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    Valve unit, microfluidic device having the same, and method of driving the valve unit
    2.
    发明授权
    Valve unit, microfluidic device having the same, and method of driving the valve unit 有权
    阀单元，具有相同的微流体装置，以及驱动阀单元的方法

    公开(公告)号：US08490655B2

    公开(公告)日：2013-07-23

    申请号：US12938777

    申请日：2010-11-03

    申请人： Jong Myeon Park ,  Do Gyoon Kim ,  Sang Bum Park

    发明人： Jong Myeon Park ,  Do Gyoon Kim ,  Sang Bum Park

    IPC分类号： F15C1/04

    CPC分类号： B01L3/502738 ,  B01L2300/0803 ,  B01L2300/1861 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0677 ,  C08L2201/12 ,  F16K99/0032 ,  F16K99/0044 ,  F16K2099/0084 ,  Y10T137/0391 ,  Y10T137/1812 ,  Y10T137/2196 ,  Y10T137/4643

    摘要： A normally open valve unit to close a channel, a microfluidic device equipped with the same, and a method of driving the valve unit are provided. The valve unit includes a valve substance including a phase transition material, a valve substance chamber which communicates with the channel and in which the valve substance is disposed, and a fusion structure formed in a section of the channel in which, wherein when the valve substance contained in the valve substance chamber is fused by applied energy and flows into the section of the channel in which the fusion structure is formed, and the valve substance is heated to melt the fusion structure and conduct fused bonding of the channel, thereby closing the channel.

    摘要翻译： 设置关闭通道的常开阀单元，配备有该通道的微流体装置以及驱动阀单元的方法。 所述阀单元包括阀体，所述阀体包括相变材料，与所述通道连通并且所述阀体配置的阀体室，以及形成在所述通道的一部分中的熔融结构，其中当所述阀体 阀体物质室中所含的气体被施加的能量熔化并流入其中形成熔融结构的通道的部分，并且阀体被加热以融化熔融结构并且导通通道的熔合，从而关闭通道 。

    Microfluidic apparatus and control method thereof
    3.
    发明授权
    Microfluidic apparatus and control method thereof 有权
    微流体装置及其控制方法

    公开(公告)号：US09101935B2

    公开(公告)日：2015-08-11

    申请号：US13604045

    申请日：2012-09-05

    申请人： Sang Bum Park ,  Na Hui Kim ,  Sang Hyun Lee

    发明人： Sang Bum Park ,  Na Hui Kim ,  Sang Hyun Lee

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  G01N21/75 ,  G01N21/66 ,  B01L3/00

    CPC分类号： B01L3/502769 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2200/141 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0677

    摘要： A microfluidic apparatus having an additional chamber containing material configured to prevent cross contamination between reaction chambers contained therein, and a control method thereof are provided. The microfluidic apparatus includes a sample chamber configured to accommodate a sample, a plurality of reaction chambers each configured to accommodate a reagent, a distribution channel configured to distribute the sample into the plurality of reaction chambers, a mixture prevention chamber connected to the distribution channel and containing a mixture prevention material configured to prevent the reagents accommodated in the plurality of reaction chambers from being mixed with each other, and a valve disposed within the distribution channel and configured to open and close the distribution channel.

    摘要翻译： 提供一种微流体装置，其具有附加的室容纳材料，其被配置为防止其中包含的反应室之间的交叉污染及其控制方法。 微流体装置包括被配置为容纳样品的样品室，各自构造成容纳试剂的多个反应室，被配置为将样品分配到多个反应室中的分配通道，连接到分配通道的混合物防止室和 所述混合物防止材料被配置为防止容纳在所述多个反应室中的试剂相互混合，以及阀，其设置在所述分配通道内并且构造成打开和关闭所述分配通道。

    Equine Amniotic Fluid-Derived Multipotent Stem Cells and a Method for Producing the Same
    5.
    发明申请
    Equine Amniotic Fluid-Derived Multipotent Stem Cells and a Method for Producing the Same 有权
    马氏羊血液衍生的多能干细胞及其生产方法

    公开(公告)号：US20130230924A1

    公开(公告)日：2013-09-05

    申请号：US13821303

    申请日：2011-09-07

    申请人： Kyung Sun Kang ,  Min Soo Seo ,  Sang Bum Park

    发明人： Kyung Sun Kang ,  Min Soo Seo ,  Sang Bum Park

    IPC分类号： C12N5/071 ,  C12N5/0735

    CPC分类号： C12N5/0655 ,  A61K35/50 ,  C12N5/0605 ,  C12N5/0606 ,  C12N5/0653 ,  C12N5/0654 ,  C12N5/0668

    摘要： The present invention relates to equine amniotic fluid-derived multipotent stem cells (eAF-MSCs) and a preparation method thereof. More particularly, the present invention relates to equine amniotic fluid-derived multipotent stem cells which exhibit all negative immunological characteristics with respect to the human markers, CD19, CD20, CD28, CD31, CD34, CD38, CD41a, CD62L, CD62P and CD200, and exhibit all positive immunological characteristics with respect to the human markers, CD44, CD90 and CD105, and have the ability to differentiate into ectoderm, mesoderm or endoderm-derived cells.The present invention confirmed that equine amniotic fluid can be a source of equine adult multipotent stem cell supply, and the equine amniotic fluid-derived multipotent stem cells exhibit excellent self-renewal ability and differentiation capability. Therefore, the cells can be used as an active ingredient for cell therapy of horses, which requires a large amount of cells. In particular, the stem cells of the present invention having excellent self-renewal ability and differentiation capability are useful for the treatment of bone, tendon, or muscle injuries and bone loss diseases of racehorses.

    摘要翻译： 本发明涉及马羊源多能干细胞（eAF-MSC）及其制备方法。 更具体地说，本发明涉及相对于人类标记物CD19，CD20，CD28，CD31，CD34，CD38，CD41a，CD62L，CD62P和CD200具有全部阴性免疫学特性的马羊羊多能干细胞，以及 相对于人类标志物CD44，CD90和CD105显示出所有阳性免疫学特征，并具有分化成外胚层，中胚层或内胚层衍生细胞的能力。 本发明证实马羊水可以成为马成人多能干细胞供应的来源，马羊羊多能干细胞表现出优异的自我更新能力和分化能力。 因此，细胞可以用作用于马的细胞治疗的活性成分，其需要大量的细胞。 特别地，本发明的具有优异的自我更新能力和分化能力的干细胞可用于治疗赛马的骨骼，肌腱或肌肉损伤和骨丢失疾病。