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    Devices and methods for controlling expandable prostheses during deployment
    1.
    发明授权
    Devices and methods for controlling expandable prostheses during deployment 有权
    在展开期间控制可扩张假体的装置和方法

    公开(公告)号：US08986362B2

    公开(公告)日：2015-03-24

    申请号：US12471064

    申请日：2009-05-22

    申请人： David W. Snow ,  Joseph Karratt ,  Jeffry J. Grainger ,  Denise Demarais

    发明人： David W. Snow ,  Joseph Karratt ,  Jeffry J. Grainger ,  Denise Demarais

    IPC分类号： A61F2/06 ,  A61F2/966 ,  A61F2/95 ,  A61F2/97 ,  A61F2/958 ,  A61F2/82

    CPC分类号： A61F2/966 ,  A61F2/95 ,  A61F2/958 ,  A61F2/97 ,  A61F2002/826 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9583 ,  A61F2002/9665

    摘要： Prosthesis delivery devices and methods are provided that enable precise control of prosthesis position during deployment. The prosthesis delivery devices may carry multiple prostheses and include deployment mechanisms for delivery of a selectable number of prostheses. Control mechanisms are provided in the prosthesis delivery devices that control either or both of the axial and rotational positions of the prostheses during deployment. This enables the deployment of multiple prostheses at a target site with precision and predictability, eliminating excessive spacing or overlap between prostheses. In particular embodiments, the prostheses of the invention are deployed in stenotic lesions in coronary or peripheral arteries, or in other vascular locations.

    摘要翻译： 提供了假体输送装置和方法，其能够在部署期间精确地控制假体位置。 假体输送装置可携带多个假体，并且包括用于输送可选数量的假体的展开机构。 在假体输送装置中提供控制机构，其在展开期间控制假体的轴向和旋转位置中的一个或两者。 这使得能够在目标位置部署具有精确度和可预测性的多个假体，从而消除假体之间的间隔或重叠。 在具体实施方案中，本发明的假体部署在冠状动脉或外周动脉或其它血管位置的狭窄病变中。

    DEVICES AND METHODS FOR CONTROLLING EXPANDABLE PROSTHESES DURING DEPLOYMENT
    2.
    发明申请
    DEVICES AND METHODS FOR CONTROLLING EXPANDABLE PROSTHESES DURING DEPLOYMENT 有权
    在部署期间控制可扩展性的设备和方法

    公开(公告)号：US20090234428A1

    公开(公告)日：2009-09-17

    申请号：US12471064

    申请日：2009-05-22

    申请人： David W. Snow ,  Joseph Karratt ,  Jeffry J. Grainger ,  Denise Demarais

    发明人： David W. Snow ,  Joseph Karratt ,  Jeffry J. Grainger ,  Denise Demarais

    IPC分类号： A61F2/06

    CPC分类号： A61F2/966 ,  A61F2/95 ,  A61F2/958 ,  A61F2/97 ,  A61F2002/826 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9583 ,  A61F2002/9665

    摘要： Prosthesis delivery devices and methods are provided that enable precise control of prosthesis position during deployment. The prosthesis delivery devices may carry multiple prostheses and include deployment mechanisms for delivery of a selectable number of prostheses. Control mechanisms are provided in the prosthesis delivery devices that control either or both of the axial and rotational positions of the prostheses during deployment. This enables the deployment of multiple prostheses at a target site with precision and predictability, eliminating excessive spacing or overlap between prostheses. In particular embodiments, the prostheses of the invention are deployed in stenotic lesions in coronary or peripheral arteries, or in other vascular locations.

    摘要翻译： 提供了假体输送装置和方法，其能够在部署期间精确地控制假体位置。 假体输送装置可携带多个假体，并且包括用于输送可选数量的假体的展开机构。 在假体输送装置中提供控制机构，其在展开期间控制假体的轴向和旋转位置中的一个或两者。 这使得能够在目标位置部署具有精确度和可预测性的多个假体，从而消除假体之间的间隔或重叠。 在具体实施方案中，本发明的假体部署在冠状动脉或外周动脉或其它血管位置的狭窄病变中。

    Devices and methods for controlling expandable prosthesis during develoyment
    3.
    发明申请
    Devices and methods for controlling expandable prosthesis during develoyment 审中-公开
    在开发期间控制可扩张假体的装置和方法

    公开(公告)号：US20050288764A1

    公开(公告)日：2005-12-29

    申请号：US10957079

    申请日：2004-09-30

    申请人： David Snow ,  Joseph Karratt ,  Jeffry Grainger ,  Denise Demarais

    发明人： David Snow ,  Joseph Karratt ,  Jeffry Grainger ,  Denise Demarais

    IPC分类号： A61F2/82 ,  A61F2/84 ,  A61F2/06

    CPC分类号： A61F2/966 ,  A61F2/95 ,  A61F2/958 ,  A61F2/97 ,  A61F2002/826 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2002/9583 ,  A61F2002/9665

    摘要： Prosthesis delivery devices and methods are provided that enable precise control of prosthesis position during deployment. The prosthesis delivery devices may carry multiple prostheses and include deployment mechanisms for delivery of a selectable number of prostheses. Control mechanisms are provided in the prosthesis delivery devices that control either or both of the axial and rotational positions of the prostheses during deployment. This enables the deployment of multiple prostheses at a target site with precision and predictability, eliminating excessive spacing or overlap between prostheses. In particular embodiments, the prostheses of the invention are deployed in stenotic lesions in coronary or peripheral arteries, or in other vascular locations.

    摘要翻译： 提供了假体输送装置和方法，其能够在部署期间精确地控制假体位置。 假体输送装置可携带多个假体，并且包括用于输送可选数量的假体的展开机构。 在假体输送装置中提供控制机构，其在展开期间控制假体的轴向和旋转位置中的一个或两者。 这使得能够在目标位置部署具有精确度和可预测性的多个假体，从而消除假体之间的间隔或重叠。 在具体实施方案中，本发明的假体部署在冠状动脉或外周动脉或其它血管位置的狭窄病变中。

    DEVICES AND METHODS FOR CONTROLLING EXPANDABLE PROSTHESES DURING DEPLOYMENT
    4.
    发明申请
    DEVICES AND METHODS FOR CONTROLLING EXPANDABLE PROSTHESES DURING DEPLOYMENT 有权
    在部署期间控制可扩展性的设备和方法

    公开(公告)号：US20080234795A1

    公开(公告)日：2008-09-25

    申请号：US11689927

    申请日：2007-03-22

    申请人： David W. Snow ,  Denise Demarais ,  Stuart Lin

    发明人： David W. Snow ,  Denise Demarais ,  Stuart Lin

    IPC分类号： A61F2/06

    CPC分类号： A61F2/966 ,  A61F2/91 ,  A61F2/915 ,  A61F2/95 ,  A61F2002/826 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2002/91591 ,  A61F2002/9517

    摘要： A catheter for delivering a prosthesis to a treatment site in a body lumen comprises an elongate flexible member and a sheath slidably disposed thereover. A plurality of self-expanding tubular prostheses are carried in axially spaced apart locations along the elongate member, within the sheath. The prostheses may be selectively interlocked with one another and are constrained by the sheath in a radially contracted configuration. The prostheses are separately releasable from the sheath when the sheath is retracted relative to the elongate member. The catheter also has a pusher member slidably disposed along the elongate member within the sheath. The pusher is adapted to move past the prostheses in a first direction without displacing the prostheses, while in a second direction the pusher engages a selected prosthesis so as to move the prosthesis with the pusher to interlock the selected prosthesis with a second prosthesis.

    摘要翻译： 用于将假体递送到体腔内的治疗部位的导管包括细长的柔性构件和可滑动地设置在其上的护套。 多个自膨胀管状假体在护套内沿着细长构件在轴向间隔开的位置被承载。 假体可以选择性地互锁地互锁并且以径向收缩的构造被护套约束。 当护套相对于细长构件缩回时，假体分开地从护套释放。 该导管还具有推动器构件，该推动构件沿着护套内的细长构件可滑动地设置。 推动器适于在第一方向上移动经过假体而不移动假体，而在第二方向上，推动器接合所选择的假体，以便借助于推动器移动假体以使所选择的假体与第二假体互锁。

    Devices and methods for controlling expandable prostheses during deployment
    5.
    发明授权
    Devices and methods for controlling expandable prostheses during deployment 有权
    在展开期间控制可扩张假体的装置和方法

    公开(公告)号：US08486132B2

    公开(公告)日：2013-07-16

    申请号：US11689927

    申请日：2007-03-22

    申请人： David W. Snow ,  Denise Demarais ,  Stuart Lin

    发明人： David W. Snow ,  Denise Demarais ,  Stuart Lin

    IPC分类号： A61F2/06

    CPC分类号： A61F2/966 ,  A61F2/91 ,  A61F2/915 ,  A61F2/95 ,  A61F2002/826 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2002/91591 ,  A61F2002/9517

    摘要： A catheter for delivering a prosthesis to a treatment site in a body lumen comprises an elongate flexible member and a sheath slidably disposed thereover. A plurality of self-expanding tubular prostheses are carried in axially spaced apart locations along the elongate member, within the sheath. The prostheses may be selectively interlocked with one another and are constrained by the sheath in a radially contracted configuration. The prostheses are separately releasable from the sheath when the sheath is retracted relative to the elongate member. The catheter also has a pusher member slidably disposed along the elongate member within the sheath. The pusher is adapted to move past the prostheses in a first direction without displacing the prostheses, while in a second direction the pusher engages a selected prosthesis so as to move the prosthesis with the pusher to interlock the selected prosthesis with a second prosthesis.

    摘要翻译： 用于将假体递送到体腔内的治疗部位的导管包括细长的柔性构件和可滑动地设置在其上的护套。 多个自膨胀管状假体在护套内沿着细长构件在轴向间隔开的位置被承载。 假体可以选择性地互锁地互锁并且以径向收缩的构造被护套约束。 当护套相对于细长构件缩回时，假体分开地从护套释放。 该导管还具有推动器构件，该推动构件沿着护套内的细长构件可滑动地设置。 推动器适于在第一方向上移动经过假体而不移动假体，而在第二方向上，推动器接合所选择的假体，以便借助于推动器移动假体以使所选择的假体与第二假体互锁。

    METHODS AND APPARATUS FOR PULSED ELECTRIC FIELD NEUROMODULATION VIA AN INTRA-TO-EXTRAVASCULAR APPROACH
    9.
    发明申请
    METHODS AND APPARATUS FOR PULSED ELECTRIC FIELD NEUROMODULATION VIA AN INTRA-TO-EXTRAVASCULAR APPROACH 有权
    脉冲电场神经网络的方法和装置，通过内向外方法

    公开(公告)号：US20110202098A1

    公开(公告)日：2011-08-18

    申请号：US13007370

    申请日：2011-01-14

    申请人： Denise Demarais ,  Benjamin J. Clark ,  Nicolas Zadno ,  Erik Thai ,  Hanson Gifford, III

    发明人： Denise Demarais ,  Benjamin J. Clark ,  Nicolas Zadno ,  Erik Thai ,  Hanson Gifford, III

    IPC分类号： A61N1/36 ,  A61M5/14

    CPC分类号： A61B18/1477 ,  A61B18/1206 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00613 ,  A61B2018/126 ,  A61M5/14 ,  A61M37/00 ,  A61N1/05 ,  A61N1/0514 ,  A61N1/0551 ,  A61N1/321 ,  A61N1/327 ,  A61N1/36007

    摘要： Methods and apparatus are provided for pulsed electric field neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other conditions in target neural fibers. In some embodiments, the ITEV PEF system comprises an intravascular catheter having one or more electrodes configured for intra-to-extravascular placement across a wall of patient's vessel into proximity with target neural fibers. With the electrode(s) passing from an intravascular position to an extravascular position prior to delivery of the PEF, a magnitude of applied voltage or energy delivered via the electrode(s) and necessary to achieve desired neuromodulation may be reduced relative to an intravascular PEF system having one or more electrodes positioned solely intravascularly. The methods and apparatus of the present invention may, for example, be used to modulate one or more target neural fibers that contribute to renal function.

    摘要翻译： 提供了通过血管外途径进行脉冲电场神经调节的方法和装置，例如，以实现不可逆的电穿孔或电融合，坏死和/或诱导细胞凋亡，基因表达的改变，细胞因子上调的变化以及目标中的其他条件 神经纤维。 在一些实施方案中，ITEV PEF系统包括具有一个或多个电极的血管内导管，其配置用于穿过患者血管的壁进行血管外放置，使其与目标神经纤维接近。 随着电极在PEF递送之前从血管内位置传递到血管外位置，可以相对于血管内PEF减少施加的电压或通过电极传递并且达到所需神经调节所必需的能量的大小 系统具有仅位于血管内的一个或多个电极。 本发明的方法和装置可以例如用于调节一种或多种有助于肾功能的靶神经纤维。