公开(公告)号：US07074812B2

公开(公告)日：2006-07-11

申请号：US10633325

申请日：2003-08-02

Applicant: David P. Summers ,  James Davidson

Inventor： David P. Summers ,  James Davidson

IPC: A61K31/44

CPC classification number: A61K31/465

Abstract: In a method of developing muscle mass in a mammal, nicotine or nicotine acetylcholine receptor agonist (nAChR) is administered in combination with exercise to stimulate, recruit and mobilize muscle cells to a specific muscle mass.

Abstract translation: 在哺乳动物中发展肌肉质量的方法中，将尼古丁或尼古丁乙酰胆碱受体激动剂（nAChR）与运动组合施用以刺激，募集和将肌细胞移动到特定肌肉块。

公开(公告)号：US20070173486A1

公开(公告)日：2007-07-26

申请号：US10554447

申请日：2004-04-29

Applicant: James Davidson ,  Jonathan Bentley ,  Claire Dawson ,  Kerry Harrison ,  Howard Mansell ,  Alan Pither ,  Robert Pratt ,  Jonathan Roffey ,  Victoria Ruston

Inventor： James Davidson ,  Jonathan Bentley ,  Claire Dawson ,  Kerry Harrison ,  Howard Mansell ,  Alan Pither ,  Robert Pratt ,  Jonathan Roffey ,  Victoria Ruston

IPC: A61K31/397 ,  A61K31/551 ,  A61K31/454 ,  C07D403/02

CPC classification number: C07D401/12 ,  C07D205/04 ,  C07D211/46 ,  C07D403/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12

Abstract: Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder mediated by CB1 receptors, such as obesity, wherein: R1 is aryl or heteroaryl; R2 is alkyl, aryl or heteroaryl; R3 is alkyl, aryl, heteroaryl, NR9R10, OR15, or NR16C(O)R17; Y is C═O, C═S, SO2, or (CR7R8); m=1 or 2; n=1 or 2; and p=1, 2, 3 or 4, R7 to R17 being as defined in the specification; wherein if —Y—R3 is —C(O)NH(alkyl) then: R1 and/or R2 is selected from heteroaryl; and/or m and/or n is 2; and/or R11 and/or R12 is lower alkyl, or a pharmaceutically acceptable salt or prodrug thereof.

Abstract translation: 式（I）化合物及其在治疗中的用途，特别是用于治疗CB 1受体介导的病症，例如肥胖症，其中：R 1是芳基或 杂芳基; R 2是烷基，芳基或杂芳基; R 3是烷基，芳基，杂芳基，NR 9 R 10，或15，或NR 15， 16 C（O）R 17; Y是C-O，C-S，SO 2，或（CR 7 R 8）。 m = 1或2; n = 1或2; 和p = 1,2,3或4，R 7至R 17如说明书中所定义; 其中如果-Y-R 3为-C（O）NH（烷基），那么：R 1和/或R 2选自杂芳基; 和/或m和/或n为2; 和/或R 11和/或R 12是低级烷基或其药学上可接受的盐或前药。

公开(公告)号：US20060160816A1

公开(公告)日：2006-07-20

申请号：US11374157

申请日：2006-03-14

Applicant: David Adams ,  Jon Bentley ,  James Davidson ,  Matthew Dunction ,  Richard Porter

Inventor： David Adams ,  Jon Bentley ,  James Davidson ,  Matthew Dunction ,  Richard Porter

IPC: A61K31/498 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: Chemical compounds of formula (I): and pharmaceutically acceptable salts and addition compounds and prodrugs thereof are useful in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes inspidus, and sleep apnea.

Abstract translation: 式（I）的化合物及其药学上可接受的盐和加成化合物及其前药可用于治疗，特别是用于治疗中枢神经系统疾病; 损害中枢神经系统; 心血管疾病; 胃肠道疾病; 糖尿病，睡眠呼吸暂停。

公开(公告)号：US20060074460A1

公开(公告)日：2006-04-06

申请号：US10825782

申请日：2004-04-16

Applicant: Mariam Maghribi ,  Peter Krulevitch ,  James Davidson ,  Julie Hamilton

Inventor： Mariam Maghribi ,  Peter Krulevitch ,  James Davidson ,  Julie Hamilton

IPC: A61N1/08 ,  A61N1/04

CPC classification number: A61N1/0543 ,  A61N1/0534 ,  A61N1/0541

Abstract: A high density polymer-based integrated electrode apparatus that comprises a central electrode body and a multiplicity of arms extending from the electrode body. The central electrode body and the multiplicity of arms are comprised of a silicone material with metal features in said silicone material that comprise electronic circuits.

Abstract translation: 一种高密度聚合物基集成电极装置，包括中心电极体和从电极体延伸的多个臂。 中心电极体和多个臂由具有包括电子电路的所述硅氧烷材料中的金属特征的硅氧烷材料构成。

公开(公告)号：US20100132181A1

公开(公告)日：2010-06-03

申请号：US12457340

申请日：2009-06-08

Applicant: Trevor Sullivan ,  James Davidson ,  Michael Burrall ,  David Solomon

Inventor： Trevor Sullivan ,  James Davidson ,  Michael Burrall ,  David Solomon

IPC: B23P17/04

CPC classification number: A47K3/16 ,  Y10T29/49826

Abstract: An enclosure for a bathtub is constructed at a factory or other location remote from a site where the bathtub is to be permanently installed. The bathtub is placed permanently in the enclosure at the factory or remote location and once placed, the bathtub and enclosure are in condition for use at its permanent site without the necessity of further assembly.

Abstract translation: 一个浴缸的外壳是在一个工厂或远离一个要永久安装浴缸的地方的其他位置建造的。 浴缸永久放置在工厂或远程位置的外壳中，一旦放置，浴缸和外壳将处于其永久位置使用的状态，无需进一步组装。

公开(公告)号：US20070144523A1

公开(公告)日：2007-06-28

申请号：US10547436

申请日：2004-02-25

Applicant: Kenneth Bolam ,  James Davidson ,  James Borgen

Inventor： Kenneth Bolam ,  James Davidson ,  James Borgen

IPC: A62B9/02

CPC classification number: G01R33/28 ,  A62B9/02 ,  F16K11/0712 ,  F16K31/122 ,  G01R33/5601

Abstract: Methods, systems, assemblies, computer program products and devices deliver hyperpolarized gas by: (a) providing a gas delivery valve with at least one gas flow path therein, the valve comprising a valve body and at least one spool held in the valve body; (b) transmitting a pilot command fluid pulse signal to the at least one spool to introduce pressure onto the spool to force the spool to translate an actuation distance in the valve body; and (c) opening and/or closing the at least one gas flow path in response to the transmitted signal to deliver hyperpolarized gas to a subject.

Abstract translation: 方法，系统，组件，计算机程序产品和装置通过以下方式提供超极化气体：（a）提供具有至少一个气体流路的气体输送阀，所述阀包括阀体和至少一个保持在阀体中的阀芯; （b）将先导指令流体脉冲信号传送到所述至少一个阀芯以将压力引导到所述阀芯上以迫使所述阀芯平移阀体中的致动距离; 和（c）响应于所传输的信号打开和​​/或关闭所述至少一个气体流动路径，以将超极化气体输送到对象。

公开(公告)号：US20070099980A1

公开(公告)日：2007-05-03

申请号：US11637036

申请日：2006-12-12

Applicant: Jonathan Roffey ,  James Davidson ,  Howard Mansell ,  Richard Hamlyn ,  David Adams

Inventor： Jonathan Roffey ,  James Davidson ,  Howard Mansell ,  Richard Hamlyn ,  David Adams

IPC: A61K31/407

CPC classification number: C07D471/04 ,  A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/437 ,  A61K31/4745 ,  C07D209/60 ,  C07D209/70 ,  C07D209/90 ,  C07D471/06 ,  C07D491/04 ,  C07D491/06 ,  C07D495/04 ,  C07D495/06

Abstract: A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independently selected from hydrogen, halogen, hydroxyl, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; and A is a 5- or 6-membered ring optionally containing one or more heteroatoms wherein the atoms of the ring A, other than the unsaturated carbon atoms of the phenyl ring to which the ring A is fused, are saturated or unsaturated, and pharmaceutically acceptable salts, addition compounds and prodrugs thereof; and the use thereof in therapy, particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT2C receptor, for instance in the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.

Abstract translation: 式（I）的化合物，其中R 1和R 2各自独立地选自氢和烷基; R 3是烷基; R 4和R 5选自氢和烷基; R 6和R 7独立地选自氢，卤素，羟基，烷基，芳基，氨基，烷基氨基，二烷基氨基，烷氧基，芳氧基，烷硫基，烷基亚砜基，硝基，腈 ，碳 - 烷氧基，碳 - 芳氧基和羧基; 并且A是任选地含有一个或多个杂原子的5-或6-元环，其中除了环A稠合的苯环的不饱和碳原子之外的环A的原子是饱和或不饱和的， 可接受的盐，加成化合物和前药; 以及其在治疗中的用途，特别是作为5HT受体，特别是5HT 2C受体的激动剂或拮抗剂，例如用于治疗中枢神经系统疾病; 损害中枢神经系统; 心血管疾病; 胃肠道疾病; 尿崩症和睡眠呼吸暂停，特别是用于治疗肥胖。

公开(公告)号：US20060113537A1

公开(公告)日：2006-06-01

申请号：US11326967

申请日：2006-01-05

Applicant: Peter Krulevitch ,  Mariam Maghribi ,  William Benett ,  Julie Hamilton ,  Klint Rose ,  James Davidson ,  Mark Strauch

Inventor： Peter Krulevitch ,  Mariam Maghribi ,  William Benett ,  Julie Hamilton ,  Klint Rose ,  James Davidson ,  Mark Strauch

IPC: H01L31/0376

CPC classification number: H01L25/165 ,  B81C1/0023 ,  H01L21/6835 ,  H01L31/048 ,  H01L31/0543 ,  H01L2221/68345 ,  H01L2924/0002 ,  H01L2924/09701 ,  H01L2924/19041 ,  H01L2924/19105 ,  Y02E10/52 ,  H01L2924/00

Abstract: A peel and stick electronic system comprises a silicone body, and at least one electronic unit operatively connected to the silicone body. The electronic system is produce by providing a silicone layer on a substrate, providing a metal layer on the silicone layer, and providing at least one electronic unit connected to the metal layer.

公开(公告)号：US6080359A

公开(公告)日：2000-06-27

申请号：US229566

申请日：1999-01-13

Applicant: James Davidson

Inventor： James Davidson

IPC: C22C38/00 ,  C21D8/02 ,  C22C38/06 ,  C22C38/08 ,  C22C38/12 ,  C22C38/14

CPC classification number: C22C38/06 ,  C21D8/0205 ,  C22C38/08 ,  C22C38/12 ,  C22C38/14 ,  C21D8/0236

Abstract: A maraging steel preferably without cobalt, having the following chemical composition: Ni 18-23 wt. %, Mo 4.5-8 wt. %, Ti 1-2 wt. %, Al 0-0.3 wt. %, C.ltoreq.0.01 wt. %, remainder Fe and impurities. The composition also preferably satisfies the following conditions:Ni+Mo=23-27 wt. %, inclusively;Ni+3.times.Mo+20.times.Ti+10.times.Al.gtoreq.60 wt. %.

Abstract translation: 具有以下化学成分的优选不含钴的马氏体时效钢：Ni 18-23wt。 ％，Mo 4.5-8wt。 ％，Ti 1-2wt。 ％，Al 0-0.3wt。 ％，C <0.01wt。 ％，余量为Fe和杂质。 该组合物还优选满足以下条件：Ni + Mo = 23-27wt。 ％，包括; Ni + 3xMo + 20xTi + 10xAl> / = 60wt。 ％。

公开(公告)号：US4704610A

公开(公告)日：1987-11-03

申请号：US809103

申请日：1985-12-16

Applicant: Michel R. Smith ,  James Davidson ,  Henry Pfister

Inventor： Michel R. Smith ,  James Davidson ,  Henry Pfister

IPC: G08G1/0968 ,  G08G1/087 ,  G08G1/07

CPC classification number: G08G1/087

Abstract: A system for providing early warning of the approach and egress of emergency vehicles in which the warning system provides a display to indicate the direction from which the emergency vehicle is approaching and in addition provides preemption control of the traffic signals at an intersection. A transmitter mounted on an emergency vehicle transmits a signal whenever it is on an emergency call which is received by infrared (I.R.) receivers positioned at an intersection to respond to the transmitted signals. The received signal is then processed by a master controller which in turn pre-empts operation of traffic signals to control traffic flow at the intersection to which the emergency vehicle is approaching. The master controller also provides an output to display signs facing approaching traffic on each road approaching the intersection which displays messages and symbols indicating the direction of the approaching emergency vehicle. Additionally, the display system indicates whether the emergency vehicle has passed through and is departing the intersection. After a predetermined interval when an emergency vehicle has passed through an intersection the display system is deactivated and the traffic signals are returned to the traffic light control system.