公开(公告)号：US20110143364A1

公开(公告)日：2011-06-16

申请号：US12883786

申请日：2010-09-16

申请人： In Wook Kim ,  Na Hui Kim

发明人： In Wook Kim ,  Na Hui Kim

IPC分类号： G01N33/566 ,  C12M1/34

CPC分类号： G01N33/723 ,  B01L3/5027 ,  B01L2200/0605 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2400/0409 ,  G01N21/07

摘要： Disclosed are a centrifugal micro-fluidic structure for measuring glycated hemoglobin, a centrifugal micro-fluidic device for measuring glycated hemoglobin, and a method for measuring glycated hemoglobin. According to the disclosure, immunosorbent assay and affinity measurements are simultaneously conducted using only a single device in order to detect hemoglobin variants or interfering substances and, therefore, the detected results are applied to analysis of measurement results so as to eliminate and/or compensate for, or calibrate errors in measurement of, glycated hemoglobin, thereby more accurately measuring the glycated hemoglobin.

摘要翻译： 公开了用于测量糖化血红蛋白的离心微流体结构，用于测量糖化血红蛋白的离心微流体装置和测定糖化血红蛋白的方法。 根据该公开内容，仅使用单个装置同时进行免疫吸附测定和亲和力测量，以便检测血红蛋白变体或干扰物质，因此将检测结果应用于测量结果的分析，以消除和/或补偿 或校准糖化血红蛋白的测量误差，从而更准确地测量糖化血红蛋白。

公开(公告)号：US09289765B2

公开(公告)日：2016-03-22

申请号：US13170927

申请日：2011-06-28

申请人： Do Gyoon Kim ,  Han Sang Kim ,  Yang Ui Lee ,  Yoon Kyoung Cho ,  Na Hui Kim ,  Sang Bum Park

发明人： Do Gyoon Kim ,  Han Sang Kim ,  Yang Ui Lee ,  Yoon Kyoung Cho ,  Na Hui Kim ,  Sang Bum Park

IPC分类号： B01L3/00 ,  G01N21/00 ,  G01N21/07 ,  G01N35/00 ,  B01J19/00 ,  G01N1/00 ,  G01N35/04 ,  G01N33/543

CPC分类号： B01L3/502753 ,  B01L3/5027 ,  B01L3/50273 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0806 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  G01N33/54386 ,  G01N2035/0449

摘要： A microfluidic device having a delay structure and a sample testing apparatus including the microfluidic device are provided. The microfluidic device includes: a reaction chamber which contains a reagent capable of reacting with a sample; a distribution channel through which the sample is provided to the reaction chamber; an inlet channel through which the at least one reaction chamber is connected with the distribution channel; and a delay structure which is located between the at least one reaction chamber and the distribution channel, and delays movement of contents of the reaction chamber to the distribution channel.

摘要翻译： 提供具有延迟结构的微流体装置和包括微流体装置的样品测试装置。 微流体装置包括：反应室，其含有能够与样品反应的试剂; 将样品提供给反应室的分配通道; 入口通道，所述至少一个反应室通过所述入口通道与所述分配通道连接; 以及延迟结构，其位于所述至少一个反应室和所述分配通道之间，并且将所述反应室的内容物的运动延迟到所述分配通道。

公开(公告)号：US20120261026A1

公开(公告)日：2012-10-18

申请号：US13364964

申请日：2012-02-02

申请人： Jong Gun Lee ,  Na Hui Kim ,  Young Goun Lee

发明人： Jong Gun Lee ,  Na Hui Kim ,  Young Goun Lee

IPC分类号： B01L3/00 ,  B81B1/00

CPC分类号： B01L3/502738 ,  B01L2200/0605 ,  B01L2300/021 ,  B01L2300/0806 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/0688 ,  B01L2400/086

摘要： A microfluidic device to meter an accurate amount of fluid is provided. The microfluidic device includes a chamber configured to accommodate a fluid therein, an inlet channel connected to the chamber to supply the fluid into the chamber, and an outlet channel connected to the chamber and provided separately from the inlet channel. The outlet channel is configured such that after the chamber is filled with a predetermined amount of the fluid introduced through the inlet channel, any additional amount of the fluid introduced into the chamber in excess of the predetermined amount exits the chamber through the outlet channel.

摘要翻译： 提供了一种用于计量精确量的流体的微流体装置。 微流体装置包括被配置为在其中容纳流体的腔室，连接到腔室以将流体供应到腔室中的入口通道，以及连接到腔室并与入口通道分开设置的出口通道。 出口通道被构造成使得在腔室中填充有通过入口通道引入的预定量的流体之后，引入腔室中超过预定量的任何额外量的流体通过出口通道离开室。

公开(公告)号：US09101935B2

公开(公告)日：2015-08-11

申请号：US13604045

申请日：2012-09-05

申请人： Sang Bum Park ,  Na Hui Kim ,  Sang Hyun Lee

发明人： Sang Bum Park ,  Na Hui Kim ,  Sang Hyun Lee

IPC分类号： C12Q1/68 ,  C12P19/34 ,  G01N21/75 ,  G01N21/66 ,  B01L3/00

CPC分类号： B01L3/502769 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2200/141 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0677

摘要： A microfluidic apparatus having an additional chamber containing material configured to prevent cross contamination between reaction chambers contained therein, and a control method thereof are provided. The microfluidic apparatus includes a sample chamber configured to accommodate a sample, a plurality of reaction chambers each configured to accommodate a reagent, a distribution channel configured to distribute the sample into the plurality of reaction chambers, a mixture prevention chamber connected to the distribution channel and containing a mixture prevention material configured to prevent the reagents accommodated in the plurality of reaction chambers from being mixed with each other, and a valve disposed within the distribution channel and configured to open and close the distribution channel.

摘要翻译： 提供一种微流体装置，其具有附加的室容纳材料，其被配置为防止其中包含的反应室之间的交叉污染及其控制方法。 微流体装置包括被配置为容纳样品的样品室，各自构造成容纳试剂的多个反应室，被配置为将样品分配到多个反应室中的分配通道，连接到分配通道的混合物防止室和 所述混合物防止材料被配置为防止容纳在所述多个反应室中的试剂相互混合，以及阀，其设置在所述分配通道内并且构造成打开和关闭所述分配通道。

公开(公告)号：US08834812B2

公开(公告)日：2014-09-16

申请号：US13370991

申请日：2012-02-10

申请人： Yong Koo Lee ,  Na Hui Kim ,  Jong Gun Lee

发明人： Yong Koo Lee ,  Na Hui Kim ,  Jong Gun Lee

IPC分类号： B01L99/00 ,  G01N21/07 ,  B01L3/00

CPC分类号： G01N21/07 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/022 ,  B01L2300/024 ,  B01L2300/0806 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/084

摘要： A microfluidic device having a chamber with a fluid discharge configuration is provided. The microfluidic device includes a platform including a chamber configured to accommodate a fluid therein. The chamber includes an inner sidewall and an outer sidewall disposed outwardly from the inner sidewall in a radial direction of the platform. The outer sidewall includes a first point located closest to a center of the platform, and a second point located farthest from the center of the platform. A distance from the center of the platform to an arbitrary third point on the outer sidewall between the first point and the second point increases from the first point to the second point, so that the fluid near the first point is guided to the second point by centrifugal force during rotation of the platform.

摘要翻译： 提供具有流体排出构造的室的微流体装置。 微流体装置包括平台，该平台包括被配置为在其中容纳流体的腔室。 所述腔室包括内侧壁和从所述内侧壁沿所述平台的径向方向设置的外侧壁。 外侧壁包括最靠近平台中心的第一点和位于距平台中心最远的第二点。 在第一点和第二点之间从平台的中心到外侧壁上的任意第三点的距离从第一点增加到第二点，使得靠近第一点的流体被引导到第二点 平台旋转时的离心力。

公开(公告)号：US08481301B2

公开(公告)日：2013-07-09

申请号：US12883786

申请日：2010-09-16

申请人： In Wook Kim ,  Na Hui Kim

发明人： In Wook Kim ,  Na Hui Kim

IPC分类号： C12M1/34

CPC分类号： G01N33/723 ,  B01L3/5027 ,  B01L2200/0605 ,  B01L2300/0806 ,  B01L2300/0864 ,  B01L2400/0409 ,  G01N21/07

摘要： Disclosed are a centrifugal micro-fluidic structure for measuring glycated hemoglobin, a centrifugal micro-fluidic device for measuring glycated hemoglobin, and a method for measuring glycated hemoglobin. According to the disclosure, immunosorbent assay and affinity measurements are simultaneously conducted using only a single device in order to detect hemoglobin variants or interfering substances and, therefore, the detected results are applied to analysis of measurement results so as to eliminate and/or compensate for, or calibrate errors in measurement of, glycated hemoglobin, thereby more accurately measuring the glycated hemoglobin.

摘要翻译： 公开了用于测量糖化血红蛋白的离心微流体结构，用于测量糖化血红蛋白的离心微流体装置和测定糖化血红蛋白的方法。 根据该公开内容，仅使用单个装置同时进行免疫吸附测定和亲和力测量，以便检测血红蛋白变体或干扰物质，因此将检测结果应用于测量结果的分析，以消除和/或补偿 或校准糖化血红蛋白的测量误差，从而更准确地测量糖化血红蛋白。

公开(公告)号：US20120207654A1

公开(公告)日：2012-08-16

申请号：US13370991

申请日：2012-02-10

申请人： Yong Koo LEE ,  Na Hui KIM ,  Jong Gun LEE

发明人： Yong Koo LEE ,  Na Hui KIM ,  Jong Gun LEE

IPC分类号： G01N33/00

CPC分类号： G01N21/07 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0647 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/022 ,  B01L2300/024 ,  B01L2300/0806 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/084

摘要： A microfluidic device having a chamber with a fluid discharge configuration is provided. The microfluidic device includes a platform including a chamber configured to accommodate a fluid therein. The chamber includes an inner sidewall and an outer sidewall disposed outwardly from the inner sidewall in a radial direction of the platform. The outer sidewall includes a first point located closest to a center of the platform, and a second point located farthest from the center of the platform. A distance from the center of the platform to an arbitrary third point on the outer sidewall between the first point and the second point increases from the first point to the second point, so that the fluid near the first point is guided to the second point by centrifugal force during rotation of the platform.

摘要翻译： 提供具有流体排出构造的室的微流体装置。 微流体装置包括平台，该平台包括被配置为在其中容纳流体的腔室。 所述腔室包括内侧壁和从所述内侧壁沿所述平台的径向方向设置的外侧壁。 外侧壁包括最靠近平台中心的第一点和位于距平台中心最远的第二点。 在第一点和第二点之间从平台的中心到外侧壁上的任意第三点的距离从第一点增加到第二点，使得靠近第一点的流体被引导到第二点 平台旋转时的离心力。

公开(公告)号：US20130065280A1

公开(公告)日：2013-03-14

申请号：US13604045

申请日：2012-09-05

申请人： Sang Bum PARK ,  Na Hui KIM ,  Sang Hyun LEE

发明人： Sang Bum PARK ,  Na Hui KIM ,  Sang Hyun LEE

IPC分类号： C12P19/34 ,  C12M1/00 ,  B82Y30/00

CPC分类号： B01L3/502769 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2200/141 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0677

摘要： A microfluidic apparatus having an additional chamber containing material configured to prevent cross contamination between reaction chambers contained therein, and a control method thereof are provided. The microfluidic apparatus includes a sample chamber configured to accommodate a sample, a plurality of reaction chambers each configured to accommodate a reagent, a distribution channel configured to distribute the sample into the plurality of reaction chambers, a mixture prevention chamber connected to the distribution channel and containing a mixture prevention material configured to prevent the reagents accommodated in the plurality of reaction chambers from being mixed with each other, and a valve disposed within the distribution channel and configured to open and close the distribution channel.

摘要翻译： 提供一种微流体装置，其具有附加的室容纳材料，其被配置为防止其中包含的反应室之间的交叉污染及其控制方法。 微流体装置包括被配置为容纳样品的样品室，各自构造成容纳试剂的多个反应室，被配置为将样品分配到多个反应室中的分配通道，连接到分配通道的混合物防止室和 所述混合物防止材料被配置为防止容纳在所述多个反应室中的试剂相互混合，以及阀，其设置在所述分配通道内并构造成打开和关闭所述分配通道。

公开(公告)号：US20110256026A1

公开(公告)日：2011-10-20

申请号：US13170927

申请日：2011-06-28

申请人： Do Gyoon KIM ,  Han Sang KIM ,  Yang Ui LEE ,  Yoon Kyoung CHO ,  Na Hui KIM ,  Sang Bum PARK

发明人： Do Gyoon KIM ,  Han Sang KIM ,  Yang Ui LEE ,  Yoon Kyoung CHO ,  Na Hui KIM ,  Sang Bum PARK

IPC分类号： G01N21/00

CPC分类号： B01L3/502753 ,  B01L3/5027 ,  B01L3/50273 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0806 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0409 ,  B01L2400/0677 ,  G01N33/54386 ,  G01N2035/0449

摘要： A microfluidic device having a delay structure and a sample testing apparatus including the microfluidic device are provided. The microfluidic device includes: a reaction chamber which contains a reagent capable of reacting with a sample; a distribution channel through which the sample is provided to the reaction chamber; an inlet channel through which the at least one reaction chamber is connected with the distribution channel; and a delay structure which is located between the at least one reaction chamber and the distribution channel, and delays movement of contents of the reaction chamber to the distribution channel.

摘要翻译： 提供具有延迟结构的微流体装置和包括微流体装置的样品测试装置。 微流体装置包括：反应室，其含有能够与样品反应的试剂; 将样品提供给反应室的分配通道; 入口通道，所述至少一个反应室通过所述入口通道与所述分配通道连接; 以及延迟结构，其位于所述至少一个反应室和所述分配通道之间，并且将所述反应室的内容物的运动延迟到所述分配通道。