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公开(公告)号：US08088749B2
公开(公告)日：2012-01-03
申请号：US12333559
申请日：2008-12-12
申请人： Diane Simeone , Mats Ljungman , Liang Xu , Lidong Wang , Fengtian He
发明人： Diane Simeone , Mats Ljungman , Liang Xu , Lidong Wang , Fengtian He
CPC分类号： A61K31/7088
摘要： The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target ATDC (TRIM29) expression in cancer with ATDC overexpression.
摘要翻译： 本发明涉及癌症的治疗靶点。 特别地，本发明涉及靶ATDC（TRIM29）在ATDC过表达的癌症中的表达的小分子和核酸。
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公开(公告)号：US20090192112A1
公开(公告)日：2009-07-30
申请号：US12333559
申请日：2008-12-12
申请人： Diane Simeone , Mats Ljungman , Liang Xu , Lidong Wang
发明人： Diane Simeone , Mats Ljungman , Liang Xu , Lidong Wang
IPC分类号： A61K31/7105 , A61P35/00 , C12N5/00 , A61K31/7068
CPC分类号： A61K31/7088
摘要： The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target ATDC (TRIM29) expression in cancer with ATDC overexpression.
摘要翻译： 本发明涉及癌症的治疗靶点。 特别地，本发明涉及靶ATDC（TRIM29）在ATDC过表达的癌症中的表达的小分子和核酸。
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公开(公告)号：US20050009067A1
公开(公告)日：2005-01-13
申请号：US10848259
申请日：2004-05-18
申请人： Craig Logsdon , Samir Hanash , Diane Simeone
发明人： Craig Logsdon , Samir Hanash , Diane Simeone
IPC分类号： A61B20060101 , C07H21/02 , C07H21/04 , C12P19/34 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： G01N33/57438 , G01N33/507 , G01N33/5082
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with pancreatic cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of pancreatic cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
摘要翻译： 本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了与胰腺癌相关的基因表达谱。 使用本发明的方法鉴定为癌症标志物的基因可用于胰腺癌的诊断和表征。 此外，这些基因为癌症药物筛选和治疗应用提供了靶标。
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4.发明授权Multimodal spectroscopic systems and methods for classifying biological tissue 有权用于分类生物组织的多峰光谱系统和方法公开(公告)号：US08694266B2
公开(公告)日：2014-04-08
申请号：US13473471
申请日：2012-05-16
申请人： Mary-Ann Mycek , Malavika Chandra , James Scheiman , Robert H. Wilson , Diane Simeone , Barbara McKenna , Jeremy Taylor , Oliver Lee , Leng-Chun Chen , William Lloyd
发明人： Mary-Ann Mycek , Malavika Chandra , James Scheiman , Robert H. Wilson , Diane Simeone , Barbara McKenna , Jeremy Taylor , Oliver Lee , Leng-Chun Chen , William Lloyd
CPC分类号： G01N21/474 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/425 , A61B5/7264 , A61B5/7267 , G01J3/10 , G01J3/4406 , G01N21/6408 , G01N21/645 , G01N21/6486 , G01N33/57438 , G01N2021/4742 , G01N2021/6484 , G01N2201/1293
摘要： Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue, either ex vivo or in vivo, and compare the response data with a model configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes.
摘要翻译： 多光谱光谱系统和方法产生光谱事件以从生物组织离体或体内获得光谱响应数据，并将响应数据与配置为将测量的响应数据与组织的最可能属性相关联的模型进行比较， 从而便于基于这些属性对组织进行分类。
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5.发明授权Multimodal spectroscopic systems and methods for classifying biological tissue 有权用于分类生物组织的多峰光谱系统和方法公开(公告)号：US08234078B2
公开(公告)日：2012-07-31
申请号：US12882131
申请日：2010-09-14
申请人： Mary-Ann Mycek , Malavika Chandra , James Scheiman , Robert H. Wilson , Diane Simeone , Barbara McKenna , Julianne Purdy , Jeremy Taylor , Oliver Lee
发明人： Mary-Ann Mycek , Malavika Chandra , James Scheiman , Robert H. Wilson , Diane Simeone , Barbara McKenna , Julianne Purdy , Jeremy Taylor , Oliver Lee
CPC分类号： A61B5/415 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/418 , A61B5/7264 , A61B5/7267 , G01J3/10 , G01J3/4406 , G01N21/474 , G01N21/6408 , G01N21/645 , G01N21/6486 , G01N33/57438 , G01N2021/4742 , G01N2021/6484 , G01N2201/1293
摘要： Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with an empirical equation configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary.
摘要翻译： 多光谱光谱系统和方法产生光谱事件以从生物组织获得光谱响应数据，并将响应数据与配置为将测量的响应数据和组织的最可能属性相关联的经验方程进行比较，从而促进基于组织的分类 关于随后活检的这些属性或必要的补救措施。
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6.发明申请Multimodal Spectroscopic Systems and Methods for Classifying Biological Tissue 有权用于分类生物组织的多峰光谱系统和方法公开(公告)号：US20100330611A1
公开(公告)日：2010-12-30
申请号：US12882131
申请日：2010-09-14
申请人： Mary-Ann Mycek , Malavika Chandra , James Scheiman , Robert H. Wilson , Diane Simeone , Barbara McKenna , Julianne Purdy , Jeremy Taylor , Oliver Lee
发明人： Mary-Ann Mycek , Malavika Chandra , James Scheiman , Robert H. Wilson , Diane Simeone , Barbara McKenna , Julianne Purdy , Jeremy Taylor , Oliver Lee
CPC分类号： A61B5/415 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/418 , A61B5/7264 , A61B5/7267 , G01J3/10 , G01J3/4406 , G01N21/474 , G01N21/6408 , G01N21/645 , G01N21/6486 , G01N33/57438 , G01N2021/4742 , G01N2021/6484 , G01N2201/1293
摘要： Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with an empirical equation configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary.
摘要翻译： 多光谱光谱系统和方法产生光谱事件以从生物组织获得光谱响应数据，并将响应数据与配置为将测量的响应数据和组织的最可能属性相关联的经验方程进行比较，从而促进基于组织的分类 关于随后活检的这些属性或必要的补救措施。
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7.发明申请Multimodal Spectroscopic Systems and Methods for Classifying Biological Tissue 有权用于分类生物组织的多峰光谱系统和方法公开(公告)号：US20090317856A1
公开(公告)日：2009-12-24
申请号：US12479600
申请日：2009-06-05
申请人： Mary-Ann Mycek , Malavika Chandra , James Scheiman , Robert H. Wilson , Diane Simeone , Barbara McKenna , Julianne Purdy
发明人： Mary-Ann Mycek , Malavika Chandra , James Scheiman , Robert H. Wilson , Diane Simeone , Barbara McKenna , Julianne Purdy
CPC分类号： G01N33/57438 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/415 , A61B5/418 , A61B5/7264 , A61B5/7267 , G01J3/10 , G01J3/4406 , G01N21/474 , G01N21/6408 , G01N21/645 , G01N21/6486 , G01N2021/4742 , G01N2021/6484 , G01N2201/1293
摘要： Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue and compare the response data with preset criteria configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes for subsequent biopsy or remedial measures as necessary.
摘要翻译： 多光谱光谱系统和方法产生光谱事件以从生物组织获得光谱响应数据，并将响应数据与配置为将测量的响应数据和组织的最可能属性相关联的预设标准进行比较，从而便于基于 这些属性用于随后的活检或必要的补救措施。
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8.发明申请公开(公告)号：US20130005598A1
公开(公告)日：2013-01-03
申请号：US13519766
申请日：2010-12-30
申请人： Brian B. Haab , Diane Simeone
发明人： Brian B. Haab , Diane Simeone
IPC分类号： G01N33/574 , C40B30/04 , A61B5/153 , C40B40/10
CPC分类号： G01N33/57438 , C07K16/18 , C07K16/3007 , C07K16/3092 , G01N33/6893 , G01N2333/42 , G01N2333/4724 , G01N2333/4725 , G01N2800/067 , G01N2800/50
摘要： A method of diagnosing the malignant potential of a pancreatic cystic lesion in a subject including: detecting a glycan alteration in MUC5AC in a sample of pancreatic cystic lesion fluid from a subject, determining whether the glycan alteration is differentially present in the sample, and diagnosing the malignant potential of the pancreatic cystic lesion. A method of diagnosing the malignant potential of a pancreatic cystic lesion in a subject including: (a) detecting a glycan alteration in MUC5AC in a sample of pancreatic cystic lesion fluid from a subject, (b) detecting CA 19-9 in the sample, (c) determining whether the glycan alteration and CA 19-9 are differentially present in the sample, and (d) diagnosing the malignant potential of the pancreatic cystic lesion. Related methods of treatment and kits also are included.
摘要翻译： 一种诊断受试者胰腺囊性病变的恶性潜力的方法，包括：检测来自受试者的胰腺囊性病变液样品中MUC5AC的聚糖改变，确定样品中是否差异存在聚糖改变，并诊断 胰腺囊性病变的恶性潜能。 一种诊断受试者胰腺囊性病变恶性潜力的方法，包括：（a）检测来自受试者的胰腺囊性病变液样品中MUC5AC的聚糖改变，（b）检测样品中的CA 19-9， （c）确定样品中聚糖改变和CA19-9是否差异存在，以及（d）诊断胰腺囊性病变的恶性潜能。 还包括相关治疗方法和试剂盒。
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9.发明申请公开(公告)号：US20120245473A1
公开(公告)日：2012-09-27
申请号：US13473471
申请日：2012-05-16
申请人： Mary-Ann Mycek , Malavika Chandra , James Scheiman , Robert H. Wilson , Diane Simeone , Barbara McKenna , Jeremy Taylor , Oliver Lee , Leng-Chun Chen , William Lloyd
发明人： Mary-Ann Mycek , Malavika Chandra , James Scheiman , Robert H. Wilson , Diane Simeone , Barbara McKenna , Jeremy Taylor , Oliver Lee , Leng-Chun Chen , William Lloyd
CPC分类号： G01N21/474 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/425 , A61B5/7264 , A61B5/7267 , G01J3/10 , G01J3/4406 , G01N21/6408 , G01N21/645 , G01N21/6486 , G01N33/57438 , G01N2021/4742 , G01N2021/6484 , G01N2201/1293
摘要： Multimodal optical spectroscopy systems and methods produce a spectroscopic event to obtain spectroscopic response data from biological tissue, either ex vivo or in vivo, and compare the response data with a model configured to correlate the measured response data and the most probable attributes of the tissue, thus facilitating classification of the tissue based on those attributes.
摘要翻译： 多光谱光谱系统和方法产生光谱事件以从生物组织离体或体内获得光谱响应数据，并将响应数据与配置为将测量的响应数据和组织的最可能属性相关联的模型进行比较， 从而便于基于这些属性对组织进行分类。
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公开(公告)号：US20120070368A1
公开(公告)日：2012-03-22
申请号：US13087094
申请日：2011-04-14
申请人： Lynne Canne Bannen , Diva Sze-Ming Chan , Timothy Patrick Forsyth , Richard George Khoury , James William Leahy , Morrison B. Mac , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Yong Wang , Wei Xu , Diane Simeone
发明人： Lynne Canne Bannen , Diva Sze-Ming Chan , Timothy Patrick Forsyth , Richard George Khoury , James William Leahy , Morrison B. Mac , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Yong Wang , Wei Xu , Diane Simeone
CPC分类号： A61K31/47 , A61K31/517 , A61K31/7068 , A61K45/06 , A61N5/10 , A61K2300/00
摘要： Disclosed are methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt thereof, in combination with gemcitabine (GEM), or a pharmaceutically acceptable salt thereof, and optionally one or more additional treatments, wherein:R1 is halo;R2 is halo;R3 is (C1-C6)alkyl;R4 is (C1-C6)alkyl; andQ is CH or N.
摘要翻译： 公开了通过给予式I化合物或其药学上可接受的盐与吉西他滨（GEM）或其药学上可接受的盐以及任选的一种或多种另外的治疗组合治疗癌症的方法，其中：R1是卤素; R2是卤素; R3是（C1-C6）烷基; R4是（C1-C6）烷基; Q为CH或N.
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