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    Isomerases, nucleic acids encoding them and methods for making and using them
    1.
    发明授权
    Isomerases, nucleic acids encoding them and methods for making and using them 有权
    异构酶，编码它们的核酸和制备和使用它们的方法

    公开(公告)号：US08541220B2

    公开(公告)日：2013-09-24

    申请号：US12810067

    申请日：2008-12-22

    申请人： David P. Weiner ,  Ellen G. Burke ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin M. Cuenca ,  Mervyn L. De Souza ,  Sherry Kollmann

    发明人： David P. Weiner ,  Ellen G. Burke ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin M. Cuenca ,  Mervyn L. De Souza ,  Sherry Kollmann

    IPC分类号： C12N9/90 ,  C12N9/88 ,  C12N9/48 ,  C12N9/42 ,  C12N9/16 ,  C02F3/34 ,  A62D3/00 ,  C07H21/04 ,  C07K1/00 ,  A21D2/00 ,  A23L1/10 ,  D21C3/20

    CPC分类号： C12N9/90 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/10 ,  A23G3/366 ,  A23G4/123 ,  A23G4/14 ,  A23K20/189 ,  A23L29/06 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/52 ,  C12Q1/533 ,  C12Y501/00 ,  C12Y501/01

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

    摘要翻译： 本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有异构酶活性的酶，例如消旋酶活性，例如氨基酸消旋酶活性，丙氨酸消旋酶活性和/或差向异构酶活性， 和/或催化分子内原子的重新排列，催化一种异构体转化为另一种异构体，催化光学活性底物转化为光学无活性的外消旋体，催化底物对映异构体的相互转化，催化立体化学 在仅具有一个不对称中心的底物中的不对称碳原子周围反转，催化具有多于一个不对称中心的底物中不对称碳原子周围的构型的立体化学反转，和/或催化氨基酸的外消旋化。 因此，本发明提供了用于生产药物组合物，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂的酶，组合物， 药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。

    ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
    2.
    发明申请
    ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
    异构体，编码它们的核酸及其制备和使用它们的方法

    公开(公告)号：US20110053245A1

    公开(公告)日：2011-03-03

    申请号：US12810067

    申请日：2008-12-22

    申请人： David P. Weiner ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin M. Cuenca ,  Mervyn L. De Souza ,  Sherry Kollmann

    发明人： David P. Weiner ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin M. Cuenca ,  Mervyn L. De Souza ,  Sherry Kollmann

    IPC分类号： C12N9/90 ,  C12N15/52 ,  C12N15/80 ,  C12N15/81 ,  C12N15/82 ,  C12N15/85 ,  C12P21/02 ,  C12P19/34 ,  A23L1/172 ,  D21C3/20 ,  C12N9/42 ,  C12N9/48 ,  C12N9/24 ,  C12N9/08 ,  C12N9/10 ,  C12N9/16 ,  C12N9/88

    CPC分类号： C12N9/90 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/10 ,  A23G3/366 ,  A23G4/123 ,  A23G4/14 ,  A23K20/189 ,  A23L29/06 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/52 ,  C12Q1/533 ,  C12Y501/00 ,  C12Y501/01

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-, arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermerdiates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

    摘要翻译： 本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有异构酶活性的酶，例如消旋酶活性，例如氨基酸消旋酶活性，丙氨酸消旋酶活性和/或差向异构酶活性， 和/或催化原子在分子内的重新排列，催化一种异构体转化为另一种异构体，催化光学活性底物转化为光学无活性的外消旋体，催化底物对映异构体的相互转化，催化 仅具有一个不对称中心的基底中的不对称碳原子周围的立体化学反转，催化具有多于一个不对称中心的底物中不对称碳原子周围的构型的立体化学反转，和/或催化氨基酸的外消旋化。 因此，本发明提供了酶，组合物，药物组合物的制备方法，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂， 药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。

    Products and Methods for In Vivo Secretion of Monatin
    4.
    发明申请
    Products and Methods for In Vivo Secretion of Monatin 有权
    Monatin的体内分泌产物和方法

    公开(公告)号：US20070105938A1

    公开(公告)日：2007-05-10

    申请号：US11379528

    申请日：2006-04-20

    申请人： James Anderson ,  Mervyn DeSouza ,  Paula Hicks ,  Sherry Kollmann ,  Jose Laplaza

    发明人： James Anderson ,  Mervyn DeSouza ,  Paula Hicks ,  Sherry Kollmann ,  Jose Laplaza

    IPC分类号： C12P13/22 ,  A61K31/405

    CPC分类号： C12P17/10 ,  A61K31/7048 ,  Y02A50/473

    摘要： Products and methods for the in vivo production of monatin sweetener are provided. The products include microorganisms that are genetically modified to secrete or to improve secretion of monatin; microorganisms that are genetically modified to produce monatin; and microorganisms that are genetically modified to both secrete or improve secretion of monatin and produce monatin. The methods include producing monatin in such genetically engineered microorganisms.

    摘要翻译： 提供了莫纳甜甜味剂体内生产的产品和方法。 产品包括经遗传修饰以分泌或改善莫纳甜分泌的微生物; 经遗传修饰以产生莫纳甜的微生物; 和经遗传修饰以分泌或改善莫纳甜分泌并产生莫纳甜的微生物。 这些方法包括在这种基因工程微生物中产生莫纳甜。

    Products and methods for in vivo secretion of monatin
    6.
    发明申请
    Products and methods for in vivo secretion of monatin 有权
    莫纳甜体内分泌的产物和方法

    公开(公告)号：US20070099277A1

    公开(公告)日：2007-05-03

    申请号：US11545024

    申请日：2006-10-10

    申请人： James Anderson ,  Mervyn DeSouza ,  Paula Hicks ,  Sherry Kollmann

    发明人： James Anderson ,  Mervyn DeSouza ,  Paula Hicks ,  Sherry Kollmann

    IPC分类号： C12P13/22 ,  C12N1/21

    CPC分类号： C12P17/10

    摘要： Products and methods for the in vivo production of monatin sweetener are provided. The products include microorganisms that are genetically modified to secrete or to improve secretion of monatin; microorganisms that are genetically modified to produce monatin; and microorganisms that are genetically modified to both secrete or improve secretion of monatin and produce monatin. The methods include producing monatin in such genetically engineered microorganisms.

    摘要翻译： 提供了莫纳甜甜味剂体内生产的产品和方法。 产品包括经遗传修饰以分泌或改善莫纳甜分泌的微生物; 经遗传修饰以产生莫纳甜的微生物; 和经遗传修饰以分泌或改善莫纳甜分泌并产生莫纳甜的微生物。 所述方法包括在这种遗传工程微生物中产生莫纳甜。