Cosmid DNA constructs and methods of making and using same
    5.
    发明授权
    Cosmid DNA constructs and methods of making and using same 有权
    粘粒DNA构建体及其制备和使用方法

    公开(公告)号:US08529884B2

    公开(公告)日:2013-09-10

    申请号:US10168694

    申请日:2000-12-22

    IPC分类号: A01N63/00 A01N43/04

    摘要: Methods of inducing immune responses in individuals against a pathogen are disclosed. Methods of treating individuals susceptible to or suffering from a disease associated with a genetic defect which results in the non-production or under production of a protein or the production of a non-functioning or partially functioning protein are disclosed. Methods of delivering a protein to an individual are disclosed. Pharmaceutical compositions that comprise cosmids are disclosed.

    摘要翻译: 公开了在针对病原体的个体中诱导免疫应答的方法。 公开了治疗导致非生产或正在产生蛋白质或产生不起作用或部分功能的蛋白质的遗传缺陷相关疾病或患有疾病的个体的方法。 公开了向个体递送蛋白质的方法。 公开了包含粘粒的药物组合物。

    Expression system for cloning toxic genes
    6.
    发明授权
    Expression system for cloning toxic genes 有权
    用于克隆有毒基因的表达系统

    公开(公告)号:US06881558B1

    公开(公告)日:2005-04-19

    申请号:US09888860

    申请日:2001-06-25

    CPC分类号: C12N15/72

    摘要: Methods of cloning and/or amplifying toxic genes in bacteria using a vector which amplifies the toxic gene in bacteria and also allows subsequent expression in mammalian systems is provided. A vector having an origin of replication, a first promoter, a polylinker, a second promoter in reverse orientation with respect to the first promoter, a poly adenylation signal, and a gene encoding a selectable marker, and optionally an enhancer operably connected to the first promoter, and/or a nucleotide sequence encoding a toxic protein is also provided.

    摘要翻译: 使用扩增细菌中的毒性基因并允许随后在哺乳动物系统中表达的载体来克隆和/或扩增细菌中的有毒基因的方法。 具有复制起点的载体,第一启动子,多接头体,相对于第一启动子反向取向的第二启动子,多腺苷酸化信号和编码可选择标记的基因,以及任选地可增强的与第一启动子连接的增强子 启动子,和/或编码毒性蛋白质的核苷酸序列。

    Cosmid dna constructs and methods of making and using same
    7.
    发明申请
    Cosmid dna constructs and methods of making and using same 有权
    粘粒dna构建及其制作和使用方法

    公开(公告)号:US20080219953A1

    公开(公告)日:2008-09-11

    申请号:US10168694

    申请日:2000-12-22

    摘要: Methods of inducing immune responses in individuals against a pathogen are disclosed. Methods of treating individuals susceptible to or suffering from a disease associated with a genetic defect which results in the non-production or under production of a protein or the production of a non-functioning or partially functioning protein are disclosed. Methods of delivering a protein to an individual are disclosed. Pharmaceutical compositions that comprise cosmids are disclosed.

    摘要翻译: 公开了在针对病原体的个体中诱导免疫应答的方法。 公开了治疗导致非生产或正在产生蛋白质或产生不起作用或部分功能的蛋白质的遗传缺陷相关疾病或患有疾病的个体的方法。 公开了向个体递送蛋白质的方法。 公开了包含粘粒的药物组合物。

    Handwritten input for Asian languages
    8.
    发明申请
    Handwritten input for Asian languages 审中-公开
    亚洲语言的手写输入

    公开(公告)号:US20050276480A1

    公开(公告)日:2005-12-15

    申请号:US10870535

    申请日:2004-06-18

    IPC分类号: G06F3/01 G06K9/18 G09G5/00

    CPC分类号: G06F3/018

    摘要: A system and process for helping users enter information in an Asian language is described. In some aspects, input for simplified Chinese and other languages is described with respect to handwritten input.

    摘要翻译: 描述了一种帮助用户输入亚洲语言信息的系统和过程。 在一些方面,针对手写输入描述了简体中文和其他语言的输入。

    Polymer synthesis from macrocycles
    10.
    发明申请
    Polymer synthesis from macrocycles 有权
    大分子合成聚合物

    公开(公告)号:US20070083019A1

    公开(公告)日:2007-04-12

    申请号:US11545092

    申请日:2006-10-06

    IPC分类号: C08F4/06

    摘要: A synthetic route is provided to prepare poly(ω-hydroxycarboxylic acid) polymers via the ring-opening polymerization of ω-hydroxycarboxylic acid cyclic oligomers. The cyclic oligomers can be prepared directly from biorenewable sources, such as 3-hydroxypropionic acid. The method can be used to prepare high molecular weight polymers from the cyclic oligomers. Good molecular weight control can be obtained for both solution state and melt polymerizations.

    摘要翻译: 提供合成途径以通过ω-羟基羧酸环状低聚物的开环聚合制备聚(ω-羟基羧酸)聚合物。 环状低聚物可以直接从生物可再生来源例如3-羟基丙酸制备。 该方法可用于从环状低聚物制备高分子量聚合物。 对于溶液状态和熔融聚合都可以获得良好的分子量控制。