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    HUMAN ANTIBODIES THAT BIND LYMPHOCYTE ACTIVATION GENE-3 (LAG-3) AND USES THEREOF
    2.
    发明申请
    HUMAN ANTIBODIES THAT BIND LYMPHOCYTE ACTIVATION GENE-3 (LAG-3) AND USES THEREOF 审中-公开
    人淋巴细胞活化基因-3（LAG-3）的人抗体及其用途

    公开(公告)号：US20110150892A1

    公开(公告)日：2011-06-23

    申请号：US13058492

    申请日：2009-08-11

    申请人： Kent B. Thudium ,  Mark Selby ,  Kyra D. Zens ,  Mark Yamanaka ,  Alan J. Korman ,  Heidi N. LeBlanc

    发明人： Kent B. Thudium ,  Mark Selby ,  Kyra D. Zens ,  Mark Yamanaka ,  Alan J. Korman ,  Heidi N. LeBlanc

    IPC分类号： A61K39/395 ,  C12P21/08 ,  C12N5/10 ,  C12N5/02 ,  C12N15/63 ,  C07K16/00 ,  C07H21/04 ,  A61P37/00 ,  A61P35/00 ,  A61P31/12

    CPC分类号： C07K16/2803 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2827 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to LAG-3 with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human LAG-3. In certain embodiments, the antibodies bind both human and monkey LAG-3 but do not bind mouse LAG-3. The invention provides anti-LAG-3 antibodies that can inhibit the binding of LAG-3 to MHC Class II molecules and that can stimulate antigen- specific T cell responses. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. This disclosure also provides methods for detecting LAG-3, as well as methods for treating stimulating immune responses using an anti-LAG-3 antibody of the invention. Combination therapy, in which an anti- LAG-3 antibody is co-administered with at least one additional immuno stimulatory antibody, is also provided.

    摘要翻译： 本公开提供了以高亲和力特别是人单克隆抗体特异性结合LAG-3的分离的单克隆抗体。 优选地，抗体结合人LAG-3。 在某些实施方案中，抗体结合人和猴LAG-3，但不结合小鼠LAG-3。 本发明提供可以抑制LAG-3与MHC II类分子的结合并可刺激抗原特异性T细胞应答的抗LAG-3抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本公开还提供了用于检测LAG-3的方法，以及使用本发明的抗LAG-3抗体治疗刺激性免疫应答的方法。 还提供了组合治疗，其中抗LAG-3抗体与至少一种额外的免疫刺激性抗体共同施用。