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15 条记录 (耗时 0.098 秒)

    Antibodies directed to the testis-specific tubulin tyrosine-ligase-like protein, BGS42
    6.
    发明授权
    Antibodies directed to the testis-specific tubulin tyrosine-ligase-like protein, BGS42 有权
    针对睾丸特异性微管蛋白酪氨酸连接酶样蛋白BGS42的抗体

    公开(公告)号：US07309779B2

    公开(公告)日：2007-12-18

    申请号：US11445988

    申请日：2006-06-02

    申请人： John N. Feder ,  Shujian Wu ,  Thomas C. Nelson ,  Liana M. Lee

    发明人： John N. Feder ,  Shujian Wu ,  Thomas C. Nelson ,  Liana M. Lee

    IPC分类号： C07K16/40 ,  C12N5/12

    CPC分类号： C12N9/93 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K2319/00 ,  G01N33/57423 ,  G01N2333/9015 ,  Y10S435/81

    摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding novel cysteine proteases of the calpain superfamily, CAN-12v1 and CAN-12v2.
    8.
    发明授权
    Polynucleotides encoding novel cysteine proteases of the calpain superfamily, CAN-12v1 and CAN-12v2. 有权
    编码钙蛋白酶超家族，CAN-12v1和CAN-12v2的新型半胱氨酸蛋白酶的多核苷酸。

    公开(公告)号：US07186564B2

    公开(公告)日：2007-03-06

    申请号：US10116519

    申请日：2002-04-03

    申请人： Jian Chen ,  Thomas C. Nelson ,  Roy J. Vaz ,  Franck Duclos

    发明人： Jian Chen ,  Thomas C. Nelson ,  Roy J. Vaz ,  Franck Duclos

    IPC分类号： C12N15/57 ,  C12N9/64 ,  C12N15/74 ,  C12N15/79

    CPC分类号： C12N9/6472 ,  A61K38/00 ,  C07K2299/00 ,  Y02A90/26

    摘要： The present invention provides novel polynucleotides encoding CAN-12 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of CAN-12 polypeptides, CAN-12v1 and CAN-12v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel CAN-12, CAN-12v1, and CAN-12v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly neuro- and musculo-degenerative conditions. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供编码CAN-12多肽的新型多核苷酸，其片段和同系物。 本发明还提供编码CAN-12多肽，CAN-12v1和CAN-12v2变体的多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型CAN-12，CAN-12v1和CAN-12v2多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法，特别是神经 - 和肌肉退行性疾病。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Method of diagnosing lung cancer using BGS42
    9.
    发明授权
    Method of diagnosing lung cancer using BGS42 有权
    使用BGS42诊断肺癌的方法

    公开(公告)号：US07741025B2

    公开(公告)日：2010-06-22

    申请号：US11900344

    申请日：2007-09-10

    申请人： John N. Feder ,  Shujian Wu ,  Thomas C. Nelson ,  Liana M. Lee

    发明人： John N. Feder ,  Shujian Wu ,  Thomas C. Nelson ,  Liana M. Lee

    IPC分类号： C12Q1/70 ,  C12Q1/68

    CPC分类号： C12N9/93 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K2319/00 ,  G01N33/57423 ,  G01N2333/9015 ,  Y10S435/81

    摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

    Polynucleotides encoding a novel metalloprotease, MP-1
    10.
    发明授权
    Polynucleotides encoding a novel metalloprotease, MP-1 有权
    编码新型金属蛋白酶MP-1的多核苷酸

    公开(公告)号：US06642041B2

    公开(公告)日：2003-11-04

    申请号：US10067443

    申请日：2002-02-05

    申请人： Jian Chen ,  John N. Feder ,  Thomas C. Nelson ,  Stanley R. Krystek ,  Franck Duclos

    发明人： Jian Chen ,  John N. Feder ,  Thomas C. Nelson ,  Stanley R. Krystek ,  Franck Duclos

    IPC分类号： C12N948

    CPC分类号： C12N9/6489 ,  C07K2299/00

    摘要： The present invention provides novel polynucleotides encoding MP-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MP-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

    摘要翻译： 本发明提供了编码MP-1多肽，其片段和同系物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型MP-1多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。