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1.发明申请公开(公告)号：US20120135535A1
公开(公告)日：2012-05-31
申请号：US13254403
申请日：2010-01-14
申请人： David G. Grier , Fook Chiong Cheong , Ke Xiao
发明人： David G. Grier , Fook Chiong Cheong , Ke Xiao
CPC分类号： G01N15/1475 , G01N15/1429 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N2015/003 , G01N2015/0065 , G01N2015/1445 , G01N2015/1454 , G01N2015/1493 , G01N2015/1497 , G02B21/0056 , G02B21/0068 , G02B21/008 , G03H1/0005 , G03H2001/005
摘要： An in-line holographic microscope can be used to analyze on a frame-by-frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.
摘要翻译： 可以使用在线全息显微镜逐帧分析视频流来跟踪各个胶体颗粒的三维运动。 该系统和方法可以提供实时的纳米分辨率，同时测量粒径和折射率。 通过结合使用Lorenz-Mie分析与选定的硬件和软件方法的组合，该分析可以近乎实时地进行。 有效的粒子识别方法以足够的精度自动进行初始位置估计，以实现无人值守的全息跟踪和表征。
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公开(公告)号：US20130278743A1
公开(公告)日：2013-10-24
申请号：US13883260
申请日：2011-11-04
申请人： Fook Chiong Cheong , Ke Xiao , David Pine , David G. Grier
发明人： Fook Chiong Cheong , Ke Xiao , David Pine , David G. Grier
IPC分类号： G02B21/36
CPC分类号： G01N15/088 , G01N15/08 , G01N15/1463 , G01N21/4133 , G01N21/453 , G01N21/47 , G01N2015/0846 , G02B21/367
摘要： A method for analyzing porosity of a particle and a medium disposed in the porosity of the particle. A video-holographic microscope is provided to analyze interference patterns produced by providing a laser source to output a collimated beam, scattering the collimated beam off a particle and interacting with an unscattered beam to generate the interference pattern for analyzation to determine the refractive index of the particle and a medium disposed in the porosity of the particle to measure porosity and the medium.
摘要翻译： 用于分析颗粒的孔隙率的方法和设置在颗粒的孔隙中的介质。 提供视频全息显微镜以分析通过提供激光源来输出准直光束产生的干涉图案，将准直光束从粒子散射并与未散射光束相互作用以产生用于分析的干涉图案，以确定折射率 颗粒和设置在颗粒孔隙中的介质以测量孔隙度和介质。
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公开(公告)号：US09519129B2
公开(公告)日：2016-12-13
申请号：US13883260
申请日：2011-11-04
申请人： Fook Chiong Cheong , Ke Xiao , David Pine , David G. Grier
发明人： Fook Chiong Cheong , Ke Xiao , David Pine , David G. Grier
CPC分类号： G01N15/088 , G01N15/08 , G01N15/1463 , G01N21/4133 , G01N21/453 , G01N21/47 , G01N2015/0846 , G02B21/367
摘要： A method for analyzing porosity of a particle and a medium disposed in the porosity of the particle. A video-holographic microscope is provided to analyze interference patterns produced by providing a laser source to output a collimated beam, scattering the collimated beam off a particle and interacting with an unscattered beam to generate the interference pattern for analyzation to determine the refractive index of the particle and a medium disposed in the porosity of the particle to measure porosity and the medium.
摘要翻译： 用于分析颗粒的孔隙率的方法和设置在颗粒的孔隙中的介质。 提供视频全息显微镜以分析通过提供激光源来输出准直光束产生的干涉图案，将准直光束从粒子散射并与未散射光束相互作用以产生用于分析的干涉图案，以确定折射率 颗粒和设置在颗粒孔隙中的介质以测量孔隙度和介质。
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4.发明授权公开(公告)号：US09316578B2
公开(公告)日：2016-04-19
申请号：US13254403
申请日：2010-01-14
申请人： David G. Grier , Fook Chiong Cheong , Ke Xiao
发明人： David G. Grier , Fook Chiong Cheong , Ke Xiao
CPC分类号： G01N15/1475 , G01N15/1429 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N2015/003 , G01N2015/0065 , G01N2015/1445 , G01N2015/1454 , G01N2015/1493 , G01N2015/1497 , G02B21/0056 , G02B21/0068 , G02B21/008 , G03H1/0005 , G03H2001/005
摘要： An in-line holographic microscope can be used to analyze on a frame-by-frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.
摘要翻译： 可以使用在线全息显微镜逐帧分析视频流来跟踪各个胶体颗粒的三维运动。 该系统和方法可以提供实时的纳米分辨率，同时测量粒径和折射率。 通过结合使用Lorenz-Mie分析与选定的硬件和软件方法的组合，该分析可以近乎实时地进行。 有效的粒子识别方法以足够的精度自动进行初始位置估计，以实现无人值守的全息跟踪和表征。
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5.发明授权Holographic microscopy of holographically trapped three-dimensional nanorod structures 有权全息捕获的三维纳米棒结构的全息显微镜公开(公告)号：US08331019B2
公开(公告)日：2012-12-11
申请号：US12759839
申请日：2010-04-14
IPC分类号： G02B21/00
CPC分类号： G01B9/021 , G02B21/0088 , G02B21/32 , G03H1/0005 , G03H1/0443 , G03H1/0866 , G03H1/2294 , G03H2001/0033 , G03H2001/0077 , G03H2001/0447
摘要： A method and system for performing three-dimensional holographic microscopy of an optically trapped one dimensional structure. The method and system use an inverted optical microscope, a laser source which generates a trapping laser beam wherein the laser beam is focused by an objective lens into a plurality of optical traps. The method and system also use a collimated laser at an imaging wavelength to illuminate the structure created by the optical traps. Imaging light scattered by the optically tapped structure forms normalized intensity holograms that are imaged by a video camera and analyzed by optical formalisms to determine light field to reconstruct 3-D images for analysis and evaluation.
摘要翻译： 用于执行光学捕获的一维结构的三维全息显微镜的方法和系统。 该方法和系统使用倒置的光学显微镜，产生捕获激光束的激光源，其中激光束被物镜聚焦成多个光阱。 该方法和系统还使用成像波长处的准直激光来照亮由光阱产生的结构。 通过光学抽头结构散射的成像光形成归一化的强度全息图，其由摄像机成像并通过光学形式进行分析，以确定光场以重建用于分析和评估的3-D图像。
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6.发明申请公开(公告)号：US20100253762A1
公开(公告)日：2010-10-07
申请号：US12759839
申请日：2010-04-14
CPC分类号： G01B9/021 , G02B21/0088 , G02B21/32 , G03H1/0005 , G03H1/0443 , G03H1/0866 , G03H1/2294 , G03H2001/0033 , G03H2001/0077 , G03H2001/0447
摘要： A method and system for performing three-dimensional holographic microscopy of an optically trapped one dimensional structure. The method and system use an inverted optical microscope, a laser source which generates a trapping laser beam wherein the laser beam is focused by an objective lens into a plurality of optical traps. The method and system also use a collimated laser at an imaging wavelength to illuminate the structure created by the optical traps. Imaging light scattered by the optically tapped structure forms normalized intensity holograms that are imaged by a video camera and analyzed by optical formalisms to determine light field to reconstruct 3-D images for analysis and evaluation.
摘要翻译： 用于执行光学捕获的一维结构的三维全息显微镜的方法和系统。 该方法和系统使用倒置的光学显微镜，产生捕获激光束的激光源，其中激光束被物镜聚焦成多个光阱。 该方法和系统还使用成像波长处的准直激光来照亮由光阱产生的结构。 通过光学抽头结构散射的成像光形成归一化的强度全息图，其由摄像机成像并通过光学形式进行分析，以确定光场以重建用于分析和评估的3-D图像。
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7.发明申请Sorting Colloidal Particles Into Multiple Channels with Optical Forces: Prismatic Optical Fractionation 有权将胶体颗粒分解成具有光学力的多个通道：棱镜光学分馏公开(公告)号：US20120273664A1
公开(公告)日：2012-11-01
申请号：US13518138
申请日：2010-12-21
申请人： David G. Grier , Ke Xiao
发明人： David G. Grier , Ke Xiao
IPC分类号： H05H3/04
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0454 , B01L2400/0487 , G01N15/1463 , G01N2015/1443 , G01N2015/1454 , G01N2015/149
摘要： A method and system for controlled fractionation of particles. A sample having a plurality of particles of different size distributions. A uniform array for the preparing of optical traps having a selected array lattice constant. The plurality of particles for inputting the plurality of particles to the uniform array of optical traps at a driving direction angle and the plurality of particles separating along different directions based on variable particle attributes.
摘要翻译： 用于粒子控制分馏的方法和系统。 具有不同尺寸分布的多个颗粒的样品。 用于制备具有选定阵列晶格常数的光阱的均匀阵列。 多个粒子，用于以驱动方向角将多个粒子输入到光阱的均匀阵列，并且多个粒子基于可变粒子属性沿着不同方向分离。
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8.发明授权Sorting colloidal particles into multiple channels with optical forces: prismatic optical fractionation 有权将胶体颗粒用光学力分解成多个通道：棱镜光学分级公开(公告)号：US08766169B2
公开(公告)日：2014-07-01
申请号：US13518138
申请日：2010-12-21
申请人： David G. Grier , Ke Xiao
发明人： David G. Grier , Ke Xiao
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0877 , B01L2400/0454 , B01L2400/0487 , G01N15/1463 , G01N2015/1443 , G01N2015/1454 , G01N2015/149
摘要： A method and system for controlled fractionation of particles. A sample having a plurality of particles of different size distributions. A uniform array for the preparing of optical traps having a selected array lattice constant. The plurality of particles for inputting the plurality of particles to the uniform array of optical traps at a driving direction angle Θ and the plurality of particles separating along different directions Θv based on variable particle attributes.
摘要翻译： 用于粒子控制分馏的方法和系统。 具有不同尺寸分布的多个颗粒的样品。 用于制备具有选定阵列晶格常数的光阱的均匀阵列。 多个粒子，用于以驱动方向角θ将多个粒子输入到光阱的均匀阵列，并且多个粒子基于可变粒子属性沿不同方向分离。
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公开(公告)号：US20120057213A1
公开(公告)日：2012-03-08
申请号：US13293597
申请日：2011-11-10
申请人： Yohai Roichman , Ilias Cholis , David G. Grier
发明人： Yohai Roichman , Ilias Cholis , David G. Grier
CPC分类号： G03H1/2294 , G03H1/0005 , G03H1/2249 , G03H2001/0077 , G03H2001/221 , G03H2210/30 , G03H2225/32
摘要： A method and system for manipulating object using a three dimensional optical trap configuration. By use of selected hologram on optical strap can be configured as a preselected three dimensional configuration for a variety of complex uses. The system can include various optical train components, such as partially transmissive mirrors and Keplerian telescope components to provide advantageously three dimensional optical traps.
摘要翻译： 一种使用三维光阱配置来操纵物体的方法和系统。 通过在光学带上使用所选择的全息图可以配置为用于各种复杂用途的预选的三维配置。 该系统可以包括各种光学组件，例如部分透射镜和开普勒望远镜组件，以有利地提供三维光阱。
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10.发明申请公开(公告)号：US20110043607A1
公开(公告)日：2011-02-24
申请号：US12740628
申请日：2008-10-30
申请人： David G. Grier , Sang-Hyuk Lee , Fook C. Cheong
发明人： David G. Grier , Sang-Hyuk Lee , Fook C. Cheong
CPC分类号： G02B21/361 , G01B9/02001 , G01N15/0227 , G01N15/10 , G01N15/1463 , G01N2015/0038 , G01N2015/025 , G01N2015/1075 , G01P5/001 , G01P5/20 , G03H1/0005 , G03H1/0866 , G03H2001/0033 , G03H2001/005 , G03H2001/0447 , G03H2001/0825 , G03H2240/56
摘要： In-line holography to create images of a specimen, such as one or more particles dispersed in a transparent medium. Analyzing these images with results from light scattering theory yields the particles' sizes with nanometer resolution, their refractive indexes to within one part in a thousand, and their three dimensional positions with nanometer resolution. This procedure can rapidly and directly characterize mechanical, optical and chemical properties of the specimen and its medium.
摘要翻译： 用于产生样品图像的在线全息术，例如分散在透明介质中的一种或多种颗粒。 使用光散射理论的结果分析这些图像会产生纳米分辨率的颗粒尺寸，其折射率在一千分之一内，其三维位置具有纳米分辨率。 该程序可以快速直接地表征样品及其介质的机械，光学和化学性质。
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