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公开(公告)号：US20130039964A1
公开(公告)日：2013-02-14
申请号：US13643247
申请日：2011-04-26
申请人： David Avnir , Rachel Ben-Knaz , Rami Pedahzur
发明人： David Avnir , Rachel Ben-Knaz , Rami Pedahzur
IPC分类号： A61K9/00 , A01P1/00 , A01P3/00 , A61P31/04 , A01N37/52 , A61P31/10 , A61P25/00 , A61P17/00 , A61K31/155 , A01N25/08 , A61P31/12
CPC分类号： A61K31/155 , A61K33/34 , A61K33/38 , A61K45/06 , A61L2/00 , B01J31/12 , C02F1/50 , C02F1/505 , C08K9/10 , A61K2300/00
摘要： The present invention provides composites comprising at least one bioactive agent entrapped within a matrix of at least one metal; wherein said composite controllably releases at least one of said bioactive agent and metal or ion thereof, processes for the preparation of composites of the invention, compositions and products comprising composites of the invention and various uses thereof.
摘要翻译： 本发明提供复合材料，其包含截留在至少一种金属的基体内的至少一种生物活性剂; 其中所述复合物可控地释放所述生物活性剂和金属或其离子中的至少一种，制备本发明复合材料的方法，包含本发明复合材料的组合物和产品及其各种用途。
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公开(公告)号：US09289402B2
公开(公告)日：2016-03-22
申请号：US13643247
申请日：2011-04-26
申请人： David Avnir , Rachel Ben-Knaz , Rami Pedahzur
发明人： David Avnir , Rachel Ben-Knaz , Rami Pedahzur
CPC分类号： A61K31/155 , A61K33/34 , A61K33/38 , A61K45/06 , A61L2/00 , B01J31/12 , C02F1/50 , C02F1/505 , C08K9/10 , A61K2300/00
摘要： The present invention provides composites comprising at least one bioactive agent entrapped within a matrix of at least one metal; wherein said composite controllably releases at least one of said bioactive agent and metal or ion thereof, processes for the preparation of composites of the invention, compositions and products comprising composites of the invention and various uses thereof.
摘要翻译： 本发明提供复合材料，其包含截留在至少一种金属的基体内的至少一种生物活性剂; 其中所述复合物可控地释放所述生物活性剂和金属或其离子中的至少一种，制备本发明复合材料的方法，包含本发明复合材料的组合物和产品及其各种用途。
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公开(公告)号：US20080262321A1
公开(公告)日：2008-10-23
申请号：US11659635
申请日：2005-08-04
申请人： Mendy Erad , Yosi Shacham-Diamand , Shimshon Belkin , Arthur Rabner , Yariv Erad , Rami Pedahzur , Yehuda Yarmut
发明人： Mendy Erad , Yosi Shacham-Diamand , Shimshon Belkin , Arthur Rabner , Yariv Erad , Rami Pedahzur , Yehuda Yarmut
CPC分类号： G01N21/253 , B01L3/5027 , B01L3/50273 , B01L7/52 , B01L2200/10 , B01L2300/023 , B01L2300/0654 , B01L2400/0406 , B01L2400/0424 , B01L2400/0457 , B01L2400/049 , B01L2400/0683 , F24F3/16 , F24F2221/44 , G01N1/2273 , G01N21/6454 , G01N35/00871 , G01N35/08 , G01N2001/021 , G01N2001/022 , G01N2201/0826 , G01N2201/0833 , Y02A90/26
摘要： A portable system for detecting agents present in a sample is disclosed. The system comprises a sensing device, having a substrate formed with a plurality of reaction chambers and a plurality of channels interconnecting at least a portion of the plurality of reaction chambers, wherein at least a portion of the plurality of reaction chambers comprises a sensor, capable of generating a detectable signal when exposed to the agents. The system further comprises a detector, which receives signals from the sensing device and provides an image of sensors generating the optical signals. The portable system is connected to a communication network via a communication unit.
摘要翻译： 公开了一种用于检测样品中存在的试剂的便携式系统。 该系统包括感测装置，其具有形成有多个反应室的基板和互连多个反应室的至少一部分的多个通道，其中多个反应室的至少一部分包括传感器，能够 当暴露于试剂时产生可检测信号。 该系统还包括检测器，其接收来自感测装置的信号并提供产生光信号的传感器的图像。 便携式系统通过通信单元连接到通信网络。
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公开(公告)号：US20080044844A1
公开(公告)日：2008-02-21
申请号：US10587515
申请日：2005-01-25
申请人： Shimshon Belkin , Rami Pedahzur , Rachel Rosen , Itai Benovici , Yosi Shacham-Diamand , Arthur Rabner , Mark Oksman
发明人： Shimshon Belkin , Rami Pedahzur , Rachel Rosen , Itai Benovici , Yosi Shacham-Diamand , Arthur Rabner , Mark Oksman
CPC分类号： C12Q1/02 , G01N33/5005
摘要： A population of cells is provided. The population of cells comprising at least two subpopulations of cells, wherein a first subpopulation of the at least two subpopulation of cells includes a first reporter expression construct being expressible in a cell of the first subpopulation when exposed to a first analyte and whereas a second subpopulation of the at least two subpopulation of cells includes a second reporter expression construct being expressible in a cell of the second subpopulation when exposed to a second analyte.
摘要翻译： 提供了一组细胞。 包含至少两个细胞亚群的细胞群体，其中所述至少两个亚群亚群的第一亚群包括当暴露于第一分析物时可在第一亚群的细胞中表达的第一报道基因表达构建体，而第二亚群 的至少两个细胞亚群包括当暴露于第二分析物时可在第二亚群的细胞中表达的第二报道基因表达构建体。
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公开(公告)号：US20070281288A1
公开(公告)日：2007-12-06
申请号：US10587516
申请日：2005-01-25
申请人： Shimshon Belkin , Rami Pedahzur , Rachel Rosen , Itai Benovici , Yosi Shacham-Diamand , Arthur Rabner , Mark Oksman
发明人： Shimshon Belkin , Rami Pedahzur , Rachel Rosen , Itai Benovici , Yosi Shacham-Diamand , Arthur Rabner , Mark Oksman
CPC分类号： G01N21/6452 , B01L3/502715 , B01L2200/143 , B01L2300/0627 , B01L2300/0819 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/049 , G01N2021/6482 , G01N2021/6484
摘要： A device for detecting a presence of an analyte in a sample. The device comprises a device body configured with at least one reaction chamber configured for containing a sensor capable of producing a detectable signal when exposed to the analyte in the sample. The reaction chambers are in fluid communication with at least one sample port and at least one actuator port via a first set of microfluidic channels arranged such that application of a negative pressure to actuator port delivers fluid placed in the sample port to the reaction chambers.
摘要翻译： 用于检测样品中分析物的存在的装置。 该装置包括装置本体，其配置有至少一个反应室，该反应室被配置用于容纳当暴露于样品中的分析物时能产生可检测信号的传感器。 反应室通过第一组微流体通道与至少一个样品端口和至少一个致动器端口流体连通，其布置成使得向致动器端口施加负压将放置在样品端口中的流体输送到反应室。
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公开(公告)号：US20110155587A1
公开(公告)日：2011-06-30
申请号：US12981592
申请日：2010-12-30
申请人： Yosi Shacham-Diamand , Hadar Ben-Yoav , Shimshon Belkin , Rami Pedahzur , Alva Biran , Georg Reifferscheid , Sebastian Buchinger
发明人： Yosi Shacham-Diamand , Hadar Ben-Yoav , Shimshon Belkin , Rami Pedahzur , Alva Biran , Georg Reifferscheid , Sebastian Buchinger
IPC分类号： G01N27/416 , G01N27/403 , G01N27/26 , H01R43/00 , C12N15/63 , C12N1/21
CPC分类号： G01N27/403 , B33Y80/00 , Y10T29/49117
摘要： A system for analyzing a liquid is provided. The system comprises: an electrochemical unit having an electrochemical microchamber for receiving a sample of the liquid and electrochemically analyzing the sample; and a microfluidic unit being attached to the electrochemical unit and having microchannels constituted for sampling the sample in situ and feeding the sample to the electrochemical microchamber. Also provided are nucleic acid constructs and cells comprising same for analyte detection.
摘要翻译： 提供了用于分析液体的系统。 该系统包括：具有用于接收液体样品并电化学分析样品的电化学微室的电化学单元; 以及微流体单元，其连接到电化学单元并且具有构造用于原位取样和将样品送入电化学微室的微通道。 还提供了核酸构建体和包含用于分析物检测的细胞的细胞。
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公开(公告)号：US08702959B2
公开(公告)日：2014-04-22
申请号：US12981592
申请日：2010-12-30
申请人： Yosi Shacham-Diamand , Hadar Ben-Yoav , Shimshon Belkin , Rami Pedahzur , Alva Biran , Georg Reifferscheid , Sebastian Buchinger
发明人： Yosi Shacham-Diamand , Hadar Ben-Yoav , Shimshon Belkin , Rami Pedahzur , Alva Biran , Georg Reifferscheid , Sebastian Buchinger
CPC分类号： G01N27/403 , B33Y80/00 , Y10T29/49117
摘要： A system for analyzing a liquid is provided. The system comprises: an electrochemical unit having an electrochemical microchamber for receiving a sample of the liquid and electrochemically analyzing the sample; and a microfluidic unit being attached to the electrochemical unit and having microchannels constituted for sampling the sample in situ and feeding the sample to the electrochemical microchamber. Also provided are nucleic acid constructs and cells comprising same for analyte detection.
摘要翻译： 提供了用于分析液体的系统。 该系统包括：具有用于接收液体样品并电化学分析样品的电化学微室的电化学单元; 以及微流体单元，其连接到电化学单元并且具有构造用于原位取样和将样品送入电化学微室的微通道。 还提供了核酸构建体和包含用于分析物检测的细胞的细胞。
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公开(公告)号：US20080255431A1
公开(公告)日：2008-10-16
申请号：US11659644
申请日：2005-08-04
申请人： Mendy Erad , Yosi Shacham-Diamand , Shimshon Belkin , Arthur Rabner , Yariv Erad , Rami Pedahzur , Yehuda Yarmut
发明人： Mendy Erad , Yosi Shacham-Diamand , Shimshon Belkin , Arthur Rabner , Yariv Erad , Rami Pedahzur , Yehuda Yarmut
CPC分类号： G08B21/12
摘要： A method of detecting the presence of harmful agents in the environment is disclosed. The method comprises: providing a plurality of portable agent detectors, placing the detectors on vectors in the environment, connecting the detectors over a communication network, and, upon detection of an agent by a first detector, signaling detectors identified as being nearby to carry out corresponding agent detection tests, thereby to confirm or localize an initial agent detection.
摘要翻译： 公开了一种在环境中检测有害物质的存在的方法。 该方法包括：提供多个便携式代理检测器，将检测器放置在环境中的向量上，通过通信网络连接检测器，并且在通过第一检测器检测到代理时，识别为附近的信令检测器执行 相应的代理检测测试，从而确认或本地化初始代理检测。
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