公开(公告)号：US20090317478A1

公开(公告)日：2009-12-24

申请号：US12255163

申请日：2008-10-21

申请人： Dong Keun HAN ,  Kwideok Park ,  Jae-Jin Kim ,  Jun Sik Son ,  Soon Eon Bae

发明人： Dong Keun HAN ,  Kwideok Park ,  Jae-Jin Kim ,  Jun Sik Son ,  Soon Eon Bae

IPC分类号： A61K9/14 ,  A61K38/21

CPC分类号： A61K9/1647 ,  A61K9/1694 ,  A61K38/00

摘要： The present invention relates to covered porous biodegradable polymer microspheres for sustained-release drug delivery and tissue regeneration which has an interconnected inner open pore structure having a wide surface area and high porosity and an outer closed pore structure in which the surface of the microsphere is covered with a thin layer of a biodegradable polymer, and thereby the pores formed on the surface and exposed to the outside are closed; and methods for preparing the same. Due to such a characteristic pore structure, the covered porous biodegradable polymer microspheres according to the present invention can prevent the biologically active material from being excessively released in the early stage immediately after administration, and after that, can gradually release the biologically active material through the interconnected inner pore structure over a prolonged period as the biodegradable polymer thin layer is degraded. Therefore, the microsphere of the present invention can be effectively used for sustained-release drug delivery and tissue regeneration.

摘要翻译： 本发明涉及用于持续释放药物递送和组织再生的覆盖多孔可生物降解聚合物微球，其具有互连的具有宽表面积和高孔隙率的内开孔结构以及微球表面被覆盖的外封闭孔结构 具有可生物降解聚合物的薄层，从而形成在表面上并暴露于外部的孔闭合; 及其制备方法。 由于这样的特征性的孔结构，本发明的被覆多孔生物降解性聚合物微球体可以防止生物活性物质在给药后立即早期过度释放，之后可以通过使用生物活性物质逐渐释放生物活性物质 随着可生物降解的聚合物薄层的退化，延长的互连内孔结构。 因此，本发明的微球体可以有效地用于缓释药物递送和组织再生。

公开(公告)号：US20100129422A1

公开(公告)日：2010-05-27

申请号：US12473850

申请日：2009-05-28

申请人： Dong Keun HAN ,  Kwideok Park ,  Jae-Jin Kim ,  Soon Eon Bae

发明人： Dong Keun HAN ,  Kwideok Park ,  Jae-Jin Kim ,  Soon Eon Bae

IPC分类号： A61F2/00

CPC分类号： A61L27/50 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/25 ,  A61L2300/414 ,  A61L2300/428 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2400/18 ,  C08L67/04

摘要： The present invention relates to an intelligent porous biodegradable polymer scaffold for in situ tissue regeneration in which two kinds of physiologically active substances having high differentiation potential and biocompatibility are introduced into the polymer scaffold and conjugated to the surface thereof, respectively, and a method for the preparation thereof. Since the intelligent porous biodegradable polymer scaffold exhibits improved biocompatibility and differentiation potential due to the introduction of physiologically active substances capable of efficiently inducing cell proliferation and differentiation into both the surface and the inside thereof, it can directly induce in situ tissue regeneration of the musculoskeletal system from stem cells in a living tissue after transplanting the polymer scaffold and stem cells into a human body without additional in vitro cultivation. Therefore, the intelligent porous biodegradable polymer scaffold according to the present invention can be effectively used in the regeneration of various kinds of tissues and organs including the musculoskeletal system.

摘要翻译： 本发明涉及一种用于原位组织再生的智能多孔可生物降解聚合物支架，其中将具有高分化潜能和生物相容性的两种生理活性物质分别引入聚合物支架并与其表面共轭， 的制备。 由于智能多孔生物可降解聚合物支架由于引入能够有效诱导细胞增殖和分化至其表面和内部的生理活性物质而显示出改善的生物相容性和分化潜能，因此可直接诱导肌肉骨骼系统的原位组织再生 从移植聚合物支架和干细胞到人体中的生物体组织中的干细胞，而不需要额外的体外培养。 因此，根据本发明的智能多孔生物可降解聚合物支架可以有效地用于包括肌肉骨骼系统在内的各种组织和器官的再生。

公开(公告)号：US08192655B2

公开(公告)日：2012-06-05

申请号：US12255163

申请日：2008-10-21

申请人： Dong Keun Han ,  Kwideok Park ,  Jae-Jin Kim ,  Jun Sik Son ,  Soon Eon Bae

发明人： Dong Keun Han ,  Kwideok Park ,  Jae-Jin Kim ,  Jun Sik Son ,  Soon Eon Bae

IPC分类号： B29B9/00

CPC分类号： A61K9/1647 ,  A61K9/1694 ,  A61K38/00

摘要： The present invention relates to covered porous biodegradable polymer microspheres for sustained-release drug delivery and tissue regeneration which has an interconnected inner open pore structure having a wide surface area and high porosity and an outer closed pore structure in which the surface of the microsphere is covered with a thin layer of a biodegradable polymer, and thereby the pores formed on the surface and exposed to the outside are closed; and methods for preparing the same. Due to such a characteristic pore structure, the covered porous biodegradable polymer microspheres according to the present invention can prevent the biologically active material from being excessively released in the early stage immediately after administration, and after that, can gradually release the biologically active material through the interconnected inner pore structure over a prolonged period as the biodegradable polymer thin layer is degraded. Therefore, the microsphere of the present invention can be effectively used for sustained-release drug delivery and tissue regeneration.

摘要翻译： 本发明涉及用于持续释放药物递送和组织再生的覆盖多孔可生物降解聚合物微球，其具有互连的具有宽表面积和高孔隙率的内开孔结构以及微球表面被覆盖的外封闭孔结构 具有可生物降解聚合物的薄层，从而形成在表面上并暴露于外部的孔闭合; 及其制备方法。 由于这样的特征性的孔结构，本发明的被覆多孔生物降解性聚合物微球体可以防止生物活性物质在给药后立即早期过度释放，之后可以通过使用生物活性物质逐渐释放生物活性物质 随着可生物降解的聚合物薄层的退化，延长的互连内孔结构。 因此，本发明的微球体可以有效地用于缓释药物递送和组织再生。

公开(公告)号：US08956643B2

公开(公告)日：2015-02-17

申请号：US12473850

申请日：2009-05-28

申请人： Dong Keun Han ,  Kwideok Park ,  Jae-Jin Kim ,  Soon Eon Bae

发明人： Dong Keun Han ,  Kwideok Park ,  Jae-Jin Kim ,  Soon Eon Bae

IPC分类号： A61F2/00 ,  A61F13/00 ,  A61L27/50 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56

CPC分类号： A61L27/50 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/25 ,  A61L2300/414 ,  A61L2300/428 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2400/18 ,  C08L67/04

摘要： The present invention relates to an intelligent porous biodegradable polymer scaffold for in situ tissue regeneration in which two kinds of physiologically active substances having high differentiation potential and biocompatibility are introduced into the polymer scaffold and conjugated to the surface thereof, respectively, and a method for the preparation thereof. Since the intelligent porous biodegradable polymer scaffold exhibits improved biocompatibility and differentiation potential due to the introduction of physiologically active substances capable of efficiently inducing cell proliferation and differentiation into both the surface and the inside thereof, it can directly induce in situ tissue regeneration of the musculoskeletal system from stem cells in a living tissue after transplanting the polymer scaffold and stem cells into a human body without additional in vitro cultivation. Therefore, the intelligent porous biodegradable polymer scaffold according to the present invention can be effectively used in the regeneration of various kinds of tissues and organs including the musculoskeletal system.

摘要翻译： 本发明涉及一种用于原位组织再生的智能多孔可生物降解聚合物支架，其中将具有高分化潜能和生物相容性的两种生理活性物质分别引入聚合物支架并与其表面共轭， 的制备。 由于智能多孔生物可降解聚合物支架由于引入能够有效诱导细胞增殖和分化至其表面和内部的生理活性物质而显示出改善的生物相容性和分化潜能，因此可直接诱导肌肉骨骼系统的原位组织再生 从移植聚合物支架和干细胞到人体中的生物体组织中的干细胞，而不需要额外的体外培养。 因此，根据本发明的智能多孔生物可降解聚合物支架可以有效地用于包括肌肉骨骼系统在内的各种组织和器官的再生。

公开(公告)号：US20110263018A1

公开(公告)日：2011-10-27

申请号：US12902537

申请日：2010-10-12

申请人： Kwideok PARK ,  Dong Keun Han ,  Dong Hoon Choi ,  Jae-Jin Kim ,  Hee Joong Kim ,  Heung Jae Chun

发明人： Kwideok PARK ,  Dong Keun Han ,  Dong Hoon Choi ,  Jae-Jin Kim ,  Hee Joong Kim ,  Heung Jae Chun

IPC分类号： C12N5/02 ,  C12N5/00

CPC分类号： C12N5/0075 ,  A61K9/1647 ,  A61K9/5036 ,  C12N2533/40

摘要： The present invention relates to a method of preparing a delivery system capable of loading bioactive growth factors that are essential for the differentiation and proliferation of cells and is characterized as loading at least two types of components comprising growth factors in a single carrier, whereby the release of each of the plurality of growth factors can be temporally controlled. Specifically, the method of preparing a microcapsule type growth factor delivery system according to the present invention includes: (1) preparing a polymeric microsphere comprising a first component, and then encapsulating the microspheres by electrodropping the polymer microsphere into another polymer comprising a second component, thereby manufacturing a core-shell structured, microcapsule type delivery system, or (2) encapsulating a polymer solution comprising a first component by electrodropping the polymer solution into another polymer comprising a second component, thereby manufacturing a core-shell structured microcapsule type delivery system. The present invention also provides a stem cell differentiation method involving bringing a microcapsule type delivery system loaded with multiple growth factors according to the present invention into contact with stem cells.

摘要翻译： 本发明涉及一种制备能够载入对细胞分化和增殖至关重要的生物活性生长因子的递送系统的方法，其特征在于将至少两种包含生长因子的组分装载在单个载体中，由此释放 可以暂时控制多个生长因子中的每一个。 具体而言，本发明的微胶囊型生长因子递送系统的制备方法包括：（1）制备包含第一成分的聚合物微球体，然后通过将聚合物微球体电渗入另一种包含第二组分的聚合物中来包封微球体， 从而制造芯壳结构的微胶囊型输送系统，或（2）通过将聚合物溶液电渗到另一种包含第二组分的聚合物中，将包含第一组分的聚合物溶液包封，由此制造核 - 壳结构的微胶囊型递送系统。 本发明还提供一种干细胞分化方法，其包括使根据本发明的负载有多种生长因子的微胶囊型递送系统与干细胞接触。

公开(公告)号：US20100098762A1

公开(公告)日：2010-04-22

申请号：US12573037

申请日：2009-10-02

申请人： Dong Keun Han ,  Kwideok Park ,  Jae-Jin Kim

发明人： Dong Keun Han ,  Kwideok Park ,  Jae-Jin Kim

IPC分类号： A61K9/10 ,  A61K38/18 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61P19/04

CPC分类号： A61K9/06 ,  A61K47/10 ,  A61K47/60

摘要： The present invention relates to a thermosensitive pluronic derivative hydrogel for tissue regeneration in which a biodegradable polymer is introduced at one end or both ends of a pluronic polymer, a methacryloxyethyl trimellitic acid anhydride is conjugated to the biodegradable polymer, and a physiologically active substance is fixed to the methacryloxyethyl trimellitic acid anhydride, as well as a method for the preparation thereof. The pluronic derivative hydrogel according to the present invention exhibits high biodegradability due to the introduction of a biodegradable polymer while still maintaining the themosensitivity of the pluronic polymer itself and shows good biocompatibility owing to the coupling with a physiologically active substance capable of improving cell adhesion, proliferation and differentiation. Therefore, the pluronic derivative hydrogel according to the present invention can be effectively used in the regeneration of various kinds of tissues and organs.

摘要翻译： 本发明涉及用于组织再生的热敏普朗尼克衍生物水凝胶，其中在聚醚聚合物的一端或两端引入可生物降解的聚合物，将甲基丙烯酰氧基乙基偏苯三酸酐与可生物降解的聚合物缀合，并且将生理活性物质固定 到甲基丙烯酰氧基乙基偏苯三酸酐，以及其制备方法。 本发明的聚醚衍生物水凝胶由于引入生物可降解聚合物而具有高生物降解性，同时仍然保持了普鲁隆聚合物本身的敏感性，并且由于与能够改善细胞粘附，增殖的生理活性物质的偶联而显示出良好的生物相容性 和分化。 因此，根据本发明的普流纶衍生物水凝胶可以有效地用于各种组织和器官的再生。

公开(公告)号：US08734911B2

公开(公告)日：2014-05-27

申请号：US12912913

申请日：2010-10-27

申请人： Dong Keun Han ,  Kwi Deok Park ,  Jae-Jin Kim ,  Chul Ho Park ,  Seong Bae Cho

发明人： Dong Keun Han ,  Kwi Deok Park ,  Jae-Jin Kim ,  Chul Ho Park ,  Seong Bae Cho

IPC分类号： B05D3/06 ,  B05D3/08 ,  H05H1/00

CPC分类号： B05D7/14 ,  A61L27/00 ,  A61L27/28 ,  A61L27/34 ,  A61L31/10 ,  A61L2400/12 ,  A61L2400/18 ,  B05D1/18 ,  B05D3/142 ,  Y10T428/273 ,  Y10T428/31678 ,  C08L67/04

摘要： Disclosed is nanocoupling of a polymer onto a surface of a metal substrate for improving coating adhesion of the polymer on the metal substrate, and in vivo stability and durability of the polymer. In accordance with the present invention, the polymers can be grafted via a chemical bonding on the surface of the metal substrate by the nanocoupling, by which adhesion, biocompatibility and durability of a polymer-coated layer which is to be formed later on the metal substrate were remarkably improved; therefore, the nanocoupling according to the present invention can be applied to surface modification of a metal implant, such as stents, mechanical valves, and an articular, a spinal, a dental and an orthopedic implants.

摘要翻译： 公开了聚合物在金属基材的表面上的纳米偶联，用于改善聚合物在金属基材上的涂层粘附性，以及聚合物的体内稳定性和耐久性。 根据本发明，聚合物可以通过纳米偶联在金属基材的表面上通过化学键接合，由此将在金属基材上稍后形成的聚合物涂覆层的粘附性，生物相容性和耐久性 显着改善; 因此，根据本发明的纳米偶联可以应用于诸如支架，机械瓣膜以及关节，脊柱，牙科和矫形植入物的金属植入物的表面改性。

公开(公告)号：US09459472B2

公开(公告)日：2016-10-04

申请号：US13642351

申请日：2011-04-22

申请人： Jae-Jin Kim ,  Bu-Gon Shin ,  Won-Jong Kwon

发明人： Jae-Jin Kim ,  Bu-Gon Shin ,  Won-Jong Kwon

IPC分类号： G02F1/153 ,  G02F1/13

CPC分类号： G02F1/1323 ,  G02F1/1533 ,  G02F2001/1536 ,  G02F2201/44

摘要： A privacy filter and its preparation method are disclosed. One embodiment of the privacy filter comprises: a first transparent substrate; a second transparent substrate positioned a predetermined distance apart from and opposite to the first transparent substrate; an electrolyte filled between the first and second transparent substrates; and a second transparent conductive layer disposed between the electrolyte and the second transparent substrate. The first transparent substrate comprises: an uneven pattern having a wire grid and trenches formed on the first transparent substrate; a first transparent conductive layer formed on the wire grid and the trenches of the uneven pattern; and an electrochromic layer being formed on the first transparent conductive layer along the sidewall of the wire grid and containing an electrochromic material to transmit or absorb visible light depending on whether an electrical signal is applied or not.

摘要翻译： 公开了一种隐私过滤器及其制备方法。 隐私过滤器的一个实施例包括：第一透明衬底; 第二透明基板，其与第一透明基板隔开并相对定位; 填充在第一和第二透明基板之间的电解质; 以及设置在电解质和第二透明基板之间的第二透明导电层。 第一透明基板包括：具有线栅的不均匀图案和形成在第一透明基板上的沟槽; 形成在线栅上的第一透明导电层和不均匀图案的沟槽; 以及电致变色层，其沿着所述导线栅格的侧壁形成在所述第一透明导电层上，并且根据是否施加电信号而含有电致变色材料以透射或吸收可见光。

公开(公告)号：US20120183739A1

公开(公告)日：2012-07-19

申请号：US13497678

申请日：2010-08-24

申请人： Jae-Jin Kim ,  Sin-Young Kim ,  Bu-Gon Shin ,  Tae-Su Kim

发明人： Jae-Jin Kim ,  Sin-Young Kim ,  Bu-Gon Shin ,  Tae-Su Kim

IPC分类号： B32B3/30 ,  G03F7/20 ,  G02B5/30 ,  B82Y30/00 ,  B82Y40/00

CPC分类号： G02B5/3058 ,  Y10T428/1005 ,  Y10T428/2457

摘要： There are provided a UV high-transmittance double-layer wire grid polarizer for a photo-alignment film and a method for manufacturing the same. The UV high-transmittance double-layer wire grid polarizer for a photo-alignment film includes: a substrate; an anti-reflection layer disposed on the substrate; a patterned photoresist layer disposed on the anti-reflection layer; and metal thin films disposed on the photoresist layer and the anti-reflection layer.

摘要翻译： 提供了用于光取向膜的UV高透光率双层线栅偏振器及其制造方法。 用于光取向膜的UV高透光率双层线栅偏振器包括：基板; 设置在所述基板上的防反射层; 设置在防反射层上的图案化光致抗蚀剂层; 以及设置在光致抗蚀剂层和抗反射层上的金属薄膜。

公开(公告)号：US08113648B2

公开(公告)日：2012-02-14

申请号：US12312858

申请日：2007-12-05

申请人： Tae-Su Kim ,  Jae-Jin Kim ,  Bu-Gon Shin ,  Duk-Sik Ha ,  Jung-Ho Park

发明人： Tae-Su Kim ,  Jae-Jin Kim ,  Bu-Gon Shin ,  Duk-Sik Ha ,  Jung-Ho Park

IPC分类号： B05D1/26 ,  B05D3/00

CPC分类号： H05K3/125 ,  H05K3/107 ,  H05K3/1208 ,  H05K3/1258 ,  H05K3/381 ,  H05K2201/09036 ,  H05K2201/09045 ,  H05K2201/2072 ,  H05K2203/013 ,  Y10T428/24355 ,  Y10T428/24521 ,  Y10T428/24537 ,  Y10T428/24545 ,  Y10T428/2457 ,  Y10T428/24612 ,  Y10T428/2462 ,  Y10T428/24669 ,  Y10T428/24694 ,  Y10T428/24802

摘要： A method for high resolution ink-jet print using a pre-patterned substrate employs an ink-jet printing device including an ink-jet head for discharging conductive ink droplets and a driving stage for supporting a substrate to which the conductive ink droplets are hit, to draw a fine line width pattern on the substrate. The method includes (A) forming a stripe pattern with repeated stripes on a substrate surface on which a fine line width pattern will be formed, thereby preparing a pre-patterned substrate; (B) loading the substrate to the ink-jet printing device; and (C) injecting conductive ink droplets to a substrate region where the stripe pattern is formed. An equivalent interval (d) of the stripe pattern and a fine line width (D) of the drawn fine line width pattern satisfy a relation of d

摘要翻译： 使用预图案化基板的高分辨率喷墨打印方法采用喷墨打印装置，其包括用于排放导电墨滴的喷墨头和用于支撑导电墨滴撞击的基板的驱动台， 以在衬底上画出细线宽度图案。 该方法包括：（A）在其上将形成细线宽度图案的基板表面上形成具有重复条纹的条纹图案，从而制备预图案化基板; （B）将基板装载到喷墨打印装置; 和（C）将导电墨滴注入形成条纹图案的基片区域。 条形图案的等效间隔（d）和所绘制的细线宽度图案的细线宽度（D）满足d << D的关系，并且所击中的墨滴以该区域内的各向异性形式流动。