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1.发明申请Compositions And Methods Comprising Alpha-Amylase Variants With Altered Properties 有权包含具有改变性质的α-淀粉酶变体的组合物和方法公开(公告)号：US20120045817A1
公开(公告)日：2012-02-23
申请号：US13260146
申请日：2010-04-01
IPC分类号： C12N9/08 , C07H21/00 , C12N15/63 , C12N1/15 , D06M16/00 , C12N1/00 , C12N1/19 , C12N9/26 , C12N1/21
CPC分类号： C11D3/386 , C11D3/38681 , C12N9/2417 , C12N9/54
摘要： Described are compositions and methods relating to variant alpha-amylases having altered biochemical properties and advantageous performance characteristics as compared to a reference alpha-amylase. The variants are suitable for use in various industrial applications such as starch conversion, ethanol production, laundry, dishwashing, pulp and paper production, textile desizing, and/or sweetener production.
摘要翻译： 描述了与参考α-淀粉酶相比具有改变的生物化学性质和有利的性能特征的变体α-淀粉酶相关的组合物和方法。 这些变体适用于各种工业应用，如淀粉转化，乙醇生产，洗衣，洗碗，纸浆和造纸，纺织品退浆和/或甜味剂生产。
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2.发明授权Compositions and methods comprising alpha-amylase variants with altered properties 有权包含具有改变性质的α-淀粉酶变体的组合物和方法公开(公告)号：US08852912B2
公开(公告)日：2014-10-07
申请号：US13260146
申请日：2010-04-01
IPC分类号： C12P21/06 , C12N9/00 , C12N9/28 , C07K1/00 , C07H21/04 , G01N33/48 , G01N31/00 , C11D3/386 , C12N9/54
CPC分类号： C11D3/386 , C11D3/38681 , C12N9/2417 , C12N9/54
摘要： Described are compositions and methods relating to variant alpha-amylases having altered biochemical properties and advantageous performance characteristics as compared to a reference alpha-amylase. The variants are suitable for use in various industrial applications such as starch conversion, ethanol production, laundry, dishwashing, pulp and paper production, textile desizing, and/or sweetener production.
摘要翻译： 描述了与参考α-淀粉酶相比具有改变的生物化学性质和有利的性能特征的变体α-淀粉酶相关的组合物和方法。 这些变体适用于各种工业应用，如淀粉转化，乙醇生产，洗衣，洗碗，纸浆和造纸，纺织品退浆和/或甜味剂生产。
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公开(公告)号：US20120045822A1
公开(公告)日：2012-02-23
申请号：US13260421
申请日：2010-04-01
CPC分类号： C11D3/386 , C11D3/38681 , C12N9/2417 , C12N9/54
摘要： Described are compositions and methods involving a Bacillus alpha-amylase and a protease. The compositions and methods are especially effective for cold water cleaning applications.
摘要翻译： 描述了涉及芽孢杆菌α-淀粉酶和蛋白酶的组合物和方法。 组合物和方法对于冷水清洗应用是特别有效的。
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公开(公告)号：US07985569B2
公开(公告)日：2011-07-26
申请号：US11809104
申请日：2007-05-31
申请人： Wolfgang Aehle , David A. Estell , Ronaldus W. J. Hommes , Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Andrew Shaw , Wilhelmus A. H. van der Kley , Leonardus P. M. van Marrewijk
发明人： Wolfgang Aehle , David A. Estell , Ronaldus W. J. Hommes , Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Andrew Shaw , Wilhelmus A. H. van der Kley , Leonardus P. M. van Marrewijk
IPC分类号： C12N9/48
CPC分类号： C12N9/52 , A23K20/189 , A23K50/75 , C11D3/386 , C12N9/96 , C12Y304/21 , D06M16/003
摘要： The present invention provides novel Micrococcineae spp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA encoding the proteases, host cells transformed with the vector DNA, and enzymes produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising these serine protease variants. In particularly preferred embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These variant proteases also find use in numerous applications.
摘要翻译： 本发明提供了具有多个取代的新型微球菌spp丝氨酸蛋白酶。 特别地，本发明提供了具有多个取代的丝氨酸蛋白酶，编码这些蛋白酶的DNA，包含编码蛋白酶的DNA的载体，用载体DNA转化的宿主细胞和由宿主细胞产生的酶。 本发明还提供了清洁组合物（例如洗涤剂组合物），动物饲料组合物以及包含这些丝氨酸蛋白酶变体的纺织和皮革加工组合物。 在特别优选的实施方案中，本发明提供衍生自本文所述的野生型蛋白酶的突变体（即，变体）蛋白酶。 这些变体蛋白酶也可用于许多应用。
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公开(公告)号：US08455234B2
公开(公告)日：2013-06-04
申请号：US13162104
申请日：2011-06-16
申请人： Wolfgang Aehle , David A. Estell , Ronaldus W. J. Hommes , Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Andrew Shaw , Wilhelmus A. H. van der Kley , Leonardus P. M. van Marrewijk
发明人： Wolfgang Aehle , David A. Estell , Ronaldus W. J. Hommes , Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Andrew Shaw , Wilhelmus A. H. van der Kley , Leonardus P. M. van Marrewijk
IPC分类号： C12N9/48
CPC分类号： C12N9/52 , A23K20/189 , A23K50/75 , C11D3/386 , C12N9/96 , C12Y304/21 , D06M16/003
摘要： The present invention provides novel Micrococcineae spp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA encoding the proteases, host cells transformed with the vector DNA, and enzymes produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising these serine protease variants. In particularly preferred embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These variant proteases also find use in numerous applications.
摘要翻译： 本发明提供了具有多个取代的新型微球菌spp丝氨酸蛋白酶。 特别地，本发明提供了具有多个取代的丝氨酸蛋白酶，编码这些蛋白酶的DNA，包含编码蛋白酶的DNA的载体，用载体DNA转化的宿主细胞和由宿主细胞产生的酶。 本发明还提供了清洁组合物（例如洗涤剂组合物），动物饲料组合物以及包含这些丝氨酸蛋白酶变体的纺织和皮革加工组合物。 在特别优选的实施方案中，本发明提供衍生自本文所述的野生型蛋白酶的突变体（即，变体）蛋白酶。 这些变体蛋白酶也可用于许多应用。
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公开(公告)号：US20110251116A1
公开(公告)日：2011-10-13
申请号：US13162104
申请日：2011-06-16
申请人： Wolfgang Aehle , David A. Estell , Ronaldus W.J. Hommes , Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Andrew Shaw , Wilhelmus A.H. Van der Kley , Leonardus P.M. Van Marrewijk
发明人： Wolfgang Aehle , David A. Estell , Ronaldus W.J. Hommes , Brian E. Jones , Marc Kolkman , Chris Leeflang , Hiroshi Oh , Ayrookaran J. Poulose , Andrew Shaw , Wilhelmus A.H. Van der Kley , Leonardus P.M. Van Marrewijk
CPC分类号： C12N9/52 , A23K20/189 , A23K50/75 , C11D3/386 , C12N9/96 , C12Y304/21 , D06M16/003
摘要： The present invention provides novel Micrococcineae spp serine proteases having multiple substitutions. In particular, the present invention provides serine proteases having multiple substitutions, DNA encoding these proteases, vectors comprising the DNA encoding the proteases, host cells transformed with the vector DNA, and enzymes produced by the host cells. The present invention also provides cleaning compositions (e.g., detergent compositions), animal feed compositions, and textile and leather processing compositions comprising these serine protease variants. In particularly preferred embodiments, the present invention provides mutant (i.e., variant) proteases derived from the wild-type proteases described herein. These variant proteases also find use in numerous applications.
摘要翻译： 本发明提供了具有多个取代的新型微球菌spp丝氨酸蛋白酶。 特别地，本发明提供了具有多个取代的丝氨酸蛋白酶，编码这些蛋白酶的DNA，包含编码蛋白酶的DNA的载体，用载体DNA转化的宿主细胞和由宿主细胞产生的酶。 本发明还提供了清洁组合物（例如洗涤剂组合物），动物饲料组合物以及包含这些丝氨酸蛋白酶变体的纺织和皮革加工组合物。 在特别优选的实施方案中，本发明提供衍生自本文所述的野生型蛋白酶的突变体（即，变体）蛋白酶。 这些变体蛋白酶也可用于许多应用。
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公开(公告)号：US20120014885A1
公开(公告)日：2012-01-19
申请号：US11919717
申请日：2006-04-25
申请人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita Van Kimmenade , Gudrun Vogtentanz
发明人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita Van Kimmenade , Gudrun Vogtentanz
IPC分类号： A61K8/64 , A61Q17/04 , A61Q5/00 , A61Q1/02 , A61Q19/10 , A61Q1/10 , A61K38/08 , A61K38/16 , A61Q7/02 , C07K19/00 , A61Q15/00 , A61Q1/06
CPC分类号： A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
摘要： The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments, the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. In alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.
摘要翻译： 本发明提供用于治疗各种疾病和病症的肽和负载肽。 在特别优选的实施方案中，本发明提供用于个人护理的组合物和方法。 在一些实施方案中，本发明提供用于皮肤和/或头发护理以及化妆品组合物的组合物。 在替代的特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载的肽，例如红斑痤疮。 在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。 在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。 在一些最优选的实施方案中，支架蛋白包含BBI。
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公开(公告)号：US09084734B2
公开(公告)日：2015-07-21
申请号：US11919717
申请日：2006-04-25
申请人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita van Kimmenade , Gudrun Vogtentanz
发明人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita van Kimmenade , Gudrun Vogtentanz
IPC分类号： A61K8/02 , A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
CPC分类号： A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
摘要： The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. IN alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.
摘要翻译： 本发明提供用于治疗各种疾病和病症的肽和负载肽。 在特别优选的实施方案中，本发明提供用于个人护理的组合物和方法。 在一些实施方案中，本发明提供用于皮肤和/或毛发护理以及化妆品组合物的组合物。 在替代的特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载的肽，例如红斑痤疮。 在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。 在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。 在一些最优选的实施方案中，支架蛋白包含BBI。
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9.发明授权公开(公告)号：US08153412B2
公开(公告)日：2012-04-10
申请号：US12264006
申请日：2008-11-03
申请人： Claudine Y. Chang , Clement Choy , Melodie Estabrook , Mansi Goyal , Thomas P. Graycar , Victoria E. Huang , Brian E. Jones , Marc Kolkman , Karsten M. Kragh , Chris Leeflang , Scott D. Power , Sandra W. Ramer , Andrew Shaw , Casper Vroemen , Walter Weyler
发明人： Claudine Y. Chang , Clement Choy , Melodie Estabrook , Mansi Goyal , Thomas P. Graycar , Victoria E. Huang , Brian E. Jones , Marc Kolkman , Karsten M. Kragh , Chris Leeflang , Scott D. Power , Sandra W. Ramer , Andrew Shaw , Casper Vroemen , Walter Weyler
IPC分类号： C12N9/28 , C12N9/26 , C12N9/24 , C12N1/20 , C12N15/00 , A23C17/00 , A23L1/28 , C11D3/02 , C12D3/00 , C12D3/386 , C07H21/04 , C07K1/00
CPC分类号： C11D3/386 , C11D3/38681 , C12N9/2417
摘要： Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased themostability, reduced calcium dependence, increased washing/cleaning performance, and baking ability. Compositions comprising these variants are useful in methods of starch processing, starch liquefaction, fermatation, starch saccharification, cleaning, laundrying, textile desizing, baking, and biofilm removal.
摘要翻译： 芽孢杆菌的变种 TS-23菌株α-淀粉酶表现出改善的酶性能，包括增加其稳定性，降低钙依赖性，提高洗涤/清洁性能和烘烤能力。 包含这些变体的组合物可用于淀粉加工，淀粉液化，粉化，淀粉糖化，清洗，洗衣，纺织品退浆，烘烤和生物膜除去的方法。
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10.发明申请Compositions and Uses for an Alpha-Amylase Polypeptide of Bacillus Species 195 失效芽孢杆菌物种的α-淀粉酶多肽的组成和用途195公开(公告)号：US20100035787A1
公开(公告)日：2010-02-11
申请号：US12519879
申请日：2007-12-06
申请人： Neelam S. Amin , Melodie Estabrook , Brian E. Jones , Marc Kolkman , Casper Vroemen , Walter Weyler
发明人： Neelam S. Amin , Melodie Estabrook , Brian E. Jones , Marc Kolkman , Casper Vroemen , Walter Weyler
IPC分类号： C11D3/386 , C12N15/56 , C12N9/24 , C12N15/75 , C12N1/21 , C11D7/42 , C12S9/00 , C12N15/70 , C12N15/76
CPC分类号： C12N9/2417
摘要： Disclosed herein are compositions comprising an alpha-amylase enzyme obtained from Bacillus sp. no. 195, and methods of using the enzyme to clean surfaces and textiles. Also disclosed are variants of the enzyme with different signal sequences.
摘要翻译： 本文公开了包含从芽孢杆菌属（Bacillus sp。）获得的α-淀粉酶的组合物。 没有。 195，以及使用酶清洁表面和纺织品的方法。 还公开了具有不同信号序列的酶的变体。
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