利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.064 秒)

    Isomerases, Nucleic Acids Encoding Them and Methods for Making and Using Them
    3.
    发明申请
    Isomerases, Nucleic Acids Encoding Them and Methods for Making and Using Them 有权
    异构酶，编码它们的核酸及其制备和使用方法

    公开(公告)号：US20140141491A1

    公开(公告)日：2014-05-22

    申请号：US13967157

    申请日：2013-08-14

    申请人： Verenium Corporation

    发明人： David P. WEINER ,  Ellen G. BURKE ,  Peter LUGINBUHL ,  Analia BUENO ,  Joslin M. CUENCA ,  Mervyn L. DE SOUZA ,  Sherry KOLLMANN

    IPC分类号： C12N9/90

    CPC分类号： C12N9/90 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/10 ,  A23G3/366 ,  A23G4/123 ,  A23G4/14 ,  A23K20/189 ,  A23L29/06 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/52 ,  C12Q1/533 ,  C12Y501/00 ,  C12Y501/01

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids.

    摘要翻译： 本发明一般涉及酶，编码具有异构酶活性的酶的多核苷酸，例如消旋酶活性，例如氨基酸消旋酶活性，丙氨酸消旋酶活性和/或差向异构酶活性，和/或催化分子内原子重新排列 催化一种异构体转化为另一种异构体，催化光学活性底物转化为光学无活性的外消旋催化底物对映异构体的相互转化，催化仅具有一个中心的底物中不对称碳原子周围的立体化学反应 的不对称性，催化具有多于一个不对称中心的底物中不对称碳原子周围构型的立体化学反转，和/或催化氨基酸的外消旋化。

    Isomerases, nucleic acids encoding them and methods for making and using them
    4.
    发明授权
    Isomerases, nucleic acids encoding them and methods for making and using them 有权
    异构酶，编码它们的核酸和制备和使用它们的方法

    公开(公告)号：US08541220B2

    公开(公告)日：2013-09-24

    申请号：US12810067

    申请日：2008-12-22

    申请人： David P. Weiner ,  Ellen G. Burke ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin M. Cuenca ,  Mervyn L. De Souza ,  Sherry Kollmann

    发明人： David P. Weiner ,  Ellen G. Burke ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin M. Cuenca ,  Mervyn L. De Souza ,  Sherry Kollmann

    IPC分类号： C12N9/90 ,  C12N9/88 ,  C12N9/48 ,  C12N9/42 ,  C12N9/16 ,  C02F3/34 ,  A62D3/00 ,  C07H21/04 ,  C07K1/00 ,  A21D2/00 ,  A23L1/10 ,  D21C3/20

    CPC分类号： C12N9/90 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/10 ,  A23G3/366 ,  A23G4/123 ,  A23G4/14 ,  A23K20/189 ,  A23L29/06 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/52 ,  C12Q1/533 ,  C12Y501/00 ,  C12Y501/01

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

    摘要翻译： 本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有异构酶活性的酶，例如消旋酶活性，例如氨基酸消旋酶活性，丙氨酸消旋酶活性和/或差向异构酶活性， 和/或催化分子内原子的重新排列，催化一种异构体转化为另一种异构体，催化光学活性底物转化为光学无活性的外消旋体，催化底物对映异构体的相互转化，催化立体化学 在仅具有一个不对称中心的底物中的不对称碳原子周围反转，催化具有多于一个不对称中心的底物中不对称碳原子周围的构型的立体化学反转，和/或催化氨基酸的外消旋化。 因此，本发明提供了用于生产药物组合物，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂的酶，组合物， 药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。

    ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
    5.
    发明申请
    ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
    异构体，编码它们的核酸及其制备和使用它们的方法

    公开(公告)号：US20160090585A1

    公开(公告)日：2016-03-31

    申请号：US14853240

    申请日：2015-09-14

    申请人： BASF ENZYMES LLC

    发明人： David P. WEINER ,  Ellen G. BURKE ,  Peter LUGINBUHL ,  Analia BUENO ,  Joslin M. CUENCA ,  Mervyn L. DE SOUZA ,  Sherry KOLLMANN

    IPC分类号： C12N9/90 ,  A61K38/52

    CPC分类号： C12N9/90 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/10 ,  A23G3/366 ,  A23G4/123 ,  A23G4/14 ,  A23K20/189 ,  A23L29/06 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/52 ,  C12Q1/533 ,  C12Y501/00 ,  C12Y501/01

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

    摘要翻译： 本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有异构酶活性的酶，例如消旋酶活性，例如氨基酸消旋酶活性，丙氨酸消旋酶活性和/或差向异构酶活性， 和/或催化分子内原子的重新排列，催化一种异构体转化为另一种异构体，催化光学活性底物转化为光学无活性的外消旋体，催化底物对映异构体的相互转化，催化立体化学 在仅具有一个不对称中心的底物中的不对称碳原子周围反转，催化具有多于一个不对称中心的底物中不对称碳原子周围的构型的立体化学反转，和/或催化氨基酸的外消旋化。 因此，本发明提供了用于生产药物组合物，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂的酶，组合物， 药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。

    PRODUCTION OF ENANTIOMERICALLY PURIFIED AMINO ACIDS
    6.
    发明申请
    PRODUCTION OF ENANTIOMERICALLY PURIFIED AMINO ACIDS 审中-公开
    生产完全纯化的氨基酸

    公开(公告)号：US20140065679A1

    公开(公告)日：2014-03-06

    申请号：US14009758

    申请日：2012-04-10

    申请人： Scott Baxter ,  Dominic Campopiano ,  Karen Elizabeth Holt-Tiffin

    发明人： Scott Baxter ,  Dominic Campopiano ,  Karen Elizabeth Holt-Tiffin

    IPC分类号： C12P13/04 ,  C12P13/22 ,  C12P13/06

    CPC分类号： C12P13/04 ,  C12N9/90 ,  C12P13/06 ,  C12P13/222 ,  C12Y501/01

    摘要： The present application relates to a mutated Amycoiatopsis sp. TS-1-60 NAAAR that shows improved activity of the enzyme compared with the wild type Amycoiatopsis sp. TS-1-60 NAAAR. The mutated NAAAR is almost five times more active than its wild type counterpart. The present application also relates to the use of mutated Amycoiatopsis sp. TS-1-60 NAAAR in the production of enantiomerically pure amino acid from its N-acyl derivative via dynamic kinetic resolution method.

    摘要翻译： 本申请涉及突变的拟南芥（Amycoiatopsis sp。） 与野生型Amycoiatopsis sp相比，显示出酶活性提高的TS-1-60 NAAAR。 TS-1-60 NAAAR。 突变的NAAAR比其野生型对应物几乎是活性的五倍。 本申请还涉及使用突变的拟南芥（Amycoiatopsis sp。） TS-1-60 NAAAR通过动态动力学拆分方法从其N-酰基衍生物生产对映体纯氨基酸。

    METHOD FOR PRODUCING CRYSTALS OF MUTIVALENT METAL SALT OF (2R, 4R) MONATIN
    7.
    发明申请
    METHOD FOR PRODUCING CRYSTALS OF MUTIVALENT METAL SALT OF (2R, 4R) MONATIN 审中-公开
    生产（2R，4R）维生素的金属盐的晶体的方法

    公开(公告)号：US20130164792A1

    公开(公告)日：2013-06-27

    申请号：US13678909

    申请日：2012-11-16

    申请人： Ajinomoto Co., Inc.

    发明人： Kenichi MORI ,  Masakazu Sugiyama ,  Mika Moriya ,  Shunichi Suzuki ,  Hidemi Fujii ,  Kyohei Fujiwara

    IPC分类号： C07D209/20 ,  C12P17/10

    CPC分类号： C07D209/20 ,  C12P17/10 ,  C12Y206/01 ,  C12Y501/01

    摘要： The present invention provides a method of efficiently producing a crystal of a (2R,4R)Monatin multivalent metal salt that has a good sweetness property and is excellent in storage stability. Specifically, the present invention provides the method of producing the crystal of the (2R,4R)Monatin multivalent metal salt comprising allowing an aldehyde or one or two or more enzymes capable of forming (2R,4R)Monatin from (2S,4R)Monatin to be acted on an aqueous solution containing the (2S,4R)Monatin in the presence of a multivalent metal ion to obtain the crystal of the (2R,4R)Monatin multivalent metal salt. The aldehyde may preferably be an aromatic aldehyde. The one or two or more enzyme may preferably be a racemase or one or more aminotransferases. The multivalent metal may preferably be a bivalent alkaline earth metal.

    摘要翻译： 本发明提供一种有效地制备具有良好的甜味性并且保存稳定性优异的（2R，4R）莫纳甜多金属盐晶体的方法。 具体地说，本发明提供了制备（2R，4R）莫纳甜多价金属盐晶体的方法，包括使（2，4R）莫纳甜能形成（2R，4R）莫纳甜的醛或一种或两种以上的酶 在含有（2S，4R）莫纳甜的水溶液中，在多价金属离子的存在下作用，得到（2R，4R）莫纳甜多晶金属盐的结晶。 醛可优选为芳族醛。 一种或两种或更多种酶可优选为消旋酶或一种或多种氨基转移酶。 多价金属可优选为二价碱土金属。

    ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
    8.
    发明申请
    ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
    异构体，编码它们的核酸及其制备和使用它们的方法

    公开(公告)号：US20110053245A1

    公开(公告)日：2011-03-03

    申请号：US12810067

    申请日：2008-12-22

    申请人： David P. Weiner ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin M. Cuenca ,  Mervyn L. De Souza ,  Sherry Kollmann

    发明人： David P. Weiner ,  Peter Luginbuhl ,  Analia Bueno ,  Joslin M. Cuenca ,  Mervyn L. De Souza ,  Sherry Kollmann

    IPC分类号： C12N9/90 ,  C12N15/52 ,  C12N15/80 ,  C12N15/81 ,  C12N15/82 ,  C12N15/85 ,  C12P21/02 ,  C12P19/34 ,  A23L1/172 ,  D21C3/20 ,  C12N9/42 ,  C12N9/48 ,  C12N9/24 ,  C12N9/08 ,  C12N9/10 ,  C12N9/16 ,  C12N9/88

    CPC分类号： C12N9/90 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/10 ,  A23G3/366 ,  A23G4/123 ,  A23G4/14 ,  A23K20/189 ,  A23L29/06 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/52 ,  C12Q1/533 ,  C12Y501/00 ,  C12Y501/01

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re-, arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermerdiates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

    摘要翻译： 本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有异构酶活性的酶，例如消旋酶活性，例如氨基酸消旋酶活性，丙氨酸消旋酶活性和/或差向异构酶活性， 和/或催化原子在分子内的重新排列，催化一种异构体转化为另一种异构体，催化光学活性底物转化为光学无活性的外消旋体，催化底物对映异构体的相互转化，催化 仅具有一个不对称中心的基底中的不对称碳原子周围的立体化学反转，催化具有多于一个不对称中心的底物中不对称碳原子周围的构型的立体化学反转，和/或催化氨基酸的外消旋化。 因此，本发明提供了酶，组合物，药物组合物的制备方法，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂， 药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。