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    Adaptive command filtering for servomechanism control systems
    1.
    发明授权
    Adaptive command filtering for servomechanism control systems 有权
    伺服机构控制系统的自适应命令过滤

    公开(公告)号：US07345448B2

    公开(公告)日：2008-03-18

    申请号：US11129059

    申请日：2005-05-12

    申请人： David Watt ,  Mehmet Alpay ,  Mark Unrath ,  John Wen ,  Ben Potsaid

    发明人： David Watt ,  Mehmet Alpay ,  Mark Unrath ,  John Wen ,  Ben Potsaid

    IPC分类号： G05B13/02

    CPC分类号： G05B13/041

    摘要： Preferred embodiments of the invention implement techniques for modifying the command trajectory, the architecture of a servomechanism control system, or both, to reduce the servo error during and/or after the command trajectory. An iterative refinement procedure generates for use by the servomechanism control system a corrective input, du, which significantly reduces the error between the desired and actual servomechanism control system outputs. In one embodiment, a uniquely identified plant model is employed in the iterative refinement procedure to compute an approximate gradient that improves the performance and reliability of the refinement procedure. In another embodiment, the actual plant response is used in place of the identified model in the iterative refinement procedure. This is accomplished by time-reversing the stored error signal from a training run, before applying it to the plant to generate an update to the corrective input signal du.

    摘要翻译： 本发明的优选实施例实现了用于修改命令轨迹，伺服机构控制系统的结构或两者的技术，以减少在命令轨迹期间和/或之后的伺服误差。 对伺服机构控制系统产生的迭代精制过程可用于校正输入du，这显着地减少了期望的和实际的伺服机构控制系统输出之间的误差。 在一个实施例中，在迭代细化过程中采用唯一识别的植物模型来计算提高细化过程的性能和可靠性的近似梯度。 在另一个实施例中，在迭代细化过程中使用实际植物响应来代替所识别的模型。 这是通过将训练运行中存储的误差信号时间反转，然后将其应用到工厂来产生对纠正输入信号du的更新来实现的。

    Adaptive command filtering for servomechanism control systems
    2.
    发明申请
    Adaptive command filtering for servomechanism control systems 有权
    伺服机构控制系统的自适应命令过滤

    公开(公告)号：US20050285558A1

    公开(公告)日：2005-12-29

    申请号：US11129059

    申请日：2005-05-12

    申请人： David Watt ,  Mehmet Alpay ,  Mark Unrath ,  John Wen ,  Ben Potsaid

    发明人： David Watt ,  Mehmet Alpay ,  Mark Unrath ,  John Wen ,  Ben Potsaid

    IPC分类号： G05B13/04 ,  G05D23/275

    CPC分类号： G05B13/041

    摘要： Preferred embodiments of the invention implement techniques for modifying the command trajectory, the architecture of a servomechanism control system, or both, to reduce the servo error during and/or after the command trajectory. An iterative refinement procedure generates for use by the servomechanism control system a corrective input, du, which significantly reduces the error between the desired and actual servomechanism control system outputs. In one embodiment, a uniquely identified plant model is employed in the iterative refinement procedure to compute an approximate gradient that improves the performance and reliability of the refinement procedure. In another embodiment, the actual plant response is used in place of the identified model in the iterative refinement procedure. This is accomplished by time-reversing the stored error signal from a training run, before applying it to the plant to generate an update to the corrective input signal du.

    摘要翻译： 本发明的优选实施例实现了用于修改命令轨迹，伺服机构控制系统的结构或两者的技术，以减少在命令轨迹期间和/或之后的伺服误差。 对伺服机构控制系统产生的迭代精制过程可用于校正输入du，这显着地减少了期望的和实际的伺服机构控制系统输出之间的误差。 在一个实施例中，在迭代细化过程中采用唯一识别的植物模型来计算提高细化过程的性能和可靠性的近似梯度。 在另一个实施例中，在迭代细化过程中使用实际植物响应来代替所识别的模型。 这是通过将训练运行中存储的误差信号时间反转，然后将其应用到工厂来产生对纠正输入信号du的更新来实现的。

    Methods for processing holes by moving precisely timed laser pulses in circular and spiral trajectories
    3.
    发明申请
    Methods for processing holes by moving precisely timed laser pulses in circular and spiral trajectories 有权
    通过以圆形和螺旋形轨迹移动精确定时的激光脉冲来处理孔的方法

    公开(公告)号：US20060027544A1

    公开(公告)日：2006-02-09

    申请号：US10912525

    申请日：2004-08-04

    申请人： Robert Pailthorp ,  Weisheng Lei ,  Hisashi Matsumoto ,  Glenn Simenson ,  David Watt ,  Mark Unrath ,  William Jordens

    发明人： Robert Pailthorp ,  Weisheng Lei ,  Hisashi Matsumoto ,  Glenn Simenson ,  David Watt ,  Mark Unrath ,  William Jordens

    IPC分类号： B23K26/38

    CPC分类号： H05K3/0026 ,  B23K26/389 ,  H05K2201/09063

    摘要： High speed removal of material from a specimen employs a beam positioner for directing a laser beam axis along various circular and spiral laser tool patterns. A preferred method of material removal entails causing relative movement between the axis of the beam and the specimen, directing the beam axis at an entry segment acceleration and along an entry trajectory to an entry position within the specimen at which laser beam pulse emissions are initiated, moving the beam axis at a circular perimeter acceleration within the specimen to remove material along a circular segment of the specimen, and setting the entry segment acceleration to less than twice the circular perimeter acceleration.

    摘要翻译： 从样品高速去除材料采用光束定位器，用于沿着各种圆形和螺旋形激光工具图案引导激光束轴线。 优选的材料去除方法需要引起梁的轴线和样品之间的相对运动，将束轴线以入口段加速度并沿着入口轨迹引导到在激光束脉冲发射开始的样本内的入口位置， 沿着试样中的圆周边加速度移动光束轴，以沿着试样的圆形段移除材料，并将进入段加速度设置为小于圆周边加速度的两倍。

    Hydroxypropyl Substitution Used to Regulate Dissolution of a Chemical
    6.
    发明申请
    Hydroxypropyl Substitution Used to Regulate Dissolution of a Chemical 审中-公开
    用于调节化学溶解度的羟丙基取代基

    公开(公告)号：US20100215744A1

    公开(公告)日：2010-08-26

    申请号：US12756962

    申请日：2010-04-08

    申请人： David Watt ,  Steven B. Newhard

    发明人： David Watt ,  Steven B. Newhard

    IPC分类号： A61K9/22 ,  A61K31/65 ,  A61P43/00

    CPC分类号： A61K31/65 ,  A61K9/2054

    摘要： A method of producing a batch of a tetracycline-class component HPMC extended release pharmaceutical product having a desired dissolution profile, comprising: selecting a dissolution rate-controlling polymer comprising an HPMC component, the HPMC component having a selected % HP value; validating that the % HP in the selected HPMC component is such that a mean sample of the product complies with the desired dissolution profile over each time point in the dissolution profile, and preparing the product by preparing a formulation comprising a pharmaceutically effective amount of the tetracycline-class chemical and the selected HPMC component with the % HP value. There is also provided a method of predicting the dissolution rate profile over a number of dosage forms.

    摘要翻译： 一种生产具有所需溶出曲线的四环素类组分HPMC缓释药物产品的批次的方法，包括：选择包含HPMC组分的所述溶出速率控制聚合物，所述HPMC组分具有选定的HP值; 验证所选HPMC组分中的％HP是否使得产物的平均样品在溶出曲线中的每个时间点符合期望的溶出曲线，并且通过制备包含药学有效量的四环素的制剂来制备产品 - 化学品和所选HPMC组分，具有％HP值。 还提供了一种在许多剂型上预测溶出速率谱的方法。

    Method for the treatment of acne and certain dosage forms thereof
    7.
    发明授权
    Method for the treatment of acne and certain dosage forms thereof 有权
    治疗痤疮的方法及其某些剂型

    公开(公告)号：US09192615B2

    公开(公告)日：2015-11-24

    申请号：US12536359

    申请日：2009-08-05

    申请人： Mitchell Wortzman ,  R. Todd Plott ,  Steven B. Newhard ,  David Watt

    发明人： Mitchell Wortzman ,  R. Todd Plott ,  Steven B. Newhard ,  David Watt

    IPC分类号： A61K31/65 ,  A61K9/20

    CPC分类号： A61K31/65 ,  A61K9/2018 ,  A61K9/2054

    摘要： An oral dosage form, including 65 mg of minocycline, an amount of lactose monohydrate, and an amount of hydroxypropylmethylcellulose. The hydroxypropylmethylcellulose is hydroxypropylmethylcellulose that is about 8.9+/−0.2% hydroxypropoxylated. An oral dosage form, including 115 mg of minocycline, an amount of lactose monohydrate, and an amount of hydroxypropylmethylcellulose. The hydroxypropylmethylcellulose is hydroxypropylmethylcellulose that is about 8.9+/−0.2% hydroxypropoxylated.

    摘要翻译： 口服剂型，包括65mg米诺环素，一定量的乳糖一水合物和一定量的羟丙基甲基纤维素。 羟丙基甲基纤维素是约8.9 +/- 0.2％羟基丙氧基化的羟丙基甲基纤维素。 口服剂型，包括115毫克米诺环素，一定量的乳糖一水合物和一定量的羟丙基甲基纤维素。 羟丙基甲基纤维素是约8.9 +/- 0.2％羟基丙氧基化的羟丙基甲基纤维素。

    Extended-release minocycline dosage forms
    8.
    发明授权
    Extended-release minocycline dosage forms 有权
    延长释放米诺环素剂型

    公开(公告)号：US08722650B1

    公开(公告)日：2014-05-13

    申请号：US12861424

    申请日：2010-08-23

    申请人： Mitchell Wortzman ,  R. Todd Plott ,  Steven B. Newhard ,  David Watt

    发明人： Mitchell Wortzman ,  R. Todd Plott ,  Steven B. Newhard ,  David Watt

    IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K9/52 ,  A61K9/54 ,  A61K31/65

    CPC分类号： A61K31/65

    摘要： An oral dosage form has the following: an amount of minocycline selected from the group consisting of 55 mg, 80 mg, and 105 mg; an amount of lactose monohydrate; an amount of hydroxypropylmethylcellulose. The hydroxypropylmethylcellulose is at least 8.3 to about 9.8% hydroxypropoxylated. The minocycline in the oral dosage form has a dissolution profile or release rates about 35% to about 50% in 1 hour, about 60% to about 75% in 2 hours, and at least about 90% in 4 hours. There is also provided a method of treating acne in a human and a method of assisting a physician in prescribing a dose of minocycline for the treatment of acne.

    摘要翻译： 口服剂型如下：一种选自55mg，80mg和105mg的米诺环素的量; 一定量的乳糖一水合物; 一定量的羟丙基甲基纤维素。 羟丙基甲基纤维素至少为8.3至9.8％羟基丙氧基化。 口服剂型中的米诺环素在1小时内具有约35％至约50％，2小时内约60％至约75％，4小时内至少约90％的释放速率。 还提供了治疗人类痤疮的方法和辅助医生处方剂量的米诺环素用于治疗痤疮的方法。