa T. Nelson
发明人： David A. DeGoey , Pamela L. Donner , Warren M. Kati , Charles W. Hutchins , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Preethi Krishnan , Neeta C. Mistry , Tami J. Pilot-Matias , Sachin V. Patel , Xiaoyan Li , Todd N. Soltwedel , Lissa T. Nelson
IPC分类号： A01N43/54 , A01N43/90 , A01N43/42 , A61K31/519 , A61K31/44 , C07D239/42 , C07D405/00 , C07D401/04 , C07D471/00 , C07D487/00 , C07D409/00 , C07D411/00
CPC分类号： C07D471/04 , C07D239/48
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：US20100160355A1
公开(公告)日：2010-06-24
申请号：US12644432
申请日：2009-12-22
申请人： David A. DeGoey , Pamela L. Donner , Warren M. Kati , Charles W. Hutchins , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Preethi Krishnan , Neeta C. Mistry , Tami J. Pilot-Matias , Sachin V. Patel , Xiaoyan Li , Todd N. Soltwedel , Lissa T. Nelson
发明人： David A. DeGoey , Pamela L. Donner , Warren M. Kati , Charles W. Hutchins , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Preethi Krishnan , Neeta C. Mistry , Tami J. Pilot-Matias , Sachin V. Patel , Xiaoyan Li , Todd N. Soltwedel , Lissa T. Nelson
IPC分类号： A61K31/519 , C07D471/04 , C12N5/071 , A61P31/12 , A61P31/14
CPC分类号： C07D471/04 , C07D239/48
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译： 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。
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公开(公告)号：US20100317568A1
公开(公告)日：2010-12-16
申请号：US12813301
申请日：2010-06-10
申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Todd N. Soltwedel , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Michael J. Lavin , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi
发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Todd N. Soltwedel , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Michael J. Lavin , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi
IPC分类号： A61K38/05 , C07D403/14 , A61P31/14 , C07D401/14 , A61K31/4178 , A61K31/4184 , C07D413/14 , C07D417/14 , A61K31/428 , A61K31/496 , A61K31/5377 , A61K31/55 , C07F9/6506 , A61K31/675 , C07D491/113 , A61K31/438 , C07D279/12 , A61K31/541
CPC分类号： C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：US20110092415A1
公开(公告)日：2011-04-21
申请号：US12903822
申请日：2010-10-13
申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Todd N. Soltwedel , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Michael J. Lavin , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Todd N. Soltwedel , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Michael J. Lavin , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
IPC分类号： A61K38/05 , C07D403/14 , C07D401/14 , C07D405/14 , C07D413/14 , C07D491/113 , A61P31/14
CPC分类号： C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：US20100267634A1
公开(公告)日：2010-10-21
申请号：US12759986
申请日：2010-04-14
申请人： Pamela L. Donner , Lissa T. Nelson , Tammie K. Jinkerson , Ryan G. Keddy , Christopher E. Motter , Mark A. Matulenko , Allan C. Krueger , David A. DeGoey , Sachin V. Patel , John T. Randolph , Warren M. Kati , Charles W. Hutchins , Todd N. Soltwedel
发明人： Pamela L. Donner , Lissa T. Nelson , Tammie K. Jinkerson , Ryan G. Keddy , Christopher E. Motter , Mark A. Matulenko , Allan C. Krueger , David A. DeGoey , Sachin V. Patel , John T. Randolph , Warren M. Kati , Charles W. Hutchins , Todd N. Soltwedel
IPC分类号： A61K38/05 , C07K5/02 , C07K5/062 , A61P31/14 , C07D403/12 , A61K31/4025 , C07D403/14 , A61K31/4184 , C07D413/14 , A61K31/5377
CPC分类号： C07D207/16 , A61K31/4025 , A61K31/4184 , A61K31/454 , A61K31/5377 , A61K38/00 , C07D205/04 , C07D207/22 , C07D209/52 , C07D211/60 , C07D263/06 , C07D277/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07K5/06034 , C07K5/06043 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06139
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：US09278922B2
公开(公告)日：2016-03-08
申请号：US12759986
申请日：2010-04-14
申请人： Pamela L. Donner , Lissa T. Nelson , Tammie K. Jinkerson , Ryan G. Keddy , Christopher E. Motter , Mark A. Matulenko , Allan C. Krueger , David A. DeGoey , Sachin V. Patel , John T. Randolph , Warren M. Kati , Charles W. Hutchins , Todd N. Soltwedel
发明人： Pamela L. Donner , Lissa T. Nelson , Tammie K. Jinkerson , Ryan G. Keddy , Christopher E. Motter , Mark A. Matulenko , Allan C. Krueger , David A. DeGoey , Sachin V. Patel , John T. Randolph , Warren M. Kati , Charles W. Hutchins , Todd N. Soltwedel
IPC分类号： A61K38/05 , A61K31/4025 , A61K31/4184 , A61K31/5377 , C07K5/02 , C07K5/062 , A61P31/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D207/16 , A61K31/454 , C07D205/04 , C07D207/22 , C07D209/52 , C07D211/60 , C07D263/06 , C07D277/06 , C07D401/14 , C07D405/14 , C07D417/14 , C07D487/04 , C07K5/065 , C07K5/078 , A61K38/00
CPC分类号： C07D207/16 , A61K31/4025 , A61K31/4184 , A61K31/454 , A61K31/5377 , A61K38/00 , C07D205/04 , C07D207/22 , C07D209/52 , C07D211/60 , C07D263/06 , C07D277/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07K5/06034 , C07K5/06043 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06139
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：US20110207699A1
公开(公告)日：2011-08-25
申请号：US12964027
申请日：2010-12-09
申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Todd N. Soltwedel , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Clarence J. Maring , Michael D. Tufano , David A. Betebenner , Todd W. Rockway , Dachun Liu , John K. Pratt , Michael J. Lavin , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Todd N. Soltwedel , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Clarence J. Maring , Michael D. Tufano , David A. Betebenner , Todd W. Rockway , Dachun Liu , John K. Pratt , Michael J. Lavin , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
IPC分类号： A61K31/695 , C07D401/14 , A61K31/454 , C07F5/02 , A61K31/69 , C07D401/10 , C07D403/14 , A61K31/4178 , A61K31/496 , A61K31/506 , C07D413/14 , A61K31/5377 , A61K31/397 , C07F7/10 , A61P31/18
CPC分类号： C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译： 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。
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公开(公告)号：US08691938B2
公开(公告)日：2014-04-08
申请号：US12813301
申请日：2010-06-10
申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi
发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi
CPC分类号： C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译： 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。
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公开(公告)号：US20120004196A1
公开(公告)日：2012-01-05
申请号：US13100827
申请日：2011-05-04
申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
IPC分类号： A61K31/4184 , C07D401/14 , C07D405/14 , C07D413/14 , C07F7/10 , A61K31/454 , A61K31/4439 , A61K31/422 , A61K31/438 , A61K31/4545 , A61K31/695 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P31/14 , C07D403/14
CPC分类号： A61K31/454 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D491/113 , C07F7/02 , Y02P20/582
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译： 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。
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公开(公告)号：US08937150B2
公开(公告)日：2015-01-20
申请号：US13100827
申请日：2011-05-04
申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Yi Gao , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
IPC分类号： A61K31/66 , C07K16/00 , C07D401/14 , C07D491/113 , C07D413/14 , C07D403/14 , C07D417/14 , C07D405/14 , C07D453/00
CPC分类号： A61K31/454 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/435 , A61K31/4355 , A61K31/438 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D491/113 , C07F7/02 , Y02P20/582
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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