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公开(公告)号:US20120230945A1
公开(公告)日:2012-09-13
申请号:US13422864
申请日:2012-03-16
IPC分类号: A61K39/395 , A61P37/02 , C07K16/18 , C12N5/02 , A61K38/20
CPC分类号: C12N15/86 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55522 , A61K2039/55555 , A61K2039/6031 , C07K14/005 , C07K14/475 , C07K14/70596 , C07K2319/00 , C07K2319/33 , C12N2740/16043 , C12N2740/16045 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2810/855
摘要: Drug delivery compositions and methods of delivering compounds are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
摘要翻译: 公开了递送组合物和递送化合物的方法。 公开了免疫个体的疫苗和方法。 公开了用于药物递送的组合物,包括基因治疗和使用这些组合物治疗个体的方法。
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公开(公告)号:US08216585B2
公开(公告)日:2012-07-10
申请号:US10478896
申请日:2002-05-28
CPC分类号: C12N15/86 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55522 , A61K2039/55555 , A61K2039/6031 , C07K14/005 , C07K14/475 , C07K14/70596 , C07K2319/00 , C07K2319/33 , C12N2740/16043 , C12N2740/16045 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2810/855
摘要: Drug delivery compositions and methods of delivering compounds into a cell or into an individual are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
摘要翻译: 公开了将化合物递送到细胞或个体中的药物递送组合物和方法。 公开了免疫个体的疫苗和方法。 公开了用于药物递送的组合物,包括基因治疗和使用这些组合物治疗个体的方法。
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公开(公告)号:US08637042B2
公开(公告)日:2014-01-28
申请号:US13422864
申请日:2012-03-16
IPC分类号: A61K39/21 , A61K39/385 , A61K39/00 , C12P21/04 , C12N5/10
CPC分类号: C12N15/86 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55522 , A61K2039/55555 , A61K2039/6031 , C07K14/005 , C07K14/475 , C07K14/70596 , C07K2319/00 , C07K2319/33 , C12N2740/16043 , C12N2740/16045 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2810/855
摘要: Drug delivery compositions and methods of delivering compounds are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
摘要翻译: 公开了递送组合物和递送化合物的方法。 公开了免疫个体的疫苗和方法。 公开了用于药物递送的组合物,包括基因治疗和使用这些组合物治疗个体的方法。
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公开(公告)号:US20050054104A1
公开(公告)日:2005-03-10
申请号:US10478896
申请日:2002-05-28
IPC分类号: A61K39/00 , C07K14/16 , C07K14/475 , C12N15/867 , C12N15/861
CPC分类号: C12N15/86 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55522 , A61K2039/55555 , A61K2039/6031 , C07K14/005 , C07K14/475 , C07K14/70596 , C07K2319/00 , C07K2319/33 , C12N2740/16043 , C12N2740/16045 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2810/855
摘要: Drug delivery compositions and methods of delivering compounds to are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
摘要翻译: 药物递送组合物和递送化合物的方法被公开。 公开了免疫个体的疫苗和方法。 公开了用于药物递送的组合物,包括基因治疗和使用这些组合物治疗个体的方法。
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公开(公告)号:US08529884B2
公开(公告)日:2013-09-10
申请号:US10168694
申请日:2000-12-22
申请人: David B. Weiner , Jeong-Im Sin , Donghui Zhang
发明人: David B. Weiner , Jeong-Im Sin , Donghui Zhang
CPC分类号: A61K39/00 , A61K39/12 , A61K39/245 , A61K48/00 , A61K2039/53 , A61K2039/54 , C12N2710/16634
摘要: Methods of inducing immune responses in individuals against a pathogen are disclosed. Methods of treating individuals susceptible to or suffering from a disease associated with a genetic defect which results in the non-production or under production of a protein or the production of a non-functioning or partially functioning protein are disclosed. Methods of delivering a protein to an individual are disclosed. Pharmaceutical compositions that comprise cosmids are disclosed.
摘要翻译: 公开了在针对病原体的个体中诱导免疫应答的方法。 公开了治疗导致非生产或正在产生蛋白质或产生不起作用或部分功能的蛋白质的遗传缺陷相关疾病或患有疾病的个体的方法。 公开了向个体递送蛋白质的方法。 公开了包含粘粒的药物组合物。
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公开(公告)号:US06881558B1
公开(公告)日:2005-04-19
申请号:US09888860
申请日:2001-06-25
申请人: David B. Weiner , Donghui Zhang , Adam Cohen
发明人: David B. Weiner , Donghui Zhang , Adam Cohen
CPC分类号: C12N15/72
摘要: Methods of cloning and/or amplifying toxic genes in bacteria using a vector which amplifies the toxic gene in bacteria and also allows subsequent expression in mammalian systems is provided. A vector having an origin of replication, a first promoter, a polylinker, a second promoter in reverse orientation with respect to the first promoter, a poly adenylation signal, and a gene encoding a selectable marker, and optionally an enhancer operably connected to the first promoter, and/or a nucleotide sequence encoding a toxic protein is also provided.
摘要翻译: 使用扩增细菌中的毒性基因并允许随后在哺乳动物系统中表达的载体来克隆和/或扩增细菌中的有毒基因的方法。 具有复制起点的载体,第一启动子,多接头体,相对于第一启动子反向取向的第二启动子,多腺苷酸化信号和编码可选择标记的基因,以及任选地可增强的与第一启动子连接的增强子 启动子,和/或编码毒性蛋白质的核苷酸序列。
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公开(公告)号:US20080219953A1
公开(公告)日:2008-09-11
申请号:US10168694
申请日:2000-12-22
申请人: David B. Weiner , Jeong-Im Sin , Donghui Zhang
发明人: David B. Weiner , Jeong-Im Sin , Donghui Zhang
IPC分类号: A61K48/00 , A61K31/445 , C12N15/86
CPC分类号: A61K39/00 , A61K39/12 , A61K39/245 , A61K48/00 , A61K2039/53 , A61K2039/54 , C12N2710/16634
摘要: Methods of inducing immune responses in individuals against a pathogen are disclosed. Methods of treating individuals susceptible to or suffering from a disease associated with a genetic defect which results in the non-production or under production of a protein or the production of a non-functioning or partially functioning protein are disclosed. Methods of delivering a protein to an individual are disclosed. Pharmaceutical compositions that comprise cosmids are disclosed.
摘要翻译: 公开了在针对病原体的个体中诱导免疫应答的方法。 公开了治疗导致非生产或正在产生蛋白质或产生不起作用或部分功能的蛋白质的遗传缺陷相关疾病或患有疾病的个体的方法。 公开了向个体递送蛋白质的方法。 公开了包含粘粒的药物组合物。
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公开(公告)号:US20050276480A1
公开(公告)日:2005-12-15
申请号:US10870535
申请日:2004-06-18
申请人: Dong Li , Donghui Zhang , Yong Zhang
发明人: Dong Li , Donghui Zhang , Yong Zhang
CPC分类号: G06F3/018
摘要: A system and process for helping users enter information in an Asian language is described. In some aspects, input for simplified Chinese and other languages is described with respect to handwritten input.
摘要翻译: 描述了一种帮助用户输入亚洲语言信息的系统和过程。 在一些方面,针对手写输入描述了简体中文和其他语言的输入。
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公开(公告)号:US20050201986A1
公开(公告)日:2005-09-15
申请号:US11123600
申请日:2005-05-06
申请人: David Weiner , Jong Kim , Donghui Zhang
发明人: David Weiner , Jong Kim , Donghui Zhang
IPC分类号: C12N15/09 , A61K31/7088 , A61K31/711 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/385 , A61K39/395 , A61K47/48 , A61K48/00 , A61P1/04 , A61P3/10 , A61P5/50 , A61P17/00 , A61P17/06 , A61P25/00 , A61P29/00 , A61P35/00 , C07K14/16 , C07K14/28 , C07K19/00 , C12N5/10 , C12N15/34 , A61K9/127 , C12N15/86
CPC分类号: A61K39/0011 , A61K39/12 , A61K39/21 , A61K2039/5152 , A61K2039/5156 , A61K2039/53 , A61K2039/545 , A61K2039/55516 , A61K2039/55522 , A61K2039/57 , C12N2740/15034 , C12N2740/16034
摘要: Drug delivery compositions and methods of delivering compounds to specific cell types are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
摘要翻译: 公开了将化合物递送到特定细胞类型的药物递送组合物和方法。 公开了免疫个体的疫苗和方法。 公开了用于药物递送的组合物,包括基因治疗和使用这些组合物治疗个体的方法。
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公开(公告)号:US20070083019A1
公开(公告)日:2007-04-12
申请号:US11545092
申请日:2006-10-06
申请人: Donghui Zhang , William Tolman , Marc Hillmyer
发明人: Donghui Zhang , William Tolman , Marc Hillmyer
IPC分类号: C08F4/06
CPC分类号: C08G65/22 , C08G63/08 , C08G63/823
摘要: A synthetic route is provided to prepare poly(ω-hydroxycarboxylic acid) polymers via the ring-opening polymerization of ω-hydroxycarboxylic acid cyclic oligomers. The cyclic oligomers can be prepared directly from biorenewable sources, such as 3-hydroxypropionic acid. The method can be used to prepare high molecular weight polymers from the cyclic oligomers. Good molecular weight control can be obtained for both solution state and melt polymerizations.
摘要翻译: 提供合成途径以通过ω-羟基羧酸环状低聚物的开环聚合制备聚(ω-羟基羧酸)聚合物。 环状低聚物可以直接从生物可再生来源例如3-羟基丙酸制备。 该方法可用于从环状低聚物制备高分子量聚合物。 对于溶液状态和熔融聚合都可以获得良好的分子量控制。
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