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公开(公告)号：US20120095696A1
公开(公告)日：2012-04-19
申请号：US13243912
申请日：2011-09-23
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Dino J. Sofianos , Karl H. Rudnick , Duane J. Knize , Roland B. Stoughton , Cecil L. Basham, JR. , Clifford T. Lewis , Brons M. Larson , Jonathan R. Bar-on , Dennis P. Murray , David W. Robbins , John P. Penhune
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Dino J. Sofianos , Karl H. Rudnick , Duane J. Knize , Roland B. Stoughton , Cecil L. Basham, JR. , Clifford T. Lewis , Brons M. Larson , Jonathan R. Bar-on , Dennis P. Murray , David W. Robbins , John P. Penhune
IPC分类号： G06F19/22
CPC分类号： G16B30/00 , Y10T436/24
摘要： Rapid and definitive bioagent detection and identification can be carried out without nucleic acid sequencing. Analysis of a variety of bioagents and samples, such as air, fluid, and body samples, can be carried out to provide information useful for industrial, medical, and environmental purposes. Nucleic acid samples of unknown or suspected bioagents may be collected, optimal primer pairs may be selected, and the nucleic acid may be amplified. Expected mass spectra signal models may be generated and selected, the actual mass spectra of the amplicons may be obtained. The expected mass spectra most closely correlating with the actual mass spectra may be determined using a joint maximum likelihood analysis, and base counts for the actual mass spectra and the expected mass spectra may be obtained. The most likely candidate bioagents may then be determined.
摘要翻译： 可以在不进行核酸测序的情况下进行快速和确定的生物鉴定检测和鉴定。 可以对各种生物标本和样品（如空气，液体和身体样品）进行分析，以提供有用的工业，医疗和环境用途的信息。 可以收集未知或疑似生物标记的核酸样品，可以选择最佳引物对，并且可以扩增核酸。 可以生成和选择预期的质谱信号模型，可以获得扩增子的实际质谱。 可以使用联合最大似然分析来确定与实际质谱最密切相关的预期质谱，并且可以获得实际质谱和预期质谱的碱值。 然后可能确定最可能的候选生物标签。
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公开(公告)号：US08046171B2
公开(公告)日：2011-10-25
申请号：US10418514
申请日：2003-04-18
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Dino J. Sofianos , Karl H. Rudnick , Duane J. Knize , Roland B. Stoughton , Cecil L. Basham, Jr. , Clifford T. Lewis , Brons M. Larson , Jonathan R. Bar-on , Dennis P. Murray , David W. Robbins , John P. Penhune
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Dino J. Sofianos , Karl H. Rudnick , Duane J. Knize , Roland B. Stoughton , Cecil L. Basham, Jr. , Clifford T. Lewis , Brons M. Larson , Jonathan R. Bar-on , Dennis P. Murray , David W. Robbins , John P. Penhune
CPC分类号： G06F19/22 , Y10T436/24
摘要： Rapid and definitive bioagent detection and identification can be carried out without nucleic acid sequencing. Analysis of a variety of bioagents and samples, such as air, fluid, and body samples, can be carried out to provide information useful for industrial, medical, and environmental purposes. Nucleic acid samples of unknown or suspected bioagents may be collected, optimal primer pairs may be selected, and the nucleic acid may be amplified. Expected mass spectra signal models may be generated and selected, the actual mass spectra of the amplicons may be obtained. The expected mass spectra most closely correlating with the actual mass spectra may be determined using a joint maximum likelihood analysis, and base counts for the actual mass spectra and the expected mass spectra may be obtained. The most likely candidate bioagents may then be determined.
摘要翻译： 可以在不进行核酸测序的情况下进行快速和确定的生物鉴定检测和鉴定。 可以对各种生物标本和样品（如空气，液体和身体样品）进行分析，以提供有用的工业，医疗和环境用途的信息。 可以收集未知或疑似生物标记的核酸样品，可以选择最佳引物对，并且可以扩增核酸。 可以生成和选择预期的质谱信号模型，可以获得扩增子的实际质谱。 可以使用联合最大似然分析来确定与实际质谱最密切相关的预期质谱，并且可以获得实际质谱和预期质谱的碱值。 然后可能确定最可能的候选生物标签。
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3.发明授权Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby 有权定义数据库的二级结构和用于确定未知生物标签的身份和地理起源的方法公开(公告)号：US08298760B2
公开(公告)日：2012-10-30
申请号：US11674538
申请日：2007-02-13
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke
IPC分类号： C12Q1/68
CPC分类号： G06F19/28 , G06F19/00 , G06F19/10 , G06F19/16 , G06F19/18 , G16H50/80 , Y02A90/24 , Y02A90/26
摘要： The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
摘要翻译： 本发明一般涉及研究生物信息学领域，更具体地涉及定义数据库的二级结构。 本发明还涉及询问数据库作为已知生物标签的分子量来源的方法，用于与未知或选择的生物标签的分子量进行比较以确定所选择的生物标签的身份，和/或确定所选生物标记的来源 所选的生物标签。 生物制剂的鉴定对于在诸如生物战争的情况下确定生物制剂的适当治疗过程和/或辐照是重要的。 此外，确定所选择的生物制剂的地理起源将有助于确定潜在的犯罪认同。
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公开(公告)号：US08071309B2
公开(公告)日：2011-12-06
申请号：US11930002
申请日：2007-10-30
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Ray Ranken , Thomas A. Hall
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Ray Ranken , Thomas A. Hall
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6872 , C12Q1/70 , C12Q1/701 , C12Q2600/16 , G01N1/30 , G01N21/64 , G01N23/00 , G06F19/20
摘要： The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
摘要翻译： 本发明提供了以下方法：鉴定来自人和动物的生物样品中的病原体，解决从人和动物获得的样品中存在的多种病原体，确定关于这种病原体或病原体的详细遗传信息，以及快速检测和鉴定生物代谢 来自环境，临床或其他样品。
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5.发明申请Methods For Rapid Forensic Analysis Of Mitochondrial DNA And Characterization Of Mitochondrial DNA Heteroplasmy 有权线粒体DNA快速法医分析方法及线粒体DNA异质性表征公开(公告)号：US20090182511A1
公开(公告)日：2009-07-16
申请号：US11929930
申请日：2007-10-30
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Thomas Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared James Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Thomas Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared James Drader
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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公开(公告)号：US20080311558A1
公开(公告)日：2008-12-18
申请号：US11869449
申请日：2007-10-09
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke
CPC分类号： C12Q1/689 , C12Q1/686 , Y10T436/24 , C12Q2565/627
摘要： The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
摘要翻译： 本发明提供了以下方法：鉴定来自人和动物的生物样品中的病原体，解决从人和动物获得的样品中存在的多种病原体，确定关于这种病原体或病原体的详细遗传信息，以及快速检测和鉴定生物代谢 来自环境，临床或其他样品。
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公开(公告)号：US08822156B2
公开(公告)日：2014-09-02
申请号：US13243960
申请日：2011-09-23
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Raymond Ranken , Thomas A. Hall
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Raymond Ranken , Thomas A. Hall
CPC分类号： C12Q1/689 , C12Q1/6872 , C12Q1/70 , C12Q1/701 , C12Q2600/16 , G01N1/30 , G01N21/64 , G01N23/00 , G06F19/20
摘要： The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
摘要翻译： 本发明提供了以下方法：鉴定来自人和动物的生物样品中的病原体，解决从人和动物获得的样品中存在的多种病原体，确定关于这种病原体或病原体的详细遗传信息，以及快速检测和鉴定生物代谢 来自环境，临床或其他样品。
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8.发明授权Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 有权线粒体DNA快速法医分析方法及线粒体DNA异质性表征公开(公告)号：US08802372B2
公开(公告)日：2014-08-12
申请号：US11929930
申请日：2007-10-30
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared James Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared James Drader
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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9.发明申请Method for Rapid Detection and Identification of Bioagents in Epidemiological and Forensic Investigations 有权在流行病学和法医学调查中快速检测和鉴定生物标本的方法公开(公告)号：US20120171679A1
公开(公告)日：2012-07-05
申请号：US11930741
申请日：2007-10-31
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
CPC分类号： C12Q1/689 , C12Q1/6813 , C12Q1/6858 , C12Q1/686 , C12Q1/6888 , C12Q2600/156 , Y02A50/59 , Y02A50/60 , Y02A90/24 , C12Q2565/627 , C12Q2545/113 , C12Q2563/167
摘要： The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.
摘要翻译： 本发明提供了通过识别与生物武器相关的生物标签和恐怖主义或犯罪行为进行快速法医调查的方法。 该方法也可用于通过基因分型生物学的流行病学调查。
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10.发明申请Secondary Structure Defining Database And Methods For Determining Identity And Geographic Origin Of An Unknown Bioagent Thereby 有权二级结构定义数据库和确定未知生物标记的身份和地理起源的方法公开(公告)号：US20110172925A1
公开(公告)日：2011-07-14
申请号：US11930108
申请日：2007-10-31
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke
CPC分类号： G06F19/28 , G06F19/00 , G06F19/10 , G06F19/16 , G06F19/18 , G16H50/80 , Y02A90/24 , Y02A90/26
摘要： The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
摘要翻译： 本发明一般涉及研究生物信息学领域，更具体地涉及定义数据库的二级结构。 本发明还涉及询问数据库作为已知生物标签的分子量来源的方法，用于与未知或选择的生物标签的分子量进行比较以确定所选择的生物标签的身份，和/或确定所选生物标记的来源 所选的生物标签。 生物制剂的鉴定对于在诸如生物战争的情况下确定生物制剂的适当治疗过程和/或辐照是重要的。 此外，确定所选择的生物制剂的地理起源将有助于确定潜在的犯罪认同。
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