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22 条记录 (耗时 0.023 秒)

    Method and circuit for bypassing spurious resonance in lumped, distributed and waveguide element networks
    3.
    发明授权
    Method and circuit for bypassing spurious resonance in lumped, distributed and waveguide element networks 有权

    公开(公告)号：US11303259B2

    公开(公告)日：2022-04-12

    申请号：US16689623

    申请日：2019-11-20

    申请人： Richard Snyder

    发明人： Richard Snyder

    IPC分类号： H03H7/01

    摘要： Disclosed herein are methods and circuits that prevent energy that would produce a spurious resonance from lumped, distributed or waveguide circuit elements by using for example a low pass filter with a cut-off below the first spurious resonance frequency and bypassing the energy at frequencies at or above the first spurious resonance frequency through a secondary path. This secondary path is high pass in nature, with a cutoff substantially similar to the low pass filter. The two paths are combined at the common output, using a lowpass matching network.

    Methods for increasing the efficiency of recombinant AAV product
    5.
    发明授权
    Methods for increasing the efficiency of recombinant AAV product 失效
    提高重组AAV产品效率的方法

    公开(公告)号：US06548286B1

    公开(公告)日：2003-04-15

    申请号：US09060102

    申请日：1998-04-14

    申请人： Richard Jude Samulski ,  Xiao Xiao ,  Richard Snyder

    发明人： Richard Jude Samulski ,  Xiao Xiao ,  Richard Snyder

    IPC分类号： C12N701

    CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2750/14121 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14152

    摘要： The present invention relates to methods and compositions for increasing the production of high titre stocks of recombinant AAV (rAAV) through regulation of expression of the AAV REP and CAP proteins. The methods and compositions of the invention are based on the observation that the low level expression of the AAV REP protein increases the production of AAV viral capsid protein and efficiency of packaging resulting in production of higher titre recombinant viral stocks. The invention encompasses recombinant AAV vectors that direct the expression of AAV REP and CAP proteins and the use of such vectors for the production of novel stable cell lines capable of generating high titre rAAV vectors. The invention provides methods for regulating the expression of the AAV REP gene at the transcriptional and post-translational level. The methods and compositions of the invention can be used to produce high titre stocks of rAAV which can be used in gene therapy for the purpose of transferring genetic information into appropriate host cells for the management and correction of human diseases including inherited and acquired disorders.

    摘要翻译： 本发明涉及通过调节AAV REP和CAP蛋白的表达来增加重组AAV（rAAV）的高滴度储备的生产的方法和组合物。 本发明的方法和组合基于AAV REP蛋白的低水平表达增加AAV病毒衣壳蛋白的产生和包装效率的观察，导致产生较高滴度的重组病毒种群。 本发明包括引导AAV REP和CAP蛋白的表达的重组AAV载体，以及这些载体用于产生能产生高滴度rAAV载体的新型稳定细胞系的用途。 本发明提供了在转录和翻译后水平调节AAV REP基因表达的方法。 本发明的方法和组合物可用于生产高滴度的rAAV，其可用于基因治疗，以将遗传信息转移到合适的宿主细胞中，用于管理和矫正包括遗传和获得性疾病在内的人类疾病。

    System and method for vertical flight planning
    6.
    发明申请
    System and method for vertical flight planning 有权
    垂直飞行计划的系统和方法

    公开(公告)号：US20050283281A1

    公开(公告)日：2005-12-22

    申请号：US10871668

    申请日：2004-06-21

    申请人： Gary Hartmann ,  Michael Jackson ,  Brian O'Laughlin ,  Richard Snyder ,  Rosa Weber

    发明人： Gary Hartmann ,  Michael Jackson ,  Brian O'Laughlin ,  Richard Snyder ,  Rosa Weber

    IPC分类号： G01C21/00 ,  G05D1/00 ,  G05D1/06

    CPC分类号： G05D1/0607 ,  G01C21/00

    摘要： A method for performing performance prediction with respect to a vertical flight plan. A system performs performance prediction with respect to a vertical flight plan of an aircraft that includes determining which vertical flight plan rules of a plurality of vertical flight rules that have been loaded in a predictions processor are active by monitoring for criteria that are used to initiate or terminate one or more of the vertical flight plan rules. Aircraft state is predicted at waypoints along a lateral flight path in view of active vertical flight plan rules, and the predicted aircraft state is updated within an integrated flight plan database that stores prediction performance data associated with the aircraft's flight.

    摘要翻译： 一种用于对垂直飞行计划进行性能预测的方法。 系统对飞行器的垂直飞行计划执行性能预测，其包括通过监视用于启动的标准来确定已经加载在预测处理器中的多个垂直飞行规则的哪些垂直飞行计划规则是活动的 终止一个或多个垂直飞行计划规则。 考虑到主动垂直飞行计划规则，沿着侧向飞行路径的航路点预测飞行器状态，并且在集成的飞行计划数据库内更新预测的飞行器状态，该飞行器状态存储与飞行器的飞行相关联的预测演奏数据。

    Filter assembly for cleaning cooling air for engines
    7.
    发明授权
    Filter assembly for cleaning cooling air for engines 失效
    用于清洁发动机冷却空气的过滤器组件

    公开(公告)号：US6162269A

    公开(公告)日：2000-12-19

    申请号：US299320

    申请日：1999-04-26

    申请人： Roy E. Greenlees ,  Richard Snyder ,  Kenneth S. Schultz ,  R. Ryan Greenlees

    发明人： Roy E. Greenlees ,  Richard Snyder ,  Kenneth S. Schultz ,  R. Ryan Greenlees

    IPC分类号： F01P11/12 ,  F02B77/00

    CPC分类号： F01P11/12 ,  Y10S55/28

    摘要： An engine filter assembly for cleaning cooling air for an internal-combustion engine for use in high-debris environment such as in roofing-removing machines includes a filter housing attached to the machine at a remote position. The filter housing houses a two-stage air filter that consists of a cylindrical-shaped filter element with an outer pre-filter covering. Both the carburetor air inlet and a fan housing leading to the cooling fan on the engine are connected to the filter housing by tubing. A shield protects the engine from direct contact with loose or air-borne materials during the operation of the machine. A thermal sensing device reads the temperature of the engine and automatically shuts down the engine if the temperature rises beyond specification, reducing the chance of engine failure.

    摘要翻译： 一种用于清洁用于高碎片环境的内燃机的冷却空气的发动机过滤器组件，例如在屋顶除尘机中包括在远程位置附接到机器的过滤器壳体。 过滤器壳体容纳两级空气过滤器，其由具有外部预过滤器覆盖物的圆柱形过滤元件组成。 化油器空气入口和通向发动机上的冷却风扇的风扇壳都通过管道连接到过滤器壳体。 屏蔽罩可保护发动机在机器运行过程中与松散或空气传播的材料直接接触。 如果温度升高超过规格，热感测装置读取发动机的温度并自动关闭发动机，减少发动机故障的机会。

    Method and Circuit for Bypassing Spurious Resonance in Lumped, Distributed and Waveguide Element Networks
    9.
    发明申请
    Method and Circuit for Bypassing Spurious Resonance in Lumped, Distributed and Waveguide Element Networks 审中-公开

    公开(公告)号：US20200177150A1

    公开(公告)日：2020-06-04

    申请号：US16689623

    申请日：2019-11-20

    申请人： Richard Snyder

    发明人： Richard Snyder

    IPC分类号： H03H7/01

    摘要： Disclosed herein are methods and circuits that prevent energy that would produce a spurious resonance from lumped, distributed or waveguide circuit elements by using for example a low pass filter with a cut-off below the first spurious resonance frequency and bypassing the energy at frequencies at or above the first spurious resonance frequency through a secondary path. This secondary path is high pass in nature, with a cutoff substantially similar to the low pass filter. The two paths are combined at the common output, using a lowpass matching network.