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公开(公告)号：US12091650B2
公开(公告)日：2024-09-17
申请号：US16286185
申请日：2019-02-26
发明人： S. Jordan Kerns , Norman Wen , Carolina Lucchesi , Christopher David Hinojosa , Jacob Fraser , Geraldine Hamilton , Gad Vatine , Samuel Sances , Clive Svendsen , Daniel Levner , Dhruv Sareen
CPC分类号： C12M23/16 , B01L3/502715 , C12M25/02 , C12N5/0068 , C12N5/0619 , C12N5/0622 , C12N5/069 , B01L2200/0647 , B01L2300/0861 , C12N2502/081 , C12N2502/28 , C12N2506/02 , C12N2506/45 , C12N2531/00 , C12N2539/00
摘要： The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
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公开(公告)号：US11174462B2
公开(公告)日：2021-11-16
申请号：US15955335
申请日：2018-04-17
发明人： S. Jordan Kerns , Norman Wen , Carolina Lucchesi , Christopher David Hinojosa , Jacob Fraser , Geraldine Hamilton , Gad Vatine , Samuel Sanees , Clive Svendsen , Daniel Levner , Dhruv Sareen
摘要： The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
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公开(公告)号：US20180305651A1
公开(公告)日：2018-10-25
申请号：US15768736
申请日：2016-10-19
发明人： S. Jordan Kerns , Norman Wen , Carolina Lucchesi , Christopher David Hinojosa , Jacob Fraser , Geraldine Hamilton , Gad Vatine , Samuel Sances , Clive Svendsen , Daniel Levner , Dhruv Sareen
IPC分类号： C12M3/06 , C12N5/0793 , C12N5/071 , B01L3/00
CPC分类号： C12N5/0619 , B01L3/5027 , B01L2200/0647 , B01L2300/0861 , C12M23/16 , C12M25/02 , C12M35/08 , C12N5/0618 , C12N5/0622 , C12N5/069 , C12N5/0692 , C12N2502/081 , C12N2502/086 , C12N2502/28 , C12N2506/45 , C12N2531/00 , C12N2533/52 , C12N2533/54 , C12N2533/56 , C12N2535/10 , C12N2539/00 , C12Q1/02
摘要： The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
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公开(公告)号：US20180298332A1
公开(公告)日：2018-10-18
申请号：US15955383
申请日：2018-04-17
发明人： S. Jordan Kerns , Norman Wen , Carolina Lucchesi , Christopher David Hinojosa , Jacob Fraser , Geraldine Hamilton , Gad Vatine , Samuel Sances , Clive Svendsen , Daniel Levner , Dhruv Sareen
IPC分类号： C12N5/0793 , C12N5/071 , C12M3/06 , C12M1/12 , C12M1/42
摘要： The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
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公开(公告)号：US20240228954A1
公开(公告)日：2024-07-11
申请号：US18529198
申请日：2023-12-05
发明人： S. Jordan Kerns , Norman Wen , Carolina Lucchesi , Christopher David Hinojosa , Jacob Fraser , Geraldine Hamilton , Gad Vatine , Samuel Sances , Clive Svendsen , Daniel Levner , Dhruv Sareen
CPC分类号： C12N5/0619 , C12N5/0622 , C12N5/069 , C12N5/0692 , C12Q1/02 , B01L3/5027 , B01L2200/0647 , B01L2300/0861 , C12M23/16 , C12M25/02 , C12M35/08 , C12N5/0618 , C12N2502/081 , C12N2502/086 , C12N2502/28 , C12N2506/45 , C12N2531/00 , C12N2533/52 , C12N2533/54 , C12N2533/56 , C12N2535/10 , C12N2539/00
摘要： The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
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公开(公告)号：US20180298331A1
公开(公告)日：2018-10-18
申请号：US15955335
申请日：2018-04-17
发明人： S. Jordan Kerns , Norman Wen , Carolina Lucchesi , Christopher David Hinojosa , Jacob Fraser , Geraldine Hamilton , Gad Vatine , Samuel Sances , Clive Svendsen , Daniel Levner , Dhruv Sareen
摘要： The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
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公开(公告)号：US12098352B2
公开(公告)日：2024-09-24
申请号：US16983850
申请日：2020-08-03
申请人： EMULATE, INC.
发明人： Janna Nawroth , Riccardo Barrile , David Conegliano , Remi Villenave , Carolina Lucchesi , Justin Nguyen , Antonio Varone , Catherine Karalis , Geraldine Hamilton
CPC分类号： C12M23/16 , B01L3/5027 , C12N5/0688 , C12N5/0696 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/155 , C12N2501/41 , C12N2502/1323 , C12N2502/27 , C12N2503/04 , C12N2506/02 , C12N2513/00 , G01N2800/12
摘要： An in vitro microfluidic “organ-on-chip” device is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a stem cell-based Lung-on-Chip is described. This in vitro microfluidic system can be used for modeling differentiation of cells on-chip into lung cells, e.g., a lung (Lung-On-Chip), bronchial (Airway-On-Chip; small-Airway-On-Chip), alveolar sac (Alveolar-On-Chip), etc., for use in modeling disease states of derived tissue, i.e. as healthy, pre-disease and diseased tissues. Additionally, stem cells under differentiation protocols for deriving (producing) differentiated lung cells off-chips may be seeded onto microfluidic devices at any desired point during the in vitro differentiation pathway for further differentiation on-chip or placed on-chip before, during or after terminal differentiation.
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公开(公告)号：US20240076625A1
公开(公告)日：2024-03-07
申请号：US18243242
申请日：2023-09-07
申请人： EMULATE, INC.
发明人： Antonio Varone , Magdalena Kasendra , Carolina Lucchesi , S. Jordan Kerns , Riccardo Barrile , Sonalee Barthakur
CPC分类号： C12N5/0679 , B01L3/502715 , B01L3/502761 , C12M23/16 , C12M23/26 , C12M25/02 , C12N5/069 , G01N1/30 , G01N33/5047 , G01N33/5064 , B01L2200/16 , B01L2300/123 , B01L2300/16 , C12N2500/00 , C12N2501/052 , C12N2501/2301 , C12N2501/2306 , C12N2501/25
摘要： The present invention contemplates compositions, devices and methods of simulating biological fluids in a fluidic device, including but not limited to a microfluidic chip. In one embodiment, fluid comprising a colloid under flow in a microfluidic chip has a fluid density or viscosity similar to a bodily fluid, e.g. blood, lymph, lung fluid, or the like. In one embodiment, a fluid is provided as a rheologically biomimetic blood surrogate or substitute for simulating physiological shear stress and cell dynamics in fluidic device, including but not limited to immune cells.
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公开(公告)号：US11833512B2
公开(公告)日：2023-12-05
申请号：US17215900
申请日：2021-03-29
申请人： EMULATE, Inc.
发明人： S. Jordan Kerns , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Daniel Levner , Carolina Lucchesi , Antonio Varone , Remi Villenave
CPC分类号： B01L3/502753 , B01L3/502715 , C12M23/16 , C12M29/04 , C12M35/08 , G01N33/5044 , C12N5/0018 , C12N5/0075
摘要： An in vitro microfluidic “organ-on-chip” is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and the associated tissue specific epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory tissue, e.g., autoimmune disorders involving epithelia and diseases involving epithelial layers. These multicellular, layered microfluidic “organ-on-chip”, e.g. “epithelia-on-chip” further allow for comparisons between types of epithelia tissues, e.g., lung (Lung-On-Chip), bronchial (Airway-On-Chip), skin (Skin-On-Chip), cervix (Cervix-On-Chip), blood brain barrier (BBB-On-Chip), etc., in additional to neurovascular tissue, (Brain-On-Chip), and between different disease states of tissue, i.e. healthy, pre-disease and diseased areas. Additionally, these microfluidic “organ-on-chips” allow identification of cells and cellular derived factors driving disease states in addition to drug testing for reducing inflammation effecting epithelial regions.
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公开(公告)号：US20240024873A1
公开(公告)日：2024-01-25
申请号：US18374319
申请日：2023-09-28
申请人： EMULATE, Inc.
发明人： S. Jordan Kerns , Riccardo Barrile , Geraldine Hamilton , Catherine Karalis , Daniel Levner , Carolina Lucchesi , Antonio Varone , Remi Villenave
CPC分类号： B01L3/502753 , C12M29/04 , C12M23/16 , C12M35/08 , B01L3/502715 , G01N33/5044 , C12N5/0018
摘要： An in vitro microfluidic “organ-on-chip” is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and the associated tissue specific epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory tissue, e.g., autoimmune disorders involving epithelia and diseases involving epithelial layers. These multicellular, layered microfluidic “organ-on-chip”, e.g. “epithelia-on-chip” further allow for comparisons between types of epithelia tissues, e.g., lung (Lung-On-Chip), bronchial (Airway-On-Chip), skin (Skin-On-Chip), cervix (Cervix-On-Chip), blood brain barrier (BBB-On-Chip), etc., in additional to neurovascular tissue, (Brain-On-Chip), and between different disease states of tissue, i.e. healthy, pre-disease and diseased areas. Additionally, these microfluidic “organ-on-chips” allow identification of cells and cellular derived factors driving disease states in addition to drug testing for reducing inflammation effecting epithelial regions.
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