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公开(公告)号：US20120230945A1
公开(公告)日：2012-09-13
申请号：US13422864
申请日：2012-03-16
IPC分类号： A61K39/395 , A61P37/02 , C07K16/18 , C12N5/02 , A61K38/20
CPC分类号： C12N15/86 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55522 , A61K2039/55555 , A61K2039/6031 , C07K14/005 , C07K14/475 , C07K14/70596 , C07K2319/00 , C07K2319/33 , C12N2740/16043 , C12N2740/16045 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2810/855
摘要： Drug delivery compositions and methods of delivering compounds are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
摘要翻译： 公开了递送组合物和递送化合物的方法。 公开了免疫个体的疫苗和方法。 公开了用于药物递送的组合物，包括基因治疗和使用这些组合物治疗个体的方法。
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公开(公告)号：US08216585B2
公开(公告)日：2012-07-10
申请号：US10478896
申请日：2002-05-28
CPC分类号： C12N15/86 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55522 , A61K2039/55555 , A61K2039/6031 , C07K14/005 , C07K14/475 , C07K14/70596 , C07K2319/00 , C07K2319/33 , C12N2740/16043 , C12N2740/16045 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2810/855
摘要： Drug delivery compositions and methods of delivering compounds into a cell or into an individual are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
摘要翻译： 公开了将化合物递送到细胞或个体中的药物递送组合物和方法。 公开了免疫个体的疫苗和方法。 公开了用于药物递送的组合物，包括基因治疗和使用这些组合物治疗个体的方法。
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3.发明申请FOOT AND MOUTH DISEASE VIRUS (FMDV) CONSENSUS PROTEINS, CODING SEQUENCES THEREFOR AND VACCINES MADE THEREFROM 有权FOOD和MOUD疾病病毒（FMDV）共识蛋白，其编码序列及其制备的疫苗公开(公告)号：US20120282217A1
公开(公告)日：2012-11-08
申请号：US13503828
申请日：2010-11-02
申请人： David B. Weiner , Bernadette Ferraro , Jian Yan , Patricia A. Brown , Rodney A. Bowling , Douglas R. Kern , Mathura P. Ramanathan , Niranjan Y. Sardesai , Karuppiah Muthumani
发明人： David B. Weiner , Bernadette Ferraro , Jian Yan , Patricia A. Brown , Rodney A. Bowling , Douglas R. Kern , Mathura P. Ramanathan , Niranjan Y. Sardesai , Karuppiah Muthumani
IPC分类号： A61K39/135 , C12N15/62 , C12N15/57 , C12N15/63 , A61M37/00 , C07K14/09 , C07K19/00 , C12N9/50 , C12Q1/70 , G01N33/569 , C12N15/42 , A61K38/20
CPC分类号： C07K14/005 , A61K39/12 , A61K39/135 , A61K39/39 , A61K2039/523 , A61K2039/53 , A61K2039/552 , A61M37/00 , A61N1/327 , C12N7/00 , C12N2770/32122 , C12N2770/32134 , G01N33/56983 , G01N2333/09 , G01N2469/20
摘要： Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
摘要翻译： 本文提供的是包含FMDV亚型A，亚洲1，C，O，SAT1，SAT2和SAT3的口蹄疫FMDV VP1-4外壳蛋白的共有氨基酸序列的核酸，以及表达 序列。 本文还提供了使用上述疫苗产生针对一种或多种FMDV亚型的免疫应答的方法以及用疫苗接种的哺乳动物和用FMDV感染的哺乳动物之间进行解密的方法。
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4.发明授权Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom 有权口蹄疫病毒（FMDV）共有蛋白质，其编码序列和由其制备的疫苗公开(公告)号：US09109014B2
公开(公告)日：2015-08-18
申请号：US13503828
申请日：2010-11-02
申请人： David B Weiner , Bernadette Ferraro , Jian Yan , Patricia A Brown , Rodney A Bowling , Douglas R Kern , Mathura P Ramanathan , Niranjan Y Sardesai , Karuppiah Muthumani
发明人： David B Weiner , Bernadette Ferraro , Jian Yan , Patricia A Brown , Rodney A Bowling , Douglas R Kern , Mathura P Ramanathan , Niranjan Y Sardesai , Karuppiah Muthumani
IPC分类号： A61K39/12 , C07K14/005 , A61K39/135 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/135 , A61K39/39 , A61K2039/523 , A61K2039/53 , A61K2039/552 , A61M37/00 , A61N1/327 , C12N7/00 , C12N2770/32122 , C12N2770/32134 , G01N33/56983 , G01N2333/09 , G01N2469/20
摘要： Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
摘要翻译： 本文提供的是包含FMDV亚型A，亚洲1，C，O，SAT1，SAT2和SAT3的口蹄疫FMDV VP1-4外壳蛋白的共有氨基酸序列的核酸，以及表达 序列。 本文还提供了使用上述疫苗产生针对一种或多种FMDV亚型的免疫应答的方法以及用疫苗接种的哺乳动物和用FMDV感染的哺乳动物之间进行解密的方法。
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公开(公告)号：US08637042B2
公开(公告)日：2014-01-28
申请号：US13422864
申请日：2012-03-16
IPC分类号： A61K39/21 , A61K39/385 , A61K39/00 , C12P21/04 , C12N5/10
CPC分类号： C12N15/86 , A61K39/00 , A61K39/0011 , A61K2039/505 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55522 , A61K2039/55555 , A61K2039/6031 , C07K14/005 , C07K14/475 , C07K14/70596 , C07K2319/00 , C07K2319/33 , C12N2740/16043 , C12N2740/16045 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2810/855
摘要： Drug delivery compositions and methods of delivering compounds are disclosed. Vaccines and methods of immunizing individuals are disclosed. Compositions for drug delivery including gene therapy and methods of treating individuals using such compositions are disclosed.
摘要翻译： 公开了递送组合物和递送化合物的方法。 公开了免疫个体的疫苗和方法。 公开了用于药物递送的组合物，包括基因治疗和使用这些组合物治疗个体的方法。
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6.发明授权Genetic constructs and compositions comprising RRE and CTE and uses thereof 有权包含RRE和CTE的遗传构建体和组合物及其用途公开(公告)号：US07455841B2
公开(公告)日：2008-11-25
申请号：US10535326
申请日：2003-11-19
IPC分类号： A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N2740/16122 , C12N2740/16134 , C12N2740/16322 , C12N2740/16334
摘要： Genetic constructs that comprise a coding sequence for HIV-1 Rev, and a coding sequence for a desired protein are disclosed. Compositions that comprise at least two nucleic acid molecules in which at least one nucleic acid molecule comprises a coding sequence for HIV-1 Rev, and at least one nucleic acid molecule comprises a coding sequence for a desired protein are disclosed. In such genetic constructs and compositions comprising nucleic acid molecules, the coding sequence for the desired protein comprises at least a portion of coding sequence for an HIV structural protein that includes an RRE and at least one CTE. Methods of inducing an immune response against an immunogen in an individual, methods of delivering proteins to an individual and methods of producing proteins are also disclosed.
摘要翻译： 公开了包含HIV-1 Rev编码序列的遗传构建体和所需蛋白质的编码序列。 包含至少两个核酸分子的组合物，其中至少一个核酸分子包含HIV-1 Rev的编码序列，并且至少一个核酸分子包含所需蛋白质的编码序列。 在包含核酸分子的这种遗传构建体和组合物中，所需蛋白质的编码序列包含HIV结构蛋白的编码序列的至少一部分，其包括RRE和至少一种CTE。 还公开了诱导针对个体免疫原的免疫应答的方法，将蛋白递送给个体的方法和生产蛋白质的方法。
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公开(公告)号：US10226528B2
公开(公告)日：2019-03-12
申请号：US14774428
申请日：2014-03-14
IPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , C07K14/52 , C12N7/00 , A61K41/00 , C07K14/47 , A61K39/00
摘要： Disclosed herein is a vaccine comprising an antigen and one or more bimolecular adjuvant. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
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8.发明申请GENETIC CONSTRUCTS AND COMPOSITIONS COMPRISING RRE AND CTE AND USES THEREOF 有权包含RRE和CTE的遗传构建体和组合物及其用途公开(公告)号：US20090170800A1
公开(公告)日：2009-07-02
申请号：US12275192
申请日：2008-11-20
IPC分类号： A61K31/7088 , C12N15/63 , C12P21/06
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N2740/16122 , C12N2740/16134 , C12N2740/16322 , C12N2740/16334
摘要： Genetic constructs that comprise a coding sequence for HIV-1 Rev, and a coding sequence for a desired protein are disclosed. Compositions that comprise at least two nucleic acid molecules in which at least one nucleic acid molecule comprises a coding sequence for HIV-1 Rev, and at least one nucleic acid molecule comprises a coding sequence for a desired protein are disclosed. In such genetic constructs and compositions comprising nucleic acid molecules, the coding sequence for the desired protein comprises at least a portion of coding sequence for an HIV structural protein that includes an RRE and at least one CTE. Methods of inducing an immune response against an immunogen in an individual, methods of delivering proteins to an individual and methods of producing proteins are also disclosed.
摘要翻译： 公开了包含HIV-1 Rev编码序列的遗传构建体和所需蛋白质的编码序列。 包含至少两个核酸分子的组合物，其中至少一个核酸分子包含HIV-1 Rev的编码序列，并且至少一个核酸分子包含所需蛋白质的编码序列。 在包含核酸分子的这种遗传构建体和组合物中，所需蛋白质的编码序列包含HIV结构蛋白的编码序列的至少一部分，其包括RRE和至少一种CTE。 还公开了诱导针对个体免疫原的免疫应答的方法，将蛋白递送给个体的方法和生产蛋白质的方法。
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公开(公告)号：US20190091322A1
公开(公告)日：2019-03-28
申请号：US16087146
申请日：2017-03-21
申请人： David B. Weiner , Karuppiah Muthumani , Seleeke Flingai , Niranjan Sardesai , Sarah Elliott , Jian Yan , Ami Patel
发明人： David B. Weiner , Karuppiah Muthumani , Seleeke Flingai , Niranjan Sardesai , Sarah Elliott , Jian Yan , Ami Patel
摘要： Disclosed herein is a composition comprising the combination of a nucleic acid sequence encoding a desired polypeptide that elicits an immune response in a mammal and a nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof.
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公开(公告)号：US10155795B2
公开(公告)日：2018-12-18
申请号：US14776516
申请日：2014-03-14
IPC分类号： C07H21/04 , C12N15/09 , C12N15/11 , C12N15/63 , A61P9/10 , C07K14/47 , A61K38/17 , A61K39/00 , A61K41/00 , A61N1/32 , A61K48/00
摘要： Disclosed herein is a therapeutic comprising hypoxia inducible factor-1 alpha (HIF-1α). Also disclosed herein is a method for treating hypoxia or ischemia in a subject in need thereof. The method may comprise administering the vaccine to the subject in need thereof.
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